ES2133546T3 - Emulsiones de fluorocarburos con propiedades reducidas de retencion de gas en los pulmones. - Google Patents

Emulsiones de fluorocarburos con propiedades reducidas de retencion de gas en los pulmones.

Info

Publication number
ES2133546T3
ES2133546T3 ES94910799T ES94910799T ES2133546T3 ES 2133546 T3 ES2133546 T3 ES 2133546T3 ES 94910799 T ES94910799 T ES 94910799T ES 94910799 T ES94910799 T ES 94910799T ES 2133546 T3 ES2133546 T3 ES 2133546T3
Authority
ES
Spain
Prior art keywords
fluorocarbon
fluorocarbide
lungs
emulsions
reduced gas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94910799T
Other languages
English (en)
Inventor
Jeffrey G Weers
Ernest G Schutt
Timothy J Pelura
Peter E Keipert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alliance Pharmaceutical Corp
Original Assignee
Alliance Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alliance Pharmaceutical Corp filed Critical Alliance Pharmaceutical Corp
Application granted granted Critical
Publication of ES2133546T3 publication Critical patent/ES2133546T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SE PRESENTA UNA EMULSION DE FLUOROCARBONO QUE EXHIBE PROPIEDADES REDUCIDAS DE ATRAPAMIENTO DEL GAS PULMONAR EN ANIMALES DE LABORATORIO. ADICIONALMENTE, LOS COMPONENTES DE FLUOROCARBONO EXHIBEN UN CORTO TIEMPO DE RETENCION DE ORGANO. LA EMULSION INCLUYE UNA FASE ACUOSA, UN EMULSIFICANTE, Y UN FLUOROCARBONO (O COMPOSICION DE FLUOROCARBONO), QUE TENGA UNA PRESION DE VAPOR INFERIOR A ALREDEDOR DE 8 TORR PARA REDUCIR EL ATRAPAMIENTO DEL GAS PULMONAR, Y QUE TENGA UNA VIDA MEDIA DE RETENCION DE ORGANO INFERIOR A 6 SEMANAS MAS PREFERIBLEMENTE MENOR A ALREDEDOR DE 3 O 4 SEMANAS.
ES94910799T 1993-03-16 1994-03-01 Emulsiones de fluorocarburos con propiedades reducidas de retencion de gas en los pulmones. Expired - Lifetime ES2133546T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/032,333 US5635538A (en) 1993-03-16 1993-03-16 Fluorocarbon emulsions with reduced pulmonary gas-trapping properties

Publications (1)

Publication Number Publication Date
ES2133546T3 true ES2133546T3 (es) 1999-09-16

Family

ID=21864383

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94910799T Expired - Lifetime ES2133546T3 (es) 1993-03-16 1994-03-01 Emulsiones de fluorocarburos con propiedades reducidas de retencion de gas en los pulmones.

Country Status (10)

Country Link
US (1) US5635538A (es)
EP (1) EP0689422B1 (es)
JP (1) JPH08507786A (es)
AT (1) ATE182071T1 (es)
AU (1) AU679052B2 (es)
DE (1) DE69419503T2 (es)
DK (1) DK0689422T3 (es)
ES (1) ES2133546T3 (es)
GR (1) GR3030793T3 (es)
WO (1) WO1994021227A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2679150A1 (fr) * 1991-07-17 1993-01-22 Atta Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations.
US5628930A (en) * 1992-10-27 1997-05-13 Alliance Pharmaceutical Corp. Stabilization of fluorocarbon emulsions
DE69831248T2 (de) * 1997-02-28 2006-04-13 The Regents Of The University Of California, Oakland Verfahren und zusammensetzungen zur optimierung des sauerstofftransportes in zellfreien systemen
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
US6420143B1 (en) 1998-02-13 2002-07-16 Caliper Technologies Corp. Methods and systems for performing superheated reactions in microscale fluidic systems
US20030153491A1 (en) * 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20050164915A1 (en) * 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
ES2305368T3 (es) * 2002-05-10 2008-11-01 THE PROCTER & GAMBLE COMPANY Tisu estampado en relieve que tiene fibras superficiales sueltas y metodo para su produccion.
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
KR101403264B1 (ko) 2002-10-11 2014-06-02 백스터 인터내셔널 인코포레이티드 할로겐화된 휘발성 마취제의 정맥내 투여에 의한 심장보호 및 신경보호방법
US20090117207A1 (en) * 2005-11-29 2009-05-07 Zoltani Csaba K Methods and compositions for treatment of poison-caused pathology
JP5205369B2 (ja) * 2006-05-22 2013-06-05 アライアンス ファーマシューティカル コーポレイション 血液代替のため、および他の治療的使用のための、最適化フルオロカーボンエマルジョン

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975512A (en) * 1970-12-21 1976-08-17 University Of Illinois Foundation Non-toxic brominated perfluorocarbons radiopaque agents
FR2515198A1 (fr) * 1981-10-22 1983-04-29 Centre Nat Rech Scient Microemulsions aqueuses de fluorocarbures indefiniment stables a une temperature donnee, procede d'obtention et application a titre de transporteurs d'oxygene
FR2523956A1 (fr) * 1982-03-26 1983-09-30 Ugine Kuhlmann Bis-(perfluoroalkyl)-1,2-ethenes ramifies, leur preparation et leur utilisation comme transporteurs d'oxygene convertisseur electromecanique
US4640833A (en) * 1983-02-28 1987-02-03 Adamantech, Inc. Use of perfluorobromoalkyl ethers as X-ray contrast agents
GB8504916D0 (en) * 1985-02-26 1985-03-27 Isc Chemicals Ltd Emulsions of perfluorocarbons in aqueous media
US5080885A (en) * 1986-01-14 1992-01-14 Alliance Pharmaceutical Corp. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
US4987154A (en) * 1986-01-14 1991-01-22 Alliance Pharmaceutical Corp. Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use
US4865836A (en) * 1986-01-14 1989-09-12 Fluoromed Pharmaceutical, Inc. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
US4866096A (en) * 1987-03-20 1989-09-12 Air Products And Chemicals, Inc. Stable fluorochemical aqueous emulsions
US4895876A (en) * 1987-03-20 1990-01-23 Air Products And Chemicals, Inc. Concentrated stable fluorochemical aqueous emulsions containing triglycerides
WO1991000110A1 (en) * 1989-07-05 1991-01-10 Alliance Pharmaceutical Corp. Fluorocarbon emulsions having saturated phospholipid emulsifiers
DE4019062A1 (de) * 1989-08-30 1991-03-07 Kali Chemie Ag Stabilisierung von perfluorcarbonemulsionen und als emulsionsstabilisierende zusaetze verwendbare perfluorierte heterocyclische verbindungen
FR2679150A1 (fr) * 1991-07-17 1993-01-22 Atta Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations.
US5264220A (en) * 1991-11-12 1993-11-23 Long David M Jr Method of extending the vascular dwell-time of particulate therapeutic and particulate diagnostic agents

Also Published As

Publication number Publication date
DE69419503T2 (de) 1999-11-18
AU679052B2 (en) 1997-06-19
JPH08507786A (ja) 1996-08-20
EP0689422B1 (en) 1999-07-14
WO1994021227A1 (en) 1994-09-29
AU6356694A (en) 1994-10-11
GR3030793T3 (en) 1999-11-30
ATE182071T1 (de) 1999-07-15
EP0689422A1 (en) 1996-01-03
US5635538A (en) 1997-06-03
DE69419503D1 (de) 1999-08-19
DK0689422T3 (da) 1999-12-06

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