ES2118714T3 - Caracterizacion de materia biologica en un estado dinamico utilizando espectroscopia de infrarrojo cercano. - Google Patents

Caracterizacion de materia biologica en un estado dinamico utilizando espectroscopia de infrarrojo cercano.

Info

Publication number
ES2118714T3
ES2118714T3 ES90310219T ES90310219T ES2118714T3 ES 2118714 T3 ES2118714 T3 ES 2118714T3 ES 90310219 T ES90310219 T ES 90310219T ES 90310219 T ES90310219 T ES 90310219T ES 2118714 T3 ES2118714 T3 ES 2118714T3
Authority
ES
Spain
Prior art keywords
property
interest
compartment
biological fluid
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90310219T
Other languages
English (en)
Inventor
James B Callis
David W Osten
Hatim M Carim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
3M Co
Original Assignee
University of Washington
Minnesota Mining and Manufacturing Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Minnesota Mining and Manufacturing Co filed Critical University of Washington
Application granted granted Critical
Publication of ES2118714T3 publication Critical patent/ES2118714T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14535Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring haematocrit
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14557Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted to extracorporeal circuits
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235Details of waveform analysis
    • A61B5/7239Details of waveform analysis using differentiation including higher order derivatives
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/12Circuits of general importance; Signal processing
    • G01N2201/129Using chemometrical methods

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

SE DISPONE UN METODO PARA PREDECIR UNA PROPIEDAD DE UNA MATERIA DE ORIGEN BIOLOGICO, TAL COMO UN FLUIDO BIOLOGICO, CONTENIENDO AGUA, EN UNA CONDICION DINAMICA DONDE EL FLUIDO BIOLOGICO PUEDA CONTENER APROXIMADAMENTE DOS COMPARTIMIENTOS DONDE UNO DE LOS COMPARTIMIENTOS TENGA UNA CANTIDAD PROPORCIONALMENTE MAYOR O MENOR DE AGUA QUE EL OTRO COMPARTIMIENTO TENIENDO LA PROPIEDAD DE INTERES. EL METODO IMPLICA EL ESTABLECIMIENTO DE UN CONJUNTO DE ADIESTRAMIENTO EN EL LUGAR (NIR) CON CUANTIFICACION INDEPENDIENTE DE LA PROPIEDAD DEL FLUIDO QUE UTILIZA TECNICAS CONOCIDAS. EL CONJUNTO DE ADIESTRAMIENTO SE ANALIZA MATEMATICAMENTE CONFORME A UNA CORRELACION DESARROLLADA MEDIANTE ANALISIS DE REGRESION DESPUES DEL EMPLEO DE UNA TECNICA DE PREPROCESAMIENTO TAL COMO UNA TRANSFORMACION DERIVADA MULTIPLE DE ESPECTROS O UNA PROPORDIONALIDAD DE DOS LONGITUDES DE ONDA EN LOS ESPECTROS. EL RESULTADO ES UNA ECUACION DE TRANSFORMACION MATEMATICA QUE CUANTITATIVAMENTE RELACIONA LAS INTENSIDADES ESPECTRALES EN LONGITUDES DE ONDA ESPECIFICAS CON LA PROPIEDAD DE INTERES. ESTA ECUACION DE TRANSFORMACION PUEDE APLICARSE A MUESTRAS DESCONOCIDAS PARA PREDECIR SUS PROPIEDADES, ELIMINANDO CON ELLO LA NECESIDAD DEL METODO DE REFERENCIA, SALVO PARA VALIDACION O RECALIBRACION. EL METODO PROPORCIONA PREDICCION RAPIDA Y EXACTA DE LA PROPIEDAD DE LA MUESTRA DESCONOCIDA, QUE PUEDE SER LA PROPIEDAD DE CONCENTRACION DE HEMOGLOBINA O HEMATOCRITO EN LA SANGRE TOTAL ANIMAL. OTROS ANALISIS DE PROPIEDADES EN EL FLUIDO BIOLOGICO TALES COMO SATURACION DE OXIGENO EN HEMOGLOBINA EN LA SANGRE TOTAL ANIMAL PUEDEN INCLUIRSE EN EL ANALISIS MATEMATICO PARA AFINAR MAS LA PREDICCION DE LA PROPIEDAD DE INTERES. TAMBIEN, SE DESCRIBE UN BUCLE DEL PACIENTE CON EL FIN DE MONITORIZAR LA PROPIEDAD DE INTERES CASI SIMULTANEAMENTE CON CAMBIOS EN ESA PROPIEDAD DE INTERES.
ES90310219T 1989-09-18 1990-09-18 Caracterizacion de materia biologica en un estado dinamico utilizando espectroscopia de infrarrojo cercano. Expired - Lifetime ES2118714T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40889089A 1989-09-18 1989-09-18

Publications (1)

Publication Number Publication Date
ES2118714T3 true ES2118714T3 (es) 1998-10-01

Family

ID=23618192

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90310219T Expired - Lifetime ES2118714T3 (es) 1989-09-18 1990-09-18 Caracterizacion de materia biologica en un estado dinamico utilizando espectroscopia de infrarrojo cercano.

Country Status (7)

Country Link
US (2) US5729333A (es)
EP (1) EP0419223B1 (es)
JP (1) JP3213308B2 (es)
CA (1) CA2025330C (es)
DE (1) DE69032339T2 (es)
DK (1) DK0419223T3 (es)
ES (1) ES2118714T3 (es)

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EP0419223A2 (en) 1991-03-27
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CA2025330A1 (en) 1991-03-19
EP0419223A3 (en) 1992-05-20
US5830133A (en) 1998-11-03
CA2025330C (en) 2002-01-22
EP0419223B1 (en) 1998-05-27
US5729333A (en) 1998-03-17
JP3213308B2 (ja) 2001-10-02
DE69032339T2 (de) 1998-12-24
JPH03118446A (ja) 1991-05-21

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