ES2141348T3 - Metodo de deteccion de la presencia de una especie de mycobacterium, kit y anticuerpos utilizados en este metodo. - Google Patents

Metodo de deteccion de la presencia de una especie de mycobacterium, kit y anticuerpos utilizados en este metodo.

Info

Publication number
ES2141348T3
ES2141348T3 ES95915263T ES95915263T ES2141348T3 ES 2141348 T3 ES2141348 T3 ES 2141348T3 ES 95915263 T ES95915263 T ES 95915263T ES 95915263 T ES95915263 T ES 95915263T ES 2141348 T3 ES2141348 T3 ES 2141348T3
Authority
ES
Spain
Prior art keywords
mycobacterium
antigens
detection
species
test
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95915263T
Other languages
English (en)
Inventor
Jan Adrianus Verschoor
Sandra Noel Bye
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adcock Ingram Ltd
Original Assignee
Adcock Ingram Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adcock Ingram Ltd filed Critical Adcock Ingram Ltd
Application granted granted Critical
Publication of ES2141348T3 publication Critical patent/ES2141348T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Mycobacteriaceae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/5695—Mycobacteria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)

Abstract

LA INVENCION SE REFIERE A UNA PRUEBA DE DIAGNOSTICO PARA LA DETECCION E IDENTIFICACION DE ESPECIES DE "MYCOBACTERIUM" EN ESPECIMENES BIOLOGICOS DE ORIGEN HUMANO Y ANIMAL. LA PRUEBA SE BASA EN LA DETECCION INMUNOLOGICA DE UNO O MAS ANTIGENOS QUE SE ORIGINAN A PARTIR DEL "MYCOBACTERIUM". PARA HACER POSIBLE LA DETECCION DE UNA REACCION DE ANTICUERPO-ANTIGENO, LOS ANTICUERPOS ESPECIFICOS PARA ESTOS ANTIGENOS PUEDEN ESTAR ETIQUETADOS CON UNA ENZIMA O UN TINTE FLUORESCENTE O UNIDOS A PARTICULAS DE LATEX O CUALQUIER OTRA ETIQUETA ADECUADA. LA PRUEBA DE DIAGNOSTICO PUEDE SER EN UNA FORMA DE ELISA O PUEDE O NO REQUERIR LA CONCENTRACION DE LOS ANTIGENOS DE "MYCOBACTERIUM" ANTES DE LA REALIZACION DE LA PRUEBA EN SI. LA INVENCION COMPRENDE: LA SELECCION Y LA OBTENCION DE UNA ESPECIE Y CEPA MICOBACTERIANA ADECUADA, EL AISLAMIENTO Y PURIFICACION DE LOS ANTIGENOS, LA PREPARACION DE LOS CONJUGADOS NECESARIOS PARA LA INMUNIZACION DE LOS ANIMALES EXPERIMENTALES UTILIZANDO DIFERENTES MOLECULAS PORTADORAS, ELDESARROLLO DE UN ENSAYO PARA MONITORIZAR LA PRODUCCION DE ANTICUERPOS, LA CARACTERIZACION DE LOS ANTICUERPOS ESPECIFICOS PARA EL ANTIGENO/ANTIGENOS DEL "MYCOBACTERIUM" Y EL DESARROLLO DE UN ENSAYO/EQUIPO DE DIAGNOSTICO.
ES95915263T 1994-04-14 1995-04-13 Metodo de deteccion de la presencia de una especie de mycobacterium, kit y anticuerpos utilizados en este metodo. Expired - Lifetime ES2141348T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA942575 1994-04-14
ZA951464 1995-02-22

Publications (1)

Publication Number Publication Date
ES2141348T3 true ES2141348T3 (es) 2000-03-16

Family

ID=27142386

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95915263T Expired - Lifetime ES2141348T3 (es) 1994-04-14 1995-04-13 Metodo de deteccion de la presencia de una especie de mycobacterium, kit y anticuerpos utilizados en este metodo.

Country Status (16)

Country Link
US (2) US6124105A (es)
EP (1) EP0755517B1 (es)
JP (1) JPH09512101A (es)
CN (1) CN1150840A (es)
AT (1) ATE187251T1 (es)
BR (1) BR9507389A (es)
CA (1) CA2187779A1 (es)
DE (1) DE69513649T2 (es)
DK (1) DK0755517T3 (es)
ES (1) ES2141348T3 (es)
GR (1) GR3032471T3 (es)
MX (1) MXPA96004705A (es)
NZ (1) NZ283784A (es)
PL (1) PL181579B1 (es)
PT (1) PT755517E (es)
WO (1) WO1995028642A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2155230C2 (ru) 1995-02-22 2000-08-27 Эдкок Ингрэм Лимитед Способ выделения и очистки компонента микробных клеточных оболочек липидной или сахарной природы
US6015681A (en) * 1995-07-28 2000-01-18 The United States Of America As Represented By The Secretary Of The Navy Rapid immunoassay for cariogenic bacteria
US6599691B1 (en) * 1995-11-27 2003-07-29 The United States Of America As Represented By The Secretary Of The Navy Rapid immunoassay to detect infection with Mycobacterium tuberculosis
WO1998039025A2 (en) 1997-03-03 1998-09-11 Adcock Ingram Limited A composition comprising a carrier and a purified mycobacterial lipid cell-wall component and its use in the prevention, treatment and diagnosis of disease
ES2535742T3 (es) 2002-10-16 2015-05-14 Purdue Pharma L.P. Anticuerpos que se unen a CA 125/0722P asociado a células y métodos de uso de los mismos
JP2007537438A (ja) * 2004-05-13 2007-12-20 ユニバーシティ オブ プレトリア ミコバクテリア感染の検出方法
DE102004024674A1 (de) * 2004-05-18 2005-12-15 Wolfgang Lorenz Mittel und Verfahren zur Diagnose, Prophylaxe und Therapie von Bindegewebserkrankungen
US9506913B2 (en) * 2010-07-15 2016-11-29 University Of Pretoria Method of detecting surrogate markers in a serum sample
US9315566B2 (en) 2011-01-24 2016-04-19 National University Of Singapore Pathogenic mycobacteria-derived mannose-capped lipoarabinomannan antigen binding proteins
EP2629095A1 (en) * 2012-02-17 2013-08-21 Biosure R & T Cell Co. Detection of mycobacterial protein targets using quantum dots (QDs) and immunomagnetic seperation
US10551391B2 (en) 2013-05-16 2020-02-04 University Of Pretoria Method of diagnosing tuberculosis
CN104897894A (zh) * 2015-06-15 2015-09-09 长春理工大学 一种检测胞内分枝杆菌的elisa检测方法
CN105651996A (zh) * 2016-02-29 2016-06-08 丹娜（天津）生物科技有限公司 一种新型隐球菌荚膜多糖抗原免疫检测试剂盒及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL71683A0 (en) * 1984-04-27 1984-09-30 Yeda Res & Dev Pharmaceutical compositions for treating arthritis type diseases comprising fractions obtained from mycobacteria
US5591632A (en) * 1987-03-02 1997-01-07 Beth Israel Hospital Recombinant BCG
DE68924265T2 (de) * 1989-01-18 1996-02-15 Sawai Seiyaku Kk Verwendung von einem reagens zum nachweis eines mit einem säurebeständigen bakterienantigen übereinstimmenden antikörpers.
ES2201078T3 (es) * 1993-06-21 2004-03-16 Brigham And Women's Hospital Metodos de aislar antigenos presentados por cd1, vacunas que comprenden antigenos presentados por cd1, y lineas celulares para usar en dichos metodos.
WO1996012190A2 (en) * 1994-10-13 1996-04-25 Brigham & Women's Hospital Presentation of hydrophobic antigens to t-cells by cd1 molecules

Also Published As

Publication number Publication date
ATE187251T1 (de) 1999-12-15
PT755517E (pt) 2000-05-31
AU695968B2 (en) 1998-08-27
BR9507389A (pt) 1997-09-16
AU2220595A (en) 1995-11-10
CA2187779A1 (en) 1995-10-26
DK0755517T3 (da) 2000-05-01
US6124105A (en) 2000-09-26
NZ283784A (en) 1998-08-26
DE69513649D1 (de) 2000-01-05
WO1995028642A1 (en) 1995-10-26
GR3032471T3 (en) 2000-05-31
US6458367B1 (en) 2002-10-01
MXPA96004705A (es) 2004-08-19
EP0755517A1 (en) 1997-01-29
PL316792A1 (en) 1997-02-17
JPH09512101A (ja) 1997-12-02
EP0755517B1 (en) 1999-12-01
DE69513649T2 (de) 2000-04-06
CN1150840A (zh) 1997-05-28
PL181579B1 (pl) 2001-08-31

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