ES2129006B1 - Procedimiento para producir cefazolina. - Google Patents

Procedimiento para producir cefazolina.

Info

Publication number
ES2129006B1
ES2129006B1 ES009702058A ES9702058A ES2129006B1 ES 2129006 B1 ES2129006 B1 ES 2129006B1 ES 009702058 A ES009702058 A ES 009702058A ES 9702058 A ES9702058 A ES 9702058A ES 2129006 B1 ES2129006 B1 ES 2129006B1
Authority
ES
Spain
Prior art keywords
procedure
phenylacetamido
cephem
methyl
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009702058A
Other languages
English (en)
Other versions
ES2129006A1 (es
Inventor
Ichiro Kawahara
Hiroaki Asai
Shigetoshi Yaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Chemical Co Ltd
Original Assignee
Otsuka Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Chemical Co Ltd filed Critical Otsuka Chemical Co Ltd
Publication of ES2129006A1 publication Critical patent/ES2129006A1/es
Application granted granted Critical
Publication of ES2129006B1 publication Critical patent/ES2129006B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para producir cefazolina que comprende hacer reaccionar un éster de ácido 7-fenilacetamido-3-halogenometil-3-cefem-4-carboxílico con 2-metil-5-mercapto-1,3,4-tiadiazol, someter el producto de reacción a una reacción de desesterificación en presencia de un compuesto fenólico, desacilar el ácido 7-fenilacetamido-3-(2-metil-1,3,4-tiadiazol-5-il)tiometil-3-cefem-4-carboxílico con penicilina G - amidasa, y hacer reaccionar el producto de la reacción enzimática con un anhídrido de ácido mixto preparado a partir del ácido 1H-tetrazol-1-acético y un haluro de ácido o un halocarbonato de alquilo.
ES009702058A 1996-10-02 1997-10-02 Procedimiento para producir cefazolina. Expired - Fee Related ES2129006B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8261976A JPH10101679A (ja) 1996-10-02 1996-10-02 セファゾリンの製造法

Publications (2)

Publication Number Publication Date
ES2129006A1 ES2129006A1 (es) 1999-05-16
ES2129006B1 true ES2129006B1 (es) 2000-01-16

Family

ID=17369282

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009702058A Expired - Fee Related ES2129006B1 (es) 1996-10-02 1997-10-02 Procedimiento para producir cefazolina.

Country Status (6)

Country Link
JP (1) JPH10101679A (es)
CN (1) CN1084750C (es)
ES (1) ES2129006B1 (es)
IN (1) IN187033B (es)
IT (1) IT1289763B1 (es)
TW (1) TW434317B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100344635C (zh) * 2003-07-22 2007-10-24 广州白云山制药股份有限公司 7－苯乙酰氨基－3－吡啶甲基－3－头孢菌素－4－羧酸对甲氧苄酯晶体及其制备方法
CN100418972C (zh) * 2004-01-19 2008-09-17 广州白云山制药股份有限公司 一种头孢烯类鎓盐化合物及其制备方法和用它制备头孢吡肟的应用
JP4046708B2 (ja) * 2004-06-04 2008-02-13 明治製菓株式会社 ３−アルケニルセフェム化合物の製造方法
CN101735248A (zh) * 2008-11-07 2010-06-16 日本化学工业株式会社 3-链烯基头孢烯化合物的制造方法
CN102321101B (zh) * 2011-07-28 2015-07-15 哈药集团制药总厂 一种制备头孢唑林钠化合物的方法
CN103965215B (zh) * 2014-04-30 2016-04-27 悦康药业集团有限公司 一种头孢唑林钠化合物及其无菌粉针
CN104910188B (zh) * 2015-05-26 2017-07-04 齐鲁安替制药有限公司 一种头孢唑林酸的合成方法
CN105017286B (zh) * 2015-07-09 2017-11-28 山东罗欣药业集团股份有限公司 一种头孢类抗感染药物的制备方法
CN105153198B (zh) * 2015-09-17 2017-06-27 浙江华方药业股份有限公司 一种头孢布烯的制备方法
CN111979287A (zh) * 2020-09-21 2020-11-24 湖北凌晟药业有限公司 一种7-苯乙酰氨基-3-无-3-头孢-4-羧酸的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE824028A (fr) * 1974-01-23 1975-06-30 Procede pour la purification de cephalosporines comportant un groupe acide carboxylique libre
US3954745A (en) * 1974-09-12 1976-05-04 Eli Lilly And Company Process for preparing cefazolin
GB9115287D0 (en) * 1991-07-15 1991-08-28 Antibioticos Spa Process for the preparation of cephalosporins intermediates
JP6326112B2 (ja) * 2016-10-21 2018-05-16 株式会社三共 遊技機

Also Published As

Publication number Publication date
CN1084750C (zh) 2002-05-15
IT1289763B1 (it) 1998-10-16
ES2129006A1 (es) 1999-05-16
TW434317B (en) 2001-05-16
JPH10101679A (ja) 1998-04-21
ITTO961040A1 (it) 1998-06-18
IN187033B (es) 2001-12-29
CN1178220A (zh) 1998-04-08

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