DE69615845T2 - Polycyclische alkaloid-derivate als nmda-rezeptor-antagonisten - Google Patents

Polycyclische alkaloid-derivate als nmda-rezeptor-antagonisten

Info

Publication number
DE69615845T2
DE69615845T2 DE69615845T DE69615845T DE69615845T2 DE 69615845 T2 DE69615845 T2 DE 69615845T2 DE 69615845 T DE69615845 T DE 69615845T DE 69615845 T DE69615845 T DE 69615845T DE 69615845 T2 DE69615845 T2 DE 69615845T2
Authority
DE
Germany
Prior art keywords
alkyl
pct
independently
receptor antagonists
nmda receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69615845T
Other languages
English (en)
Other versions
DE69615845D1 (de
Inventor
John Dimaio
M Dixit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Canada Inc
Original Assignee
Shire BioChem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire BioChem Inc filed Critical Shire BioChem Inc
Publication of DE69615845D1 publication Critical patent/DE69615845D1/de
Application granted granted Critical
Publication of DE69615845T2 publication Critical patent/DE69615845T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/08—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/16—Eight-membered rings
    • C07D313/20—Eight-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/16—Eight-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69615845T 1995-07-14 1996-07-12 Polycyclische alkaloid-derivate als nmda-rezeptor-antagonisten Expired - Fee Related DE69615845T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9514448.1A GB9514448D0 (en) 1995-07-14 1995-07-14 Novel heterocyclic NMDA-receptor antagonists
PCT/CA1996/000468 WO1997003979A1 (en) 1995-07-14 1996-07-12 Polycyclic alcaloid-derivatives as nmda-receptor antagonists

Publications (2)

Publication Number Publication Date
DE69615845D1 DE69615845D1 (de) 2001-11-15
DE69615845T2 true DE69615845T2 (de) 2002-06-20

Family

ID=10777682

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69615845T Expired - Fee Related DE69615845T2 (de) 1995-07-14 1996-07-12 Polycyclische alkaloid-derivate als nmda-rezeptor-antagonisten

Country Status (12)

Country Link
US (1) US5990104A (de)
EP (1) EP0840731B1 (de)
JP (1) JPH11509533A (de)
CN (1) CN1195344A (de)
AT (1) ATE206616T1 (de)
AU (1) AU696502B2 (de)
CA (1) CA2223644A1 (de)
DE (1) DE69615845T2 (de)
ES (1) ES2164901T3 (de)
GB (1) GB9514448D0 (de)
NO (1) NO980145D0 (de)
WO (1) WO1997003979A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1267896A1 (de) * 2000-03-28 2003-01-02 Robert J. Delorenzo Hemmung eines neuen calcium-strom, der sich bildet in neuronen während verletzungen darin, verhütet neuronalen zelltod
AUPR215700A0 (en) * 2000-12-19 2001-01-25 Fujisawa Pharmaceutical Co., Ltd. Carboxylic acid compound having cyclopropane ring
JP2008525439A (ja) * 2004-12-23 2008-07-17 ボイジャー・ファーマシューティカル・コーポレーション アルツハイマー病の治療のための酢酸ロイプロリド及びアセチルコリンエステラーゼインヒビターまたはｎｍｄａレセプターアゴニスト
WO2020156522A1 (zh) * 2019-02-02 2020-08-06 扬子江药业集团有限公司 地佐辛衍生物及其医药用途
CN112137996B (zh) * 2020-10-23 2023-08-25 湖南农业大学 一种预防钩吻中毒的药物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3836670A (en) * 1971-11-19 1974-09-17 American Home Prod Benzobicycloalkane amines for inducing analgesia
US4957909A (en) * 1989-05-04 1990-09-18 American Home Products Corporation Benzobicycloalkane derivatives as anticonvulsant neuroprotective agents

Also Published As

Publication number Publication date
ATE206616T1 (de) 2001-10-15
NO980145L (no) 1998-01-13
JPH11509533A (ja) 1999-08-24
DE69615845D1 (de) 2001-11-15
ES2164901T3 (es) 2002-03-01
WO1997003979A1 (en) 1997-02-06
CN1195344A (zh) 1998-10-07
AU6350296A (en) 1997-02-18
CA2223644A1 (en) 1997-02-06
AU696502B2 (en) 1998-09-10
NO980145D0 (no) 1998-01-13
GB9514448D0 (en) 1995-09-13
EP0840731B1 (de) 2001-10-10
EP0840731A1 (de) 1998-05-13
US5990104A (en) 1999-11-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee