ES2128966B1 - Composiciones farmaceuticas parenterales a base de calcitoninas sinteticas, de ph controlado, con bajo indice de dolor y buena estabilidad. - Google Patents
Composiciones farmaceuticas parenterales a base de calcitoninas sinteticas, de ph controlado, con bajo indice de dolor y buena estabilidad.Info
- Publication number
- ES2128966B1 ES2128966B1 ES009700129A ES9700129A ES2128966B1 ES 2128966 B1 ES2128966 B1 ES 2128966B1 ES 009700129 A ES009700129 A ES 009700129A ES 9700129 A ES9700129 A ES 9700129A ES 2128966 B1 ES2128966 B1 ES 2128966B1
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical compositions
- compositions based
- controlled
- good stability
- synthetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- 102000055006 Calcitonin Human genes 0.000 abstract 1
- 108060001064 Calcitonin Proteins 0.000 abstract 1
- 229960000583 acetic acid Drugs 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
- 229960004015 calcitonin Drugs 0.000 abstract 1
- 239000012362 glacial acetic acid Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000007927 intramuscular injection Substances 0.000 abstract 1
- 238000010255 intramuscular injection Methods 0.000 abstract 1
- 239000003182 parenteral nutrition solution Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000007929 subcutaneous injection Substances 0.000 abstract 1
- 238000010254 subcutaneous injection Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Composiciones farmacéuticas parenterales a base de calcitoninas sintéticas, de pH controlado, con bajo índice de dolor y, buena estabilidad. La invención se refiere a composiciones farmacéuticas a base de soluciones acuosas parenterales, que contienen como principio activo una calcitonina natural o sintética modificada. La misma ha sido ventajosamente formulada sin el uso de ácido acético glacial, sino solamente con el empleo de un único tampón, para que el pH de las mismas no alcance valores ácidos demasiado bajos, sino que se encuentre más cerca de los valores fisiológicos, y de un único otro segundo ingrediente, utilizado para obtener la isotonicidad. Las preparaciones parenterales resultantes han evidenciado un sorprendentemente bajo índice de dolor, especialmente en el caso de las inyecciones subcutáneas e intramusculares, una menor histolesividad y una mayor tolerancia, manteniendo niveles de actividad residual adecuados y satisfactorios, inclusive cuando se conservan a temperaturas ordinarias.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI000171A IT1282374B1 (it) | 1996-01-31 | 1996-01-31 | Composizioni farmaceutiche parenterali a base di calcitonine sintetiche a ph controllato con basso indice di dolorosita' |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2128966A1 ES2128966A1 (es) | 1999-05-16 |
| ES2128966B1 true ES2128966B1 (es) | 2000-01-16 |
Family
ID=11373091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES009700129A Expired - Fee Related ES2128966B1 (es) | 1996-01-31 | 1997-01-23 | Composiciones farmaceuticas parenterales a base de calcitoninas sinteticas, de ph controlado, con bajo indice de dolor y buena estabilidad. |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE19703449A1 (es) |
| ES (1) | ES2128966B1 (es) |
| IT (1) | IT1282374B1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0422644D0 (en) * | 2004-10-12 | 2004-11-10 | Novartis Ag | Organic compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU572815B2 (en) * | 1982-12-29 | 1988-05-19 | Armour Pharmaceutical Company | Pharmaceutical calcitonin compositions for intranasal application |
| IT1204400B (it) * | 1986-06-20 | 1989-03-01 | Sclavo Spa | Composizioni farmaceutiche contenente una calcitonina |
| IL91856A0 (en) * | 1988-10-11 | 1990-06-10 | Schiapparelli Salute Spa | Pharmaceutical compositions comprising calcitonin for intranasal administration and a spray unit for the administration of the same |
| JPH06340548A (ja) * | 1993-04-08 | 1994-12-13 | Asahi Chem Ind Co Ltd | カルシトニン遺伝子関連ペプチド類の水溶液組成物 |
-
1996
- 1996-01-31 IT IT96MI000171A patent/IT1282374B1/it active IP Right Grant
-
1997
- 1997-01-23 ES ES009700129A patent/ES2128966B1/es not_active Expired - Fee Related
- 1997-01-30 DE DE19703449A patent/DE19703449A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| IT1282374B1 (it) | 1998-03-20 |
| DE19703449A1 (de) | 1997-08-07 |
| ITMI960171A1 (it) | 1997-07-31 |
| ES2128966A1 (es) | 1999-05-16 |
| ITMI960171A0 (es) | 1996-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19990516 Kind code of ref document: A1 Effective date: 19990516 |
|
| FD1A | Patent lapsed |
Effective date: 20040601 |