ES2124307T3 - Derivados de 3-hidroxipiridin-4-ona como agentes de quelacion. - Google Patents
Derivados de 3-hidroxipiridin-4-ona como agentes de quelacion.Info
- Publication number
- ES2124307T3 ES2124307T3 ES93910215T ES93910215T ES2124307T3 ES 2124307 T3 ES2124307 T3 ES 2124307T3 ES 93910215 T ES93910215 T ES 93910215T ES 93910215 T ES93910215 T ES 93910215T ES 2124307 T3 ES2124307 T3 ES 2124307T3
- Authority
- ES
- Spain
- Prior art keywords
- ethyl
- pct
- methylpropionyloxy
- alpha
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
3-HIDROXIPIRIDINAS-4-ONAS DE FORMULA (I) EN LA CUAL R1 ES UN METILO, ETILO, GRUPO 2-((ALFA)-METILPROPIONILOXI)METILO O GRUPO 2-PIVALOILOXIETILO Y R2, R3 Y R4 SON CADA UNO ELEGIDOS SEPARADAMENTE DE HIDROGENO Y METILO, ETILO Y GRUPOS 2-((ALFA)-METILPROPIONILOXI)METILO O 2-PIVALOILOXIETILO CON LA PROVISION DE QUE (A) SOLO UNO DE R1 A R4 ES BIEN UN GRUPO 2-((ALFA)-METILPROPIONILOXI)METILO O UN GRUPO 2-PIVALOILOXIETILO, (B)AL MENOS UNO DE R2 Y R3 ES DISTINTO DE HIDROGENO Y (C) EL NUMERO TOTAL DE ATOMOS DE CARBONO EN R1 A R4 NO ES MAYOR DE ONCE. Y SALES FISIOLOGICAMENTE ACEPTABLES DE ELLOS SON DE USO EN TERAPIA, PARTICULARMENTE EN EL TRATAMIENTO DE CONDICIONES EN LAS QUE HAY UNA CONCENTRACION TOXICA DE UN METAL, POR EJEMPLO HIERRO, EN EL CUERPO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929217099A GB9217099D0 (en) | 1992-08-12 | 1992-08-12 | Pharmaceutical compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2124307T3 true ES2124307T3 (es) | 1999-02-01 |
Family
ID=10720221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93910215T Expired - Lifetime ES2124307T3 (es) | 1992-08-12 | 1993-05-18 | Derivados de 3-hidroxipiridin-4-ona como agentes de quelacion. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5480894A (es) |
EP (1) | EP0619808B1 (es) |
JP (1) | JPH07500120A (es) |
AT (1) | ATE173726T1 (es) |
CA (1) | CA2119020C (es) |
DE (1) | DE69322250T2 (es) |
ES (1) | ES2124307T3 (es) |
GB (2) | GB9217099D0 (es) |
WO (1) | WO1994004498A1 (es) |
ZA (1) | ZA935084B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0833627B1 (en) | 1995-06-10 | 2004-08-18 | Vitra Pharmaceuticals Ltd. | Iron compounds, compositions, methods of making the same and uses thereof |
ES2244967T3 (es) * | 1995-09-29 | 2005-12-16 | Novartis Ag | Nuevas hidroxipiridinonas. |
US6767741B1 (en) * | 1999-08-27 | 2004-07-27 | Invitrogen Corporation | Metal binding compounds and their use in cell culture medium compositions |
IL135884A (en) * | 2000-04-30 | 2005-08-31 | Yissum Res Dev Co | Method for measuring non-transferrin bound iron |
DE60107272T2 (de) | 2000-09-19 | 2005-10-27 | Vitra Pharmaceuticals Ltd., Saffron Walden | Eisenverbindungen |
KR100863159B1 (ko) | 2000-12-22 | 2008-10-13 | 에어 프로덕츠 앤드 케미칼스, 인코오포레이티드 | 산화 화합물 및 착물화 화합물을 함유하는 조성물 |
US6426418B1 (en) | 2001-11-02 | 2002-07-30 | Apotex, Inc. | Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide |
AU2003210850A1 (en) | 2002-02-05 | 2003-09-02 | Bristol-Myers Squibb Company | N-substituted3-hydroxy-4-pyridinones and pharmaceuticals containing thereof |
GB0211500D0 (en) | 2002-05-18 | 2002-06-26 | Vitra Pharmaceuticals Ltd | Method of forming iron hydroxypyrone compounds |
EP1578999B1 (en) | 2002-10-30 | 2013-01-16 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Method for measuring non-transferrin bound iron |
US7707255B2 (en) | 2003-07-01 | 2010-04-27 | Microsoft Corporation | Automatic grouping of electronic mail |
NZ529657A (en) * | 2003-11-20 | 2004-07-30 | Apotex Inc | Iron chelating cycloalkyl derivatives of 3-hydroxy-4-pyridinones |
CA2488034C (en) * | 2004-11-19 | 2009-10-06 | Apotex Inc. | Process for the manufacture of 3-hydroxy-n-alkyl-1-cycloalkyl-6-alkyl-4-oxo-1,4-dihydropyridine-2-carboxamide and its related analogues |
US9588781B2 (en) | 2008-03-31 | 2017-03-07 | Microsoft Technology Licensing, Llc | Associating command surfaces with multiple active components |
GB201007209D0 (en) | 2010-04-29 | 2010-06-16 | King S College London | Compound |
WO2012137202A1 (en) | 2011-04-05 | 2012-10-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Composition comprising an iron indicator attached to a microparticle and uses of same for quantifying non-transferrin bound iron (ntbi) and cellular labile iron (lci) |
DE102012007558A1 (de) | 2012-04-14 | 2013-10-17 | Alf Hammes | Gabe substituierter bis-aryl-harnstoffderivate zur behandlung von anämien |
GB201215675D0 (en) * | 2012-09-03 | 2012-10-17 | Univ Exeter | Compound |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1074038B (it) * | 1976-08-05 | 1985-04-17 | Simes | Esteri della epinina |
GB8308054D0 (en) * | 1983-03-24 | 1983-05-05 | Hider R C | Pharmaceutical compositions |
GB8308055D0 (en) * | 1983-03-24 | 1983-05-05 | Hider R C | Pharmaceutical compositions |
EP0305646B1 (en) * | 1983-03-24 | 1996-11-13 | Btg International Limited | 3-Hydroxypyrid-4-ones and pharmaceutical compositions |
US4908371A (en) * | 1987-11-10 | 1990-03-13 | Ciba-Geigy Corporation | Esterified hydroxy dihydropyridinones for treating diseases associated with trivalent metal ion overload |
EP0335745A1 (en) * | 1988-03-31 | 1989-10-04 | The Royal Free Hospital School Of Medicine | Process for producing pyrid-4-ones |
GB8910521D0 (en) * | 1989-05-08 | 1989-06-21 | Nat Res Dev | The stabilization of organic compounds |
GB9100465D0 (en) * | 1991-01-09 | 1991-02-20 | Hider Robert C | Pharmaceutical compositions |
GB9209078D0 (en) * | 1992-04-27 | 1992-06-10 | Hider Robert C | Pharmaceutical compositions |
-
1992
- 1992-08-12 GB GB929217099A patent/GB9217099D0/en active Pending
-
1993
- 1993-05-18 ES ES93910215T patent/ES2124307T3/es not_active Expired - Lifetime
- 1993-05-18 JP JP6505976A patent/JPH07500120A/ja active Pending
- 1993-05-18 AT AT93910215T patent/ATE173726T1/de not_active IP Right Cessation
- 1993-05-18 WO PCT/GB1993/001007 patent/WO1994004498A1/en active IP Right Grant
- 1993-05-18 DE DE69322250T patent/DE69322250T2/de not_active Expired - Fee Related
- 1993-05-18 EP EP93910215A patent/EP0619808B1/en not_active Expired - Lifetime
- 1993-05-18 CA CA002119020A patent/CA2119020C/en not_active Expired - Fee Related
- 1993-05-18 US US08/204,202 patent/US5480894A/en not_active Expired - Fee Related
- 1993-07-01 GB GB9313557A patent/GB2269589B/en not_active Revoked
- 1993-07-14 ZA ZA935084A patent/ZA935084B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP0619808A1 (en) | 1994-10-19 |
GB2269589A (en) | 1994-02-16 |
US5480894A (en) | 1996-01-02 |
EP0619808B1 (en) | 1998-11-25 |
ATE173726T1 (de) | 1998-12-15 |
CA2119020A1 (en) | 1994-03-03 |
JPH07500120A (ja) | 1995-01-05 |
CA2119020C (en) | 2003-12-16 |
ZA935084B (en) | 1995-01-16 |
WO1994004498A1 (en) | 1994-03-03 |
GB9217099D0 (en) | 1992-09-23 |
DE69322250T2 (de) | 1999-05-20 |
DE69322250D1 (de) | 1999-01-07 |
GB2269589B (en) | 1996-06-26 |
GB9313557D0 (en) | 1993-08-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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