ES2129384T3 - Un procedimiento para la preparacion de derivados del acido 5-amino-2,4,6-triyodo-1,3-bencenocarboxilico. - Google Patents
Un procedimiento para la preparacion de derivados del acido 5-amino-2,4,6-triyodo-1,3-bencenocarboxilico.Info
- Publication number
- ES2129384T3 ES2129384T3 ES97952841T ES97952841T ES2129384T3 ES 2129384 T3 ES2129384 T3 ES 2129384T3 ES 97952841 T ES97952841 T ES 97952841T ES 97952841 T ES97952841 T ES 97952841T ES 2129384 T3 ES2129384 T3 ES 2129384T3
- Authority
- ES
- Spain
- Prior art keywords
- triyod
- amino
- bencendicarboxilico
- acid
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002253 acid Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- -1 HYDROXY GROUPS Chemical group 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 241000047703 Nonion Species 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 238000009413 insulation Methods 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
- 239000002699 waste material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI002545A IT1286522B1 (it) | 1996-12-04 | 1996-12-04 | Processo per la preparazione di derivati dell'acido 5-ammino-2,4,6- triiodo-1,3-benzenedicarbossilico |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2129384T1 ES2129384T1 (es) | 1999-06-16 |
| ES2129384T3 true ES2129384T3 (es) | 2003-04-01 |
Family
ID=11375347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97952841T Expired - Lifetime ES2129384T3 (es) | 1996-12-04 | 1997-12-01 | Un procedimiento para la preparacion de derivados del acido 5-amino-2,4,6-triyodo-1,3-bencenocarboxilico. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0901460B1 (OSRAM) |
| JP (1) | JP4219409B2 (OSRAM) |
| AU (1) | AU5657798A (OSRAM) |
| CA (1) | CA2244884A1 (OSRAM) |
| DE (2) | DE901460T1 (OSRAM) |
| ES (1) | ES2129384T3 (OSRAM) |
| IN (1) | IN185038B (OSRAM) |
| IT (1) | IT1286522B1 (OSRAM) |
| NO (1) | NO322067B1 (OSRAM) |
| PT (1) | PT901460E (OSRAM) |
| WO (1) | WO1998024757A1 (OSRAM) |
| ZA (1) | ZA9710862B (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6803485B2 (en) | 1999-02-26 | 2004-10-12 | Bracco Imaging S.P.A. | Process for the preparation of iopamidol |
| CN100344606C (zh) * | 2005-12-28 | 2007-10-24 | 江苏省原子医学研究所 | 一种碘昔兰的制备方法 |
| KR101098553B1 (ko) | 2008-04-30 | 2011-12-26 | 주식회사 엘지생명과학 | 이오프로마이드의 신규한 제조방법 |
| JP5536087B2 (ja) | 2008-11-18 | 2014-07-02 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | ヨウ化造影剤の製造方法 |
| EP2230227A1 (en) | 2009-03-20 | 2010-09-22 | Bracco Imaging S.p.A | Process for the preparation of triiodinated carboxylic aromatic derivatives |
| EP2243767A1 (en) | 2009-04-21 | 2010-10-27 | Bracco Imaging S.p.A | Process for the iodination of aromatic compounds |
| DK2931696T3 (en) | 2012-12-11 | 2018-12-17 | Bracco Imaging Spa | CONTINUOUS PROCEDURE FOR THE PREPARATION OF (S) -2-ACETYLOXYPROPIONIC ACID |
| KR101520187B1 (ko) | 2013-10-25 | 2015-05-13 | 주식회사 대웅제약 | 이오프로마이드의 중간체의 제조방법 |
| LT3369724T (lt) | 2013-11-05 | 2021-02-25 | Bracco Imaging Spa | Iopamidolio gamybos būdas |
| MX390437B (es) | 2014-06-10 | 2025-03-20 | Bracco Imaging Spa | Metodo para la preparacion de acido (s)-2-acetiloxipropionico y derivados del mismo. |
| PT108524B (pt) * | 2015-06-02 | 2017-12-15 | Hovione Farmaciência S A | Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos |
| EP3548461B1 (en) | 2016-12-05 | 2021-02-03 | Bracco Imaging SpA | Mechanochemical synthesis of radiographic agents intermediates |
| CN116354842B (zh) * | 2021-12-20 | 2024-12-03 | 重庆圣华曦药业股份有限公司 | 一种改进的碘美普尔制备方法及其在制剂中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH608189A5 (OSRAM) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
| US5075502A (en) * | 1989-12-13 | 1991-12-24 | Mallinckrodt, Inc. | Nonionic x-ray contrast agents, compositions and methods |
| CA2130829A1 (en) * | 1992-02-28 | 1993-09-02 | William Z. Mccarthy | Synthesis of ioversol using a minimal excess of acetoxyacetylchloride |
-
1996
- 1996-12-04 IT IT96MI002545A patent/IT1286522B1/it active IP Right Grant
-
1997
- 1997-12-01 CA CA002244884A patent/CA2244884A1/en not_active Abandoned
- 1997-12-01 DE DE0901460T patent/DE901460T1/de active Pending
- 1997-12-01 ES ES97952841T patent/ES2129384T3/es not_active Expired - Lifetime
- 1997-12-01 DE DE69715616T patent/DE69715616T2/de not_active Expired - Lifetime
- 1997-12-01 PT PT97952841T patent/PT901460E/pt unknown
- 1997-12-01 EP EP97952841A patent/EP0901460B1/en not_active Expired - Lifetime
- 1997-12-01 AU AU56577/98A patent/AU5657798A/en not_active Abandoned
- 1997-12-01 JP JP52518298A patent/JP4219409B2/ja not_active Expired - Fee Related
- 1997-12-01 WO PCT/EP1997/006720 patent/WO1998024757A1/en active IP Right Grant
- 1997-12-03 IN IN2768MA1997 patent/IN185038B/en unknown
- 1997-12-03 ZA ZA9710862A patent/ZA9710862B/xx unknown
-
1998
- 1998-08-03 NO NO19983563A patent/NO322067B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT901460E (pt) | 2003-01-31 |
| ES2129384T1 (es) | 1999-06-16 |
| IN185038B (OSRAM) | 2000-10-21 |
| NO322067B1 (no) | 2006-08-07 |
| NO983563D0 (no) | 1998-08-03 |
| CA2244884A1 (en) | 1998-06-11 |
| JP2000505114A (ja) | 2000-04-25 |
| ITMI962545A0 (it) | 1996-12-04 |
| DE69715616D1 (de) | 2002-10-24 |
| EP0901460B1 (en) | 2002-09-18 |
| EP0901460A1 (en) | 1999-03-17 |
| NO983563L (no) | 1998-10-02 |
| DE901460T1 (de) | 1999-08-19 |
| WO1998024757A1 (en) | 1998-06-11 |
| JP4219409B2 (ja) | 2009-02-04 |
| DE69715616T2 (de) | 2003-08-07 |
| AU5657798A (en) | 1998-06-29 |
| ZA9710862B (en) | 1998-06-23 |
| IT1286522B1 (it) | 1998-07-15 |
| ITMI962545A1 (it) | 1998-06-04 |
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