ES2138111T3 - Peptido con afinidad hacia tumores, y agente de diagnostico radiactivo y agente terapeutico radiactivo que contienen el peptido. - Google Patents

Peptido con afinidad hacia tumores, y agente de diagnostico radiactivo y agente terapeutico radiactivo que contienen el peptido.

Info

Publication number
ES2138111T3
ES2138111T3 ES95108681T ES95108681T ES2138111T3 ES 2138111 T3 ES2138111 T3 ES 2138111T3 ES 95108681 T ES95108681 T ES 95108681T ES 95108681 T ES95108681 T ES 95108681T ES 2138111 T3 ES2138111 T3 ES 2138111T3
Authority
ES
Spain
Prior art keywords
amino acid
peptide
radioactive
acid sequence
acid residues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95108681T
Other languages
English (en)
Inventor
Ikuya Seki
Yoshitoshi Itaya
Yoshifumi Shirakami
Komei Washino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nihon Medi Physics Co Ltd
Original Assignee
Nihon Medi Physics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Medi Physics Co Ltd filed Critical Nihon Medi Physics Co Ltd
Application granted granted Critical
Publication of ES2138111T3 publication Critical patent/ES2138111T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1018—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE PRESENTA UN PEPTIDO QUE PRESENTA UNA AFINIDAD A LOS TUMORES O UNA SAL DEL MISMO, QUE COMPRENDE UNA SECUENCIA DE AMINOACIDOS QUE CONTIENE 20 O MENOS RESIDUOS AMINOACIDOS, EN DONDE DICHA SECUENCIA DE AMINOACIDOS SE DESCRIBE COMO X{SUB,1} - YCAREPPT X{SUB,2} EN DONDE A, C, E, P, R T E Y REPRESENTAN RESIDUOS AMINOACIDOS EXPRESADOS POR SIMBOLOS ESTANDAR DE UNA LETRA, CADA UNO DE LOS RESIDUOS AMINOACIDOS A, C, R E Y DE LA SECUENCIA DE AMINOACIDOS YCAR PUEDE PRESENTARSE BIEN EN FORMA L O BIEN EN FORMA D, X{SUB,1} REPRESENTA UN COMPUESTO ORGANICO BASICO QUE TIENE DE 1 A 3 GRUPOS AMINO Y X{SUB,2} REPRESENTA CUALQUIER SECUENCIA DE AMINOACIDOS DADA, ASI COMO UN AGENTE DE DIAGNOSTICO RADIACTIVO Y UN AGENTE TERAPEUTICO RADIACTIVO QUE CONTIENEN EL PEPTIDO MENCIONADO O UNA SAL DEL MISMO. EL PRESENTE PEPTIDO CON AFINIDAD A LOS TUMORES PRESENTA UN GRAN RENDIMIENTO A LA HORA DE ETIQUETAR METALES RADIACTIVOS, ES UTIL PARA LA FORMACION DE IMAGENES Y TRATAMIENTO DE TEJIDOS PATOLOGICOS TALES COMO EL CANCER DEMAMA, CANCER DE OVARIOS Y CANCER DE COLON DE MAMIFEROS INCLUIDOS LOS SERES HUMANOS Y ES DIFICIL QUE SE METABOLICE FACILMENTE EN ORGANISMOS Y SE ACUMULE EN TEJIDOS NORMALES ESPECIALMENTE EN LOS DEL RIÑON Y LOS DEL HIGADO.
ES95108681T 1994-06-07 1995-06-06 Peptido con afinidad hacia tumores, y agente de diagnostico radiactivo y agente terapeutico radiactivo que contienen el peptido. Expired - Lifetime ES2138111T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14865594 1994-06-07

Publications (1)

Publication Number Publication Date
ES2138111T3 true ES2138111T3 (es) 2000-01-01

Family

ID=15457667

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95108681T Expired - Lifetime ES2138111T3 (es) 1994-06-07 1995-06-06 Peptido con afinidad hacia tumores, y agente de diagnostico radiactivo y agente terapeutico radiactivo que contienen el peptido.

Country Status (11)

Country Link
US (1) US5827498A (es)
EP (1) EP0700930B1 (es)
KR (1) KR960000250A (es)
AT (1) ATE175977T1 (es)
AU (1) AU684348B2 (es)
CA (1) CA2151099A1 (es)
DE (1) DE69507408T2 (es)
DK (1) DK0700930T3 (es)
ES (1) ES2138111T3 (es)
MC (1) MC2397A1 (es)
TW (1) TW394777B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2165228A1 (en) * 1994-12-27 1996-06-28 Yoshitoshi Itaya Metal chelate forming peptides and use thereof
ES2804476T3 (es) * 2010-12-14 2021-02-08 Recepta Biopharma S A Péptido antitumoral derivado de una región determinante de complementariedad de un anticuerpo monoclonal humanizado contra el transportador NaPI2B
CN104519898A (zh) 2012-06-06 2015-04-15 国家健康与医学研究院 用于治疗癌症的方法和药物组合物
CN111225679B (zh) * 2017-08-19 2024-03-29 俄亥俄州创新基金会 新型基于肽的癌症显像剂
CN107550864B (zh) * 2017-08-23 2020-12-18 科笛生物医药(上海)有限公司 Eppt多肽-聚乙二醇-磷脂复合膜材料、其制备方法及主动靶向脂质体递药系统和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5322678A (en) * 1988-02-17 1994-06-21 Neorx Corporation Alteration of pharmacokinetics of proteins by charge modification
JPH04501719A (ja) * 1988-11-10 1992-03-26 インペリアル・キヤンサー・リサーチ・テクノロジー・リミテツド ポリペプチド
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
DK0570493T3 (da) * 1991-02-08 2000-06-26 Diatide Inc Technetium-99m-mærkede polypeptider til billeddannelse.
GB9108652D0 (en) * 1991-04-23 1991-06-12 Antisoma Ltd Immunoreactive compounds

Also Published As

Publication number Publication date
US5827498A (en) 1998-10-27
KR960000250A (ko) 1996-01-25
TW394777B (en) 2000-06-21
DE69507408D1 (de) 1999-03-04
DE69507408T2 (de) 2000-05-18
ATE175977T1 (de) 1999-02-15
CA2151099A1 (en) 1995-12-08
AU684348B2 (en) 1997-12-11
EP0700930A1 (en) 1996-03-13
DK0700930T3 (da) 1999-09-13
MC2397A1 (fr) 1996-07-26
EP0700930B1 (en) 1999-11-03
AU2049995A (en) 1995-12-14

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