ES2145864T3 - Utilizacion de acido d,l-alfa-lipoico, sus enantiomeros y/o derivados como aditivo en conservas liquidas de eritrocitos y crioconservas para concentrados homologos y antologos de eritrocitos. - Google Patents

Utilizacion de acido d,l-alfa-lipoico, sus enantiomeros y/o derivados como aditivo en conservas liquidas de eritrocitos y crioconservas para concentrados homologos y antologos de eritrocitos.

Info

Publication number
ES2145864T3
ES2145864T3 ES95117109T ES95117109T ES2145864T3 ES 2145864 T3 ES2145864 T3 ES 2145864T3 ES 95117109 T ES95117109 T ES 95117109T ES 95117109 T ES95117109 T ES 95117109T ES 2145864 T3 ES2145864 T3 ES 2145864T3
Authority
ES
Spain
Prior art keywords
erythrocytes
alpha
derivatives
erythrocyte
concentrates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95117109T
Other languages
English (en)
Inventor
Frank Dr Conrad
Hermann-August Prof Dr Henrich
Wolfgang Dr Geise
Heinz Dr Ulrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Medica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica GmbH filed Critical Asta Medica GmbH
Application granted granted Critical
Publication of ES2145864T3 publication Critical patent/ES2145864T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A TRAVES DEL ESTADO ACTUAL DE LOS METODOS HOY DIA UTILIZADOS PARA LA CONSERVACION DE SANGRE, PUEDEN CONSEGUIRSE MEDIANTE ADICION DE ACUERDO CON LA INVENCION DE D,L - ALFA - ACIDO LIPONICO Y/O SUS ENANTIOMEROS Y/O SUS DERIVADOS LAS SIGUIENTES VENTAJAS EN SU CONSERVACION: LAS PROPIEDADES DE LOS CONCENTRADOS DE ERITROCITOS EN 4 PROPIAS DEL CUERPO ANTES INDICADAS, O FISIOLOGICAS, CON RESPECTO A SU CAPACIDAD PARA EL SUMINISTRO DE OXIGENO (2,3 - DPG) Y VISCOELASTICIDAD, ASI COMO CON REFERENCIA A SU PEROXIDACION DE MEMBRANA DURANTE LA CONSERVACION Y PARA LA TRANSFUSION QUE TIENE LUGAR A CONTINUACION. LO MISMO ES VALIDO PARA ERITROCITOS CONSERVADOS, QUE SON PROTEGIDOS ADICIONALMENTE DE DAÑOS DE LOS PROCESOS, SIENDO MEJORADA LA AGREGABILIDAD DE ERITROCITOS,
ES95117109T 1994-11-08 1995-10-31 Utilizacion de acido d,l-alfa-lipoico, sus enantiomeros y/o derivados como aditivo en conservas liquidas de eritrocitos y crioconservas para concentrados homologos y antologos de eritrocitos. Expired - Lifetime ES2145864T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4439480A DE4439480C1 (de) 1994-11-08 1994-11-08 Verwendung von D,L- alpha-Liponsäure und/oder ihren Enantiomeren, und/oder ihren Derivaten als Zusatz bei Erythrozyten-Flüssigkonserven für homologe und autologe Erythrozyten-Konzentrate und als Zusatz bei Erythrozyten-Kryokonserven für homologe und autologe Erythrozytenkonzentrate

Publications (1)

Publication Number Publication Date
ES2145864T3 true ES2145864T3 (es) 2000-07-16

Family

ID=6532522

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95117109T Expired - Lifetime ES2145864T3 (es) 1994-11-08 1995-10-31 Utilizacion de acido d,l-alfa-lipoico, sus enantiomeros y/o derivados como aditivo en conservas liquidas de eritrocitos y crioconservas para concentrados homologos y antologos de eritrocitos.

Country Status (10)

Country Link
US (1) US5827643A (es)
EP (1) EP0712574B1 (es)
JP (1) JPH08208401A (es)
AT (1) ATE191124T1 (es)
CA (1) CA2162305C (es)
DE (2) DE4439480C1 (es)
DK (1) DK0712574T3 (es)
ES (1) ES2145864T3 (es)
GR (1) GR3033668T3 (es)
PT (1) PT712574E (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197340B1 (en) 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
US6905707B2 (en) * 1998-05-28 2005-06-14 Medical Research Institute Controlled release arginine alpha ketoglutarate
US20040259895A1 (en) * 1998-05-28 2004-12-23 Medical Research Institute Oral formulation of lipid soluble thiamine and lipoic acid
US6191162B1 (en) 1998-05-28 2001-02-20 Medical Research Institute Method of reducing serum glucose levels
US20030054331A1 (en) * 2001-09-14 2003-03-20 Stemsource, Inc. Preservation of non embryonic cells from non hematopoietic tissues
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US9597395B2 (en) 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US20050048035A1 (en) 2001-12-07 2005-03-03 Fraser John K. Methods of using regenerative cells in the treatment of stroke and related diseases and disorders
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
KR100930139B1 (ko) 2001-12-07 2009-12-07 사이토리 테라퓨틱스, 인크. 처리된 리포애스퍼레이트 세포로 환자를 치료하기 위한시스템 및 방법
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
JP2006321732A (ja) * 2005-05-18 2006-11-30 Fancl Corp 異常蛋白質除去及び８−ヒドロキシ２’−デオキシグアノシン増加抑制用組成物
US20070225354A1 (en) * 2006-03-21 2007-09-27 Eric Marchewitz Use of dihydrolipoamide for enhancing physical performance
US8871434B2 (en) * 2008-03-21 2014-10-28 Fenwal, Inc. Red blood cell storage medium for extended storage
US8968992B2 (en) * 2008-03-21 2015-03-03 Fenwal, Inc. Red blood cell storage medium for extended storage
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
CA2760574C (en) 2009-05-01 2020-10-27 Cytori Therapeutics, Inc. Device and method for preparing tissue for an adipose graft
WO2011049709A1 (en) 2009-10-23 2011-04-28 Fenwal, Inc. Methods and systems for providing red blood cell products with reduced plasma
CN110157667A (zh) * 2019-06-06 2019-08-23 广州鸿泉生物科技有限公司 一种小鼠红细胞悬液的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE443293B (sv) * 1978-01-25 1986-02-24 Blombaeck E G B Blodfraktionsframstellning
US5248506A (en) * 1986-03-19 1993-09-28 American National Red Cross Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets
GB8902791D0 (en) * 1989-02-08 1989-03-30 Secr Defence A method of freezing blood
EP0382066A3 (de) * 1989-02-09 1992-01-08 ASTA Medica Aktiengesellschaft Verwendung von Dihydroliponsäure als Analgetikum, Antiphlogistikum und/oder Zytoprotektivum
CA2067134C (en) * 1989-10-06 2001-02-13 Harold T. Meryman Procedure for storing red cells with prolonged maintenance of cellular concentrations of atp and 2,3 dpg
DK173585B1 (da) * 1989-11-09 2001-04-02 Asta Medica Ag Anvendelse af alfa-liponsyre til fremstilling af et lægemiddel til bekæmpelse af sygdomme fremkaldt af retrovirus
JPH03169813A (ja) * 1989-11-09 1991-07-23 Asta Pharma Ag 細胞保護作用を有する疼痛及び炎症性疾患及び／又はレトロウイルスに起因する病気の治療用医薬並びにその製法
EP0530446B1 (de) * 1991-07-05 1998-01-28 ASTA Medica Aktiengesellschaft Verwendung von Schwefel enthaltenden Carbonsäuren zur Bekämpfung von pathophysiologisch bedingten Erregungsstörungen
DE4137773A1 (de) * 1991-11-16 1993-05-19 Degussa Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure
DE4201196C2 (de) * 1992-01-18 1997-05-15 Rabien Margarethe Arzneimittel zur Behandlung der Polyneuropathie
EP0560092B1 (de) * 1992-03-11 1997-12-03 ASTA Medica Aktiengesellschaft Tabletten, Granulate und Pellets mit hohem Gehalt an Wirkstoffen für hochkonzentrierte, feste Darreichungsformen
DE4218572A1 (de) * 1992-06-05 1993-12-09 Asta Medica Ag Synergistische Kombination von Arzneimitteln enthaltend als Wirkstoff alpha-Liponsäure, Dihydroliponsäure, deren Metaboliten sowie die oxidierten und reduzierten Enantiomere der alpha-Liponsäure wie die R-alpha-Liponsäure oder S-alpha-Liponsäure sowie Metaboliten der alpha-Liponsäure mit den Vitaminen A, B1-6, B12, C und E
DE4317646A1 (de) * 1993-05-27 1994-12-01 Asta Medica Ag Tabletten mit Thioctsäure und mindestens einer basischen Komponente

Also Published As

Publication number Publication date
EP0712574A2 (de) 1996-05-22
PT712574E (pt) 2000-09-29
EP0712574A3 (de) 1997-02-05
JPH08208401A (ja) 1996-08-13
DE59508090D1 (de) 2000-05-04
DK0712574T3 (da) 2000-07-31
GR3033668T3 (en) 2000-10-31
CA2162305A1 (en) 1996-05-09
DE4439480C1 (de) 1996-06-05
ATE191124T1 (de) 2000-04-15
CA2162305C (en) 2010-01-26
EP0712574B1 (de) 2000-03-29
US5827643A (en) 1998-10-27

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