ES2136082T3 - El proto-oncogen met como receptor del factor de crecimiento hepatico. - Google Patents

El proto-oncogen met como receptor del factor de crecimiento hepatico.

Info

Publication number
ES2136082T3
ES2136082T3 ES92905178T ES92905178T ES2136082T3 ES 2136082 T3 ES2136082 T3 ES 2136082T3 ES 92905178 T ES92905178 T ES 92905178T ES 92905178 T ES92905178 T ES 92905178T ES 2136082 T3 ES2136082 T3 ES 2136082T3
Authority
ES
Spain
Prior art keywords
receptor
growth factor
proto
met
oncogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92905178T
Other languages
English (en)
Spanish (es)
Inventor
Donald P Bottaro
Jeffrey S Rubin
Donna Faletto
Andrew M-L Chan
Woude George F Vande
Stuart A Aaronson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of ES2136082T3 publication Critical patent/ES2136082T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57446—Specifically defined cancers of stomach or intestine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
ES92905178T 1991-01-18 1992-01-15 El proto-oncogen met como receptor del factor de crecimiento hepatico. Expired - Lifetime ES2136082T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/642,971 US5648273A (en) 1989-12-27 1991-01-18 Hepatic growth factor receptor is the MET proto-oncogene

Publications (1)

Publication Number Publication Date
ES2136082T3 true ES2136082T3 (es) 1999-11-16

Family

ID=24578815

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92905178T Expired - Lifetime ES2136082T3 (es) 1991-01-18 1992-01-15 El proto-oncogen met como receptor del factor de crecimiento hepatico.

Country Status (11)

Country Link
US (1) US5648273A (ja)
EP (1) EP0567585B1 (ja)
JP (2) JP2598362B2 (ja)
AT (1) ATE182902T1 (ja)
AU (1) AU652031B2 (ja)
CA (2) CA2099865C (ja)
DE (1) DE69229720T2 (ja)
DK (1) DK0567585T3 (ja)
ES (1) ES2136082T3 (ja)
GR (1) GR3031381T3 (ja)
WO (1) WO1992013097A1 (ja)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5871959A (en) * 1989-12-27 1999-02-16 The United States Of America As Represented By The Department Of Health And Human Services Method of producing hepatocycte growth factor/scatter factor and related cell lines
US5362716A (en) * 1989-12-27 1994-11-08 The United States Of America As Represented By The Department Of Health And Human Services Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines
EP0584125B1 (en) * 1991-05-10 1997-07-16 PHARMACIA & UPJOHN S.p.A. Truncated forms of the hepatocyte growth factor (hgf) receptor
AU675968B2 (en) * 1992-09-18 1997-02-27 United States Of America, As Represented By The Secretary, Department Of Health And Human Services A method of preventing tumor metastasis
US6214344B1 (en) 1995-06-02 2001-04-10 Genetech, Inc. Hepatocyte growth factor receptor antagonists and uses thereof
US5686292A (en) * 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
US5646036A (en) * 1995-06-02 1997-07-08 Genentech, Inc. Nucleic acids encoding hepatocyte growth factor receptor antagonist antibodies
US5855918A (en) * 1995-09-12 1999-01-05 Genentech, Inc. Cystic fibrosis therapy
US5866329A (en) * 1995-09-27 1999-02-02 Demetriou; Achilles A. Method and probe for detection of gene associated with liver neoplastic disease
AU7254896A (en) * 1995-10-05 1997-04-28 Genentech Inc. Improved angiogenesis using hepatocyte growth factor
WO1997012628A1 (en) * 1995-10-05 1997-04-10 Genentech, Inc. Methods and compositions for treating vascular stenosis
DK0922102T3 (da) * 1996-07-03 2010-08-16 Genentech Inc Receptor-agonister af hepatocyt-vækstfaktor og anvendelser deraf
JP4006058B2 (ja) * 1997-03-11 2007-11-14 第一三共株式会社 多臓器不全予防及び／又は治療剤
WO1998041230A1 (fr) 1997-03-14 1998-09-24 Snow Brand Milk Products Co., Ltd. Agent preventif et/ou curatif de la cachexie
EP1840575A1 (en) 2000-08-28 2007-10-03 Damavand Wound AB Kit for determining HGF
US20030118585A1 (en) * 2001-10-17 2003-06-26 Agy Therapeutics Use of protein biomolecular targets in the treatment and visualization of brain tumors
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
HN2004000285A (es) 2003-08-04 2006-04-27 Pfizer Prod Inc ANTICUERPOS DIRIGIDOS A c-MET
ES2321105T3 (es) * 2003-09-29 2009-06-02 Peas Institut Ab Determinacion rapida de formas diferentes del factor de crecimiento de hepatocitos (hgf) en los fluidos corporales.
EP1697415A1 (en) 2003-11-12 2006-09-06 Biogen Idec MA Inc. NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
PL1773885T3 (pl) 2004-08-05 2010-09-30 Genentech Inc Humanizowani antagoniści anty c-met
SG173313A1 (en) 2005-01-05 2011-08-29 Biogen Idec Inc Cripto binding molecules
TWI362940B (en) 2005-03-31 2012-05-01 Gen Hospital Corp A use of agonist and/or antagonist of hgf/hgfr activity
SG161281A1 (en) 2005-04-15 2010-05-27 Genentech Inc Hgf beta chain variants
WO2007049620A1 (ja) * 2005-10-24 2007-05-03 Fujifilm Ri Pharma Co., Ltd. 肝細胞増殖因子受容体が関与する疾患の診断薬及び治療薬
EP1957541A2 (en) * 2005-11-21 2008-08-20 Laboratoires Serono SA Compositions and methods of producing hybrid antigen binding molecules and uses thereof
KR101671378B1 (ko) * 2009-10-30 2016-11-01 삼성전자 주식회사 ｃ-Ｍｅｔ에 특이적으로 결합하는 항체 및 그의 용도
KR102059663B1 (ko) 2010-03-10 2019-12-26 젠맵 에이/에스 Ｃ―ｍｅｔ에 대한 모노클로날 항체
KR20140002601A (ko) 2010-07-09 2014-01-08 바이오겐 이데크 헤모필리아 인코포레이티드 키메라 응고 인자
EP3165538A1 (en) 2010-11-03 2017-05-10 Argen-X Nv Anti c-met antibodies
AR086823A1 (es) 2011-06-30 2014-01-22 Genentech Inc Formulaciones de anticuerpo anti-c-met, metodos
WO2013012733A1 (en) 2011-07-15 2013-01-24 Biogen Idec Ma Inc. Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
EP2773660A2 (en) 2011-11-03 2014-09-10 Argen-X B.V. Chimeric human-camel antigens and their use
AU2013207927B2 (en) 2012-01-10 2017-11-02 Biogen Ma Inc. Enhancement of transport of therapeutic molecules across the blood brain barrier
UY35463A (es) 2013-03-15 2014-10-31 Biogen Idec Inc Formulaciones de polipéptido fc-factor ix.
MA39776A (fr) 2014-03-24 2017-02-01 Hoffmann La Roche Traitement du cancer avec des antagonistes de c-met et corrélation de ces derniers avec l'expression de hgf
CN107636159B (zh) 2015-02-04 2022-06-14 百时美施贵宝公司 选择治疗性分子的方法
EP3253875B1 (en) 2015-02-04 2020-01-08 H. Hoffnabb-La Roche Ag Tau antisense oligomers and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5030565A (en) * 1983-08-17 1991-07-09 Scripps Clinic And Research Foundation Polypeptide-induced monoclonal receptors to protein ligands

Also Published As

Publication number Publication date
US5648273A (en) 1997-07-15
EP0567585B1 (en) 1999-08-04
DK0567585T3 (da) 1999-12-13
JP3387745B2 (ja) 2003-03-17
CA2099865C (en) 1997-11-25
AU652031B2 (en) 1994-08-11
EP0567585A1 (en) 1993-11-03
CA2176620A1 (en) 1992-07-19
EP0567585A4 (ja) 1994-08-03
GR3031381T3 (en) 2000-01-31
DE69229720D1 (de) 1999-09-09
ATE182902T1 (de) 1999-08-15
JP2598362B2 (ja) 1997-04-09
CA2099865A1 (en) 1992-07-19
WO1992013097A1 (en) 1992-08-06
JPH09127107A (ja) 1997-05-16
DE69229720T2 (de) 2000-04-27
JPH06505968A (ja) 1994-07-07
CA2176620C (en) 2001-04-24
AU1273892A (en) 1992-08-27

Similar Documents

Publication Publication Date Title
ES2136082T3 (es) El proto-oncogen met como receptor del factor de crecimiento hepatico.
NL7801372A (nl) Nieuwe fysiologisch werkzame verbinding en werkwijze voor het bereiden daarvan langs microbiologische weg, alsmede farmaceutische preparaten met immunosuppressieve werking die de verbinding bevatten.
IT1063138B (it) Cannula,particolarmente per angio grafia
ES2089316T3 (es) Agente viral asociado con la enfermedad porcina misteriosa (mystery swine desease).
FI872756A0 (fi) Med laserstraolning fungerande terapeutisk anordning.
NL7607637A (nl) Werkwijze voor het bereiden van 2'.4-dichloor 4'-benzoylureidodifenylethers, alsmede de toe- passing daarvan als insecticiden.
NL930112I2 (nl) Benzazepine-2-onen, werkwijzen ter bereiding daarvan, farmaceutische preparaten die deze verbindingen bevatten, alsmede de verbindingen voor de therapeutische toepassing.
ZA877859B (en) 5-nitrobenzo(de)isoquinoline-1.3-diones,their preparation and their use
ATE87484T1 (de) Physiologisch aktive substanzen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
OA05223A (fr) Dérivés de l'alcoyloxy-5 phényl-3 oxadiazoline-1,3,4 one-2, leur préparation et les compositions insecticides et acaricides qui les contiennent.
FR2346332A1 (fr) Nouveaux derives de prostaglandine, leur procede de preparation ainsi que les compositions therapeutiques les contenant
MD940152A (ro) Compoziţie farmaceutică pentru tratarea infecţiilor şi bolilor, provocate de virusul hepatitei V (HBV)
FR2397385A1 (fr) Derives du resorcinol, leur preparation et leurs utilisations therapeutiques
NO901631D0 (no) Fremgangsmaate for fremstilling av 2-substituerte n,n'-ditrimetoksybenzoyl-piperaziner.
ES513974A0 (es) Procedimiento de preparacion de derivados del 3,4-difenil-5-metil pirazol.
IT1141183B (it) Incastellatura tubolare per palchi,banchi,scaffalature,armadi o simili
NO144411C (no) Anordning for gradering av biologisk vaeslke, saerlig blod, etter molekylvekt.
SE8402327L (sv) Anordning for att underletta forflyttning av stolar
IT8026232A0 (it) Composizioni farmaceutiche. derivato dell'alfa-mercapto propionilglicina ad attivita'terapeutica, procedimento per lasua preparazione e relative
ATE32027T1 (de) Pflegebett.
FR2304340A1 (fr) Nouveaux derives de prostaglandine, leur procede de preparation ainsi que les compositions therapeutiques les contenant
NL171585C (nl) Werkwijze voor de bereiding van farmaceutische preparaten met werking op het centrale zenuwstelsel op basis van 6-fenyl-1-oxoimidazo-Ÿ1,2-aŸbenzoŸfŸ-1,4-diazepinen en werkwijze voor de bereiding van deze verbindingen.
NL186006C (nl) Verbindingen en farmaceutische preparaten met een anticholinergische, anti-histaminische, hoeststillende en/of analgetische werking, en werkwijze voor de bereiding van de verbindingen.
GB1403342A (en) Sportswear
IT7820190A0 (it) Composti carbonilici, procedimento per la loro preparazione e loro impiego.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 567585

Country of ref document: ES