DE69331048T2 - Verfahren zur Herstellung von Cis-Oxalato (Trans-L-1,2-Cyclohexandiamin) Pt Komplex mit hoher optischer Reinheit - Google Patents

Verfahren zur Herstellung von Cis-Oxalato (Trans-L-1,2-Cyclohexandiamin) Pt Komplex mit hoher optischer Reinheit

Info

Publication number
DE69331048T2
DE69331048T2 DE69331048T DE69331048T DE69331048T2 DE 69331048 T2 DE69331048 T2 DE 69331048T2 DE 69331048 T DE69331048 T DE 69331048T DE 69331048 T DE69331048 T DE 69331048T DE 69331048 T2 DE69331048 T2 DE 69331048T2
Authority
DE
Germany
Prior art keywords
oxalato
cyclohexanediamine
cis
trans
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69331048T
Other languages
English (en)
Other versions
DE69331048D1 (de
Inventor
Koji Okamoto
Chihiro Nakanishi
Junichi Taniushi
Junji Ohnishi
Yasunibu Komoda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debiopharm SA
Original Assignee
Debiopharm SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15324481&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69331048(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Debiopharm SA filed Critical Debiopharm SA
Application granted granted Critical
Publication of DE69331048D1 publication Critical patent/DE69331048D1/de
Publication of DE69331048T2 publication Critical patent/DE69331048T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/86—Separation
    • C07C209/88—Separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69331048T 1993-05-21 1993-09-16 Verfahren zur Herstellung von Cis-Oxalato (Trans-L-1,2-Cyclohexandiamin) Pt Komplex mit hoher optischer Reinheit Expired - Lifetime DE69331048T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5142824A JP3025602B2 (ja) 1993-05-21 1993-05-21 光学的に高純度なシス−オキザラート（トランス−ｌ−１，２−シクロヘキサンジアミン）白金（ＩＩ）錯体の製造方法

Publications (2)

Publication Number Publication Date
DE69331048D1 DE69331048D1 (de) 2001-12-06
DE69331048T2 true DE69331048T2 (de) 2002-03-21

Family

ID=15324481

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69331048T Expired - Lifetime DE69331048T2 (de) 1993-05-21 1993-09-16 Verfahren zur Herstellung von Cis-Oxalato (Trans-L-1,2-Cyclohexandiamin) Pt Komplex mit hoher optischer Reinheit

Country Status (5)

Country Link
US (1) US5420319A (de)
EP (1) EP0625523B1 (de)
JP (1) JP3025602B2 (de)
DE (1) DE69331048T2 (de)
ES (1) ES2167328T3 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5555833A (en) * 1994-08-22 1996-09-17 Jet Sew Technologies, Inc. Sleeve insertion system for the manufacture of shirts
JPH09278785A (ja) * 1996-04-10 1997-10-28 Tanaka Kikinzoku Kogyo Kk 白金化合物の製造方法
JP3154399B2 (ja) * 1996-07-04 2001-04-09 デビオファーム エス．アー． 白金化合物の製造方法
GB9804013D0 (en) * 1998-02-25 1998-04-22 Sanofi Sa Formulations
ES2183714B1 (es) * 2001-05-25 2004-01-16 Desynth S A Un procedimiento para la fabricacion de oxalato de (1r,2r-ciclohexanodiamina)-platino (ii).
US20040186172A1 (en) * 2001-07-02 2004-09-23 Houssam Ibrahim Oxaliplatin active substance with a very low content of oxalic acid
US6476068B1 (en) 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
CZ297703B6 (cs) * 2003-10-17 2007-03-07 Pliva-Lachema A.S. Oxaliplatina s nízkým obsahem doprovodných necistot a zpusob její výroby
US7576126B2 (en) 2003-11-25 2009-08-18 Platco Technologies (Proprietary) Limited Platinum (II) complexes, preparation and use
SI1695991T1 (sl) * 2003-12-10 2010-04-30 Toudai Tlo Ltd Koordinacijski kompleks diaminocikloheksan platine (II) z blok kopolimerom, ki vsebuje segment poli(karboksilne kisline) in antitumorni agens, ki jih vsebuje
WO2005075489A1 (en) * 2004-02-05 2005-08-18 Dabur Pharma Limited A process for the perparation of an anti-tumor platinum (ii) - complex
DE102004005906B3 (de) * 2004-02-05 2005-09-29 W.C. Heraeus Gmbh Verfahren zur Herstellung von 1,2-Diaminocylohexan-Platin(II)-Komplexen
TW200617014A (en) 2004-07-12 2006-06-01 Sicor Inc Cis-diiodo-(trans-l-1,2-cyclohexanediamine) platinum (Ⅱ) complex and processes for preparing high purity oxaliplatin
AU2005278924A1 (en) * 2004-09-01 2006-03-09 Platco Technologies (Proprietary) Limited Preparation of platinum(II) complexes
JP2006248978A (ja) * 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
JP4992089B2 (ja) * 2005-03-18 2012-08-08 国立大学法人 東京大学 ジアミノシクロヘキサン白金（ｉｉ）とブロック共重合体との配位化合物及びそれを含有する抗がん剤
CA2604862A1 (en) 2005-04-09 2006-10-19 Vuab Pharma A.S. A process for the preparation of an oxaliplatin preparation
WO2007011962A2 (en) * 2005-07-18 2007-01-25 Bipar Sciences, Inc. Treatment of cancer
BRPI0708004A2 (pt) * 2006-01-30 2011-05-17 Platco Technologies Proprietary Ltd preparação de complexos de platina (ii)
EP2004175A4 (de) * 2006-03-16 2010-12-15 Bionumerik Pharmaceuticals Inc Verbindungen und formulierungen zur verstärkung der wirkung gegen krebs und verfahren zu deren verwendung
AR060635A1 (es) 2006-04-27 2008-07-02 Banyu Pharma Co Ltd Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer
EP2029615B8 (de) 2006-06-08 2011-02-02 Vuab Pharma A. S. Verfahren zur herstellung eines oxaliplatins
JP2010504079A (ja) * 2006-06-12 2010-02-12 バイパー サイエンシズ，インコーポレイティド Ｐａｒｐ阻害剤を用いる疾病の治療方法
US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
AU2007292306A1 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof
US8143447B2 (en) * 2006-09-05 2012-03-27 Bipar Sciences, Inc. Treatment of cancer
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
US20090076139A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched oxalplatin
EP2211854A4 (de) * 2007-10-19 2011-01-12 Bipar Sciences Inc Verfahren und zusammensetzungen zur behandlung von krebs mit parp-inhibitoren vom benzopyrontyp
US8329711B2 (en) 2007-10-23 2012-12-11 Msd K.K. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
NZ586123A (en) * 2007-11-12 2012-12-21 Bipar Sciences Inc Treatment of ovarian cancer with 4-iodo-3-nitrobenzamide in combination with topoisomerase inhibitors
EP2217227B1 (de) * 2007-11-12 2013-08-21 BiPar Sciences, Inc. Behandlung von brustkrebs mit 4-iodo-3-nitrobenzamid in kombination mit antitumoralen mitteln
RU2010128107A (ru) * 2007-12-07 2012-01-20 Байпар Сайенсиз, Инк. (Us) Лечение рака ингибиторами топоизомеразы в комбинации с ингибиторами parp
AU2008352603B2 (en) 2008-03-14 2012-05-31 Bionumerik Pharmaceuticals, Inc. Compositions and methods of use of compounds to increase cancer patient survival time
EP2249825B1 (de) 2008-03-14 2015-10-07 Bionumerik Pharmaceuticals, Inc. Behandlungsverfahren und zusammensetzungen gegen lungenkrebs, adenokarzinom und andere medizinische krankheitszustände
WO2009157561A1 (ja) * 2008-06-26 2009-12-30 独立行政法人科学技術振興機構 Mri造影能を有する重合体－金属錯体複合体、並びにそれを用いたmri造影用及び／又は抗腫瘍用組成物
WO2010098367A1 (en) 2009-02-25 2010-09-02 Banyu Pharmaceutical Co.,Ltd. Pyrimidopyrimidoindazole derivative
US8481503B2 (en) 2009-03-06 2013-07-09 Merck Sharp & Dohme Corp. Combination cancer therapy with an AKT inhibitor and other anticancer agents
CN102643308B (zh) * 2012-05-11 2014-05-07 海南锦瑞制药股份有限公司 一种奥沙利铂结晶化合物及其冻干粉针剂
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
KR102377252B1 (ko) 2013-02-28 2022-03-22 저니 메디컬 코퍼레이션 글리코피롤레이트 염
US8558008B2 (en) 2013-02-28 2013-10-15 Dermira, Inc. Crystalline glycopyrrolate tosylate
US20160009694A1 (en) * 2013-03-15 2016-01-14 Portola Pharmaceuticals, Inc. Cyclohexanediamine compounds and methods for their preparation
WO2017192290A1 (en) 2016-05-04 2017-11-09 The Wistar Institute Of Anatomy And Biology Methods of treating cancers overexpressing carm1 with ezh2 inhibitors and platinum-based antineoplastic drugs

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1443548A (en) * 1973-12-17 1976-07-21 Sumitomo Chemical Co 3-benzazocine compounds and their production
JPS6041077B2 (ja) * 1976-09-06 1985-09-13 喜徳 喜谷 １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体
YU93877A (en) * 1977-04-08 1982-06-30 Krka Process for the resolution of racemic alpha-aminonitrils
JPS6034958B2 (ja) * 1978-09-02 1985-08-12 喜徳 喜谷 新規白金錯体
US4661516A (en) * 1983-06-20 1987-04-28 Research Corporation Diaminocyclohexane platinum complexes
US4599352A (en) * 1984-03-01 1986-07-08 The United States Of America As Represented By The Department Of Health And Human Services Antineoplastic platinum (IV) complexes and compositions
JPS63203692A (ja) * 1987-02-19 1988-08-23 Nippon Kayaku Co Ltd 新規白金錯体
IT1205758B (it) * 1987-03-18 1989-03-31 Sigma Tau Ind Farmaceuti Procedimento per la produzione di (-) n-acetil ammino carnitina e di (+) n-acetil ammino carnitina
US5068368A (en) * 1990-05-10 1991-11-26 Cyprus Foote Mineral Company Stabilized lithium acetylide and reactions therewith
JPH0776230B2 (ja) * 1992-01-13 1995-08-16 田中貴金属工業株式会社 白金化合物の製造方法
JPH06287021A (ja) * 1992-04-22 1994-10-11 Tanaka Kikinzoku Kogyo Kk 光学活性な白金錯化合物の光学的分割方法

Also Published As

Publication number Publication date
ES2167328T3 (es) 2002-05-16
EP0625523A1 (de) 1994-11-23
JPH06329692A (ja) 1994-11-29
EP0625523B1 (de) 2001-10-31
JP3025602B2 (ja) 2000-03-27
US5420319A (en) 1995-05-30
DE69331048D1 (de) 2001-12-06

Similar Documents

Publication Publication Date Title
DE69331048T2 (de) Verfahren zur Herstellung von Cis-Oxalato (Trans-L-1,2-Cyclohexandiamin) Pt Komplex mit hoher optischer Reinheit
DE69010857D1 (de) Verfahren zur Herstellung dünner Schichten von hoher Reinheit.
DE69411468T2 (de) Verfahren zur Herstellung optischer Linsen
DE69010249D1 (de) Verfahren zur Herstellung optischer Wellenleiter.
DE69227786T2 (de) Verfahren zur Herstellung von Polycarbonat
DE3782783D1 (de) Verfahren zur herstellung optischer bauteile.
DE69104280D1 (de) Verfahren zur Herstellung von hochreiner Isophthalsäure.
DE69009909D1 (de) Gesteuertes Verfahren zur Herstellung mehrfacher optischer Rasterfilter.
DE69229898T2 (de) Verfahren zur Herstellung von Polycarbonat
DE68915676D1 (de) Verfahren zur Herstellung von Linsen.
DE69012535D1 (de) Verfahren zur Herstellung von Hydrogensiloxanen.
DE69103192D1 (de) Verfahren zur Herstellung von integrierten optischen Geräten mit feldunterstütztem Ionenaustausch.
DE69110590D1 (de) Verfahren zur Herstellung von Anilin von hoher Reinheit.
DE68916474D1 (de) Verfahren zur Herstellung von Polycarbonat.
DE69101337D1 (de) Verfahren zur Herstellung von Anilin hoher Reinheit.
DE3771751D1 (de) Verfahren zur herstellung von polyarylenthioaethern mit hoher stabilitaet.
DE69218663D1 (de) Verfahren zur Herstellung von optoelektronischen, hybriden Modulen
DE69127222D1 (de) Verfahren zur Herstellung von Epoxyalkoholen von hoher optischer Reinheit
DE69009682D1 (de) Verfahren zur Herstellung von Cyclohexanolderivaten.
DE3667271D1 (de) Verfahren zur herstellung von 5-ethyliden-2-norbornen von hoher qualitaet.
DE68918050D1 (de) Verfahren zur Herstellung von Windschutzscheiben.
DE68920351D1 (de) Verfahren zur Herstellung von Indigoverbindungen.
DE59407675D1 (de) Verfahren zur Herstellung von 6H-Dibenz-(c,e)(1,2)-oxaphosphorin-6-on
DE69105615D1 (de) Verfahren zur Herstellung von hochreiner Isophthalsäure.
DE68923312D1 (de) Verfahren zur Herstellung von Caprolactam mit hoher Reinheit.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition