ES2161532T3 - Procedimiento y dispositivo para el control de un proceso de liofilizacion. - Google Patents

Procedimiento y dispositivo para el control de un proceso de liofilizacion.

Info

Publication number
ES2161532T3
ES2161532T3 ES98922751T ES98922751T ES2161532T3 ES 2161532 T3 ES2161532 T3 ES 2161532T3 ES 98922751 T ES98922751 T ES 98922751T ES 98922751 T ES98922751 T ES 98922751T ES 2161532 T3 ES2161532 T3 ES 2161532T3
Authority
ES
Spain
Prior art keywords
drying
main
temperature
procedure
control
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98922751T
Other languages
English (en)
Inventor
Georg-Wilhelm Oetjen
Peter Haseley
Hubert Klutsch
Marion Leineweber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GEA Lyophil GmbH
Original Assignee
Steris GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Steris GmbH filed Critical Steris GmbH
Application granted granted Critical
Publication of ES2161532T3 publication Critical patent/ES2161532T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Drying Of Solid Materials (AREA)

Abstract

Procedimiento para el control de un proceso de liofilización, en el que: el producto congelado, situado dentro de una cámara al vacío y sobre unas superficies de temperatura regulable, se somete primero a un secado principal y a continuación a un secado posterior, durante el secado principal se realiza la medición constante de la temperatura del hielo contenido en el producto a secar, en el tránsito del secado principal al secado posterior se modifica la presión de la cámara y/o la temperatura de las superficies, caracterizado porque: las modificaciones de la presión, típicas del tránsito del secado principal al posterior, y de la temperatura de las superficies se llevan a cabo en dependencia de la reducción de la temperatura del hielo.
ES98922751T 1997-05-07 1998-04-21 Procedimiento y dispositivo para el control de un proceso de liofilizacion. Expired - Lifetime ES2161532T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19719398A DE19719398A1 (de) 1997-05-07 1997-05-07 Verfahren zur Steuerung eines Gefriertrocknungsprozesses

Publications (1)

Publication Number Publication Date
ES2161532T3 true ES2161532T3 (es) 2001-12-01

Family

ID=7828961

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98922751T Expired - Lifetime ES2161532T3 (es) 1997-05-07 1998-04-21 Procedimiento y dispositivo para el control de un proceso de liofilizacion.

Country Status (7)

Country Link
US (1) US6163979A (es)
EP (1) EP0980503B1 (es)
JP (1) JP2001525049A (es)
DE (2) DE19719398A1 (es)
DK (1) DK0980503T3 (es)
ES (1) ES2161532T3 (es)
WO (1) WO1998050744A1 (es)

Families Citing this family (31)

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DE19936281C2 (de) * 1999-08-02 2002-04-04 Bayer Ag Verfahren zur Gefriertrocknung
DE60120346T2 (de) 2001-03-01 2007-05-16 Incorporated Administrative Agency National Agriculture And Bio-Oriented Research Organization, Tsukuba Verfahren und Vorrichtung zur Herstellung eines gefriergetrockneten Produktes
US6543155B2 (en) 2001-03-01 2003-04-08 National Agricultural Research Organization Freeze-dried product and process and apparatus for producing it
DE10136498A1 (de) 2001-07-27 2003-02-06 Steris Gmbh Kammer für eine Gefriertrocknungseinrichtung
DE10218007A1 (de) * 2002-04-23 2003-11-06 Bayer Ag Gefriertrockenvorrichtung
EP1563237A2 (en) * 2002-11-21 2005-08-17 Transform Pharmaceuticals, Inc. Freeze-drying microscope stage apparatus and process of using the same
WO2005018410A1 (de) * 2003-07-30 2005-03-03 BSH Bosch und Siemens Hausgeräte GmbH Verfahren zum betreiben eines gerätes mit wenigstens einem teilprogrammschritt 'trocknen'
DE102004007526A1 (de) * 2004-02-17 2005-09-01 Oetjen, Georg-Wilhelm, Dr. Verfahren und Einrichtung zur Gefriertrocknung von Produkten
US7520670B2 (en) * 2005-04-26 2009-04-21 John Jeffrey Schwegman Wireless temperature sensing system for lyophilization processes
US20090175315A1 (en) * 2005-04-26 2009-07-09 John Jeffrey Schwegman Wireless temperature sensing system for lyophilization processes
US20060275863A1 (en) * 2005-05-17 2006-12-07 Yamaha Hatsudoki Kabushiki Kaisha Method for preserving xanthophyll in algal cell
DE102005024536A1 (de) * 2005-05-28 2006-11-30 Hans-Georg Hof Horizontale Gefriertrocknungsanlage
US20070098591A1 (en) * 2005-10-31 2007-05-03 Georg Frinke Method and apparatus for low energy vaporization of liquid oxidizing agents or solutions
EP1903291A1 (en) * 2006-09-19 2008-03-26 Ima-Telstar S.L. Method and system for controlling a freeze drying process
IT1397930B1 (it) 2009-12-23 2013-02-04 Telstar Technologies S L Metodo per monitorare l'essiccamento primario di un processo di liofilizzazione.
US9687603B2 (en) 2010-04-16 2017-06-27 Medtronic, Inc. Volume monitoring for implantable fluid delivery devices
US8810394B2 (en) * 2010-04-16 2014-08-19 Medtronic, Inc. Reservoir monitoring for implantable fluid delivery devices
US8434240B2 (en) 2011-01-31 2013-05-07 Millrock Technology, Inc. Freeze drying method
JP5876424B2 (ja) * 2011-02-08 2016-03-02 共和真空技術株式会社 凍結乾燥装置に適用される被乾燥材料の昇華面温度、底部品温及び昇華速度の算出方法及び算出装置
US8549768B2 (en) * 2011-03-11 2013-10-08 Linde Aktiengesellschaft Methods for freeze drying
DE102012007422B4 (de) 2012-04-16 2024-02-08 Martin Christ Gefriertrocknungsanlagen Gmbh Verfahren zur Gefriertrocknung von Substanzen und Anlage zur Durchführung dieses Verfahrens
US8904664B2 (en) 2012-08-15 2014-12-09 Mimedx Group, Inc. Dehydration device and methods for drying biological materials
US10206977B1 (en) 2013-01-18 2019-02-19 Mimedx Group, Inc. Isolated placental stem cell recruiting factors
JP6545102B2 (ja) 2013-01-18 2019-07-17 ミメディクス グループ インコーポレイテッド 心病態を治療する方法
US9121637B2 (en) * 2013-06-25 2015-09-01 Millrock Technology Inc. Using surface heat flux measurement to monitor and control a freeze drying process
EP3094336A4 (en) 2014-01-17 2018-02-14 MIMEDX Group Inc. Method for inducing angiogenesis
US10605527B2 (en) 2015-09-22 2020-03-31 Millrock Technology, Inc. Apparatus and method for developing freeze drying protocols using small batches of product
DE102016215844B4 (de) 2016-08-23 2018-03-29 OPTIMA pharma GmbH Verfahren und Vorrichtung zur Gefriertrocknung
SI3392584T1 (sl) * 2017-04-21 2020-09-30 Gea Lyophil Gmbh Zamrzovalni sušilnik in postopek za induciranje nukleacije v proizvodih
EP3775740A4 (en) * 2018-04-10 2021-12-15 IMA Life North America Inc. FREEZE-DRYING PROCEDURES AND ALIGNMENT HEALTH MONITORING
CN116972601B (zh) * 2023-09-22 2023-12-08 昆海生物技术(三亚)有限公司 一种白番茄真空冷冻干燥装置及其冷冻干燥方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1038988B (de) * 1956-08-22 1958-09-11 Leybold Hochvakuum Anlagen Steuerungsverfahren einer Gefriertrocknung und Vorrichtung zu seiner Ausfuehrung
US2994132A (en) * 1956-08-22 1961-08-01 Neumann Karlheinz Freeze drying apparatus
DE1135828B (de) * 1959-01-10 1962-08-30 Leybold Hochvakuum Anlagen Gefriertrocknungsverfahren und -vorrichtung
FR1236607A (fr) * 1959-06-11 1960-07-22 Centre Nat Rech Scient Procédé et dispositif pour le contrôle et la régulation de la congélation et dudégel de différentes substances, et notamment pour le contrôle et la régulation d'opérations de congélation-dessiccation
AU135466A (en) * 1966-02-08 1967-08-10 Abbott Laboratories Freese drying method and apparatus
GB1190319A (en) * 1968-08-15 1970-05-06 George Jarvis Tooby Method for Dehydrating Materials
DE2104499A1 (de) * 1971-02-01 1972-08-10 Leybold Heraeus Gmbh & Co Kg Steuerung und/oder Überwachung von Prozessen in Abhängigkeit vom Dampfdruck, insbesondere bei der Gefriertrocknung
US3964174A (en) * 1975-06-06 1976-06-22 The Regents Of The University Of California Controlled humidity freeze drying process
GB1587409A (en) * 1976-10-04 1981-04-01 Boc Ltd Freeze drying
US4780964A (en) * 1987-11-30 1988-11-01 Fts Systems, Inc. Process and device for determining the end of a primary stage of freeze drying
US5035065A (en) * 1988-06-03 1991-07-30 Parkinson Martin C Method and apparatus using molecular sieves for freeze drying
US5154007A (en) * 1989-08-17 1992-10-13 Board Of Regents University Of Texas System Method and apparatus for cryopreparing biological tissue
US5367786A (en) * 1990-11-06 1994-11-29 Jennings; Thomas A. Method and apparatus for monitoring the processing of a material
FR2685065B1 (fr) * 1991-12-12 1994-03-04 Guy Beurel Procede de regulation de lyophilisation.
DE4334902C2 (de) * 1993-10-13 1998-07-02 Martin Christ Gefriertrocknung Gefriertrocknungsanlage
FR2719656B1 (fr) * 1994-05-03 1996-07-26 Agronomique Inst Nat Rech Procédé et dispositif de contrôle de la lyophilisation sous vide.
JP3850442B2 (ja) * 1995-02-14 2006-11-29 ヴィルヘルム エートイェン ゲオルク 凍結乾燥工程での後乾燥中の残留湿分の測定方法

Also Published As

Publication number Publication date
WO1998050744A1 (de) 1998-11-12
US6163979A (en) 2000-12-26
EP0980503A1 (de) 2000-02-23
DK0980503T3 (da) 2001-10-22
DE19719398A1 (de) 1998-11-12
JP2001525049A (ja) 2001-12-04
EP0980503B1 (de) 2001-07-11
DE59801008D1 (de) 2001-08-16

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