ES2131331T3 - Uso de benzotiofenos para la preparacion de un medicamento para reducir la formacion de cicatrices en la curacion de heridas. - Google Patents

Uso de benzotiofenos para la preparacion de un medicamento para reducir la formacion de cicatrices en la curacion de heridas.

Info

Publication number
ES2131331T3
ES2131331T3 ES95930892T ES95930892T ES2131331T3 ES 2131331 T3 ES2131331 T3 ES 2131331T3 ES 95930892 T ES95930892 T ES 95930892T ES 95930892 T ES95930892 T ES 95930892T ES 2131331 T3 ES2131331 T3 ES 2131331T3
Authority
ES
Spain
Prior art keywords
benzotiofenes
scars
wounds
medication
healing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95930892T
Other languages
English (en)
Inventor
George Joseph Cullinan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2131331T3 publication Critical patent/ES2131331T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

METODO PARA INHIBIR LA CICATRIZACION QUE SUPONE LA ADMINISTRACION A UN SER HUMANO QUE LO NECESITE DE UNA CANTIDAD EFECTIVA DE UN COMPUESTO QUE TENGA LA FORMULA (I) DONDE R{SUP,1} Y R{SUP,3} SON INDEPENDIENTEMENTE HIDROGENO ,CH{SUB,3}, (A), O (B), DONDE AR ES OPCIONALMENTE FENIL SUSTITUTIVO; R{SUP,2} SE SELECCIONA A PARTIR DEL GRUPO INTEGRADO POR PIRROLIDINA, HEXAMETILENEIMINO, Y PIPERIDINO O UNA SAL ACEPTABLE FARMACEUTICAMENTE O UN SOLVATO DE ESTOS.
ES95930892T 1994-08-22 1995-08-21 Uso de benzotiofenos para la preparacion de un medicamento para reducir la formacion de cicatrices en la curacion de heridas. Expired - Lifetime ES2131331T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/293,851 US5550151A (en) 1994-08-22 1994-08-22 Methods of reducing scarring in wound healing

Publications (1)

Publication Number Publication Date
ES2131331T3 true ES2131331T3 (es) 1999-07-16

Family

ID=23130857

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95930892T Expired - Lifetime ES2131331T3 (es) 1994-08-22 1995-08-21 Uso de benzotiofenos para la preparacion de un medicamento para reducir la formacion de cicatrices en la curacion de heridas.

Country Status (14)

Country Link
US (1) US5550151A (es)
EP (1) EP0772438B1 (es)
JP (1) JPH10504823A (es)
AT (1) ATE179890T1 (es)
AU (1) AU3411195A (es)
CA (1) CA2198011A1 (es)
DE (1) DE69509657T2 (es)
DK (1) DK0772438T3 (es)
ES (1) ES2131331T3 (es)
GR (1) GR3030255T3 (es)
IL (1) IL115023A0 (es)
MX (1) MX9701328A (es)
WO (1) WO1996005826A1 (es)
ZA (1) ZA956995B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4688046B2 (ja) * 2004-11-05 2011-05-25 株式会社ポーラファルマ 肥厚性瘢痕動物モデル

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US5075321A (en) * 1987-03-24 1991-12-24 University Of Pennsylvania Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体

Also Published As

Publication number Publication date
EP0772438A1 (en) 1997-05-14
AU3411195A (en) 1996-03-14
GR3030255T3 (en) 1999-08-31
DE69509657T2 (de) 1999-09-30
CA2198011A1 (en) 1996-02-29
US5550151A (en) 1996-08-27
MX9701328A (es) 1997-05-31
WO1996005826A1 (en) 1996-02-29
ZA956995B (en) 1997-02-21
ATE179890T1 (de) 1999-05-15
EP0772438A4 (en) 1997-09-03
JPH10504823A (ja) 1998-05-12
IL115023A0 (en) 1995-12-08
DK0772438T3 (da) 1999-11-01
EP0772438B1 (en) 1999-05-12
DE69509657D1 (de) 1999-06-17

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