ES2149957T3 - Derivados aminicos y amidicos de la vitamina d. - Google Patents
Derivados aminicos y amidicos de la vitamina d.Info
- Publication number
- ES2149957T3 ES2149957T3 ES95902896T ES95902896T ES2149957T3 ES 2149957 T3 ES2149957 T3 ES 2149957T3 ES 95902896 T ES95902896 T ES 95902896T ES 95902896 T ES95902896 T ES 95902896T ES 2149957 T3 ES2149957 T3 ES 2149957T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- pct
- vitamin
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE PRESENTA UN COMPUESTO DE LA FORMULA GENERAL (I) EN LA QUE R REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ORGANICO ALIFATICO, CICLOALIFATICO, ARALIFATICO O DE ARILO, O UN GRUPO DE AZILO QUE COMPRENDE EL GRUPO ORGANICO UNIDO AL ATOMO DE NITROGENO POR MEDIO DE UN GRUPO DE CARBONILO; R1 Y R2 SE SELECCIONAN CADA UNA DE ELLAS ENTRE GRUPOS DE ALQUILO INFERIOR Y DE CICLOALQUILO O JUNTO CON EL ATOMO DE CARBONO AL CUAL ESTAN UNIDAS FORMAN UN GRUPO DE CICLOALQUILO INFERIOR; R3 REPRESENTA UN GRUPO DE METILO QUE TIENE UNA CONFIGURACION {AL} O {BE}; Y REPRESENTA UN GRUPO DE ALQUILENO INFERIOR, ALQUENILENO O ALQUINILENO OPCIONALMENTE SUSTITUIDO POR UN GRUPO DE HIDROXILO, HIDROXILO ETERIFICADO O HIDROXILO ESTERIFICADO; Y A= REPRESENTA UNA MOLECULA DE CICLOHEXILIDENO, CARACTERISTICA DEL ANILLO A DE LA VITAMINA D 1{AL}-HIDROXILADA O UN ANALOGO DE LA MISMA. LOS COMPUESTOS ACTIVOS DE LA INVENCION EXHIBEN UNA BUENA ACTIVIDAD DE MODULACION CELULAR Y EN CIERTOS CASOS TAMBIEN PUEDEN TENER UN EFECTO SOBRE EL METABOLISMO DEL CALCIO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939325415A GB9325415D0 (en) | 1993-12-13 | 1993-12-13 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2149957T3 true ES2149957T3 (es) | 2000-11-16 |
Family
ID=10746493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95902896T Expired - Lifetime ES2149957T3 (es) | 1993-12-13 | 1994-12-13 | Derivados aminicos y amidicos de la vitamina d. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5786347A (es) |
| EP (1) | EP0734376B1 (es) |
| JP (1) | JP3779991B2 (es) |
| KR (1) | KR100399661B1 (es) |
| CN (1) | CN1080718C (es) |
| AT (1) | ATE196468T1 (es) |
| AU (1) | AU681223B2 (es) |
| CA (1) | CA2178090A1 (es) |
| CZ (1) | CZ291623B6 (es) |
| DE (1) | DE69425980T2 (es) |
| DK (1) | DK0734376T3 (es) |
| ES (1) | ES2149957T3 (es) |
| FI (1) | FI112360B (es) |
| GB (1) | GB9325415D0 (es) |
| GR (1) | GR3035028T3 (es) |
| HU (1) | HU223469B1 (es) |
| IL (1) | IL111975A (es) |
| NO (1) | NO313800B1 (es) |
| NZ (1) | NZ277086A (es) |
| PT (1) | PT734376E (es) |
| WO (1) | WO1995016672A1 (es) |
| ZA (1) | ZA949921B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19619036A1 (de) | 1996-04-30 | 1997-11-13 | Schering Ag | Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| EP1011683A4 (en) * | 1997-05-22 | 2003-06-11 | Cephalon Inc | VITAMIN D ANALOGS AND THEIR EFFECTS ON NEURONS |
| US6043385A (en) * | 1997-12-16 | 2000-03-28 | Hoffman-La Roche Inc. | Vitamin D derivatives |
| DE19935771A1 (de) * | 1999-07-23 | 2001-02-01 | Schering Ag | Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| US6989377B2 (en) | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| US6358939B1 (en) | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| AU9654201A (en) | 2000-10-02 | 2002-04-15 | Univ Emory | Triptolide analogs for the treatment of autoimmune and inflammatory disorders |
| WO2005027928A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | 2-alkylidene-19-nor-vit amin d derivatives for the treatment of hypocalcemic tetany or hyproparathyroidism |
| TW200714580A (en) * | 2005-10-14 | 2007-04-16 | Formosa Lab Inc | Process for preparing vitamin D analogs |
| CN107019795A (zh) * | 2009-01-27 | 2017-08-08 | 博格有限责任公司 | 用于减轻与化疗有关的副作用的维生素d3化合物 |
| MX366076B (es) | 2009-08-14 | 2019-06-27 | Berg Llc | Vitamina d3 y analogos de la misma para tratar alopecia. |
| WO2012158794A1 (en) | 2011-05-17 | 2012-11-22 | Wisconsin Alumni Research Foundation | N-cyclopropyl-(20r)-2-methylene-19,26,27-trinor-25-aza-vitamin d analogs and their uses |
| US8785603B2 (en) | 2011-05-20 | 2014-07-22 | Siemens Healthcare Diagnostics Inc. | Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof |
| US9244083B2 (en) | 2012-11-30 | 2016-01-26 | Siemens Healthcare Diagnostics Inc. | Compositions and methods for detecting vitamin D |
| US9618523B2 (en) | 2013-02-28 | 2017-04-11 | Siemens Healthcare Diagnostics Inc. | Methods and reagents for determining isomeric analytes |
| NZ714801A (en) | 2013-05-29 | 2021-07-30 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU664213B2 (en) * | 1991-11-07 | 1995-11-09 | Research Institute For Medicine And Chemistry Inc. | Vitamin D amide derivatives |
| JPH06107625A (ja) * | 1992-01-13 | 1994-04-19 | Asahi Chem Ind Co Ltd | 新規な１α、２５−ジヒドロキシビタミンＤ誘導体、およびその製造法 |
-
1993
- 1993-12-13 GB GB939325415A patent/GB9325415D0/en active Pending
-
1994
- 1994-12-13 KR KR1019960703082A patent/KR100399661B1/ko not_active IP Right Cessation
- 1994-12-13 AT AT95902896T patent/ATE196468T1/de not_active IP Right Cessation
- 1994-12-13 JP JP51660195A patent/JP3779991B2/ja not_active Expired - Fee Related
- 1994-12-13 WO PCT/GB1994/002725 patent/WO1995016672A1/en active IP Right Grant
- 1994-12-13 NZ NZ277086A patent/NZ277086A/en unknown
- 1994-12-13 ZA ZA949921A patent/ZA949921B/xx unknown
- 1994-12-13 CN CN94194822A patent/CN1080718C/zh not_active Expired - Fee Related
- 1994-12-13 CA CA002178090A patent/CA2178090A1/en not_active Abandoned
- 1994-12-13 PT PT95902896T patent/PT734376E/pt unknown
- 1994-12-13 ES ES95902896T patent/ES2149957T3/es not_active Expired - Lifetime
- 1994-12-13 AU AU12158/95A patent/AU681223B2/en not_active Ceased
- 1994-12-13 DE DE69425980T patent/DE69425980T2/de not_active Expired - Fee Related
- 1994-12-13 EP EP95902896A patent/EP0734376B1/en not_active Expired - Lifetime
- 1994-12-13 CZ CZ19961704A patent/CZ291623B6/cs not_active IP Right Cessation
- 1994-12-13 US US08/652,597 patent/US5786347A/en not_active Expired - Fee Related
- 1994-12-13 IL IL11197594A patent/IL111975A/xx not_active IP Right Cessation
- 1994-12-13 HU HU9601622A patent/HU223469B1/hu not_active IP Right Cessation
- 1994-12-13 DK DK95902896T patent/DK0734376T3/da active
-
1996
- 1996-06-12 NO NO19962479A patent/NO313800B1/no not_active IP Right Cessation
- 1996-06-12 FI FI962440A patent/FI112360B/fi not_active IP Right Cessation
-
2000
- 2000-12-12 GR GR20000402715T patent/GR3035028T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ291623B6 (cs) | 2003-04-16 |
| ZA949921B (en) | 1995-10-12 |
| ATE196468T1 (de) | 2000-10-15 |
| JP3779991B2 (ja) | 2006-05-31 |
| US5786347A (en) | 1998-07-28 |
| FI962440A0 (fi) | 1996-06-12 |
| WO1995016672A1 (en) | 1995-06-22 |
| NO313800B1 (no) | 2002-12-02 |
| AU681223B2 (en) | 1997-08-21 |
| EP0734376B1 (en) | 2000-09-20 |
| IL111975A (en) | 1999-07-14 |
| JPH09511224A (ja) | 1997-11-11 |
| DE69425980T2 (de) | 2001-02-08 |
| AU1215895A (en) | 1995-07-03 |
| NO962479L (no) | 1996-08-12 |
| CA2178090A1 (en) | 1995-06-22 |
| HU9601622D0 (en) | 1996-08-28 |
| CN1141625A (zh) | 1997-01-29 |
| DK0734376T3 (da) | 2000-12-11 |
| GR3035028T3 (en) | 2001-03-30 |
| NZ277086A (en) | 1997-04-24 |
| HU223469B1 (hu) | 2004-07-28 |
| CZ170496A3 (en) | 1997-02-12 |
| FI112360B (fi) | 2003-11-28 |
| PT734376E (pt) | 2000-12-29 |
| KR100399661B1 (ko) | 2004-04-30 |
| EP0734376A1 (en) | 1996-10-02 |
| FI962440A (fi) | 1996-06-12 |
| GB9325415D0 (en) | 1994-02-16 |
| DE69425980D1 (de) | 2000-10-26 |
| CN1080718C (zh) | 2002-03-13 |
| NO962479D0 (no) | 1996-06-12 |
| HUT75515A (en) | 1997-05-28 |
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| NO950849D0 (no) | Derivater av valproin og 2-valproensyreamider og anvendelse som antikonvulsanter | |
| ATE243688T1 (de) | Taxol derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen | |
| DE69414115T2 (de) | Vitamin d analoge | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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