ES2118807T3 - Anticuerpos contra el complejo inhibidor de plasmina humana-plasmina alfa 2, hibridoma e inmunoensayo. - Google Patents

Anticuerpos contra el complejo inhibidor de plasmina humana-plasmina alfa 2, hibridoma e inmunoensayo.

Info

Publication number
ES2118807T3
ES2118807T3 ES92901440T ES92901440T ES2118807T3 ES 2118807 T3 ES2118807 T3 ES 2118807T3 ES 92901440 T ES92901440 T ES 92901440T ES 92901440 T ES92901440 T ES 92901440T ES 2118807 T3 ES2118807 T3 ES 2118807T3
Authority
ES
Spain
Prior art keywords
plasmine
human
inhibitor
pic
immuno
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92901440T
Other languages
English (en)
Inventor
Gilbu Soe
Isao Kohno
Mami Shiiba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kagaku Iatron Inc
Original Assignee
Iatron Laboratories Inc
Mitsubishi Kagaku Iatron Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18520741&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2118807(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Iatron Laboratories Inc, Mitsubishi Kagaku Iatron Inc filed Critical Iatron Laboratories Inc
Application granted granted Critical
Publication of ES2118807T3 publication Critical patent/ES2118807T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

UN PRIMER ANTICUERPO MONOCLONAL QUE REACCIONA ESPECIFICAMENTE CON UN COMPLEJO INHIBIDOR DE LA PLASMINA-O2-PLASMINA HUMANA (PIC) Y CON UN PLASMINOGEN HUMANO; UN SEGUNDO ANTICUERPO MONOCLONAL QUE REACCIONA CON EL PIC Y TAMBIEN CON UN INHIBIDOR DE LA O-PLASMINA HUMANA; UN TERCER ANTICUERPO MONOCLONAL QUE REACCIONA CON UN PIC PERO NO CON UN PLASMINOGEN HUMANO Y CON UN INHIBIDOR DE LA O2PLASMINA HUMANA; HIBRIDOMAS QUE SEGREGAN DEL PRIMER AL TERCER ANTICUERPOS MONOCLONALES; Y UN INMUNOENSAYO UTILIZANDO ESTOS ANTICUERPOS. ESTA INVENCION HACE QUE SEA POSIBLE DETERMINAR EL CONTENIDO DEL PIC EN EL PLASMA DE UN PACIENTE MEDIANTE UNA AGLUTINACION DE MANERA ESPECIFICA, CONVENIENTE Y RAPIDA SIN SUFRIR LA INTERFERENCIA DE UN PLASMINOGEN LIBRE Y DE UN INHIBIDOR DE O2-PLASMINA LIBRE PRESENTE EN EL PLASMA INCLUSO CUANDO LA MUESTRA DE PLASMA SE ENCUENTRA SIN DILUIR
ES92901440T 1990-12-20 1991-12-19 Anticuerpos contra el complejo inhibidor de plasmina humana-plasmina alfa 2, hibridoma e inmunoensayo. Expired - Lifetime ES2118807T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP41180590 1990-12-20

Publications (1)

Publication Number Publication Date
ES2118807T3 true ES2118807T3 (es) 1998-10-01

Family

ID=18520741

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92901440T Expired - Lifetime ES2118807T3 (es) 1990-12-20 1991-12-19 Anticuerpos contra el complejo inhibidor de plasmina humana-plasmina alfa 2, hibridoma e inmunoensayo.

Country Status (9)

Country Link
US (1) US5888749A (es)
EP (1) EP0516863B1 (es)
JP (1) JP3291525B2 (es)
KR (1) KR100207351B1 (es)
AU (1) AU657504B2 (es)
CA (1) CA2075937C (es)
DE (1) DE69129582T2 (es)
ES (1) ES2118807T3 (es)
WO (1) WO1992011384A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8133421B2 (en) * 1999-02-23 2012-03-13 Warsaw Orthopedic, Inc. Methods of making shaped load-bearing osteoimplant
EP2042870A1 (en) * 2007-09-28 2009-04-01 Fujifilm Corporation Method of high sensitive immunoassay
EP2745115B1 (de) * 2011-08-19 2016-05-18 Protagen AG Neues verfahren zur diagnostik von hochaffinen bindern und markersequenzen
EP4519325A1 (en) * 2022-05-04 2025-03-12 Rheinische Friedrich-Wilhelms-Universität Bonn Plasmin-binding vhhs
CN117126283B (zh) * 2022-05-19 2025-05-27 深圳市新产业生物医学工程股份有限公司 抗pic的抗体、试剂盒及检测pic的方法
CN115873120B (zh) * 2022-09-08 2025-10-21 厦门英博迈生物科技有限公司 一种纤溶酶α2纤溶酶抑制物复合物抗体及应用
CN116284415B (zh) * 2022-12-29 2023-11-14 山东大学 一种纤溶酶-α2抗纤溶酶复合物单克隆抗体及其制备和应用
CN117568445B (zh) * 2024-01-18 2024-04-09 西南交通大学 一种tat、pic复合质控品的制备方法及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7511055A (nl) * 1975-09-19 1977-03-22 Leuven Res & Dev Vzw Trombosetest.
EP0044219A1 (en) * 1980-07-16 1982-01-20 Unilever Plc Methods of immuno analysis using monoclonal antibodies
US4849353A (en) * 1980-09-30 1989-07-18 Cornell Research Foundation, Inc. Immunocapture of enzyme inhibitor, enzyme complexes and uses thereof
US4629694A (en) * 1983-07-12 1986-12-16 Cornell Research Foundation, Inc. Detecting and distinguishing between plasminogen activators
GB8408193D0 (en) * 1984-03-30 1984-05-10 Cambridge Patent Dev Antibodies
DK166627B1 (da) * 1984-04-17 1993-06-21 Teijin Ltd Monoklont antistof, der er specifikt over for human-alfa-2-plasmininhibitor, fremgangsmaade til fremstilling af et hybridom, der producerer antistoffet, anvendelse af antistoffet til immunologisk analyse for human-alfa-2-plasmininhibitor og anvendelse af antistoffet til fraskillelse og udvinding af human-alfa-2-plasmininhibitor
JPS60222426A (ja) * 1984-04-17 1985-11-07 Teijin Ltd モノクローナル抗体及びモノクローナル抗体の製造方法
JPS61213671A (ja) * 1985-03-20 1986-09-22 Teijin Ltd ヒトプラスミン−α↓２−プラスミンインヒビタ−複合体の測定法
EP0169549B1 (en) * 1984-07-26 1992-09-02 Teijin Limited Immunological determination of human plasmin/alpha2-plasmin inhibitor
US4820635A (en) * 1985-08-27 1989-04-11 The United States Of America As Represented By The Department Of Health And Human Services Kit for assaying activation of terminal complement cascade
JPH074270B2 (ja) * 1986-06-24 1995-01-25 帝人株式会社 モノクローナル抗体
AT398004B (de) * 1992-04-14 1994-08-25 Berbi Gmbh Verfahren zur bestimmung von plasmin-alpha2- antiplasmin-komplexen unter verwendung eines komplexspezifischen monoklonalen antikörpers

Also Published As

Publication number Publication date
EP0516863A4 (en) 1993-06-09
CA2075937C (en) 2002-01-29
KR927003838A (ko) 1992-12-18
KR100207351B1 (ko) 1999-07-15
DE69129582D1 (de) 1998-07-16
EP0516863B1 (en) 1998-06-10
AU657504B2 (en) 1995-03-16
CA2075937A1 (en) 1992-06-21
DE69129582T2 (de) 1999-02-18
JP3291525B2 (ja) 2002-06-10
WO1992011384A1 (fr) 1992-07-09
AU9100191A (en) 1992-07-22
EP0516863A1 (en) 1992-12-09
US5888749A (en) 1999-03-30

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