ES2164901T3 - Derivados de alcaloides policiclicos como antagonistas de los receptores del nmda. - Google Patents
Derivados de alcaloides policiclicos como antagonistas de los receptores del nmda.Info
- Publication number
- ES2164901T3 ES2164901T3 ES96922703T ES96922703T ES2164901T3 ES 2164901 T3 ES2164901 T3 ES 2164901T3 ES 96922703 T ES96922703 T ES 96922703T ES 96922703 T ES96922703 T ES 96922703T ES 2164901 T3 ES2164901 T3 ES 2164901T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- pct
- antagonists
- independently
- nmda
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/08—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/16—Eight-membered rings
- C07D313/20—Eight-membered rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/16—Eight-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
ALCALOIDES POLICICLICOS DE FORMULA (I) EN LOS QUE R SUB,1} ES H, ALQUILO C SUB,1-6}, O ARILO C SUB,6-12} OPCIONALMENTE SUSTITUIDO CON GRUPOS POLARES; R SUB,2} Y R SUB,3} SON INDEPENDIENTEMENTE H, OH, ALQUILO C SUB,1-6} O HALOGENO; O R SUB,2} Y R SUB,3} JUNTOS FORMAN UN ANILLO DE 5 A 6 MIEMBROS QUE INCORPORA OPCIONALMENTE UN HETEROATOMO; R SUB,4} ES H, ALQUILO C SUB,1-6}, OR SUB,6}, SR SUB,6} O N(R SUB,6}) SUB,2}, EN DONDE CADA R SUB,6} ES INDEPENDIENTEMENTE H, ALQUILO C SUB,1-3}; X ES O, S, SO, SO SUB,2}, N DE CADA R SUB,5} ES INDEPENDIENTEMENTE H, ALQUILO C SUB,1-6}, O ARALQUILO C SUB,7-13} OPCIONALMENTE INTERRUMPIDO CON UNO O MAS HETEROATOMOS; N ES UN ENTERO DE 0 A 2; M ES UN ENTERO DE 0 A 3; CON LA CONDICION DE QUE CUANDO X ES CH SUB,2} ENTONCES R SUB,1} NO ES CH SUB,3}, R SUB,2} Y R SUB,3} NO SON AMBOS H, R SUB,4} NO ES OH, M NO ES 3 Y N NO ES 0. PUEDEN ACTUAR COMO ANTAGONISTAS EN EL RECEPTOR IONOTROPICO NMDA (ACIDO N D) ASPARTICO).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9514448.1A GB9514448D0 (en) | 1995-07-14 | 1995-07-14 | Novel heterocyclic NMDA-receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2164901T3 true ES2164901T3 (es) | 2002-03-01 |
Family
ID=10777682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96922703T Expired - Lifetime ES2164901T3 (es) | 1995-07-14 | 1996-07-12 | Derivados de alcaloides policiclicos como antagonistas de los receptores del nmda. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5990104A (es) |
| EP (1) | EP0840731B1 (es) |
| JP (1) | JPH11509533A (es) |
| CN (1) | CN1195344A (es) |
| AT (1) | ATE206616T1 (es) |
| AU (1) | AU696502B2 (es) |
| CA (1) | CA2223644A1 (es) |
| DE (1) | DE69615845T2 (es) |
| ES (1) | ES2164901T3 (es) |
| GB (1) | GB9514448D0 (es) |
| NO (1) | NO980145D0 (es) |
| WO (1) | WO1997003979A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001247762A1 (en) * | 2000-03-28 | 2001-10-08 | Delorenzo, Robert, J | Inhibition of a novel calcium injury current that forms in neurons during injury prevents neuronal cell death |
| AUPR215700A0 (en) * | 2000-12-19 | 2001-01-25 | Fujisawa Pharmaceutical Co., Ltd. | Carboxylic acid compound having cyclopropane ring |
| EP2425845A1 (en) * | 2004-12-23 | 2012-03-07 | Voyager Pharmaceutical Corporation | Acetylcholinesterase Inhibitors and leuprolide acetate for the treatment of Alzheimer's disease |
| US20220117913A1 (en) * | 2019-02-02 | 2022-04-21 | Yangtze River Pharmaceutical Group Co., Ltd. | Dezocine derivative and medical use thereof |
| CN112137996B (zh) * | 2020-10-23 | 2023-08-25 | 湖南农业大学 | 一种预防钩吻中毒的药物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3836670A (en) * | 1971-11-19 | 1974-09-17 | American Home Prod | Benzobicycloalkane amines for inducing analgesia |
| US4957909A (en) * | 1989-05-04 | 1990-09-18 | American Home Products Corporation | Benzobicycloalkane derivatives as anticonvulsant neuroprotective agents |
-
1995
- 1995-07-14 GB GBGB9514448.1A patent/GB9514448D0/en active Pending
-
1996
- 1996-07-12 ES ES96922703T patent/ES2164901T3/es not_active Expired - Lifetime
- 1996-07-12 DE DE69615845T patent/DE69615845T2/de not_active Expired - Fee Related
- 1996-07-12 EP EP96922703A patent/EP0840731B1/en not_active Expired - Lifetime
- 1996-07-12 AT AT96922703T patent/ATE206616T1/de not_active IP Right Cessation
- 1996-07-12 US US08/981,935 patent/US5990104A/en not_active Expired - Fee Related
- 1996-07-12 JP JP9506032A patent/JPH11509533A/ja not_active Ceased
- 1996-07-12 CA CA002223644A patent/CA2223644A1/en not_active Abandoned
- 1996-07-12 WO PCT/CA1996/000468 patent/WO1997003979A1/en active IP Right Grant
- 1996-07-12 CN CN96196727A patent/CN1195344A/zh active Pending
- 1996-07-12 AU AU63502/96A patent/AU696502B2/en not_active Ceased
-
1998
- 1998-01-13 NO NO980145A patent/NO980145D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU696502B2 (en) | 1998-09-10 |
| DE69615845T2 (de) | 2002-06-20 |
| GB9514448D0 (en) | 1995-09-13 |
| EP0840731A1 (en) | 1998-05-13 |
| US5990104A (en) | 1999-11-23 |
| NO980145L (no) | 1998-01-13 |
| CA2223644A1 (en) | 1997-02-06 |
| EP0840731B1 (en) | 2001-10-10 |
| JPH11509533A (ja) | 1999-08-24 |
| ATE206616T1 (de) | 2001-10-15 |
| DE69615845D1 (de) | 2001-11-15 |
| WO1997003979A1 (en) | 1997-02-06 |
| AU6350296A (en) | 1997-02-18 |
| CN1195344A (zh) | 1998-10-07 |
| NO980145D0 (no) | 1998-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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