KR940014436A - 2-아미노-6,7-디히드록시-4-티아헵탄산 유도체, 그의 제조방법 및 용도 - Google Patents

2-아미노-6,7-디히드록시-4-티아헵탄산 유도체, 그의 제조방법 및 용도 Download PDF

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KR940014436A
KR940014436A KR1019930030357A KR930030357A KR940014436A KR 940014436 A KR940014436 A KR 940014436A KR 1019930030357 A KR1019930030357 A KR 1019930030357A KR 930030357 A KR930030357 A KR 930030357A KR 940014436 A KR940014436 A KR 940014436A
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South Korea
Prior art keywords
compound
amino
amino acid
aliphatic acyl
salt
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KR1019930030357A
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English (en)
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세이이찌 다니다
스네아끼 히다
미쓰히로 와끼마스
세쓰오 하라다
고이찌 유끼시게
Original Assignee
다께다 구니오
다께다야꾸힝고오교 가부시끼가이샤
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Publication of KR940014436A publication Critical patent/KR940014436A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

하기 식의 화합물 또는 그의 염은 조혈장해를 현저히 개선하는 활성을 가지며 면역자극제 또는 혈소판 감소중 치료제로 유용하다:
(상기 식중, R1및 R2은 각각 수소 또는 지방족 아실이고 ; A은 보호될 수 있는 아미노이며; X는 수용성 향상기를 갖는 하나 이상의 아미노산 잔기를 함유하는 1~10개 아미노산 잔기로 구성된 아미노산 서열이다).

Description

2-아미노-6, 7-디히드록시-4-티아헵탄산 유도체, 그의 제조방법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (17)

  1. 하기 식의 화합물 또는 그의 염.
    (상기 식중, R1및 R2은 각각 수소 또는 지방족 아실이고 ; A은 보호될 수 있는 아미노이며; X는 수용성 향상기를 갖는 하나 이상의 아미노산 잔기를 함유하는 1~10개 아미노산 잔기로 구성된 아미노산 서열이다).
  2. 제1항에 있어서, A가 아미노인 화합물.
  3. 제1항에 있어서, A가 치환 옥시카르보닐로 치환될 수 있는 아미노인 화합물.
  4. 제1항에 있어서, 수용성 향상기를 갖는 아미노산 잔기가 산성 아미노산 잔기인 화합물.
  5. 제1항에 있어서, 수용성 향상기를 갖는 아미노산 잔기가 염기성 아미노산 잔기인 화합물.
  6. 제1항에 있어서, 지방족 아실이 C2~30지방족 아실인 화합물.
  7. 제1항에 있어서, R1및 R2중 적어도 하나가 지방족 아실인 화합물.
  8. 제1항에 있어서, R1가 지방족 아실인 화합물.
  9. 제1항에 있어서, R2가 지방족 아실인 화합물.
  10. 제1항에 있어서, 화합물이 (2R, 6R)-2-아미노-6, 7-비스(헥사데카노일옥시)-4-티아헵타노일-글리실-글루타밀-글루타민산인 화합물.
  11. 제1항에 있어서, 화합물이 (2R, 6R)-2-아미노-6, 7-비스(헥사데카노일옥시)-4-티아헵타노일-글리실-글리실-글루타민산인 화합물.
  12. 제1항에 있어서, 화합물이 (2R, 6R)-2-아미노-6, 7-비스(헥사데카노일옥시)-4-티아헵타노일-글루타밀-글루실-글루타민산인 화합물.
  13. 제1항에 있어서, 화합물이 (2R, 6R)-2-아미노-6, 7-비스(헥사데카노일옥시)-4-티아헵타노일-글리실-D-글루타민산인 화합물.
  14. 제1항의 화합물 또는 그의 염을 함유하는 백혈구 증가작용을 갖는 면역자극 조성물.
  15. 제14항에 있어서, R1및 R2중 적어도 하나가 지방족 아실인 면역자극 조성물.
  16. 제1항에 화합물 또는 그의 염을 함유하는 혈소판 감소중 치료용 조성물.
  17. 하기 식의 화합물 또는 그의 염을 탈보호 반응시킴을 특징으로 하는 제1항의 화합물 또는 그의 염의 제조방법.
    (상기 식중, R1및 R2은 각각 수소 또는 지방족 아실이고; R3은 보호기이며; A은 보호될 수 있는 아미노이고; X′은 수용성 향상기를 갖는 하나 이상의 임의로 보호된 아미노산 잔기를 함유하는 1~10개의 임의로 보호된 아미노산 잔기로 구성된 아미노산 서열이다).
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930030357A 1992-12-28 1993-12-28 2-아미노-6,7-디히드록시-4-티아헵탄산 유도체, 그의 제조방법 및 용도 KR940014436A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP34906292 1992-12-28
JP92-349062 1992-12-28
JP93-56185 1993-03-16
JP5618593 1993-03-16
JP93-181735 1993-07-22
JP18173593 1993-07-22

Publications (1)

Publication Number Publication Date
KR940014436A true KR940014436A (ko) 1994-07-18

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KR1019930030357A KR940014436A (ko) 1992-12-28 1993-12-28 2-아미노-6,7-디히드록시-4-티아헵탄산 유도체, 그의 제조방법 및 용도

Country Status (15)

Country Link
US (1) US5478808A (ko)
EP (1) EP0604957B1 (ko)
KR (1) KR940014436A (ko)
CN (1) CN1094731A (ko)
AT (1) ATE170871T1 (ko)
AU (1) AU666789B2 (ko)
CA (1) CA2112523A1 (ko)
DE (1) DE69320931T2 (ko)
FI (1) FI935888A (ko)
HU (1) HUT65865A (ko)
IL (1) IL108173A (ko)
NO (1) NO934834L (ko)
NZ (1) NZ250588A (ko)
PH (1) PH30687A (ko)
TW (1) TW264479B (ko)

Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
MXPA03001449A (es) * 2000-09-01 2004-12-13 Gryphon Therapeutics Inc Compuestos generadores de tioester estables a nucleofilos, metodos para su produccion y su uso.
EP1382352A1 (de) * 2002-07-19 2004-01-21 GBF Gesellschaft für Biotechnologische Forschung mbH Bisacyloxypropylcystein-Konjugate und deren Verwendung
DE102005024040A1 (de) * 2005-05-25 2006-12-14 Rovi Gmbh & Co. Kosmetische Rohstoffe Kg Kosmetisches oder therapeutisches Kombinationspräparat mit Theanin
ES2421447T3 (es) * 2005-06-13 2013-09-02 Cleveland Biolabs Inc Métodos para proteger frente a apoptosis usando lipopéptidos
CN101421293B (zh) * 2006-03-01 2013-09-25 福冈县政府 含有肽脂质的载体和使用该载体将化合物引入细胞的方法
DE102009034779A1 (de) * 2009-07-25 2011-02-03 Emc Microcollections Gmbh Synthetische Analoga bakterieller Lipopeptide und ihre Anwendung zur Therapie und Prophylaxe allergischer Erkrankungen
EP2549990A1 (en) * 2010-03-23 2013-01-30 Irm Llc Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2860893D1 (en) * 1977-06-20 1981-11-05 Ciba Geigy Ag Lipopeptides, process for their preparation and pharmaceutical compositions containing them
EP0014815A3 (de) * 1978-12-20 1980-10-29 Ciba-Geigy Ag Peptidderivate, Verfahren zu deren Herstellung und Zwischenprodukte sowie pharmazeutische Präparate mit einer dieser Verbindungen
EP0114787B1 (de) * 1983-01-25 1991-09-25 Ciba-Geigy Ag Neue Peptidderivate
DE3546150A1 (de) * 1985-06-24 1987-01-22 Hoechst Ag Membrananker-wirkstoffkonjugat, seine herstellung sowie seine verwendung
JPH0446194A (ja) * 1990-06-13 1992-02-17 Fujisawa Pharmaceut Co Ltd Ｗｓ１２７９ａ物質、その生産法及び用途
JPH0499796A (ja) * 1990-08-13 1992-03-31 Kazuo Achinami 新規リポペプタイド及び抗腫瘍剤
ES2096064T3 (es) * 1991-12-19 1997-03-01 Ciba Geigy Ag Derivados del acido aminosulfonico y procedimiento para su obtencion.

Also Published As

Publication number Publication date
IL108173A0 (en) 1994-04-12
EP0604957A1 (en) 1994-07-06
FI935888A0 (fi) 1993-12-27
IL108173A (en) 1998-03-10
NO934834L (no) 1994-06-29
HU9303761D0 (en) 1994-04-28
NZ250588A (en) 1995-03-28
CA2112523A1 (en) 1994-06-29
DE69320931T2 (de) 1999-05-20
PH30687A (en) 1997-09-16
AU666789B2 (en) 1996-02-22
TW264479B (ko) 1995-12-01
AU5261493A (en) 1994-07-07
DE69320931D1 (de) 1998-10-15
EP0604957B1 (en) 1998-09-09
NO934834D0 (no) 1993-12-27
FI935888A (fi) 1994-06-29
ATE170871T1 (de) 1998-09-15
US5478808A (en) 1995-12-26
HUT65865A (en) 1994-07-28
CN1094731A (zh) 1994-11-09

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