AU7220596A - Gel for the local hormonotherapy of vaginal dryness - Google Patents
Gel for the local hormonotherapy of vaginal drynessInfo
- Publication number
- AU7220596A AU7220596A AU72205/96A AU7220596A AU7220596A AU 7220596 A AU7220596 A AU 7220596A AU 72205/96 A AU72205/96 A AU 72205/96A AU 7220596 A AU7220596 A AU 7220596A AU 7220596 A AU7220596 A AU 7220596A
- Authority
- AU
- Australia
- Prior art keywords
- gel
- oestrogen
- estradiol
- beta
- intended
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Abstract
The disclosed gel is intended to a local treatment, essentially non systemic, of the vaginal dryness, particularly in menopaused women. It is characterized by the synergic combination of a natural oestrogen selected amongst 17 beta -estradiol and its salts and a biodegradable, hydrophilic, lubricant and bioadhesive gel. The oestrogen contents is selected so as to obtain a unit dose equivalent to 15 mu g at the most, preferably less than 10 mu g of 17 beta -estradiol, and this special substance is intended to be applied to the vulvo-vaginal mucosa. The oestrogen is present in the gel either in a preferably micronized free form, or in a vectorized form, particularly by encapsulation in vectors of the nanoparticle type such as supramolecular biovectors. The excipient comprises preferably carboxyvinylic acid, glycerin, a pH adjusting substance, a preservation adjuvant and an aqueous excipient.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9511731A FR2739559B1 (en) | 1995-10-05 | 1995-10-05 | GEL FOR LOCAL HORMONOTHERAPY OF VAGINAL DROUGHT |
FR9511731 | 1995-10-05 | ||
PCT/FR1996/001556 WO1997012618A1 (en) | 1995-10-05 | 1996-10-04 | Gel for the local hormonotherapy of vaginal dryness |
Publications (1)
Publication Number | Publication Date |
---|---|
AU7220596A true AU7220596A (en) | 1997-04-28 |
Family
ID=9483282
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU72205/96A Abandoned AU7220596A (en) | 1995-10-05 | 1996-10-04 | Gel for the local hormonotherapy of vaginal dryness |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0813412B1 (en) |
JP (1) | JPH11512732A (en) |
CN (1) | CN1198672A (en) |
AT (1) | ATE188120T1 (en) |
AU (1) | AU7220596A (en) |
CA (1) | CA2233923A1 (en) |
DE (1) | DE69605899T2 (en) |
ES (1) | ES2143230T3 (en) |
FR (1) | FR2739559B1 (en) |
WO (1) | WO1997012618A1 (en) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7005408B2 (en) | 2002-05-01 | 2006-02-28 | Mcneil-Ppc, Inc. | Warming and nonirritating lubricant compositions and method of comparing irritation |
US7658941B2 (en) | 2002-05-01 | 2010-02-09 | Johnson & Johnson Consumer Companies, Inc. | Warming and nonirritating lubricant compositions and method of comparing irritation |
US7695730B2 (en) | 2002-05-01 | 2010-04-13 | Mcneil-Ppc, Inc. | Warming and nonirritating lubricant compositions and method of comparing irritation |
CN101232869B (en) * | 2005-06-16 | 2016-03-02 | 沃纳奇尔科特有限责任公司 | The gel combination of topical |
US10016442B2 (en) * | 2005-06-16 | 2018-07-10 | Allergan Pharmaceuticals International Limited | Estrogen compositions for vaginal administration |
AR056453A1 (en) * | 2005-08-12 | 2007-10-10 | Drug Tech Corp | COMPOSITIONS WITH STROGEN AND THERAPEUTIC METHODS FOR USE |
EP1890704A1 (en) * | 2005-12-16 | 2008-02-27 | Lyle Corporate Development, Inc. | Regeneration of vaginal tissue with non-systemic vaginal administration of estrogen |
WO2013012430A1 (en) * | 2011-07-19 | 2013-01-24 | Riepl Michael S | Dhea bioadhesive controlled release gel |
US9320744B2 (en) | 2011-10-19 | 2016-04-26 | Dhea Llc | DHEA bioadhesive controlled release gel |
BR112014012444B1 (en) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | A PHARMACEUTICAL COMPOSITION COMPRISING SOLUBILIZED ESTRADIOL, PROGESTERONE AND A SOLUBILIZING AGENT, AND USES THEREOF TO TREAT A MENOPAUSE-RELATED SYMPTOM IN A WOMAN |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
JP2017516768A (en) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. | Natural combination hormone replacement therapy and therapy |
CN104117135A (en) * | 2014-08-11 | 2014-10-29 | 崔仁海 | Endovaginal implantable treatment device |
EP4091601A1 (en) * | 2016-01-07 | 2022-11-23 | Viramal Limited | Gel compositions for transdermal delivery to maximize drug concentrations in the stratum corneum and serum and methods of use thereof |
SE1750680A1 (en) * | 2017-05-30 | 2018-12-01 | Peptonic Medical Ab | Composition for treating or preventing climacteric disorders |
CN113164384A (en) | 2018-10-26 | 2021-07-23 | 维拉莫有限公司 | Mucoadhesive gel compositions |
EP3659583B1 (en) | 2018-11-30 | 2023-06-07 | Viramal Limited | A method of preparing a gelling agent, the gelling agent obtained thereby, and the use of said gelling agent |
US11510961B2 (en) | 2019-12-19 | 2022-11-29 | Creative Bio-Peptides, Inc. | Methods and compositions for use of a chemokine receptor antagonist peptide to treat addiction, substance abuse disorders or symptoms thereof |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
CN114588252A (en) * | 2022-04-08 | 2022-06-07 | 暨南大学附属第一医院(广州华侨医院) | Composition for relieving vaginal atrophy and xerosis and application thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52156913A (en) * | 1976-06-21 | 1977-12-27 | Toko Yakuhin Kogyo Kk | Production of injectionable medicine |
JP3131667B2 (en) * | 1992-09-07 | 2001-02-05 | 光洋精工株式会社 | Torque sensor |
DE4229820C2 (en) * | 1992-09-07 | 1998-12-03 | Jenapharm Gmbh | Progestogen-based pharmaceutical preparation |
-
1995
- 1995-10-05 FR FR9511731A patent/FR2739559B1/en not_active Expired - Fee Related
-
1996
- 1996-10-04 AT AT96933493T patent/ATE188120T1/en not_active IP Right Cessation
- 1996-10-04 CN CN96197404A patent/CN1198672A/en active Pending
- 1996-10-04 ES ES96933493T patent/ES2143230T3/en not_active Expired - Lifetime
- 1996-10-04 CA CA002233923A patent/CA2233923A1/en not_active Abandoned
- 1996-10-04 DE DE69605899T patent/DE69605899T2/en not_active Expired - Fee Related
- 1996-10-04 JP JP9514040A patent/JPH11512732A/en active Pending
- 1996-10-04 WO PCT/FR1996/001556 patent/WO1997012618A1/en active IP Right Grant
- 1996-10-04 AU AU72205/96A patent/AU7220596A/en not_active Abandoned
- 1996-10-04 EP EP96933493A patent/EP0813412B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
FR2739559A1 (en) | 1997-04-11 |
DE69605899D1 (en) | 2000-02-03 |
ES2143230T3 (en) | 2000-05-01 |
EP0813412B1 (en) | 1999-12-29 |
CA2233923A1 (en) | 1997-04-10 |
DE69605899T2 (en) | 2000-07-27 |
CN1198672A (en) | 1998-11-11 |
WO1997012618A1 (en) | 1997-04-10 |
ATE188120T1 (en) | 2000-01-15 |
EP0813412A1 (en) | 1997-12-29 |
FR2739559B1 (en) | 1997-11-28 |
JPH11512732A (en) | 1999-11-02 |
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Turner et al. | Trade Names Index |