ES2144582T3 - Procedimiento para tratar la ansiedad usando oxadiazol o tiadiazol azabiciclico. - Google Patents

Procedimiento para tratar la ansiedad usando oxadiazol o tiadiazol azabiciclico.

Info

Publication number
ES2144582T3
ES2144582T3 ES95307741T ES95307741T ES2144582T3 ES 2144582 T3 ES2144582 T3 ES 2144582T3 ES 95307741 T ES95307741 T ES 95307741T ES 95307741 T ES95307741 T ES 95307741T ES 2144582 T3 ES2144582 T3 ES 2144582T3
Authority
ES
Spain
Prior art keywords
branched
straight
alkyl
phenyl
alkynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95307741T
Other languages
English (en)
Inventor
Neil Clayton Bodick
Franklin Porter Bymaster
Walter William Offen
Harlan Edgar Shannon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/332,186 external-priority patent/US5488056A/en
Priority claimed from US08/336,589 external-priority patent/US5484794A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2144582T3 publication Critical patent/ES2144582T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

EN LA PRESENTE INVENCION SE PRESENTA EL USO DE UN COMPUESTO EN DONDE X ES OXIGENO O AZUFRE; R ES HIDROGENO, AMINO, HALOGENO, -CHO, -NO{SUB,2}, -OR{SUP,4}, SR{SUP,4}, -SO{SUB,2}R{SUP,4}, CICLOALQUILO C{SUB,3-7}, (CICLOALQUILALQUILO) C{SUB,4-8}, -Z-CICLOALQUILO C{SUB,3-7} Y -Z(CICLOALQUILALQUILO) C{SUB,4-8} EN DONDE R{SUP,4} ES ALQUILO C{SUB,1-15} LINEAL O RAMIFICADO, ALQUENILO C{SUB,2-15} LINEAL O RAMIFICADO, ALQUINILO C{SUB,2-15} LINEAL O RAMIFICADO, CADA UNO DE LOS CUALES PUEDE SER OPCIONALMENTE SUSTITUIDO POR UNO O MAS HALOGENOS, -CF{SUB,3}, -CN, FENILO O FENOXI EN ENDE EL FENILO O EL FENOXI PUEDEN SER OPCIONALMENTE SUSTITUIDOS POR HALOGENO, -CN, ALQUILO C{SUB,1-4}, ALCOXI C{SUB,1-4}, -OCF{SUB,3}, -CONH{SUB,2} O -CSNH{SUB,2}; O R ES FENILO O BENCILOXICARBONILO, CADA UNO DE LOS CUALES PUEDE SER OPCIONALMENTE SUSTITUIDO POR HALOGENO, -CN, ALQUILO C{SUB,1-4}, ALCOXI C{SUB,1-4}, -OCF{SUB,3}, -CONH{SUB,2} O -CSNH{SUB,2}; O R ES -OR{SUP,5}Y, -SR{SUP,5}Y, -OR{SUP,5}ZY, O-R{SUP,4}-Z-R{SUP,5} O -S-R{SUP,4}-Z-R{SUP,5} EN DONDE Z ES OXIGENO O AZUFRE, R{SUP,5} ES ALQUINILO C{SUB,1-15} LINEAL O RAMIFICADO, E Y ES UN GRUPO HETEROCICLICO DE 5 O 6 ELEMENTOS QUE CONTIENE DE UNO A CUATRO ATOMO(S) DE N, O O S O UNA COMBINACION DE LOS MISMOS, CUYO GRUPO HETEROCICLICO ES OPCIONALMENTE SUSTITUIDO EN EL O LOS ATOMO(S) DE CARBONO O NITROGENO POR ALQUILO C{SUB,1-6} LINEAL O RAMIFICADO, FENILO O BENCILO, O CUYO GRUPO HETEROCICLICO SE FUSIONA OPCIONALMENTE CON UN GRUPO FENILO; Y G SE SELECCIONA DE UNO DE LOS SIGUIENTES ANILLOS AZABICICLICOS EN DONDE EL ANILLO DE TIADIAZOL U OXADIAZOL PUEDE ESTAR UNIDO A CUALQUIER ATOMO DE CARBONO DEL ANILLO AZABICICLICO; R{SUP,1} Y R{SUP,2} PUEDEN ESTAR PRESENTES EN CUALQUIER POSICION, INCLUIDO EL PUNTO DE UNION DEL ANILLO DE TIADIAZOL U OXADIAZOL, Y SON, INDEPENDIENTEMENTE, HIDROGENO, ALQUILO C{SUB,1-5} LINEAL O RAMIFICADO, ALQUENILO C{SUB,2-5} LINEAL O RAMIFICADO, ALQUINILO C{SUB,2-5} LINEAL O RAMIFICADO, ALCOXI C{SUB,1-10} LINEAL O RAMIFICADO, ALQUILO C{SUB,1-5} LINEAL O RAMIFICADO SUSTITUIDO POR -OH, OR{SUP,4}, HALOGENO, -NH{SUB,2} O CARBOXI; R{SUP,3} ES H, ALQUILO C{SUB,1-5} LINEAL O RAMIFICADO, ALQUENILO C{SUB,2-5} LINEAL O RAMIFICADO, ALQUINILO C{SUB,2-5} LINEAL O RAMIFICADO; N ES 0, 1 O 2; M ES 0, 1 O 2; P ES 0, 1 O 2; Q ES 1 O 2; Y LA LINEA DE PUNTOS ES UN ENLACE DOBLE O SENCILLO; O DE UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO PARA LA FABRICACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE LA ANSIEDAD.
ES95307741T 1994-10-31 1995-10-30 Procedimiento para tratar la ansiedad usando oxadiazol o tiadiazol azabiciclico. Expired - Lifetime ES2144582T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/332,186 US5488056A (en) 1994-10-31 1994-10-31 Method for treating anxiety
US08/336,589 US5484794A (en) 1994-11-09 1994-11-09 Method for treating anxiety

Publications (1)

Publication Number Publication Date
ES2144582T3 true ES2144582T3 (es) 2000-06-16

Family

ID=26988105

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95307741T Expired - Lifetime ES2144582T3 (es) 1994-10-31 1995-10-30 Procedimiento para tratar la ansiedad usando oxadiazol o tiadiazol azabiciclico.

Country Status (13)

Country Link
US (1) US5726193A (es)
EP (1) EP0709093B1 (es)
JP (1) JPH10508027A (es)
AT (1) ATE191343T1 (es)
AU (1) AU4017295A (es)
CA (1) CA2202781A1 (es)
DE (1) DE69516075T2 (es)
DK (1) DK0709093T3 (es)
ES (1) ES2144582T3 (es)
GR (1) GR3033783T3 (es)
IL (1) IL115810A0 (es)
PT (1) PT709093E (es)
WO (1) WO1996013166A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763457A (en) * 1995-11-13 1998-06-09 Eli Lilly And Company Method for treating anxiety
US5852037A (en) * 1995-11-13 1998-12-22 Eli Lilly And Company Method for treating anxiety
US5998434A (en) * 1995-12-06 1999-12-07 Eli Lilly And Company Composition for treating pain
US6391922B1 (en) 1998-01-13 2002-05-21 Synchroneuron, Llc Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders
EP2291181B9 (en) 2008-04-18 2013-09-11 University College Dublin National University Of Ireland, Dublin Captodiamine for the treatment of depression symptoms

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL83275A (en) * 1986-09-08 1994-02-27 Novo Nordisk As Compounds 1,2, 4-Oxadiazolyl Pipridine Transformed, their preparation and pharmaceutical preparations containing them
NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
DK198490D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK198390D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5330994A (en) * 1992-03-24 1994-07-19 Warner-Lambert Company Tetrahydropyridine isoxazoline derivatives
CZ285030B6 (cs) * 1993-08-19 1999-05-12 Novo Nordisk A/S Použití thiadiazolových a oxadiazolových sloučenin pro výrobu farmaceutického prostředku a farmacetický prostředek pro léčení schizofrenie nebo schizofrenních nemocí
CN1040979C (zh) * 1993-08-19 1998-12-02 诺沃-诺迪斯克有限公司 抑制精神活动的方法

Also Published As

Publication number Publication date
EP0709093A2 (en) 1996-05-01
EP0709093A3 (es) 1996-05-29
US5726193A (en) 1998-03-10
DK0709093T3 (da) 2000-07-10
CA2202781A1 (en) 1996-05-09
IL115810A0 (en) 1996-01-19
EP0709093B1 (en) 2000-04-05
DE69516075T2 (de) 2000-09-14
WO1996013166A1 (en) 1996-05-09
GR3033783T3 (en) 2000-10-31
PT709093E (pt) 2000-08-31
AU4017295A (en) 1996-05-23
DE69516075D1 (de) 2000-05-11
JPH10508027A (ja) 1998-08-04
ATE191343T1 (de) 2000-04-15

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