ES2143230T3 - Gel para hormonoterapia local de la sequedad vaginal. - Google Patents

Gel para hormonoterapia local de la sequedad vaginal.

Info

Publication number
ES2143230T3
ES2143230T3 ES96933493T ES96933493T ES2143230T3 ES 2143230 T3 ES2143230 T3 ES 2143230T3 ES 96933493 T ES96933493 T ES 96933493T ES 96933493 T ES96933493 T ES 96933493T ES 2143230 T3 ES2143230 T3 ES 2143230T3
Authority
ES
Spain
Prior art keywords
gel
oestrogen
estradiol
beta
vaginal dryness
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96933493T
Other languages
English (en)
Inventor
Catherine Meignant
Corinne Vieillard-Baron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Innothera SAS
Original Assignee
Laboratoires Innothera SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Innothera SAS filed Critical Laboratoires Innothera SAS
Application granted granted Critical
Publication of ES2143230T3 publication Critical patent/ES2143230T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)

Abstract

ESTE GEL ESTA DESTINADO A UN TRATAMIENTO LOCAL, ESENCIALMENTE NO SISTEMICO, DE LA SEQUEDAD VAGINAL, PARTICULARMENTE EN LA MUJER MENOPAUSICA. SE CARACTERIZA POR LA COMBINACION SINERGICA DE UN ESTROGENO NATURAL ELEGIDO ENTRE EL 17{BE} Y SUS SALES Y DE UN GEL BIODEGRADABLE, HIDROFILO, LUBRICANTE Y BIOADHESIVO. EL CONTENIDO EN ESTROGENO SE ELIGE DE MANERA A PROCURAR UNA DOSIS UNITARIA EQUIVALENTE A LO SUMO A 15 {MI}G, PREFERENTEMENTE MENOS DE 10 {MI}G, DE 17{BE} TA ESPECIALIDAD SE DESTINA A SER APLICADA SOBRE LA MUCOSA VULVOVAGINAL. EL ESTROGENO SE PRESENTA EN EL GEL BIEN EN FORMA LIBRE, VENTAJOSAMENTE MICRONIZADA, BIEN EN FORMA VECTORIZADA, PARTICULARMENTE POR ENCAPSULACION EN VECTORES DE TIPO NANOPARTICULAS TALES COMO BIOVECTORES SUPRAMOLECULARES. EL EXCIPIENTE COMPRENDE VENTAJOSAMENTE ACIDO CARBOXIVINILICO, GLICERINA, UNA SUSTANCIA DE AJUSTE DEL PH, UN AYUDANTE CONSERVADOR Y UN EXCIPIENTE ACUOSO.
ES96933493T 1995-10-05 1996-10-04 Gel para hormonoterapia local de la sequedad vaginal. Expired - Lifetime ES2143230T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9511731A FR2739559B1 (fr) 1995-10-05 1995-10-05 Gel pour hormonotherapie locale de la secheresse vaginale

Publications (1)

Publication Number Publication Date
ES2143230T3 true ES2143230T3 (es) 2000-05-01

Family

ID=9483282

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96933493T Expired - Lifetime ES2143230T3 (es) 1995-10-05 1996-10-04 Gel para hormonoterapia local de la sequedad vaginal.

Country Status (10)

Country Link
EP (1) EP0813412B1 (es)
JP (1) JPH11512732A (es)
CN (1) CN1198672A (es)
AT (1) ATE188120T1 (es)
AU (1) AU7220596A (es)
CA (1) CA2233923A1 (es)
DE (1) DE69605899T2 (es)
ES (1) ES2143230T3 (es)
FR (1) FR2739559B1 (es)
WO (1) WO1997012618A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7005408B2 (en) 2002-05-01 2006-02-28 Mcneil-Ppc, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
US7695730B2 (en) 2002-05-01 2010-04-13 Mcneil-Ppc, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
US7658941B2 (en) 2002-05-01 2010-02-09 Johnson & Johnson Consumer Companies, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
US10016442B2 (en) * 2005-06-16 2018-07-10 Allergan Pharmaceuticals International Limited Estrogen compositions for vaginal administration
EP1898880A2 (en) * 2005-06-16 2008-03-19 Warner Chilcott Company Inc. Gel compositions for topical administration
BRPI0614625A2 (pt) * 2005-08-12 2011-04-12 Drugtech Corp composição farmacêutica que compreende pelo menos um composto estrogênico, sistema de distribuição de estrogênio vaginal, uso de uma composição e kit que compreende uma pluralidade de cremes vaginais
US20090124584A1 (en) * 2005-12-16 2009-05-14 Lyle Corporate Development, Inc. Regeneration of vaginal tissue with non-systemic vaginal administration of estrogen
US20130231317A1 (en) * 2011-07-19 2013-09-05 Michael S. Riepl Dhea bioadhesive controlled release gel
US9320744B2 (en) 2011-10-19 2016-04-26 Dhea Llc DHEA bioadhesive controlled release gel
EP3936133A1 (en) 2011-11-23 2022-01-12 TherapeuticsMD, Inc. Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
CA2947767A1 (en) 2014-05-22 2015-11-26 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
CN104117135A (zh) * 2014-08-11 2014-10-29 崔仁海 阴道内植入式治疗装置
GB2551598B (en) * 2016-01-07 2022-03-09 Viramal Ltd Gel compositions for transdermal delivery to maximize drug concentrations in the stratum corneum and serum and methods of use thereof
SE1750680A1 (en) * 2017-05-30 2018-12-01 Peptonic Medical Ab Composition for treating or preventing climacteric disorders
EP3870150A1 (en) 2018-10-26 2021-09-01 Viramal Limited Mucoadhesive gel composition
ES2948955T3 (es) 2018-11-30 2023-09-22 Viramal Ltd Un método de preparación de un agente gelificante, el agente gelificante obtenido de este modo y el uso de dicho agente gelificante
US11510961B2 (en) 2019-12-19 2022-11-29 Creative Bio-Peptides, Inc. Methods and compositions for use of a chemokine receptor antagonist peptide to treat addiction, substance abuse disorders or symptoms thereof
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
CN114588252A (zh) * 2022-04-08 2022-06-07 暨南大学附属第一医院（广州华侨医院） 一种用于缓解阴道萎缩和干燥症的组合物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52156913A (en) * 1976-06-21 1977-12-27 Toko Yakuhin Kogyo Kk Production of injectionable medicine
DE4229820C2 (de) * 1992-09-07 1998-12-03 Jenapharm Gmbh Pharmazeutische Zubereitung auf Gestagen-Basis
JP3131667B2 (ja) * 1992-09-07 2001-02-05 光洋精工株式会社 トルクセンサ

Also Published As

Publication number Publication date
FR2739559B1 (fr) 1997-11-28
DE69605899T2 (de) 2000-07-27
WO1997012618A1 (fr) 1997-04-10
CA2233923A1 (fr) 1997-04-10
EP0813412B1 (fr) 1999-12-29
CN1198672A (zh) 1998-11-11
ATE188120T1 (de) 2000-01-15
AU7220596A (en) 1997-04-28
FR2739559A1 (fr) 1997-04-11
JPH11512732A (ja) 1999-11-02
EP0813412A1 (fr) 1997-12-29
DE69605899D1 (de) 2000-02-03

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