ATE81778T1 - Verwendung einer adenosin, hypoxanthin und ribose enthaltender loesung zur schonung des herzens waehrend chirurgischer eingriffe. - Google Patents

Verwendung einer adenosin, hypoxanthin und ribose enthaltender loesung zur schonung des herzens waehrend chirurgischer eingriffe.

Info

Publication number
ATE81778T1
ATE81778T1 AT87906894T AT87906894T ATE81778T1 AT E81778 T1 ATE81778 T1 AT E81778T1 AT 87906894 T AT87906894 T AT 87906894T AT 87906894 T AT87906894 T AT 87906894T AT E81778 T1 ATE81778 T1 AT E81778T1
Authority
AT
Austria
Prior art keywords
hypoxanthine
ribose
adenosin
protect
heart during
Prior art date
Application number
AT87906894T
Other languages
English (en)
Inventor
Robert M Mentzer Jr
Stephen W Ely
Robert M Berne
Robert D Lasley
Original Assignee
Univ Virginia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Virginia filed Critical Univ Virginia
Application granted granted Critical
Publication of ATE81778T1 publication Critical patent/ATE81778T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT87906894T 1986-10-06 1987-10-05 Verwendung einer adenosin, hypoxanthin und ribose enthaltender loesung zur schonung des herzens waehrend chirurgischer eingriffe. ATE81778T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91555786A 1986-10-06 1986-10-06
PCT/US1987/002524 WO1988002258A1 (en) 1986-10-06 1987-10-05 Use of an adenosine, hypoxanthine and ribose-containing solution for improved protection of the heart during surgery
EP87906894A EP0290496B2 (de) 1986-10-06 1987-10-05 Verwendung einer adenosin, hypoxanthin und ribose enthaltender lösung zur schonung des herzens während chirurgischer eingriffe

Publications (1)

Publication Number Publication Date
ATE81778T1 true ATE81778T1 (de) 1992-11-15

Family

ID=25435935

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87906894T ATE81778T1 (de) 1986-10-06 1987-10-05 Verwendung einer adenosin, hypoxanthin und ribose enthaltender loesung zur schonung des herzens waehrend chirurgischer eingriffe.

Country Status (10)

Country Link
US (1) US4880783A (de)
EP (1) EP0290496B2 (de)
JP (1) JP2930589B2 (de)
AT (1) ATE81778T1 (de)
AU (1) AU618723B2 (de)
CA (1) CA1317225C (de)
DE (1) DE3782427T2 (de)
DK (1) DK173372B1 (de)
NZ (1) NZ222051A (de)
WO (1) WO1988002258A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5070877A (en) * 1988-08-11 1991-12-10 Medco Research, Inc. Novel method of myocardial imaging
IE882585L (en) * 1988-08-25 1990-02-25 Prendergast Patrick T Viral treatment system
KR0137786B1 (ko) * 1988-11-15 1998-05-15 하마구찌 미찌오 심장 또는 뇌의 허혈성 질환의 치료, 예방제
US6004945A (en) * 1990-05-10 1999-12-21 Fukunaga; Atsuo F. Use of adenosine compounds to relieve pain
US5677290A (en) * 1990-05-10 1997-10-14 Fukunaga; Atsuo F. Therapeutic use of adenosine compounds as surgical anesthetics
US6180616B1 (en) 1990-05-10 2001-01-30 Atsuo F. Fukunaga Use of purine receptor agonists to alleviate or normalize physiopathologically excited sensory nerve function
US5679650A (en) * 1993-11-24 1997-10-21 Fukunaga; Atsuo F. Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine
US5320846A (en) * 1991-04-17 1994-06-14 New England Deaconess Hospital Corp. Method and composition for testing patients with metabolic depleting diseases
IT1252174B (it) * 1991-12-09 1995-06-05 Crinos Industria Farmaco Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento
US5466680A (en) * 1992-03-26 1995-11-14 Cytologics, Inc. Method and compositions for enhancing white blood cell functioning on a mucosal or cutaneous surface
US5852000A (en) * 1993-08-25 1998-12-22 Otsuka Pharmaceutical Factory, Inc. Cardiac rehabilitation agent
US5629298A (en) * 1995-03-13 1997-05-13 University Of Massachusetts Medical Center Adenosine as a positive inotrop in the compromised heart
GB9814039D0 (en) * 1998-06-29 1998-08-26 Univ London Materials and methods relating to the prevention or treatment of ischaemia-reperfusion injury
US20030166605A1 (en) * 1999-04-27 2003-09-04 Edward Leung Method of minimizing damage to heart tissue during cardiac surgery and cardiac transplantation
AU2001228325A1 (en) * 2000-02-01 2001-08-14 Novo-Nordisk A/S Use of compounds for the regulation of food intake
US20010020012A1 (en) * 2000-02-01 2001-09-06 Andersen Maibritt Bansholm Use of compounds for the regulation of food intake
WO2002067778A2 (en) 2001-02-26 2002-09-06 Ben-Ami Ballin Syringe for use in blood analysis
US20040111079A1 (en) * 2002-12-03 2004-06-10 Richard Hayes Targeted sanguinous drug solution delivery to a targeted organ
CA2464175A1 (en) * 2003-04-14 2004-10-14 Queen's University At Kingston Methods and compositions for modulating proteins modified in preconditioning against ischemia/hypoxia
IT1391588B1 (it) * 2008-10-15 2012-01-11 Giellepi Chemicals S P A Composizione sinergica per il recupero e la riduzione del danno ischemico lieve
US20210219542A1 (en) * 2018-05-15 2021-07-22 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for storage of red blood cells

Family Cites Families (24)

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Publication number Priority date Publication date Assignee Title
US2994640A (en) * 1957-02-22 1961-08-01 Byk Gulden Lomberg Chem Fab Anti-inflammatory therapy with purine molecular compounds
US3868451A (en) * 1971-03-30 1975-02-25 Abbott Lab Adenosine-5{40 -esters in treating angina pectoris
US3914414A (en) * 1973-06-14 1975-10-21 Abbott Lab Method of increasing coronary pO{HD 2 {B in mammals
US3992531A (en) * 1973-12-26 1976-11-16 Abbott Laboratories 2-Substituted adenosine-5'-carboxylates in the treatment of anginal pain
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
EP0011399A1 (de) * 1978-11-11 1980-05-28 FISONS plc N-Substituierte Theophylline, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US4338319A (en) * 1979-11-27 1982-07-06 Aktiebolaget Draco Method for the treatment of chronic obstructive airway or cardiac diseases
US4481197A (en) * 1980-04-25 1984-11-06 Burroughs Wellcome Co. Anti-inflammatory deoxyribosides
DE3019322A1 (de) * 1980-05-21 1981-12-03 Merck Patent Gmbh, 6100 Darmstadt Psychopharmakon sowie verwendung von adenosinderivaten
US4388308A (en) * 1980-06-09 1983-06-14 G.D. Searle & Co. N6 -[(2-Hydroxypropyl)aryl]adenosines
US4546095A (en) * 1980-07-21 1985-10-08 Markov Angel K Use of fructose-1,6-diphosphate for treating myocardial infarction
US4673563A (en) * 1980-10-14 1987-06-16 The University Of Virginia Alumni Patents Foundation Adenosine in the treatment of supraventricular tachycardia
ATE11736T1 (de) * 1980-12-23 1985-02-15 Dr. Franz Koehler Chemie Gmbh Protektive loesung fuer herz und niere und verfahren zu deren herstellung.
US4514405A (en) * 1981-09-17 1985-04-30 Merck Patent Gesellschaft Mit Beschrankter Haftung Use of adenosine derivatives as anticonvulsants
SE8200252L (sv) * 1982-01-18 1983-07-19 Pharmacia Ab Farmaceutisk komposition
IT1200944B (it) * 1982-08-10 1989-01-27 Malesci Sas Derivati xantinici,procedimento per la loro preparazione,composizione farmaceutiche che il contengono e loro impiego terapeutico
US4473571A (en) * 1983-01-17 1984-09-25 Sterling Drug Inc. 8-Substituted-2-(4-pyridinyl)-9H-purin-6-amines and their cardiotonic use
US4501735A (en) * 1983-12-05 1985-02-26 Warner-Lambert Company N6-(1- and 2-benzocycloalkyl) adenosines
IT1206341B (it) * 1984-02-16 1989-04-14 Crinos Industria Farmaco Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.
US4614732A (en) * 1984-10-26 1986-09-30 Warner-Lambert Company N6 -acenaphthyl adenosines and analogs thereof
US4593019A (en) * 1984-10-26 1986-06-03 Warner-Lambert Company N6 -tricyclic adenosines
US4605644A (en) * 1985-02-07 1986-08-12 Regents Of The University Of Minnesota Method for stimulating recovery from ischemia employing ribose and adenine
DE3590855T1 (de) * 1985-09-24 1988-08-25
US4693996A (en) * 1985-12-23 1987-09-15 Warner-Lambert Company Method of treating heart failure and medicaments therefor

Also Published As

Publication number Publication date
US4880783A (en) 1989-11-14
NZ222051A (en) 1990-07-26
DE3782427T2 (de) 1996-07-18
WO1988002258A1 (en) 1988-04-07
DK305788A (da) 1988-06-03
DK173372B1 (da) 2000-09-11
CA1317225C (en) 1993-05-04
JPH01501311A (ja) 1989-05-11
EP0290496A1 (de) 1988-11-17
DK305788D0 (da) 1988-06-03
AU8078987A (en) 1988-04-21
EP0290496A4 (de) 1989-11-29
EP0290496B1 (de) 1992-10-28
JP2930589B2 (ja) 1999-08-03
AU618723B2 (en) 1992-01-09
EP0290496B2 (de) 1995-12-20
DE3782427D1 (de) 1992-12-03

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