ES2161953T3 - Utilizacion del monosialogangliosido gm1 o del n-dicloroacetil-liso-gm1 para prevenir o invertir la degeneracion neuronal inducida por un tratamiento de larga duracion con l-dopa en la terapia de la enfermedad de parkinson. - Google Patents

Utilizacion del monosialogangliosido gm1 o del n-dicloroacetil-liso-gm1 para prevenir o invertir la degeneracion neuronal inducida por un tratamiento de larga duracion con l-dopa en la terapia de la enfermedad de parkinson.

Info

Publication number
ES2161953T3
ES2161953T3 ES96116051T ES96116051T ES2161953T3 ES 2161953 T3 ES2161953 T3 ES 2161953T3 ES 96116051 T ES96116051 T ES 96116051T ES 96116051 T ES96116051 T ES 96116051T ES 2161953 T3 ES2161953 T3 ES 2161953T3
Authority
ES
Spain
Prior art keywords
liso
dopa
prevent
long
dicloroacetil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96116051T
Other languages
English (en)
Inventor
Gino Toffano
Aurelio Romeo
Stephen Drake Skaper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia Farmaceutici SpA
Original Assignee
Fidia Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Farmaceutici SpA filed Critical Fidia Farmaceutici SpA
Application granted granted Critical
Publication of ES2161953T3 publication Critical patent/ES2161953T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE AL USO DE GANGLIOSIDOS GM{SUB,1} O EL DERIVADO DEL MISMO, N-DICLORO-ACETIL-LISO-GM1 (LIGA 20) PARA PREVENIR O REVERTIR LA DEGENERACION NEURONAL INDUCIDA POR UN TRATAMIENTO DE LARGA DURACION CON L-DOPA EN LA TERAPIA DE LA ENFERMEDAD DE PARKINSON.
ES96116051T 1992-03-13 1993-03-12 Utilizacion del monosialogangliosido gm1 o del n-dicloroacetil-liso-gm1 para prevenir o invertir la degeneracion neuronal inducida por un tratamiento de larga duracion con l-dopa en la terapia de la enfermedad de parkinson. Expired - Lifetime ES2161953T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI920591A IT1254280B (it) 1992-03-13 1992-03-13 Composizioni farmaceutiche comprendenti monosialoganglioside gm1 o un suo derivato atte al trattamento della malattia di parkinson

Publications (1)

Publication Number Publication Date
ES2161953T3 true ES2161953T3 (es) 2001-12-16

Family

ID=11362423

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96116051T Expired - Lifetime ES2161953T3 (es) 1992-03-13 1993-03-12 Utilizacion del monosialogangliosido gm1 o del n-dicloroacetil-liso-gm1 para prevenir o invertir la degeneracion neuronal inducida por un tratamiento de larga duracion con l-dopa en la terapia de la enfermedad de parkinson.

Country Status (8)

Country Link
US (1) US6620792B1 (es)
EP (2) EP0630250A1 (es)
JP (1) JP2872809B2 (es)
AT (1) ATE206053T1 (es)
DE (1) DE69330842T2 (es)
ES (1) ES2161953T3 (es)
IT (1) IT1254280B (es)
WO (1) WO1993017691A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1259176B (it) * 1992-10-23 1996-03-11 Fidia Spa Composizioni farmaceutiche comprendenti monosialoganglioside gm1 (o suo derivato) e fattore neuronotrofico ciliare (cntf) atte al trattamento di patologie del sistema nervoso
JP2005527467A (ja) * 2001-08-29 2005-09-15 ネオーズ テクノロジーズ， インコーポレイテッド 新規な合成ガングリオシド誘導体およびその組成物
EP1358910A1 (de) * 2002-05-02 2003-11-05 B.R.A.H.M.S Aktiengesellschaft Verfahren und Mittel zur Prävention, Hemmung und Therapie von Krebserkrankungen
EP1367395A1 (de) 2002-05-02 2003-12-03 B.R.A.H.M.S Aktiengesellschaft Diagnose von Neoplasmen mit Hilfe von anti-Gangliosid-Antikörpern
US7943750B2 (en) * 2007-06-18 2011-05-17 Laboratoire Medidom S.A. Process for obtaining pure monosialoganglioside GM1 for medical use
CN101732331B (zh) * 2008-11-20 2012-05-23 北京四环制药有限公司 一种单唾液酸四己糖神经节苷脂钠与谷氨酸的组合物
US9463186B2 (en) 2013-04-15 2016-10-11 Northwestern University Treatment for dopaminergic disorders
CN104490837A (zh) * 2014-12-30 2015-04-08 哈尔滨医科大学科技开发总公司 单唾液酸四己糖神经节苷脂钠的口服制剂
RU2632710C2 (ru) * 2016-03-31 2017-10-09 Лонг Шенг Фарма Лимитед Способ получения натрий моносиалового ганглиозида и нейропротекторное средство на его основе
CN108815131B (zh) * 2018-09-11 2021-01-01 四川奇格曼药业有限公司 一种神经节苷脂缓释片及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199116B (it) 1984-07-03 1988-12-30 Fidia Farmaceutici Derivati di gangliosidi
IT1208751B (it) * 1986-06-30 1989-07-10 Fidia Farmaceutici Possibile uso dei gangliosidi esogeni in malattie tumorali come fattore protettivo contro la neurotossicita' da farmaci antitumorali
IT1235161B (it) * 1988-12-02 1992-06-22 Fidia Farmaceutici Derivati di lisogangliosidi
IT1249034B (it) * 1990-06-29 1995-02-11 Fidia Spa Impiego del monosialoganglioside gm1 e del suo derivato estere interno per impedire l'instaurarsi della tolleranza nell'uomo all'effetto analgesico della morfina e analoghi
IT1253832B (it) * 1991-08-01 1995-08-29 Fidia Spa Derivati di gangliosidi

Also Published As

Publication number Publication date
DE69330842D1 (de) 2001-10-31
JP2872809B2 (ja) 1999-03-24
WO1993017691A3 (en) 1993-11-11
EP0770389B1 (en) 2001-09-26
ATE206053T1 (de) 2001-10-15
JPH07508258A (ja) 1995-09-14
EP0770389A1 (en) 1997-05-02
WO1993017691A2 (en) 1993-09-16
ITMI920591A1 (it) 1993-09-13
ITMI920591A0 (it) 1992-03-13
IT1254280B (it) 1995-09-14
EP0630250A1 (en) 1994-12-28
US6620792B1 (en) 2003-09-16
DE69330842T2 (de) 2002-04-04

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