ES2136059T3 - Deteccion de una secuencia de acidos nucleicos o de un cambio en la misma. - Google Patents
Deteccion de una secuencia de acidos nucleicos o de un cambio en la misma.Info
- Publication number
- ES2136059T3 ES2136059T3 ES90903297T ES90903297T ES2136059T3 ES 2136059 T3 ES2136059 T3 ES 2136059T3 ES 90903297 T ES90903297 T ES 90903297T ES 90903297 T ES90903297 T ES 90903297T ES 2136059 T3 ES2136059 T3 ES 2136059T3
- Authority
- ES
- Spain
- Prior art keywords
- primer
- polynucleotide sequence
- fraction
- extended
- extended primer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
Abstract
SE DESCRIBE UN METODO PARA DETECTAR UNA SECUENCIA ESPECIFICA DE POLINUCLEOTIDO EN UNA MATERIA. EL METODO INCLUYE LA EXPOSICION DE DICHA MATERIA A UN OLIGONUCLEOTIDO PRIMARIO, CON UNA SECUENCIA COMPLEMENTARIA, A PARTE DE LA SECUENCIA ESPECIFICA DE POLINUCLEOTIDO MENCIONADA EN LA QUE ESTE ELEMENTO PRIMARIO SE ADHIERE A PARTE DE LA SECUENCIA DE POLINUCLEOTIDO MENCIONADA CUANDO ESTA PRESENTE EN DICHA MATERIA. EL ELEMENTO PRIMARIO UNIDO A LA SECUENCIA DE POLINUCLEOTIDO SE EXTIENDE EN DONDE CUALQUIER ELEMENTO PRIMARIO INCLUYE UN ELEMENTO DETECTABLE Y/O UN ELEMENTO DE SEPARACION. CUALQUIER ELEMENTO PRIMARIO EXTENDIDO SE SEPARA DESPUES EN UNA FRACCION EN DONDE DICHA FRACCION NO TIENE ELEMENTO DETECTABLE NO INCLUIDO EN DICHO ELEMENTO PRIMARIO EXTENDIDO. SE DETERMINA ENTONCES SI CUALQUIER ELEMENTO PRIMARIO EXTENDIDO ESTA PRESENTE EN DICHA FRACCION PROBANDO DICHA FRACCION PARA EL ELEMENTO PRIMARIO EXTENDIDO EN DONDE LA PRESENCIA DE DICHO ELEMENTO PRIMARIO EXTENDIDO ES INDICATIVO DE LA PRESENCIA DE LASECUENCIA ESPECIFICA DE POLINUCLEOTIDO EN DICHA MATERIA Y LA AUSENCIA DE DICHO ELEMENTO PRIMARIO EXTENDIDO EN DICHA FRACCION ES INDICATIVA DE LA AUSENCIA DE LA SECUENCIA ESPECIFICA DE POLINUCLEOTIDO EN DICHA MATERIA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPJ270389 | 1989-02-13 | ||
AU270389 | 1989-02-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2136059T3 true ES2136059T3 (es) | 1999-11-16 |
ES2136059T5 ES2136059T5 (es) | 2005-02-16 |
Family
ID=3773706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90903297T Expired - Lifetime ES2136059T5 (es) | 1989-02-13 | 1990-02-13 | Deteccion de una secuencia de acidos nucleicos o de un cambio en la misma. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0457824B2 (es) |
JP (1) | JP3021036B2 (es) |
AT (1) | ATE181576T1 (es) |
AU (1) | AU656514B2 (es) |
CA (1) | CA2044591C (es) |
DE (1) | DE69033179T3 (es) |
DK (1) | DK0457824T4 (es) |
ES (1) | ES2136059T5 (es) |
IE (1) | IE66572B1 (es) |
SG (1) | SG50434A1 (es) |
WO (1) | WO1990009455A1 (es) |
Families Citing this family (74)
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US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
JPH03123500A (ja) * | 1989-10-06 | 1991-05-27 | Canon Inc | 核酸の分別方法 |
US6013431A (en) | 1990-02-16 | 2000-01-11 | Molecular Tool, Inc. | Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators |
IL97222A (en) * | 1990-02-16 | 1995-08-31 | Orion Yhtymae Oy | Method and Responder for Determining Special Changes to Nucleotide |
US5126239A (en) * | 1990-03-14 | 1992-06-30 | E. I. Du Pont De Nemours And Company | Process for detecting polymorphisms on the basis of nucleotide differences |
IE66125B1 (en) * | 1991-01-31 | 1995-12-13 | Zeneca Ltd | Detection method for variant nucleotides |
US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
US5294534A (en) * | 1991-08-13 | 1994-03-15 | Miles, Inc. | Amplification method for polynucleotide assays |
ATE192503T1 (de) * | 1991-12-24 | 2000-05-15 | Tepnel Medical Ltd | Manipulation von nukleinsäuresequenzen |
GB9127415D0 (en) * | 1991-12-24 | 1992-02-19 | Swordfish Int Ltd | Solid support bound detection and diagnostic system |
EP1302547A3 (en) * | 1992-06-17 | 2003-11-12 | City Of Hope | A method of detecting and discriminating between nucleic acid sequences |
WO1993025563A1 (en) * | 1992-06-17 | 1993-12-23 | City Of Hope | A method of detecting and discriminating between nucleic acid sequences |
US5981176A (en) * | 1992-06-17 | 1999-11-09 | City Of Hope | Method of detecting and discriminating between nucleic acid sequences |
SE9201929D0 (sv) * | 1992-06-23 | 1992-06-23 | Pharmacia Lkb Biotech | Method and system for molecular-biological diagnostics |
CA2139433A1 (en) * | 1992-07-02 | 1994-01-20 | Nurit Eyal | Methods of single nucleotide primer extension to detect specific alleles and kits therefor |
US5710028A (en) * | 1992-07-02 | 1998-01-20 | Eyal; Nurit | Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor |
US6153379A (en) * | 1993-06-22 | 2000-11-28 | Baylor College Of Medicine | Parallel primer extension approach to nucleic acid sequence analysis |
US7001722B1 (en) | 1993-06-22 | 2006-02-21 | Baylor College Of Medicine | Parallel primer extension approach to nucleic acid sequence analysis |
AU8132194A (en) * | 1993-11-03 | 1995-05-23 | Molecular Tool, Inc. | Single nucleotide polymorphisms and their use in genetic analysis |
US6027883A (en) * | 1994-03-30 | 2000-02-22 | Mitokor | Optimal procedure for isolation of mutant mitochondrial alleles |
US5976798A (en) * | 1994-03-30 | 1999-11-02 | Mitokor | Methods for detecting mitochondrial mutations diagnostic for Alzheimer's disease and methods for determining heteroplasmy of mitochondrial nucleic acid |
CN1152946A (zh) * | 1994-05-28 | 1997-06-25 | 特普尼尔医学有限公司 | 生产核酸的拷贝 |
US5641658A (en) * | 1994-08-03 | 1997-06-24 | Mosaic Technologies, Inc. | Method for performing amplification of nucleic acid with two primers bound to a single solid support |
US6090592A (en) * | 1994-08-03 | 2000-07-18 | Mosaic Technologies, Inc. | Method for performing amplification of nucleic acid on supports |
US6060288A (en) * | 1994-08-03 | 2000-05-09 | Mosaic Technologies | Method for performing amplification of nucleic acid on supports |
AU5296496A (en) * | 1995-03-24 | 1996-10-16 | Mitokor | Mutation detection by differential primer extension of mutant and wildtype target sequences |
GB9507238D0 (en) | 1995-04-07 | 1995-05-31 | Isis Innovation | Detecting dna sequence variations |
GB9517914D0 (en) * | 1995-09-02 | 1995-11-01 | Tepnel Medical Ltd | Identification of bases in nucleic acid sequences |
WO1997010359A1 (fr) * | 1995-09-13 | 1997-03-20 | Wakunaga Seiyaku Kabushiki Kaisha | Procede de concentration d'acide nucleique variant et materiel de test de concentration d'acide nucleique de mise en application du procede |
AU2320597A (en) | 1996-03-19 | 1997-10-10 | Molecular Tool, Inc. | Method for determining the nucleotide sequence of a polynucleotide |
US6146828A (en) * | 1996-08-14 | 2000-11-14 | Exact Laboratories, Inc. | Methods for detecting differences in RNA expression levels and uses therefor |
EP3034626A1 (en) | 1997-04-01 | 2016-06-22 | Illumina Cambridge Limited | Method of nucleic acid sequencing |
US6566101B1 (en) | 1997-06-16 | 2003-05-20 | Anthony P. Shuber | Primer extension methods for detecting nucleic acids |
US6268136B1 (en) | 1997-06-16 | 2001-07-31 | Exact Science Corporation | Methods for stool sample preparation |
US6194160B1 (en) * | 1998-03-19 | 2001-02-27 | Immunetics, Inc. | Systems and methods for rapid blot screening |
US6818404B2 (en) | 1997-10-23 | 2004-11-16 | Exact Sciences Corporation | Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples |
WO2000011215A2 (en) * | 1998-08-14 | 2000-03-02 | Exact Laboratories, Inc. | Method for diagnostic screening |
US6203990B1 (en) | 1998-11-06 | 2001-03-20 | Mitokor | Method and system for pattern analysis, such as for analyzing oligonucleotide primer extension assay products |
US6280947B1 (en) | 1999-08-11 | 2001-08-28 | Exact Sciences Corporation | Methods for detecting nucleotide insertion or deletion using primer extension |
US6503718B2 (en) | 1999-01-10 | 2003-01-07 | Exact Sciences Corporation | Methods for detecting mutations using primer extension for detecting disease |
DE60038109T2 (de) * | 1999-04-09 | 2008-11-27 | Keygene N.V. | Verfahren zur Analyse von AFLP Reaktionsmischungen unter Verwendung von Primer Verlängerungstechniken |
US6573047B1 (en) | 1999-04-13 | 2003-06-03 | Dna Sciences, Inc. | Detection of nucleotide sequence variation through fluorescence resonance energy transfer label generation |
EP1171637A2 (en) * | 1999-04-27 | 2002-01-16 | The University Of Chicago | Nucleotide extension on a microarray of gel-immobilized primers |
WO2001021838A2 (en) * | 1999-09-22 | 2001-03-29 | Motorola Inc. | Three-dimensional microarray system for parallel genotyping of single nucleotide polymorphisms |
JP2003517309A (ja) | 1999-12-02 | 2003-05-27 | ディーエヌエー サイエンシーズ インコーポレーテッド | 単一ヌクレオチドの変異及びジェノタイピングの決定方法 |
US20020018999A1 (en) * | 2000-02-24 | 2002-02-14 | Jan Henriksson | Methods for characterizing polymorphisms |
US6376191B1 (en) * | 2000-03-22 | 2002-04-23 | Mergen, Ltd. | Microarray-based analysis of polynucleotide sequence variations |
US6355433B1 (en) | 2000-06-02 | 2002-03-12 | Dna Sciences, Inc. | Determination of nucleotide sequence variations through limited primer extension |
JP2004520812A (ja) * | 2000-08-30 | 2004-07-15 | ハプロゲン・エルエルシー | 対立遺伝子を決定するための方法 |
AR031640A1 (es) | 2000-12-08 | 2003-09-24 | Applied Research Systems | Amplificacion isotermica de acidos nucleicos en un soporte solido |
US6428964B1 (en) | 2001-03-15 | 2002-08-06 | Exact Sciences Corporation | Method for alteration detection |
AU2002358110A1 (en) | 2001-12-10 | 2003-07-09 | Novartis Ag | Methods of treating psychosis and schizophrenia based on a polymorphism in the ctf gene |
EP1571210A4 (en) * | 2002-12-10 | 2006-08-16 | Olympus Corp | METHOD FOR ANALYZING THE VARIATION OF NUCLEIC ACID MUTATION AND METHOD FOR GENE EXPRESSION ANALYSIS |
DE602004030271D1 (de) | 2003-09-12 | 2011-01-05 | Univ Cincinnati | Verfahren zur risikobeurteilung, überlebensvorhersage und behandlung von herzversagen und anderen leiden auf der grundlage von polymorphismen adrenerger rezeptoren |
ATE469245T1 (de) | 2004-09-14 | 2010-06-15 | Univ Colorado | Auf genetischem targeting basierendes verfahren zur behandlung mit bucindolol |
WO2006047787A2 (en) | 2004-10-27 | 2006-05-04 | Exact Sciences Corporation | Method for monitoring disease progression or recurrence |
US9777314B2 (en) | 2005-04-21 | 2017-10-03 | Esoterix Genetic Laboratories, Llc | Analysis of heterogeneous nucleic acid samples |
WO2008093098A2 (en) | 2007-02-02 | 2008-08-07 | Illumina Cambridge Limited | Methods for indexing samples and sequencing multiple nucleotide templates |
AU2008260029B2 (en) | 2007-05-31 | 2015-02-12 | Yale University | A genetic lesion associated with cancer |
EP2149612A1 (en) | 2008-07-29 | 2010-02-03 | Merck Serono SA | Genetic markers of response to efalizumab |
WO2010038042A1 (en) | 2008-10-02 | 2010-04-08 | Illumina Cambridge Ltd. | Nucleic acid sample enrichment for sequencing applications |
WO2010077832A1 (en) | 2008-12-15 | 2010-07-08 | Wisconsin Alumni Research Foundation | Methods and compositions for testing and breeding cattle for improved fertility and embryonic survival |
CA2751287A1 (en) | 2009-02-06 | 2010-09-10 | Yale University | A snp marker of breast and ovarian cancer risk |
EP2446056A2 (en) | 2009-06-25 | 2012-05-02 | Yale University | Single nucleotide polymorphisms in brca1 and cancer risk |
US8182994B2 (en) | 2009-09-15 | 2012-05-22 | Illumina Cambridge Limited | Centroid markers for image analysis of high denisty clusters in complex polynucleotide sequencing |
US20140024590A1 (en) | 2011-02-18 | 2014-01-23 | Yale University | KRAS-Variant And Endometriosis |
US20140065615A1 (en) | 2011-03-21 | 2014-03-06 | Yale University | The KRAS Variant and Tumor Biology |
WO2013045505A1 (en) | 2011-09-28 | 2013-04-04 | Novartis Ag | Biomarkers for raas combination therapy |
US10221456B2 (en) | 2012-08-06 | 2019-03-05 | Merck Patent Gmbh | Genetic markers for predicting responsiveness to FPG-18 compound |
EP2912194B1 (en) | 2012-10-26 | 2019-05-08 | Memorial Sloan-Kettering Cancer Center | Androgen receptor variants and methods for making and using |
EP3008211A4 (en) | 2013-06-11 | 2016-12-21 | Courtagen Life Sciences Inc | METHOD AND KITS FOR TREATMENT AND CLASSIFICATION OF PERSONS WITHOUT THE RISK OF AN EXISTING OR EXISTING TRAP1 FUNCTIONAL CHANGE |
KR20180033235A (ko) | 2015-07-23 | 2018-04-02 | 머크 샤프 앤드 돔 코포레이션 | Crth2 수용체 길항제에 대한 반응과 연관된 유전자 마커 |
JP2019515035A (ja) | 2016-04-27 | 2019-06-06 | ミラ ディーエックス, インコーポレイテッド | Krasバリアントがん患者の免疫ベースの処置 |
WO2018111662A1 (en) | 2016-12-14 | 2018-06-21 | Merck Sharp & Dohme Corp. | Human genetic markers associated with response to treatments that target clostridium difficile toxin b |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4307189A (en) * | 1980-03-21 | 1981-12-22 | Malon Kit | Method for the quantitative determination of terminal deoxynucleotidyl transferase in biological samples |
GB8311018D0 (en) * | 1983-04-22 | 1983-05-25 | Amersham Int Plc | Detecting mutations in dna |
US4868104A (en) * | 1985-09-06 | 1989-09-19 | Syntex (U.S.A.) Inc. | Homogeneous assay for specific polynucleotides |
US4851331A (en) * | 1986-05-16 | 1989-07-25 | Allied Corporation | Method and kit for polynucleotide assay including primer-dependant DNA polymerase |
AU622104B2 (en) * | 1987-03-11 | 1992-04-02 | Sangtec Molecular Diagnostics Ab | Method of assaying of nucleic acids, a reagent combination and kit therefore |
CA1317535C (en) | 1987-06-30 | 1993-05-11 | Nanibhushan Dattagupta | Assay of sequences using amplified genes |
DE68908054T2 (de) * | 1988-01-21 | 1994-03-10 | Genentech Inc | Verstärkung und nachweis von nukleinsäuresequenzen. |
WO1989010414A1 (en) † | 1988-04-28 | 1989-11-02 | Robert Bruce Wallace | AMPLIFIED SEQUENCE POLYMORPHISMS (ASPs) |
WO1990001069A1 (en) * | 1988-07-20 | 1990-02-08 | Segev Diagnostics, Inc. | Process for amplifying and detecting nucleic acid sequences |
GB8827160D0 (en) † | 1988-11-21 | 1988-12-29 | Apothekernes Lab | Detection & quantitative determination of rna & dna |
-
1990
- 1990-02-13 IE IE50190A patent/IE66572B1/en not_active IP Right Cessation
- 1990-02-13 DK DK90903297T patent/DK0457824T4/da not_active Application Discontinuation
- 1990-02-13 AT AT90903297T patent/ATE181576T1/de not_active IP Right Cessation
- 1990-02-13 EP EP90903297A patent/EP0457824B2/en not_active Expired - Lifetime
- 1990-02-13 AU AU51069/90A patent/AU656514B2/en not_active Expired
- 1990-02-13 ES ES90903297T patent/ES2136059T5/es not_active Expired - Lifetime
- 1990-02-13 DE DE69033179T patent/DE69033179T3/de not_active Expired - Lifetime
- 1990-02-13 JP JP2503566A patent/JP3021036B2/ja not_active Expired - Lifetime
- 1990-02-13 SG SG1996001326A patent/SG50434A1/en unknown
- 1990-02-13 CA CA002044591A patent/CA2044591C/en not_active Expired - Lifetime
- 1990-02-13 WO PCT/AU1990/000058 patent/WO1990009455A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP0457824A1 (en) | 1991-11-27 |
DK0457824T4 (da) | 2004-10-11 |
EP0457824A4 (en) | 1992-07-08 |
IE900501L (en) | 1990-08-13 |
DE69033179T3 (de) | 2005-01-27 |
ES2136059T5 (es) | 2005-02-16 |
DE69033179D1 (de) | 1999-07-29 |
AU5106990A (en) | 1990-09-05 |
CA2044591C (en) | 2002-08-13 |
DE69033179T2 (de) | 2000-01-05 |
EP0457824B2 (en) | 2004-06-09 |
DK0457824T3 (da) | 2000-01-24 |
CA2044591A1 (en) | 1990-08-14 |
AU656514B2 (en) | 1995-02-09 |
JPH04503158A (ja) | 1992-06-11 |
SG50434A1 (en) | 1998-07-20 |
JP3021036B2 (ja) | 2000-03-15 |
IE66572B1 (en) | 1996-01-24 |
WO1990009455A1 (en) | 1990-08-23 |
EP0457824B1 (en) | 1999-06-23 |
ATE181576T1 (de) | 1999-07-15 |
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