ES2146253T3 - Peptidos de tgf-beta 1 y tgf-beta 2 biologicamente activos. - Google Patents
Peptidos de tgf-beta 1 y tgf-beta 2 biologicamente activos.Info
- Publication number
- ES2146253T3 ES2146253T3 ES94907287T ES94907287T ES2146253T3 ES 2146253 T3 ES2146253 T3 ES 2146253T3 ES 94907287 T ES94907287 T ES 94907287T ES 94907287 T ES94907287 T ES 94907287T ES 2146253 T3 ES2146253 T3 ES 2146253T3
- Authority
- ES
- Spain
- Prior art keywords
- tgf
- beta
- monomerical
- acid sequence
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Abstract
LA INVENCION SE REFIERE A PEPTIDOS CORRESPONDIENTES A REGIONES DE LA SECUENCIA AMINOACIDA DE TGF-{BE}1 Y TGF-{BE}2, QUE CONSERVAN, BIEN EN FORMAS MONOMERICAS O POLIMERICAS, AL MENOS ALGO DE LA ACTIVIDAD BIOLOGICA DEL TGF-{BE} RESPECTIVO DE LONGITUD COMPLETA. LA FORMA MONOMERICA DEL PEPTIDO DERIVADO DE TFG-{BE}1, COMPRENDE LA SIGUIENTE SECUENCIA AMINOACIDA: CVRQLYIDFRKDLGWKWIHEPKGYHANFCLGP. LA FORMA MONOMERICA DEL PEPTIDO DERIVADO DE TGF-{BE}2, COMPRENDE LA SIGUIENTE SECUENCIA AMINOACIDA: CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGA. LOS DIMEROS PUEDEN FORMARSE POR MEDIO DE ENLACES DISULFURO ENTRE LOS RESIDUOS DE CISTEINA AMINO-TERMINALES, LOS RESIDUOS DE CISTEINA CARBOXITERMINALES, O RESIDUOS DE CISTEINA AMINO- Y CARBOXI-TERMINALES DE LAS SUBUNIDADES MONOMERICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/009,448 US5420243A (en) | 1993-01-26 | 1993-01-26 | Biologically active TGF-β2 peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2146253T3 true ES2146253T3 (es) | 2000-08-01 |
Family
ID=21737716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94907287T Expired - Lifetime ES2146253T3 (es) | 1993-01-26 | 1994-01-21 | Peptidos de tgf-beta 1 y tgf-beta 2 biologicamente activos. |
Country Status (8)
Country | Link |
---|---|
US (2) | US5420243A (es) |
EP (1) | EP0791011B1 (es) |
JP (1) | JP3763479B2 (es) |
AU (1) | AU685084B2 (es) |
CA (1) | CA2153789C (es) |
DE (1) | DE69424576T2 (es) |
ES (1) | ES2146253T3 (es) |
WO (1) | WO1994017099A2 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
DE69233022T2 (de) | 1991-11-04 | 2004-02-12 | Genetics Institute, LLC, Cambridge | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
US20080070842A1 (en) * | 1991-11-04 | 2008-03-20 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
US6395494B1 (en) * | 1993-05-13 | 2002-05-28 | Neorx Corporation | Method to determine TGF-β |
US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
DE69435137D1 (de) | 1993-05-13 | 2008-10-16 | Poniard Pharmaceuticals Inc | Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind |
US6291206B1 (en) * | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
US5955430A (en) * | 1993-09-24 | 1999-09-21 | University Of Southern California | Use of angiotensin II fragments and analogs thereof in tissue repair |
US5780436A (en) * | 1995-05-01 | 1998-07-14 | The Regents Of The University Of California | Peptide compositions with growth factor-like activity |
US5661127A (en) * | 1995-05-01 | 1997-08-26 | The Regents Of The University Of California | Peptide compositions with growth factor-like activity |
US5767078A (en) * | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
US6040431A (en) | 1995-06-07 | 2000-03-21 | Stryker Corporation | Single chain analogs of the TGF-β superfamily (morphons) |
JP3638614B2 (ja) * | 1996-07-25 | 2005-04-13 | ジェンザイム・コーポレーション | 軟骨細胞培地組成および培養方法 |
EP1074620A1 (en) | 1999-08-06 | 2001-02-07 | HyGene AG | Monomeric protein of the TGF-beta family |
WO1998046588A2 (en) | 1997-04-11 | 1998-10-22 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
EP0877031A1 (en) * | 1997-05-06 | 1998-11-11 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | TGF-Beta1 derived peptides mimicking the activity of transforming growth factor-Beta1 |
CA2259956A1 (en) * | 1997-05-12 | 1998-11-19 | Kyowa Hakko Kogyo Co., Ltd. | Peptides promoting the activation of latent tgf-.beta. and method for screening tgf-.beta. activity regulators |
US6727224B1 (en) * | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
EP1292330A1 (en) * | 2000-03-31 | 2003-03-19 | Vaccine Chip Technology APS | Immunostimulating properties of a fragment of tgf- beta |
US20030082233A1 (en) * | 2000-12-01 | 2003-05-01 | Lyons Karen M. | Method and composition for modulating bone growth |
EP1399023B1 (en) * | 2001-06-01 | 2008-04-30 | Wyeth | COMPOSITIONS FOR SYSTEMIC ADMINISTRATION OF SEQUENCES ENCODING BONE MORPHOGENETIC PROTEINS& x9; |
TWI267378B (en) * | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
MXPA04011337A (es) * | 2002-05-17 | 2005-07-01 | Wyeth Corp | Portadores de acido hialuronico solidos y susceptibles de ser inyectados para la liberacion de proteinas osteogenicas. |
JP3887588B2 (ja) * | 2002-08-30 | 2007-02-28 | 株式会社リガク | X線回折による応力測定法 |
BRPI0413720A (pt) * | 2003-09-12 | 2006-10-17 | Wyeth Corp | bastões e pastas sólidas de fosfato de cálcio injetável para liberação de proteìnas osteogênicas |
US20060166251A1 (en) * | 2005-01-26 | 2006-07-27 | Archambault Joanne M | Use of sFRPs as markers of BMP activity |
MX2007011591A (es) * | 2005-03-30 | 2007-12-10 | Wyeth Corp | Metodo para estimular el crecimiento de cabello administrando bmps. |
US20060293228A1 (en) * | 2005-06-24 | 2006-12-28 | Bhatnagar Rajendra S | Therapeutic compositions and methods using transforming growth factor-beta mimics |
US8691195B2 (en) * | 2009-04-14 | 2014-04-08 | Caregen Co., Ltd. | Peptide having activity of transforming growth factor and production method therefor |
JP5890100B2 (ja) * | 2011-02-09 | 2016-03-22 | 雪印メグミルク株式会社 | 皮膚コラーゲン産生促進剤 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4806523A (en) * | 1985-08-06 | 1989-02-21 | Collagen Corporation | Method of treating inflammation |
US4822606A (en) * | 1986-04-07 | 1989-04-18 | Duke University | Immunosuppressive synthetic peptides and analogs thereof based on retroviral envelope sequences |
US5218140A (en) * | 1988-08-02 | 1993-06-08 | Union Carbide Chemicals & Plastics Technology Corporation | Carbonylation reaction and catalyst therefor |
CA2005120A1 (en) * | 1988-12-15 | 1990-06-15 | Anthony F. Purchio | Tgf-beta 1/beta 2: a novel chimeric transforming growth factor-beta |
US5061786A (en) * | 1989-05-25 | 1991-10-29 | Genentech, Inc. | Biologically active polypeptides based on transforming growth factor-β |
JPH05501500A (ja) * | 1989-10-18 | 1993-03-25 | クリエイティブ・バイオマリキュールズ・インコーポレーテッド | TGF―βの生合成構築物 |
-
1993
- 1993-01-26 US US08/009,448 patent/US5420243A/en not_active Expired - Lifetime
-
1994
- 1994-01-21 ES ES94907287T patent/ES2146253T3/es not_active Expired - Lifetime
- 1994-01-21 CA CA002153789A patent/CA2153789C/en not_active Expired - Fee Related
- 1994-01-21 EP EP94907287A patent/EP0791011B1/en not_active Expired - Lifetime
- 1994-01-21 AU AU60932/94A patent/AU685084B2/en not_active Ceased
- 1994-01-21 WO PCT/US1994/000782 patent/WO1994017099A2/en active IP Right Grant
- 1994-01-21 JP JP51721994A patent/JP3763479B2/ja not_active Expired - Fee Related
- 1994-01-21 DE DE69424576T patent/DE69424576T2/de not_active Expired - Fee Related
-
1995
- 1995-03-08 US US08/400,607 patent/US5658883A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5658883A (en) | 1997-08-19 |
AU6093294A (en) | 1994-08-15 |
DE69424576D1 (de) | 2000-06-21 |
EP0791011A2 (en) | 1997-08-27 |
JPH08510443A (ja) | 1996-11-05 |
AU685084B2 (en) | 1998-01-15 |
EP0791011B1 (en) | 2000-05-17 |
WO1994017099A2 (en) | 1994-08-04 |
CA2153789C (en) | 2007-04-17 |
US5420243A (en) | 1995-05-30 |
JP3763479B2 (ja) | 2006-04-05 |
DE69424576T2 (de) | 2001-01-18 |
WO1994017099A3 (en) | 1995-01-05 |
CA2153789A1 (en) | 1994-08-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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