ES2119894T3 - Substancia fo-1289 y su produccion. - Google Patents

Substancia fo-1289 y su produccion.

Info

Publication number
ES2119894T3
ES2119894T3 ES93906828T ES93906828T ES2119894T3 ES 2119894 T3 ES2119894 T3 ES 2119894T3 ES 93906828 T ES93906828 T ES 93906828T ES 93906828 T ES93906828 T ES 93906828T ES 2119894 T3 ES2119894 T3 ES 2119894T3
Authority
ES
Spain
Prior art keywords
substance
hydrogen
acetyl
propionyl
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93906828T
Other languages
English (en)
Inventor
Satoshi Omura
Hiroshi Tomoda
Rokuro Masuma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kitasato Institute
Original Assignee
Kitasato Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kitasato Institute filed Critical Kitasato Institute
Application granted granted Critical
Publication of ES2119894T3 publication Critical patent/ES2119894T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/66—Aspergillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/913—Aspergillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Wire Bonding (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA SUSTANCIA FO-1289 COMPRENDE SUSTANCIA FO-1289A, SUSTANCIA FO1289B, SUSTANCIA FO-1289C Y SUSTANCIA FO-1289D, LA CUAL TIENE ACTIVIDAD INHIBIDORA DE LA ACILOCOENZIMA A DEL COLESTEROL. LA ACILOTRANSFERASA ES PRODUCIDA POR CULTIVO DEL ASPERGILLUS SP. FO1289. LA SUSTANCIA ES UTIL PARA EL TRATAMIENTO Y PREVENCION DE UNA ENFERMEDAD ATRIBUIDA A LA ACUMULACION DE COLESTEROL.
ES93906828T 1992-10-22 1993-03-26 Substancia fo-1289 y su produccion. Expired - Lifetime ES2119894T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28475992 1992-10-22
JP03526193A JP3233476B2 (ja) 1992-10-22 1993-02-24 Ｆｏ−１２８９物質およびその製造法

Publications (1)

Publication Number Publication Date
ES2119894T3 true ES2119894T3 (es) 1998-10-16

Family

ID=26374213

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93906828T Expired - Lifetime ES2119894T3 (es) 1992-10-22 1993-03-26 Substancia fo-1289 y su produccion.

Country Status (15)

Country Link
US (1) US5807721A (es)
EP (1) EP0667914B1 (es)
JP (1) JP3233476B2 (es)
KR (1) KR100323572B1 (es)
AT (1) ATE168722T1 (es)
AU (1) AU664437B2 (es)
CA (1) CA2127878C (es)
DE (1) DE69319920T2 (es)
DK (1) DK0667914T3 (es)
ES (1) ES2119894T3 (es)
FI (1) FI103670B (es)
HU (1) HU218015B (es)
NO (1) NO307519B1 (es)
NZ (1) NZ249975A (es)
WO (1) WO1994009147A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI388282B (zh) 2005-06-01 2013-03-11 Meiji Seika Pharma Co Ltd 害蟲控制劑
JP5037164B2 (ja) * 2005-06-01 2012-09-26 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 害虫防除剤
US7491738B2 (en) 2005-06-01 2009-02-17 Meiji Seika Kaisha, Ltd. Pest control agents
KR101486094B1 (ko) * 2007-03-08 2015-01-28 메이지 세이카 파루마 가부시키가이샤 유해생물 방제용 조성물
EP2186815A4 (en) 2007-08-13 2012-01-25 Meiji Seika Kaisha PROCESS FOR PREPARING A PYRIPYROPEN DERIVATIVE AND INTERMEDIATE PRODUCT
AU2008342070B2 (en) 2007-12-21 2014-07-31 Meiji Seika Pharma Co., Ltd. Novel systemic pesticide
CA2710791A1 (en) * 2007-12-25 2009-07-02 The Kitasato Institute Pyripyropene derivatives having an acat2-inhibiting activity
ES2453665T3 (es) 2008-07-24 2014-04-08 Meiji Seika Pharma Co., Ltd. Genes biosintéticos de piripiropeno A
EP2426124B1 (en) 2009-05-13 2013-08-07 Meiji Seika Pharma Co., Ltd. Process for producing pyripyropene derivative
BR112012019456B8 (pt) 2010-01-26 2022-08-02 Mmag Co Ltd Plasmídio compreendendo um ou mais polinucleotídeos e um promotor que é heterólogo para o um ou mais polinucleotídeos
BR112012019458B8 (pt) 2010-01-26 2022-08-02 Mmag Co Ltd construção de ácidos nucleicos, transformante, e métodos para produzir piripiropenos
RU2012136447A (ru) 2010-01-26 2014-03-10 Мейдзи Сейка Фарма Ко., Лтд. Способ получения пирипиропеновых производных ферментативным способом
UA111151C2 (uk) 2010-03-01 2016-04-11 Мейдзі Сейка Фарма Ко., Лтд. Спосіб одержання похідних пірипіропену
CN103025161A (zh) * 2010-05-24 2013-04-03 明治制果药业株式会社 有害生物防治剂
AU2011303970B2 (en) 2010-09-14 2015-08-13 Basf Se Composition containing a pyripyropene insecticide and an adjuvant
CN103118537B (zh) 2010-09-14 2015-08-12 巴斯夫欧洲公司 含有pyripyropene杀虫剂和碱的农药组合物
KR102056608B1 (ko) 2012-03-12 2019-12-17 바스프 에스이 피리피로펜 살곤충제의 수성 현탁액 농축물 제형의 제조 방법
MX360700B (es) 2012-03-12 2018-11-14 Basf Se Formulacion concentrada liquida que contiene un insecticida de piripiropeno ii.
US9596843B2 (en) 2012-03-12 2017-03-21 Basf Se Liquid concentrate formulation containing a pyripyropene insecticide I
CN102936252B (zh) * 2012-10-22 2015-03-04 中山大学 一类二倍半萜类化合物及其制备方法与应用
CN105102625A (zh) 2013-03-28 2015-11-25 巴斯夫欧洲公司 自干生物质制备啶南平
CN103910746B (zh) * 2014-02-28 2016-08-03 中山大学 一类海洋真菌来源的Berkeleyones化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US5250935A (en) * 1990-09-24 1993-10-05 Snap-On Tools Corporation Waveform peak capture circuit for digital engine analyzer
US5151365A (en) * 1991-03-18 1992-09-29 Merck & Co., Inc. Culture of Asperigillus versicolor and mutants thereof
JP2993767B2 (ja) * 1991-06-06 1999-12-27 社団法人北里研究所 Ｆｏ−１２８９ａ物質およびその製造法

Also Published As

Publication number Publication date
DK0667914T3 (da) 1998-11-02
EP0667914A1 (en) 1995-08-23
KR950701976A (ko) 1995-05-17
US5807721A (en) 1998-09-15
HUT69789A (en) 1995-09-28
FI103670B1 (fi) 1999-08-13
JPH06184158A (ja) 1994-07-05
ATE168722T1 (de) 1998-08-15
NO942634L (no) 1995-04-21
JP3233476B2 (ja) 2001-11-26
EP0667914B1 (en) 1998-07-22
FI943383A0 (fi) 1994-07-15
NO942634D0 (no) 1994-07-13
FI103670B (fi) 1999-08-13
AU664437B2 (en) 1995-11-16
AU3767993A (en) 1994-05-09
NO307519B1 (no) 2000-04-17
CA2127878A1 (en) 1994-04-28
NZ249975A (en) 1996-06-25
HU218015B (hu) 2000-05-28
KR100323572B1 (ko) 2002-09-04
CA2127878C (en) 1997-07-08
HU9402127D0 (en) 1994-09-28
DE69319920D1 (de) 1998-08-27
WO1994009147A1 (en) 1994-04-28
FI943383A (fi) 1994-08-31
DE69319920T2 (de) 1998-12-10

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