ES2143780T3 - Compuestos que enlazan las quinasas ciclinodependientes. - Google Patents

Compuestos que enlazan las quinasas ciclinodependientes.

Info

Publication number
ES2143780T3
ES2143780T3 ES96931174T ES96931174T ES2143780T3 ES 2143780 T3 ES2143780 T3 ES 2143780T3 ES 96931174 T ES96931174 T ES 96931174T ES 96931174 T ES96931174 T ES 96931174T ES 2143780 T3 ES2143780 T3 ES 2143780T3
Authority
ES
Spain
Prior art keywords
protein
amino acid
full length
acid residues
substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96931174T
Other languages
English (en)
Inventor
Robin Fahraeus
David Philip Lane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cyclacel Ltd
Original Assignee
Cyclacel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cyclacel Ltd filed Critical Cyclacel Ltd
Application granted granted Critical
Publication of ES2143780T3 publication Critical patent/ES2143780T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION IDENTIFICA SUSTANCIAS QUE POSEEN LA PROPIEDAD DE UNIRSE A CINASA DEPENDIENTE DE CICLINA (CDK) QUE COMPRENDEN LAS SIGUIENTES: (I) UN PEPTIDO QUE INCLUYE LOS RESIDUOS AMINOACIDOS 84 A 103 DE LA CADENA COMPLETA DE LA PROTEINA P16, O UN DERIVADO O PORCION ACTIVA DE ELLO; O (II) UN MIMETICO FUNCIONAL DEL FRAGMENTO, DE LA PORCION ACTIVA O DEL DERIVADO; LA SUSTANCIA EXCLUYE LA CADENA COMPLETA DE LAS PROTEINAS P16, P15, P18 Y P19. ESAS SUSTANCIAS SON UTILES EN LA SUPRESION DE TUMORES AL INHIBIR LA FOSFORILIZACION DE LA PROTEINA RB. TAMBIEN SE DESCRIBE AQUI LA RESOLUCION DE LOS MOTIVOS AMINOACIDOS RESPONSABLES DE LA UNION A LAS CDK, UN MOTIVO FLD QUE CORRESPONDE A LOS RESIDUOS AMINOACIDOS 90 A 92 DE LA CADENA COMPLETA DE LA PROTEINA P16, Y UN MOTIVO LWL QUE CORRESPONDE A LOS RESIDUOS AMINOACIDOS 94 A 97 DE LA CADENA COMPLETA DE LA PROTEINA P16. LAS SUSTANCIAS AQUI REVELADAS PUEDEN SER USADAS EN EL TRATAMIENTO DE TRASTORNOS HIPERPROLIFERATIVOS Y PARA EFECTUAR SELECCION POR CRIBADO Y DISEÑAR MOLECULAS CON PROPIEDADES SIMILARES.
ES96931174T 1995-09-21 1996-09-23 Compuestos que enlazan las quinasas ciclinodependientes. Expired - Lifetime ES2143780T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9519275.3A GB9519275D0 (en) 1995-09-21 1995-09-21 Substances and their therapeutic use

Publications (1)

Publication Number Publication Date
ES2143780T3 true ES2143780T3 (es) 2000-05-16

Family

ID=10781044

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96931174T Expired - Lifetime ES2143780T3 (es) 1995-09-21 1996-09-23 Compuestos que enlazan las quinasas ciclinodependientes.

Country Status (10)

Country Link
US (2) US6569833B1 (es)
EP (1) EP0851922B1 (es)
JP (1) JP4077514B2 (es)
KR (1) KR19990045761A (es)
AT (1) ATE188254T1 (es)
AU (1) AU6996796A (es)
DE (1) DE69605934T2 (es)
ES (1) ES2143780T3 (es)
GB (1) GB9519275D0 (es)
WO (1) WO1997011174A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9519275D0 (en) 1995-09-21 1995-11-22 Univ Dundee Substances and their therapeutic use
US6495526B2 (en) 1996-01-23 2002-12-17 Gpc Biotech, Inc. Inhibitors of cell-cycle progression and uses related thereto
US6489305B1 (en) 1998-05-08 2002-12-03 Canji, Inc. Methods and compositions for the treatment of ocular diseases
KR19990086091A (ko) * 1998-05-25 1999-12-15 성재갑 곤충세포를 이용한 가용성 cdk４／p１６ 복합체의 대량발현 방법
KR20000019889A (ko) * 1998-09-16 2000-04-15 성재갑 곤충세포를 이용한 cdk4/p16 복합체의 제조방법
KR20000019888A (ko) * 1998-09-16 2000-04-15 성재갑 곤충세포를 이용한 cdk4/hc△p16 복합체의 제조방법 및이로부터 cdk4 단백질의 정제방법
US6644696B2 (en) 1998-10-23 2003-11-11 Coinstar, Inc. Coin-discriminator voucher anti-counterfeiting method and apparatus
US7166475B2 (en) * 1999-02-26 2007-01-23 Cyclacel Ltd. Compositions and methods for monitoring the modification state of a pair of polypeptides
WO2001011367A1 (fr) * 1999-08-04 2001-02-15 Medical & Biological Laboratories Co., Ltd. Methode d'analyse de l'activite enzymatique de phosphorylation du complexe cycline/cdk
GB0012528D0 (en) * 2000-05-23 2000-07-12 Univ Palackeho Triterpenoid derivatives
GB0030378D0 (en) 2000-12-13 2001-01-24 Cyclacel Ltd Compound
DE60200248T2 (de) * 2002-08-01 2005-01-27 Mtm Laboratories Ag Verfahren für Lösung-basierte Diagnose
AU2004285745A1 (en) * 2003-10-21 2005-05-12 Cyclacel Limited Pyrimidin-4-YL-3, 4-thione compounds and their use in therapy
NZ546983A (en) 2003-11-24 2009-05-31 Canji Inc Reduction of dermal scarring
GB0402653D0 (en) * 2004-02-06 2004-03-10 Cyclacel Ltd Compounds
GB0411791D0 (en) * 2004-05-26 2004-06-30 Cyclacel Ltd Compounds
ATE502931T1 (de) 2004-08-19 2011-04-15 Dsm Ip Assets Bv Verfahren zur rektifikation von vitamin e acetat
ES2403558T3 (es) 2004-08-27 2013-05-20 Cyclacel Limited Inhibidores purínicos y pirimidínicos de CDK y su uso para el tratamiento de enfermedades autoinmunitarias
GB0419416D0 (en) * 2004-09-01 2004-10-06 Inst Of Ex Botany Ascr 4-Arylazo-3,5-Diamino-Pyrazole compounds and use thereof
RU2456297C1 (ru) * 2010-11-19 2012-07-20 Федеральное государственное учреждение "Российский научный центр рентгенрадиологии" Министерства здравоохранения и социального развития России Химерный пептид для лечения фиброаденомы молочной железы
EA201100464A1 (ru) * 2011-04-06 2012-10-30 Ооо "Метамакс" (Ооо "Метамах") Фармацевтическая композиция для лечения гиперпролиферативных заболеваний и её применение
EA028151B1 (ru) 2013-04-03 2017-10-31 ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "МетаМакс" (ООО "МетаМакс") Химерный пептид и фармацевтическая композиция для лечения онкологических заболеваний
CA2986730C (en) * 2015-05-22 2020-04-14 Expression Pathology, Inc. Srm/mrm assay for the cyclin-dependent kinase inhibitor 2a (p16) protein
WO2024036044A1 (en) * 2022-08-08 2024-02-15 The Johns Hopkins University Compositions and methods for treating and preventing metabolic disorders

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362623A (en) 1991-06-14 1994-11-08 The John Hopkins University Sequence specific DNA binding by p53
FR2662698A1 (fr) 1990-06-05 1991-12-06 Centre Nat Rech Scient Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite.
ATE152629T1 (de) 1990-07-09 1997-05-15 Res Corp Technologies Inc Diagnose von krebs-metastasen durch das mts-1 gen
NO312681B1 (no) 1990-08-24 2002-06-17 Univ California Fremgangsmåte for fremstilling av en farmasöytisk blanding med suppresiv virkning/aktivitet
US5331573A (en) * 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
WO1994009135A1 (en) 1992-10-16 1994-04-28 Cold Spring Harbor Laboratory Cyclin complex rearrangement and uses related thereto
EP1421947A1 (en) 1992-07-22 2004-05-26 The Trustees Of Princeton University p53 vaccine
US6211334B1 (en) 1992-10-16 2001-04-03 Cold Spring Harbor Cell-cycle regulatory proteins, and uses related thereto
US5700657A (en) 1993-12-13 1997-12-23 Genzyme Corporation Vectors and vector systems including genes encoding tumor suppressor proteins and producer cells transformed thereby
CN1128049A (zh) 1994-03-18 1996-07-31 犹他大学研究基金会 多肿瘤抑制因子基因种系突变及检测该基因癌肿倾向性的方法
US5631156A (en) * 1994-06-21 1997-05-20 The University Of Michigan DNA encoding and 18 KD CDK6 inhibiting protein
US6399296B1 (en) * 1994-07-20 2002-06-04 The General Hospital Corporation Interaction trap systems for detecting protein interactions
AU724324B2 (en) 1995-07-17 2000-09-14 Board Of Regents, The University Of Texas System p16 expression constructs and their application in cancer therapy
GB9519275D0 (en) 1995-09-21 1995-11-22 Univ Dundee Substances and their therapeutic use
US5669833A (en) * 1996-08-21 1997-09-23 Stone; David B. Soccer training system

Also Published As

Publication number Publication date
KR19990045761A (ko) 1999-06-25
ATE188254T1 (de) 2000-01-15
DE69605934T2 (de) 2000-06-15
AU6996796A (en) 1997-04-09
JP2001507669A (ja) 2001-06-12
GB9519275D0 (en) 1995-11-22
US6569833B1 (en) 2003-05-27
EP0851922A1 (en) 1998-07-08
JP4077514B2 (ja) 2008-04-16
US20040029791A1 (en) 2004-02-12
DE69605934D1 (de) 2000-02-03
EP0851922B1 (en) 1999-12-29
WO1997011174A1 (en) 1997-03-27

Similar Documents

Publication Publication Date Title
ES2143780T3 (es) Compuestos que enlazan las quinasas ciclinodependientes.
Huttner et al. Differential phosphorylation of multiple sites in purified protein I by cyclic AMP-dependent and calcium-dependent protein kinases.
Goodenough et al. Structural comparison of purified dynein proteins with in situ dynein arms
Saito et al. Neurofilament-associated protein phosphatase 2A: its possible role in preserving neurofilaments in filamentous states
Cleveland et al. Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins
ATE397621T1 (de) Hemmer der interaktion zwischen p53 und mdm2
DE69533855D1 (de) UNTERBRECHUNG DER BINDUNG DER PROTEINE MDM2 UND p53 UND ENTSPRECHENDE THERAPEUTISCHE ANWENDUNG
MX9606404A (es) Composiciones farmaceuticas y metodos para formular trasnduccion de señales.
BRPI0407058A (pt) Métodos de profilaxia e de tratamento de uma doença, composição farmacêutica, e, uso de um fragmento
Lindner et al. The Microheterogeneity of the Mammalian H10Histone: EVIDENCE FOR AN AGE-DEPENDENT DEAMIDATION
Huang et al. Purification and characterization of protein IIIb, a mammalian brain phosphoprotein.
BR9609424A (pt) Novos peptìdeos, compostos, composição farmacêutica, processo para tratar um tumor em um mamìfero, e, processo para preparar os compostos
BR9910573A (pt) Compostos antipicornavirais, preparação e uso dos mesmos
RU95111308A (ru) Производные 2-амино-4-фенил-4-оксомасляной кислоты, способы получения, фармацевтическая композиция
BR0215395A (pt) Compostos; processo para a preparação de um composto; composição farmacêutica; e método para o tratamento e/ou profilaxia de doenças que estão relacionadas com o nìvel de glicose no sangue
ATE107859T1 (de) Verwendung von antiprogestomimetika zur stimulierung des eisprungs.
NO971966L (no) Proteinkinase NPK-110
ATE251886T1 (de) Verwendunf von apoe zum binden von tau und map2c proteinen und zur behandlung von alzheimer's krankheit
DE69607034D1 (de) Pcna bindende substanz
Keung et al. Structure and function of ovotransferrin. I. Production of iron-binding fragments from iron-ovotransferrin by the action of immobilized subtilisin. Purification and characterization of the fragments.
Reisfeld et al. Apolipoprotein B exhibits phospholipase A1 and phospholipase A2 activities
Marion et al. Histone phosphorylation in native chromatin induces local structural changes as probed by electric birefringence
Spector et al. The identification of O-phosphoserine in the soluble anionic phosphoproteins of bone
Juskevich et al. Phosphorylation of brain cytosol proteins. Effects of phospholipids and calmodulin.
Seyedin et al. H1 histones of trout.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 851922

Country of ref document: ES