ES2120448T3 - Ensayos multiples simultaneos. - Google Patents
Ensayos multiples simultaneos.Info
- Publication number
- ES2120448T3 ES2120448T3 ES92912635T ES92912635T ES2120448T3 ES 2120448 T3 ES2120448 T3 ES 2120448T3 ES 92912635 T ES92912635 T ES 92912635T ES 92912635 T ES92912635 T ES 92912635T ES 2120448 T3 ES2120448 T3 ES 2120448T3
- Authority
- ES
- Spain
- Prior art keywords
- particles
- fpa
- simultaneous multiple
- multiple trials
- agglutination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N2015/0092—Monitoring flocculation or agglomeration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N2021/4704—Angular selective
- G01N2021/4707—Forward scatter; Low angle scatter
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/808—Optical sensing apparatus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Ecology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Luminescent Compositions (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Hard Magnetic Materials (AREA)
- Farming Of Fish And Shellfish (AREA)
- Optical Measuring Cells (AREA)
Abstract
UN METODO CINETICO ESTABLE BASADO EN LA AGLUTINACION DE PARTICULAS PARA DETERMINAR SIMULTANEAMENTE LAS CONCENTRACIONES DE MULTIPLES PRODUCTOS DE ANALISIS EN UNICA MUESTRA DE FLUIDO DE UN UNICO REACTIVO, QUE SUPONE EL USO DE UNA NUEVA CELULA DE FLUJO DE FUNDA DE ALTA RESOLUCION, UN NUEVO ANALIZADOR DE PARTICULAS DE FLUJO OPTICO (FPA), Y LUZ DELANTERA DE BAJO ANGULO UNIDIRECCIONAL QUE SE DISPERSA DESDE PARTICULAS DISTINTAMENTE REVESTIDAS CLASIFICADAS DE REFRACCION DE MULTIPLES DIMENSIONES Y SUS AGREGADOS. TAMBIEN SE PRESENTAN LAS REALIZACIONES FPA DE LA INVENCION.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70230291A | 1991-05-20 | 1991-05-20 | |
| US07/883,574 US5286452A (en) | 1991-05-20 | 1992-05-15 | Simultaneous multiple assays |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2120448T3 true ES2120448T3 (es) | 1998-11-01 |
Family
ID=27106944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92912635T Expired - Lifetime ES2120448T3 (es) | 1991-05-20 | 1992-05-19 | Ensayos multiples simultaneos. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5286452A (es) |
| EP (1) | EP0585369B1 (es) |
| JP (1) | JPH06507972A (es) |
| KR (1) | KR100215348B1 (es) |
| AT (1) | ATE169116T1 (es) |
| AU (1) | AU656399B2 (es) |
| CA (1) | CA2103455A1 (es) |
| DE (1) | DE69226433T2 (es) |
| DK (1) | DK0585369T3 (es) |
| ES (1) | ES2120448T3 (es) |
| FI (1) | FI935128A0 (es) |
| IE (1) | IE921598A1 (es) |
| NO (1) | NO934205L (es) |
| RU (1) | RU2111488C1 (es) |
| TW (1) | TW197940B (es) |
| WO (1) | WO1992021024A1 (es) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW239881B (es) * | 1992-12-22 | 1995-02-01 | Sienna Biotech Inc | |
| US6200820B1 (en) * | 1992-12-22 | 2001-03-13 | Sienna Biotech, Inc. | Light scatter-based immunoassay |
| US5503982A (en) * | 1993-09-30 | 1996-04-02 | Research Corporation Technologies, Inc. | Detection of an acute myocardial infarction in a patient |
| US5547833A (en) * | 1994-01-04 | 1996-08-20 | Intracel Corporation | Radial flow assay, delivering member, test kit, and methods |
| US5561045A (en) * | 1994-01-04 | 1996-10-01 | Intracel Corporation | Detection reagent, article, and immunoassay method |
| US5485270A (en) * | 1994-07-25 | 1996-01-16 | General Signal Corporation | Dynamic light scattering microvolume cell assembly for continuous flow dialysis |
| US6159748A (en) * | 1995-03-13 | 2000-12-12 | Affinitech, Ltd | Evaluation of autoimmune diseases using a multiple parameter latex bead suspension and flow cytometry |
| US20030008410A1 (en) * | 1995-03-13 | 2003-01-09 | Hechinger Mark K. | Immunoassay apparatus, kit and methods |
| US6951716B2 (en) * | 1995-03-13 | 2005-10-04 | Mark Hechinger | Anti-platelet immunoglobulin bead positive control |
| WO1997003347A1 (en) * | 1995-07-10 | 1997-01-30 | Kramer Donald L | Light transmittance type analytical system, variable transmittance optical component, and test device |
| US5736330A (en) * | 1995-10-11 | 1998-04-07 | Luminex Corporation | Method and compositions for flow cytometric determination of DNA sequences |
| US5981180A (en) * | 1995-10-11 | 1999-11-09 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
| AU7398996A (en) | 1995-10-11 | 1997-04-30 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and method |
| US6025201A (en) * | 1995-12-28 | 2000-02-15 | Bayer Corporation | Highly sensitive, accurate, and precise automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples |
| US5817519A (en) * | 1995-12-28 | 1998-10-06 | Bayer Corporation | Automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples |
| US5851777A (en) * | 1996-02-05 | 1998-12-22 | Dade Behring Inc. | Homogeneous sol-sol assay |
| US5649576A (en) * | 1996-02-26 | 1997-07-22 | Pharmacopeia, Inc. | Partitioning device |
| IL126544A (en) | 1996-04-25 | 2004-08-31 | Genicon Sciences Inc | Analyte assay using scattered-light detectable particles |
| US6586193B2 (en) | 1996-04-25 | 2003-07-01 | Genicon Sciences Corporation | Analyte assay using particulate labels |
| US6449562B1 (en) | 1996-10-10 | 2002-09-10 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and method |
| US5858648A (en) * | 1996-11-04 | 1999-01-12 | Sienna Biotech, Inc. | Assays using reference microparticles |
| US6002788A (en) * | 1997-09-24 | 1999-12-14 | Compucyte Corporation | Method and device for rendering cells observable with laser scanning cytometry |
| EP0919568A1 (en) | 1997-12-01 | 1999-06-02 | Sorin Diagnostics S.r.l. | Escape mutant of the surface antigen of hepatitis B virus |
| WO1999036564A1 (en) * | 1998-01-16 | 1999-07-22 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
| ITTO980473A1 (it) * | 1998-06-02 | 1999-12-02 | Sorin Diagnostics S R L | Nuovo procedimento per la rivelazione di anticorpi e/o isotipi di anticorpi specifici per almeno due differenti fasi di un'infezione |
| US6315952B1 (en) | 1998-10-05 | 2001-11-13 | The University Of New Mexico | Plug flow cytometry for high throughput screening and drug discovery |
| JP2000214070A (ja) * | 1999-01-21 | 2000-08-04 | Sysmex Corp | シ―スフロ―セルとそれを用いた血液分析装置 |
| US6480276B1 (en) | 1999-07-13 | 2002-11-12 | Clemson University | Enhanced photon-migration methods for particle sizing in concentrated suspensions |
| US7416903B2 (en) * | 1999-09-30 | 2008-08-26 | Stc.Unm | Wavy interface mixer |
| US6890487B1 (en) | 1999-09-30 | 2005-05-10 | Science & Technology Corporation ©UNM | Flow cytometry for high throughput screening |
| US6392327B1 (en) | 2000-03-29 | 2002-05-21 | James L. Sackrison | Sonic transducer and feedback control method thereof |
| US20020028434A1 (en) * | 2000-09-06 | 2002-03-07 | Guava Technologies, Inc. | Particle or cell analyzer and method |
| CA2439307A1 (en) * | 2001-02-23 | 2002-09-06 | Genicon Sciences Corporation | Methods for providing extended dynamic range in analyte assays |
| DE10122806A1 (de) * | 2001-05-10 | 2002-11-14 | Holger Kiesewetter | Verfahren zum Nachweis von Blutzell-Antigenen und gegen diese gerichtete Antikörper |
| AU2002368023A1 (en) * | 2001-05-16 | 2004-03-04 | Burstein Technologies, Inc. | Variable sampling for rendering pixelization of analysis results in optical bio-disc assembly |
| US20030139886A1 (en) * | 2001-09-05 | 2003-07-24 | Bodzin Leon J. | Method and apparatus for normalization and deconvolution of assay data |
| US20030109067A1 (en) | 2001-12-06 | 2003-06-12 | Immunetech, Inc. | Homogeneous immunoassays for multiple allergens |
| FR2834796B1 (fr) * | 2002-01-11 | 2006-01-06 | Biomedical Diagnostics Sa | Procede d'obtention d'un systeme d'etalonnage unique applique aux dosages multiparametriques d'echantillons biologiques, reactif immunologique prepare a cette fin et procede de dosage |
| RU2213974C1 (ru) * | 2002-04-09 | 2003-10-10 | Баженов Алексей Иванович | Способ одновременного определения нескольких аналитов |
| DE60308259T2 (de) * | 2002-05-22 | 2007-04-05 | Sysmex Corp. | Immunologische Verfahren, Vorrichtungen und Reagenzien |
| US7560239B2 (en) * | 2002-06-04 | 2009-07-14 | Lin-Zhi International Inc. | Homogeneous enzyme immunoassay for simultaneous detection of multiple analytes |
| US7016791B2 (en) * | 2002-10-02 | 2006-03-21 | Airadvice, Inc. | Particle sizing refinement system |
| AU2003279801A1 (en) * | 2002-10-02 | 2004-04-23 | Airadvice, Inc. | Method and apparatus for particle sizing |
| KR20040044336A (ko) * | 2002-11-12 | 2004-05-28 | 마쯔시다덴기산교 가부시키가이샤 | 특이결합반응 측정방법과 이에 이용하는 시약키트 및특이결합반응 측정장치 |
| US7053783B2 (en) | 2002-12-18 | 2006-05-30 | Biovigilant Systems, Inc. | Pathogen detector system and method |
| EP1664784A1 (en) * | 2003-09-17 | 2006-06-07 | Guava Technologies, Inc. | Compositions and methods for analysis of target analytes |
| US20070054405A1 (en) * | 2003-10-23 | 2007-03-08 | Ortho-Clinical Diagnostics, Inc. | Patient sample classification based upon low angle light scattering |
| US20050141843A1 (en) * | 2003-12-31 | 2005-06-30 | Invitrogen Corporation | Waveguide comprising scattered light detectable particles |
| US7430046B2 (en) * | 2004-07-30 | 2008-09-30 | Biovigilant Systems, Inc. | Pathogen and particle detector system and method |
| EP1907818A4 (en) * | 2005-07-15 | 2012-03-14 | Biovigilant Systems Inc | PATHOGENIC AND PARTICULATE DETECTOR SYSTEM AND METHOD |
| US7851229B2 (en) * | 2006-05-12 | 2010-12-14 | Primus Corporation | Two-phase optical assay with unitized container and double or single sensor systems |
| US7859664B2 (en) * | 2007-09-13 | 2010-12-28 | Brightwell Technologies Inc. | Plurality of samples and method for selecting a target sample therefrom |
| US8628976B2 (en) | 2007-12-03 | 2014-01-14 | Azbil BioVigilant, Inc. | Method for the detection of biologic particle contamination |
| FR2928656B1 (fr) * | 2008-03-14 | 2011-08-26 | Biomerieux Sa | Procede de detection en temps reel de microorganismes dans un milieu de culture liquide par agglutination. |
| US8154273B2 (en) * | 2008-10-10 | 2012-04-10 | Beckman Coulter, Inc. | Detecting and handling coincidence in particle analysis |
| WO2010135627A1 (en) | 2009-05-21 | 2010-11-25 | Intellicyt | System and method for separating samples in a continuous flow |
| US9752964B1 (en) | 2009-06-22 | 2017-09-05 | Stc.Unm | Flow cytometry apparatus pulling sample stream through observation chamber |
| KR101139954B1 (ko) * | 2010-01-28 | 2012-04-30 | 서울대학교산학협력단 | 입자면역응집반응 산란광 측정 장치 및 방법 |
| EP2576759A4 (en) | 2010-05-25 | 2014-01-22 | Arryx Inc | METHODS AND APPARATUSES FOR DETECTING FREEDOM OF POSITION OF PARTICLES IN BIOLOGICAL AND CHEMICAL ANALYZES AND APPLICATION IN IMMUNODIAGNOSTICS |
| EP2466292B1 (en) * | 2010-10-29 | 2017-12-13 | F. Hoffmann-La Roche AG | System for performing scattering and absorbance assays |
| US20130000738A1 (en) * | 2011-02-28 | 2013-01-03 | Pathogenetix, Inc. | Method and system for transferring and/or concentrating a sample |
| US9677990B2 (en) * | 2014-04-30 | 2017-06-13 | Particles Plus, Inc. | Particle counter with advanced features |
| DE102013212539B4 (de) * | 2013-06-27 | 2015-07-23 | Carl Von Ossietzky Universität Oldenburg | Verfahren und Vorrichtung zur Analyse |
| US10578537B2 (en) * | 2016-03-30 | 2020-03-03 | Sintrol Oy | Method for measuring the properties of particles in a medium and a device for measuring the properties of particles in a flue gas |
| US11009504B2 (en) * | 2017-01-31 | 2021-05-18 | Maxim Integrated Products. Inc. | System and method for performing an assay with sub-pixel sized beads |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4027971A (en) * | 1973-01-08 | 1977-06-07 | Philip Kolman | Method of simultaneously counting blood cells |
| US4184849A (en) * | 1977-12-05 | 1980-01-22 | Technicon Instruments Corporation | Mixed agglutination |
| GB2045431B (en) * | 1979-02-26 | 1983-04-20 | Technicon Instr | Immunoassay utilising two particulate reagents |
| US4766083A (en) * | 1982-04-04 | 1988-08-23 | Wako Pure Chemical Industries, Ltd. | Method for the photometric determination of biological agglutination |
| US4521521A (en) * | 1983-03-11 | 1985-06-04 | E. I. Du Pont De Nemours And Company | Particle reagent size distribution measurements for immunoassay |
| US4665020A (en) * | 1984-05-30 | 1987-05-12 | United States Department Of Energy | Flow cytometer measurement of binding assays |
| US4963498A (en) * | 1985-08-05 | 1990-10-16 | Biotrack | Capillary flow device |
| US4850707A (en) * | 1986-06-06 | 1989-07-25 | Massachusetts Institute Of Technology | Optical pulse particle size analyzer |
| US4851329A (en) * | 1986-06-06 | 1989-07-25 | Massachusetts Institute Of Technology | Immunoassay employing optical pulse particle size analysis |
| US4765737A (en) * | 1987-03-30 | 1988-08-23 | Cornell Research Foundation | Cell size measurements using light in flow cytometry and cell sorting |
| US4988630A (en) * | 1987-04-27 | 1991-01-29 | Hoffmann-La Roche Inc. | Multiple beam laser instrument for measuring agglutination reactions |
| US5162863A (en) * | 1988-02-15 | 1992-11-10 | Canon Kabushiki Kaisha | Method and apparatus for inspecting a specimen by optical detection of antibody/antigen sensitized carriers |
| JPH0718879B2 (ja) * | 1988-02-15 | 1995-03-06 | キヤノン株式会社 | 検体検査方法 |
| JP2667867B2 (ja) * | 1988-03-30 | 1997-10-27 | 東亜医用電子株式会社 | 粒子解析装置 |
| NO164622C (no) * | 1988-05-11 | 1990-10-24 | Tore Lindmo | Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav. |
| AT394114B (de) * | 1989-07-13 | 1992-02-10 | Immuno Ag | Verfahren zur bestimmung von antigenen und/oder antikoerpern in menschlichen koerperfluessigkeiten sowie set zur durchfuehrung des verfahrens |
| US5198369A (en) * | 1990-04-25 | 1993-03-30 | Canon Kabushiki Kaisha | Sample measuring method using agglomeration reaction of microcarriers |
| US5144224A (en) * | 1991-04-01 | 1992-09-01 | Larsen Lawrence E | Millimeter wave flow cytometer |
-
1992
- 1992-05-15 US US07/883,574 patent/US5286452A/en not_active Expired - Fee Related
- 1992-05-19 DK DK92912635T patent/DK0585369T3/da active
- 1992-05-19 AT AT92912635T patent/ATE169116T1/de not_active IP Right Cessation
- 1992-05-19 TW TW081103896A patent/TW197940B/zh active
- 1992-05-19 FI FI935128A patent/FI935128A0/fi unknown
- 1992-05-19 AU AU21420/92A patent/AU656399B2/en not_active Ceased
- 1992-05-19 ES ES92912635T patent/ES2120448T3/es not_active Expired - Lifetime
- 1992-05-19 EP EP92912635A patent/EP0585369B1/en not_active Expired - Lifetime
- 1992-05-19 WO PCT/US1992/004155 patent/WO1992021024A1/en not_active Ceased
- 1992-05-19 RU RU93058382A patent/RU2111488C1/ru active
- 1992-05-19 JP JP5500246A patent/JPH06507972A/ja active Pending
- 1992-05-19 DE DE69226433T patent/DE69226433T2/de not_active Expired - Fee Related
- 1992-05-19 KR KR1019930703520A patent/KR100215348B1/ko not_active Expired - Fee Related
- 1992-05-19 CA CA002103455A patent/CA2103455A1/en not_active Abandoned
- 1992-07-01 IE IE159892A patent/IE921598A1/en not_active Application Discontinuation
-
1993
- 1993-08-30 US US08/113,327 patent/US5369037A/en not_active Expired - Fee Related
- 1993-11-19 NO NO934205A patent/NO934205L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IE921598A1 (en) | 1992-12-02 |
| AU656399B2 (en) | 1995-02-02 |
| WO1992021024A1 (en) | 1992-11-26 |
| US5286452A (en) | 1994-02-15 |
| JPH06507972A (ja) | 1994-09-08 |
| FI935128L (fi) | 1993-11-19 |
| DK0585369T3 (da) | 1999-04-26 |
| FI935128A7 (fi) | 1993-11-19 |
| EP0585369A1 (en) | 1994-03-09 |
| NO934205D0 (no) | 1993-11-19 |
| DE69226433T2 (de) | 1998-12-03 |
| FI935128A0 (fi) | 1993-11-19 |
| ATE169116T1 (de) | 1998-08-15 |
| EP0585369B1 (en) | 1998-07-29 |
| NO934205L (no) | 1993-11-19 |
| RU2111488C1 (ru) | 1998-05-20 |
| CA2103455A1 (en) | 1992-11-21 |
| US5369037A (en) | 1994-11-29 |
| AU2142092A (en) | 1992-12-30 |
| KR100215348B1 (ko) | 1999-08-16 |
| DE69226433D1 (de) | 1998-09-03 |
| TW197940B (es) | 1993-01-11 |
| EP0585369A4 (en) | 1996-07-10 |
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