DE69322250D1 - 3-hydroxypyridin-4-on-derivate als chelatbildner - Google Patents

3-hydroxypyridin-4-on-derivate als chelatbildner

Info

Publication number
DE69322250D1
DE69322250D1 DE69322250T DE69322250T DE69322250D1 DE 69322250 D1 DE69322250 D1 DE 69322250D1 DE 69322250 T DE69322250 T DE 69322250T DE 69322250 T DE69322250 T DE 69322250T DE 69322250 D1 DE69322250 D1 DE 69322250D1
Authority
DE
Germany
Prior art keywords
ethyl
pct
methylpropionyloxy
alpha
hydroxypyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69322250T
Other languages
English (en)
Other versions
DE69322250T2 (de
Inventor
Robert Hider
Surinder Kimberley Road Singh
Gary Tilbrook
Paul Dobbin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
BTG International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BTG International Ltd filed Critical BTG International Ltd
Application granted granted Critical
Publication of DE69322250D1 publication Critical patent/DE69322250D1/de
Publication of DE69322250T2 publication Critical patent/DE69322250T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69322250T 1992-08-12 1993-05-18 3-hydroxypyridin-4-on-derivate als chelatbildner Expired - Fee Related DE69322250T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929217099A GB9217099D0 (en) 1992-08-12 1992-08-12 Pharmaceutical compositions
PCT/GB1993/001007 WO1994004498A1 (en) 1992-08-12 1993-05-18 3-hydroxypyridin-4-one derivatives as chelating agents

Publications (2)

Publication Number Publication Date
DE69322250D1 true DE69322250D1 (de) 1999-01-07
DE69322250T2 DE69322250T2 (de) 1999-05-20

Family

ID=10720221

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69322250T Expired - Fee Related DE69322250T2 (de) 1992-08-12 1993-05-18 3-hydroxypyridin-4-on-derivate als chelatbildner

Country Status (10)

Country Link
US (1) US5480894A (de)
EP (1) EP0619808B1 (de)
JP (1) JPH07500120A (de)
AT (1) ATE173726T1 (de)
CA (1) CA2119020C (de)
DE (1) DE69322250T2 (de)
ES (1) ES2124307T3 (de)
GB (2) GB9217099D0 (de)
WO (1) WO1994004498A1 (de)
ZA (1) ZA935084B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0833627B1 (de) 1995-06-10 2004-08-18 Vitra Pharmaceuticals Ltd. Eisenverbindungen, zusammensetzungen, herstellungsverfahren und verwendungen davon
ES2244967T3 (es) * 1995-09-29 2005-12-16 Novartis Ag Nuevas hidroxipiridinonas.
US6767741B1 (en) * 1999-08-27 2004-07-27 Invitrogen Corporation Metal binding compounds and their use in cell culture medium compositions
IL135884A (en) * 2000-04-30 2005-08-31 Yissum Res Dev Co Method for measuring non-transferrin bound iron
DE60107272T2 (de) 2000-09-19 2005-10-27 Vitra Pharmaceuticals Ltd., Saffron Walden Eisenverbindungen
KR100863159B1 (ko) 2000-12-22 2008-10-13 에어 프로덕츠 앤드 케미칼스, 인코오포레이티드 산화 화합물 및 착물화 화합물을 함유하는 조성물
US6426418B1 (en) 2001-11-02 2002-07-30 Apotex, Inc. Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide
AU2003210850A1 (en) 2002-02-05 2003-09-02 Bristol-Myers Squibb Company N-substituted3-hydroxy-4-pyridinones and pharmaceuticals containing thereof
GB0211500D0 (en) 2002-05-18 2002-06-26 Vitra Pharmaceuticals Ltd Method of forming iron hydroxypyrone compounds
EP1578999B1 (de) 2002-10-30 2013-01-16 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Verfahren zur messung von nichttransferringebundenem eisen
US7707255B2 (en) 2003-07-01 2010-04-27 Microsoft Corporation Automatic grouping of electronic mail
NZ529657A (en) * 2003-11-20 2004-07-30 Apotex Inc Iron chelating cycloalkyl derivatives of 3-hydroxy-4-pyridinones
CA2488034C (en) * 2004-11-19 2009-10-06 Apotex Inc. Process for the manufacture of 3-hydroxy-n-alkyl-1-cycloalkyl-6-alkyl-4-oxo-1,4-dihydropyridine-2-carboxamide and its related analogues
US9588781B2 (en) 2008-03-31 2017-03-07 Microsoft Technology Licensing, Llc Associating command surfaces with multiple active components
GB201007209D0 (en) 2010-04-29 2010-06-16 King S College London Compound
WO2012137202A1 (en) 2011-04-05 2012-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Composition comprising an iron indicator attached to a microparticle and uses of same for quantifying non-transferrin bound iron (ntbi) and cellular labile iron (lci)
DE102012007558A1 (de) 2012-04-14 2013-10-17 Alf Hammes Gabe substituierter bis-aryl-harnstoffderivate zur behandlung von anämien
GB201215675D0 (en) * 2012-09-03 2012-10-17 Univ Exeter Compound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1074038B (it) * 1976-08-05 1985-04-17 Simes Esteri della epinina
GB8308054D0 (en) * 1983-03-24 1983-05-05 Hider R C Pharmaceutical compositions
GB8308055D0 (en) * 1983-03-24 1983-05-05 Hider R C Pharmaceutical compositions
EP0305646B1 (de) * 1983-03-24 1996-11-13 Btg International Limited 3-Hydroxypyrid-4-one und pharmazeutische Zusammensetzungen
US4908371A (en) * 1987-11-10 1990-03-13 Ciba-Geigy Corporation Esterified hydroxy dihydropyridinones for treating diseases associated with trivalent metal ion overload
EP0335745A1 (de) * 1988-03-31 1989-10-04 The Royal Free Hospital School Of Medicine Verfahren zur Herstellung von Pyridin-4-onen
GB8910521D0 (en) * 1989-05-08 1989-06-21 Nat Res Dev The stabilization of organic compounds
GB9100465D0 (en) * 1991-01-09 1991-02-20 Hider Robert C Pharmaceutical compositions
GB9209078D0 (en) * 1992-04-27 1992-06-10 Hider Robert C Pharmaceutical compositions

Also Published As

Publication number Publication date
EP0619808A1 (de) 1994-10-19
GB2269589A (en) 1994-02-16
US5480894A (en) 1996-01-02
EP0619808B1 (de) 1998-11-25
ATE173726T1 (de) 1998-12-15
CA2119020A1 (en) 1994-03-03
JPH07500120A (ja) 1995-01-05
CA2119020C (en) 2003-12-16
ZA935084B (en) 1995-01-16
WO1994004498A1 (en) 1994-03-03
GB9217099D0 (en) 1992-09-23
DE69322250T2 (de) 1999-05-20
GB2269589B (en) 1996-06-26
GB9313557D0 (en) 1993-08-18
ES2124307T3 (es) 1999-02-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee