ES2126759T3 - O-acil-4-fenil-ciclohexanoles, sus sales, medicamentos que contienen a estos compuestos y su utilizacion, asi como procedimiento para su preparacion. - Google Patents

O-acil-4-fenil-ciclohexanoles, sus sales, medicamentos que contienen a estos compuestos y su utilizacion, asi como procedimiento para su preparacion.

Info

Publication number
ES2126759T3
ES2126759T3 ES94915531T ES94915531T ES2126759T3 ES 2126759 T3 ES2126759 T3 ES 2126759T3 ES 94915531 T ES94915531 T ES 94915531T ES 94915531 T ES94915531 T ES 94915531T ES 2126759 T3 ES2126759 T3 ES 2126759T3
Authority
ES
Spain
Prior art keywords
sup
compounds
ciclohexanoles
fenil
acil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94915531T
Other languages
English (en)
Inventor
Eberhard Woitun
Roland Maier
Peter Muller
Rudolf Hurnaus
Michael Mark
Bernhard Eisele
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Application granted granted Critical
Publication of ES2126759T3 publication Critical patent/ES2126759T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/24—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Feed For Specific Animals (AREA)
  • Fodder In General (AREA)
  • Fats And Perfumes (AREA)

Abstract

SE DESCRIBEN O-ACIL-4-FENIL-CICLOHEXANOLES DE FORMULA GENERAL (I), EN LA CUAL N SON LOS NUMERO S0 O 1, M LOS NUMEROS 1 O 2, P LOS NUMEROS 0 O 1, R{SUP,1} Y R{SUP,2} SON CADA UNO HIDROGENO, ALQUILO DE CADENA CORTA, ALQUENILO O ALQUINILO, PUDIENDO ESTAR ESTOS GRUPOS SUSTITUIDOS, O FORMAR JUNTOS CON EL ATOMO DE NITROGENO QUE SE ENCUENTRA ENTRE ELLOS ANILLOS DE 5 A 7 MIEMBROS, QUE SON SATURADOS, MONOCICLICOS Y HETEROCICLICOS, QUE PUEDEN ESTAR OPCIONALMENTE INTERRUMPIDOS POR UN ATOMO DE OXIGENO O DE AZUFRE O POR UN GRUPO IMINO, R{SUP,3}, R{SUP,4}, R{SUP,5} Y R{SUP,6} SON HIDROGENO O ALQUILO DE CADENA CORTA, ADEMAS R{SUP,5} PUEDE SER TAMBIEN ALCOXILO DE CADENA CORTA, R{SUP,7} ES HIDROGENO, CICLOALQUILO, FENILO O FENILO SUSTITUIDO, NAFTILO, TETRAHIDRONAFTILO, TIENILO, FURILO O PIRIDILO, Y A ES UN ENLACE QUIMICO O ALQUILO, ALQUENILO O ALQUINILO DE HASTA 17 ATOMOS DE C; TAMBIEN TRATA DEL PROCEDIMIENTO PARA SU OBTENCION, MEDICAMENTOS QUE CONTIENE ESTOS COMPUESTOS, Y LA UTILIZACION DE ESTOS COMPUESTOS, QUE SON EFECTIVOS EN LA SINTESIS DEL COLESTEROL. LA SUSTANCIAS ANTI-HIPERCOLESTEROLEMICAS SIRVEN PARA EL TRATAMIENTO Y PROFILAXIS DE LA ATEROESCLEROSIS, INHIBEN LA ENZIMA 2,3-EPOXIESCUALEN-LANOSTEROL-CICLASA.
ES94915531T 1992-11-20 1994-04-25 O-acil-4-fenil-ciclohexanoles, sus sales, medicamentos que contienen a estos compuestos y su utilizacion, asi como procedimiento para su preparacion. Expired - Lifetime ES2126759T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4239150A DE4239150A1 (de) 1992-11-20 1992-11-20 O-Acyl-4-phenyl-cyclohexanole, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
PCT/EP1994/001276 WO1995029148A1 (de) 1992-11-20 1994-04-25 O-acyl-4-phenyl-cyclohexanole, deren salze, diese verbindungen enthaltende arzneimittel und deren verwendung sowie verfahren zu ihrer herstellung
BR9408573A BR9408573A (pt) 1992-11-20 1994-04-25 O-acil-4-fenil-ciclohexanóis seus sais medicamentos contendo estes compostos e seu uso bem como para sua preparação

Publications (1)

Publication Number Publication Date
ES2126759T3 true ES2126759T3 (es) 1999-04-01

Family

ID=27160120

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94915531T Expired - Lifetime ES2126759T3 (es) 1992-11-20 1994-04-25 O-acil-4-fenil-ciclohexanoles, sus sales, medicamentos que contienen a estos compuestos y su utilizacion, asi como procedimiento para su preparacion.

Country Status (17)

Country Link
US (1) US5726205A (es)
EP (1) EP0757669B1 (es)
JP (1) JPH09512255A (es)
AT (1) ATE173460T1 (es)
BG (1) BG62961B1 (es)
BR (1) BR9408573A (es)
DE (2) DE4239150A1 (es)
DK (1) DK0757669T3 (es)
ES (1) ES2126759T3 (es)
FI (1) FI964277A0 (es)
LV (1) LV11832B (es)
NO (1) NO307175B1 (es)
NZ (1) NZ266138A (es)
PL (1) PL179890B1 (es)
RU (1) RU2130921C1 (es)
SK (1) SK281213B6 (es)
WO (1) WO1995029148A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4239150A1 (de) * 1992-11-20 1994-05-26 Thomae Gmbh Dr K O-Acyl-4-phenyl-cyclohexanole, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
DE19626771C2 (de) * 1996-07-03 1998-09-24 Merck Patent Gmbh 4-(4-Oxocyclohexyl)-benzamide
FR2754255B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Procede de preparation de derives de trans-4-(4- aminomethylphenyl) cyclohexanols
DE19704401C1 (de) * 1997-02-06 1998-05-07 Thomae Gmbh Dr K Verfahren zur Herstellung von trans-4-(4-Aminomethyl)phenyl-cyclohexanolen
DE19754795A1 (de) * 1997-12-10 1999-06-17 Boehringer Ingelheim Pharma Neue Urethane, ihre Thio- und Dithioanaloga, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
CA2478184A1 (en) * 2002-03-12 2003-09-25 Merck & Co., Inc. Drug combination therapy
US8217064B2 (en) 2007-12-20 2012-07-10 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
IN2014DN11181A (es) 2012-07-04 2015-10-02 Univ Sydney
US20170035862A1 (en) 2014-04-16 2017-02-09 Zz Biotech Llc Use of APC analogue for wound healing
PL3137102T3 (pl) 2014-04-16 2022-02-07 Zz Biotech Llc Apc do stosowania w leczeniu nieprawidłowego bliznowacenia skóry

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4431564A (en) * 1981-05-01 1984-02-14 Chisso Corporation Liquid-crystalline biphenyl or terphenyl derivatives
FI832128A0 (fi) * 1983-06-14 1983-06-14 Farmos Oy Foerfarande foer framstaellning av en amin
US5391571A (en) * 1989-11-15 1995-02-21 American Home Products Corporation Cholesterol ester hydrolase inhibitors
CA2044533A1 (en) * 1990-06-29 1991-12-30 Philippe Guerry Substituted aminoalkylbiphenyl derivatives
DE4239150A1 (de) * 1992-11-20 1994-05-26 Thomae Gmbh Dr K O-Acyl-4-phenyl-cyclohexanole, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
DE4239151A1 (de) * 1992-11-20 1994-05-26 Thomae Gmbh Dr K N,N-Disubstituierte Arylcycloalkylamine, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
EP0757669A1 (de) 1997-02-12
NO964525D0 (no) 1996-10-24
ATE173460T1 (de) 1998-12-15
DK0757669T3 (da) 1999-08-02
RU2130921C1 (ru) 1999-05-27
BR9408573A (pt) 1997-08-26
FI964277A7 (fi) 1996-10-24
NZ266138A (en) 1998-03-25
NO307175B1 (no) 2000-02-21
AU685118B2 (en) 1998-01-15
LV11832A (lv) 1997-08-20
NO964525L (no) 1996-10-24
WO1995029148A1 (de) 1995-11-02
LV11832B (en) 1997-12-20
BG62961B1 (bg) 2000-12-29
PL179890B1 (pl) 2000-11-30
FI964277A0 (fi) 1996-10-24
DE59407317D1 (de) 1998-12-24
PL316964A1 (en) 1997-03-03
DE4239150A1 (de) 1994-05-26
JPH09512255A (ja) 1997-12-09
US5726205A (en) 1998-03-10
EP0757669B1 (de) 1998-11-18
SK135996A3 (en) 1997-05-07
BG100912A (en) 1997-07-31
SK281213B6 (sk) 2001-01-18
AU6721194A (en) 1995-11-16

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