ES8401964A1 - Un procedimiento para la preparacion de un derivado de piridoindol. - Google Patents

Un procedimiento para la preparacion de un derivado de piridoindol.

Info

Publication number
ES8401964A1
ES8401964A1 ES518295A ES518295A ES8401964A1 ES 8401964 A1 ES8401964 A1 ES 8401964A1 ES 518295 A ES518295 A ES 518295A ES 518295 A ES518295 A ES 518295A ES 8401964 A1 ES8401964 A1 ES 8401964A1
Authority
ES
Spain
Prior art keywords
hexahydro
trans
tetrahydropyridoindole
neuroleptic agents
pyrido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518295A
Other languages
English (en)
Other versions
ES518295A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES518295A0 publication Critical patent/ES518295A0/es
Publication of ES8401964A1 publication Critical patent/ES8401964A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN DERIVADO DE PIRIDOINDOL, DE FORMULA (I), EN LA QUE K ES 1 O 2; X E Y SON CADA UNO DE ELLOS INDEPENDIENTEMENTE H, F, CL, BR O CH2-CH3; M ES UN NUMERO ENTERO COMPRENDIDO ENTRE 2 Y 6; Y R ES ALQUILO C1-C5, FENILO, BENCILO O FENILSULFONILO.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN LA QUE X, Y, K Y M TIENEN LOS SIGNIFICADOS YA INDICADOS, CON UN COMPUESTO DE FORMULA: (D-CH2-CH2)2NR, EN LA QUE D ES UN GRUPO SALIENTE; Y R TIENE EL SIGNIFICADO YA INDICADO.DE APLICACION EN FARMACIA COMO AGENTES NEUROLEPTICOSUTILES EN EL TRATAMIENTO DE CIERTAS PSICOSIS Y NEUROSIS.
ES518295A 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de piridoindol. Expired ES8401964A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/225,569 US4337250A (en) 1979-07-30 1981-01-16 Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents

Publications (2)

Publication Number Publication Date
ES518295A0 ES518295A0 (es) 1984-01-01
ES8401964A1 true ES8401964A1 (es) 1984-01-01

Family

ID=22845384

Family Applications (11)

Application Number Title Priority Date Filing Date
ES508809A Expired ES8304966A1 (es) 1981-01-16 1982-01-15 Un procediemento para la preparacion de un derivado de piridoindol.
ES518289A Expired ES8404851A1 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de piridoindol.
ES518293A Granted ES518293A0 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de piridoindol.
ES518295A Expired ES8401964A1 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de piridoindol.
ES518288A Granted ES518288A0 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de piridoindol.
ES518294A Granted ES518294A0 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de piridoindol.
ES518292A Expired ES8401963A1 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de piridoindol.
ES518296A Granted ES518296A0 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de piridoindol.
ES518290A Granted ES518290A0 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de 4a-9b-trans-hexahidro-1h-piridoindol enantiomerico (+) o racemico(+-)
ES518297A Expired ES8405391A1 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de tetrahidro-1h-piridoindol.
ES518291A Expired ES8405785A1 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de piridoindol.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES508809A Expired ES8304966A1 (es) 1981-01-16 1982-01-15 Un procediemento para la preparacion de un derivado de piridoindol.
ES518289A Expired ES8404851A1 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de piridoindol.
ES518293A Granted ES518293A0 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de piridoindol.

Family Applications After (7)

Application Number Title Priority Date Filing Date
ES518288A Granted ES518288A0 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de piridoindol.
ES518294A Granted ES518294A0 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de piridoindol.
ES518292A Expired ES8401963A1 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de piridoindol.
ES518296A Granted ES518296A0 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de piridoindol.
ES518290A Granted ES518290A0 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de 4a-9b-trans-hexahidro-1h-piridoindol enantiomerico (+) o racemico(+-)
ES518297A Expired ES8405391A1 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de tetrahidro-1h-piridoindol.
ES518291A Expired ES8405785A1 (es) 1981-01-16 1982-12-16 Un procedimiento para la preparacion de un derivado de piridoindol.

Country Status (27)

Country Link
US (1) US4337250A (es)
EP (1) EP0060610B1 (es)
JP (2) JPS57139078A (es)
KR (1) KR860001819B1 (es)
AR (1) AR230283A1 (es)
AT (1) ATE15372T1 (es)
AU (1) AU528710B2 (es)
CA (1) CA1177830A (es)
CS (1) CS248020B2 (es)
DD (3) DD222027A5 (es)
DE (1) DE3265922D1 (es)
DK (1) DK15282A (es)
EG (1) EG15796A (es)
ES (11) ES8304966A1 (es)
FI (1) FI71936C (es)
GR (1) GR74757B (es)
HU (1) HU189090B (es)
IE (1) IE51954B1 (es)
IL (1) IL64774A (es)
NO (1) NO159090C (es)
NZ (1) NZ199473A (es)
PH (1) PH19614A (es)
PL (2) PL138924B1 (es)
PT (1) PT74283A (es)
SU (2) SU1179930A3 (es)
YU (1) YU45854B (es)
ZA (1) ZA82264B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4672117A (en) * 1985-09-16 1987-06-09 American Home Products Corporation Antipsychotic gamma-carbolines
US4636563A (en) * 1985-09-16 1987-01-13 American Home Products Corporation Antipsychotic γ-carbolines
US4732984A (en) * 1985-10-17 1988-03-22 American Home Products Corporation Piperazinoisothiazolones with psychotropic activity
US4748182A (en) * 1986-03-05 1988-05-31 Merrell Dow Pharmaceuticals Inc. Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives and their use as anti-hypertensive and anxiolytic agents
JPH01140486A (ja) * 1987-11-27 1989-06-01 Hitachi Ltd ブロッホラインメモリ駆動回路
FR2661177A1 (fr) * 1990-04-23 1991-10-25 Rhone Poulenc Sante Derives du naphtosultame antagonistes de la serotonine, leur preparation et les medicaments les contenant.
TW470745B (en) * 1996-05-23 2002-01-01 Janssen Pharmaceutica Nv Hexahydro-pyrido[4,3-b]indole derivatives
US5879444A (en) * 1997-09-02 1999-03-09 Bayer Corporation Organic pigment compositions
ATE306486T1 (de) * 2001-08-08 2005-10-15 Pharmacia & Upjohn Co Llc Therapeutische 1h-pyrido(4,3-b)indole
EP2919788A4 (en) 2012-11-14 2016-05-25 Univ Johns Hopkins METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687961A (en) * 1971-05-03 1972-08-29 Abbott Lab 8-fluoro-2-{8 3-(4-fluorophenylanilinopropyl{9 -gamma-carboline
AR205452A1 (es) * 1973-12-06 1976-05-07 Endo Lab Metodo para preparar nuevos trans-2, 3, 4, 4a, 5, 9b-hexahidro-5-fenil-1h-pirido(4,3-b) indoles
JPS50126699A (es) * 1974-03-20 1975-10-04
US4001263A (en) * 1974-04-01 1977-01-04 Pfizer Inc. 5-Aryl-1,2,3,4-tetrahydro-γ-carbolines
SE7702301L (sv) * 1976-04-08 1977-10-09 Endo Lab Trans-hexahydro-pyrido-indoler
US4224329A (en) * 1979-01-23 1980-09-23 Pfizer Inc. 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles
US4252811A (en) * 1979-07-30 1981-02-24 Pfizer Inc. Hexahydro-trans-pyridoindole neuroleptic agents

Also Published As

Publication number Publication date
SU1152522A3 (en) 1985-04-23
ES8405003A1 (es) 1984-05-16
ES8405002A1 (es) 1984-05-16
GR74757B (es) 1984-07-11
DD222027A5 (de) 1985-05-08
IL64774A0 (en) 1982-03-31
ES518295A0 (es) 1984-01-01
ATE15372T1 (de) 1985-09-15
KR830009095A (ko) 1983-12-17
EG15796A (en) 1986-12-30
FI71936C (fi) 1987-03-09
ES508809A0 (es) 1983-03-16
NZ199473A (en) 1985-10-11
ES518291A0 (es) 1984-06-16
ES8401965A1 (es) 1984-01-01
ES8405617A1 (es) 1984-06-16
ES518293A0 (es) 1984-06-16
CS248020B2 (en) 1987-01-15
ES518289A0 (es) 1984-05-16
YU9882A (en) 1986-04-30
DE3265922D1 (en) 1985-10-10
ES8304966A1 (es) 1983-03-16
ES8404851A1 (es) 1984-05-16
EP0060610A1 (en) 1982-09-22
FI820138L (fi) 1982-07-17
SU1179930A3 (ru) 1985-09-15
PL138924B1 (en) 1986-11-29
NO820112L (no) 1982-07-19
ES518292A0 (es) 1984-01-01
ZA82264B (en) 1982-12-29
ES8405785A1 (es) 1984-06-16
AR230283A1 (es) 1984-03-01
PL241179A1 (en) 1984-03-26
PL235180A1 (en) 1983-11-21
FI71936B (fi) 1986-11-28
ES518297A0 (es) 1984-06-01
ES518294A0 (es) 1984-05-16
PT74283A (pt) 1982-02-01
DK15282A (da) 1982-08-27
ES8401962A1 (es) 1984-01-01
ES518290A0 (es) 1984-05-16
PL137682B1 (en) 1986-07-31
AU7955282A (en) 1982-07-22
CA1177830A (en) 1984-11-13
JPS6130674B2 (es) 1986-07-15
ES8401963A1 (es) 1984-01-01
JPS57139078A (en) 1982-08-27
ES518288A0 (es) 1984-01-01
EP0060610B1 (en) 1985-09-04
ES8405391A1 (es) 1984-06-01
KR860001819B1 (ko) 1986-10-24
NO159090C (no) 1988-11-30
ES518296A0 (es) 1984-01-01
AU528710B2 (en) 1983-05-12
IE51954B1 (en) 1987-04-29
IL64774A (en) 1985-06-30
NO159090B (no) 1988-08-22
IE820061L (en) 1982-07-16
DD211348A5 (de) 1984-07-11
PH19614A (en) 1986-05-30
JPS60185780A (ja) 1985-09-21
US4337250A (en) 1982-06-29
YU45854B (sh) 1992-09-07
HU189090B (en) 1986-06-30
DD208980A5 (de) 1984-04-18

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