DE69226433D1 - Verfahren zur simultanen analyse - Google Patents

Verfahren zur simultanen analyse

Info

Publication number
DE69226433D1
DE69226433D1 DE69226433T DE69226433T DE69226433D1 DE 69226433 D1 DE69226433 D1 DE 69226433D1 DE 69226433 T DE69226433 T DE 69226433T DE 69226433 T DE69226433 T DE 69226433T DE 69226433 D1 DE69226433 D1 DE 69226433D1
Authority
DE
Germany
Prior art keywords
simultaneous analysis
fpa
entails
multiply
aggregates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69226433T
Other languages
English (en)
Other versions
DE69226433T2 (de
Inventor
W Peter Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diasorin SpA
Original Assignee
Sienna Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sienna Biotech Inc filed Critical Sienna Biotech Inc
Application granted granted Critical
Publication of DE69226433D1 publication Critical patent/DE69226433D1/de
Publication of DE69226433T2 publication Critical patent/DE69226433T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N2015/0092—Monitoring flocculation or agglomeration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4707—Forward scatter; Low angle scatter
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Luminescent Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Complex Calculations (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Hard Magnetic Materials (AREA)
  • Optical Measuring Cells (AREA)
DE69226433T 1991-05-20 1992-05-19 Verfahren zur simultanen analyse Expired - Fee Related DE69226433T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70230291A 1991-05-20 1991-05-20
US07/883,574 US5286452A (en) 1991-05-20 1992-05-15 Simultaneous multiple assays
PCT/US1992/004155 WO1992021024A1 (en) 1991-05-20 1992-05-19 Simultaneous multiple assays

Publications (2)

Publication Number Publication Date
DE69226433D1 true DE69226433D1 (de) 1998-09-03
DE69226433T2 DE69226433T2 (de) 1998-12-03

Family

ID=27106944

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69226433T Expired - Fee Related DE69226433T2 (de) 1991-05-20 1992-05-19 Verfahren zur simultanen analyse

Country Status (16)

Country Link
US (2) US5286452A (de)
EP (1) EP0585369B1 (de)
JP (1) JPH06507972A (de)
KR (1) KR100215348B1 (de)
AT (1) ATE169116T1 (de)
AU (1) AU656399B2 (de)
CA (1) CA2103455A1 (de)
DE (1) DE69226433T2 (de)
DK (1) DK0585369T3 (de)
ES (1) ES2120448T3 (de)
FI (1) FI935128A (de)
IE (1) IE921598A1 (de)
NO (1) NO934205D0 (de)
RU (1) RU2111488C1 (de)
TW (1) TW197940B (de)
WO (1) WO1992021024A1 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6200820B1 (en) * 1992-12-22 2001-03-13 Sienna Biotech, Inc. Light scatter-based immunoassay
TW239881B (de) * 1992-12-22 1995-02-01 Sienna Biotech Inc
US5503982A (en) * 1993-09-30 1996-04-02 Research Corporation Technologies, Inc. Detection of an acute myocardial infarction in a patient
US5561045A (en) * 1994-01-04 1996-10-01 Intracel Corporation Detection reagent, article, and immunoassay method
US5547833A (en) * 1994-01-04 1996-08-20 Intracel Corporation Radial flow assay, delivering member, test kit, and methods
US5485270A (en) * 1994-07-25 1996-01-16 General Signal Corporation Dynamic light scattering microvolume cell assembly for continuous flow dialysis
US6159748A (en) * 1995-03-13 2000-12-12 Affinitech, Ltd Evaluation of autoimmune diseases using a multiple parameter latex bead suspension and flow cytometry
US20030008410A1 (en) * 1995-03-13 2003-01-09 Hechinger Mark K. Immunoassay apparatus, kit and methods
US6951716B2 (en) * 1995-03-13 2005-10-04 Mark Hechinger Anti-platelet immunoglobulin bead positive control
AU3094195A (en) * 1995-07-10 1997-02-10 Donald L. Kramer Light transmittance type analytical system, variable transmittance optical component, and test device
AU7398996A (en) 1995-10-11 1997-04-30 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5736330A (en) * 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US6025201A (en) * 1995-12-28 2000-02-15 Bayer Corporation Highly sensitive, accurate, and precise automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples
US5817519A (en) * 1995-12-28 1998-10-06 Bayer Corporation Automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples
US5851777A (en) * 1996-02-05 1998-12-22 Dade Behring Inc. Homogeneous sol-sol assay
US5649576A (en) * 1996-02-26 1997-07-22 Pharmacopeia, Inc. Partitioning device
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
CA2253710A1 (en) 1996-04-25 1997-10-30 Spectrametrix Inc. Analyte assay using particulate labels
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5858648A (en) * 1996-11-04 1999-01-12 Sienna Biotech, Inc. Assays using reference microparticles
US6002788A (en) * 1997-09-24 1999-12-14 Compucyte Corporation Method and device for rendering cells observable with laser scanning cytometry
EP0919568A1 (de) 1997-12-01 1999-06-02 Sorin Diagnostics S.r.l. Fluchtmutanten des Oberflächenantigens des Hepatitis B Virus
AU2322099A (en) * 1998-01-16 1999-08-02 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
ITTO980473A1 (it) * 1998-06-02 1999-12-02 Sorin Diagnostics S R L Nuovo procedimento per la rivelazione di anticorpi e/o isotipi di anticorpi specifici per almeno due differenti fasi di un'infezione
US6315952B1 (en) 1998-10-05 2001-11-13 The University Of New Mexico Plug flow cytometry for high throughput screening and drug discovery
JP2000214070A (ja) * 1999-01-21 2000-08-04 Sysmex Corp シ―スフロ―セルとそれを用いた血液分析装置
US6480276B1 (en) 1999-07-13 2002-11-12 Clemson University Enhanced photon-migration methods for particle sizing in concentrated suspensions
US7416903B2 (en) * 1999-09-30 2008-08-26 Stc.Unm Wavy interface mixer
US6890487B1 (en) * 1999-09-30 2005-05-10 Science & Technology Corporation ©UNM Flow cytometry for high throughput screening
US6392327B1 (en) 2000-03-29 2002-05-21 James L. Sackrison Sonic transducer and feedback control method thereof
US20020028434A1 (en) * 2000-09-06 2002-03-07 Guava Technologies, Inc. Particle or cell analyzer and method
CA2439307A1 (en) * 2001-02-23 2002-09-06 Genicon Sciences Corporation Methods for providing extended dynamic range in analyte assays
DE10122806A1 (de) * 2001-05-10 2002-11-14 Holger Kiesewetter Verfahren zum Nachweis von Blutzell-Antigenen und gegen diese gerichtete Antikörper
US20020171838A1 (en) * 2001-05-16 2002-11-21 Pal Andrew Attila Variable sampling control for rendering pixelization of analysis results in a bio-disc assembly and apparatus relating thereto
WO2003021853A2 (en) * 2001-09-05 2003-03-13 Genicon Sciences Corporation Apparatus for reading signals generated from resonance light scattered particle labels
US20030109067A1 (en) 2001-12-06 2003-06-12 Immunetech, Inc. Homogeneous immunoassays for multiple allergens
FR2834796B1 (fr) * 2002-01-11 2006-01-06 Biomedical Diagnostics Sa Procede d'obtention d'un systeme d'etalonnage unique applique aux dosages multiparametriques d'echantillons biologiques, reactif immunologique prepare a cette fin et procede de dosage
DE60308259T2 (de) * 2002-05-22 2007-04-05 Sysmex Corp. Immunologische Verfahren, Vorrichtungen und Reagenzien
US7560239B2 (en) * 2002-06-04 2009-07-14 Lin-Zhi International Inc. Homogeneous enzyme immunoassay for simultaneous detection of multiple analytes
US7016791B2 (en) * 2002-10-02 2006-03-21 Airadvice, Inc. Particle sizing refinement system
WO2004031756A1 (en) * 2002-10-02 2004-04-15 Airadvice, Inc. Method and apparatus for particle sizing
EP1420251B1 (de) * 2002-11-12 2013-01-09 Panasonic Corporation Spezifische Bindereaktions-Messmethode
US7053783B2 (en) 2002-12-18 2006-05-30 Biovigilant Systems, Inc. Pathogen detector system and method
WO2005029078A1 (en) * 2003-09-17 2005-03-31 Guava Technologies, Inc. Compositions and methods for analysis of target analytes
US20070054405A1 (en) * 2003-10-23 2007-03-08 Ortho-Clinical Diagnostics, Inc. Patient sample classification based upon low angle light scattering
US20050141843A1 (en) * 2003-12-31 2005-06-30 Invitrogen Corporation Waveguide comprising scattered light detectable particles
CN100595564C (zh) * 2004-07-30 2010-03-24 百维吉伦特系统有限公司 病原体和粒子检测器系统和方法
CN101223560B (zh) * 2005-07-15 2012-12-12 百维吉伦特系统有限公司 病原体和颗粒的检测器系统和方法
US7851229B2 (en) * 2006-05-12 2010-12-14 Primus Corporation Two-phase optical assay with unitized container and double or single sensor systems
US7859664B2 (en) * 2007-09-13 2010-12-28 Brightwell Technologies Inc. Plurality of samples and method for selecting a target sample therefrom
US8628976B2 (en) 2007-12-03 2014-01-14 Azbil BioVigilant, Inc. Method for the detection of biologic particle contamination
FR2928656B1 (fr) * 2008-03-14 2011-08-26 Biomerieux Sa Procede de detection en temps reel de microorganismes dans un milieu de culture liquide par agglutination.
US8154273B2 (en) * 2008-10-10 2012-04-10 Beckman Coulter, Inc. Detecting and handling coincidence in particle analysis
EP2432869B1 (de) 2009-05-21 2020-08-12 Essen Instruments, Inc. d/b/a Essen BioScience, Inc. System und verfahren zur trennung von proben in einem kontinuierlichen fluss
US9752964B1 (en) 2009-06-22 2017-09-05 Stc.Unm Flow cytometry apparatus pulling sample stream through observation chamber
KR101139954B1 (ko) * 2010-01-28 2012-04-30 서울대학교산학협력단 입자면역응집반응 산란광 측정 장치 및 방법
WO2011149526A2 (en) 2010-05-25 2011-12-01 Arryx, Inc. Methods and apparatuses for detection of positional freedom of particles in biological and chemical analyses and applications in immunodiagnostics
EP2466292B1 (de) * 2010-10-29 2017-12-13 F. Hoffmann-La Roche AG System zur Durchführung von Streuungs- und Absorptionsassays
US20130000738A1 (en) * 2011-02-28 2013-01-03 Pathogenetix, Inc. Method and system for transferring and/or concentrating a sample
DE102013212539B4 (de) * 2013-06-27 2015-07-23 Carl Von Ossietzky Universität Oldenburg Verfahren und Vorrichtung zur Analyse
EP3436798B1 (de) * 2016-03-30 2021-10-13 Sintrol Oy Verfahren zur messung der eigenschaften von partikeln in einem medium und vorrichtung zur messung der eigenschaften von partikeln in einem abgas
US11009504B2 (en) * 2017-01-31 2021-05-18 Maxim Integrated Products. Inc. System and method for performing an assay with sub-pixel sized beads

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4027971A (en) * 1973-01-08 1977-06-07 Philip Kolman Method of simultaneously counting blood cells
US4184849A (en) * 1977-12-05 1980-01-22 Technicon Instruments Corporation Mixed agglutination
GB2045431B (en) * 1979-02-26 1983-04-20 Technicon Instr Immunoassay utilising two particulate reagents
US4766083A (en) * 1982-04-04 1988-08-23 Wako Pure Chemical Industries, Ltd. Method for the photometric determination of biological agglutination
US4521521A (en) * 1983-03-11 1985-06-04 E. I. Du Pont De Nemours And Company Particle reagent size distribution measurements for immunoassay
US4665020A (en) * 1984-05-30 1987-05-12 United States Department Of Energy Flow cytometer measurement of binding assays
US4963498A (en) * 1985-08-05 1990-10-16 Biotrack Capillary flow device
US4851329A (en) * 1986-06-06 1989-07-25 Massachusetts Institute Of Technology Immunoassay employing optical pulse particle size analysis
US4850707A (en) * 1986-06-06 1989-07-25 Massachusetts Institute Of Technology Optical pulse particle size analyzer
US4765737A (en) * 1987-03-30 1988-08-23 Cornell Research Foundation Cell size measurements using light in flow cytometry and cell sorting
US4988630A (en) * 1987-04-27 1991-01-29 Hoffmann-La Roche Inc. Multiple beam laser instrument for measuring agglutination reactions
JPH0718879B2 (ja) * 1988-02-15 1995-03-06 キヤノン株式会社 検体検査方法
US5162863A (en) * 1988-02-15 1992-11-10 Canon Kabushiki Kaisha Method and apparatus for inspecting a specimen by optical detection of antibody/antigen sensitized carriers
JP2667867B2 (ja) * 1988-03-30 1997-10-27 東亜医用電子株式会社 粒子解析装置
NO164622C (no) * 1988-05-11 1990-10-24 Tore Lindmo Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.
US5198369A (en) * 1990-04-25 1993-03-30 Canon Kabushiki Kaisha Sample measuring method using agglomeration reaction of microcarriers
US5144224A (en) * 1991-04-01 1992-09-01 Larsen Lawrence E Millimeter wave flow cytometer

Also Published As

Publication number Publication date
IE921598A1 (en) 1992-12-02
DE69226433T2 (de) 1998-12-03
WO1992021024A1 (en) 1992-11-26
KR100215348B1 (ko) 1999-08-16
CA2103455A1 (en) 1992-11-21
RU2111488C1 (ru) 1998-05-20
EP0585369A1 (de) 1994-03-09
US5369037A (en) 1994-11-29
TW197940B (de) 1993-01-11
FI935128A0 (fi) 1993-11-19
ES2120448T3 (es) 1998-11-01
DK0585369T3 (da) 1999-04-26
US5286452A (en) 1994-02-15
AU2142092A (en) 1992-12-30
ATE169116T1 (de) 1998-08-15
EP0585369A4 (en) 1996-07-10
NO934205L (no) 1993-11-19
EP0585369B1 (de) 1998-07-29
JPH06507972A (ja) 1994-09-08
AU656399B2 (en) 1995-02-02
FI935128A (fi) 1993-11-19
NO934205D0 (no) 1993-11-19

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: SIENNA BIOTECH, INC., COLUMBIA, MD., US

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DIASORIN S.R.L., SALUGGIA, VERCELLI, IT

8339 Ceased/non-payment of the annual fee