ES2118394T3 - Procedimiento para la preparacion de derivados de beta-fenilisoserina. - Google Patents

Procedimiento para la preparacion de derivados de beta-fenilisoserina.

Info

Publication number
ES2118394T3
ES2118394T3 ES94911225T ES94911225T ES2118394T3 ES 2118394 T3 ES2118394 T3 ES 2118394T3 ES 94911225 T ES94911225 T ES 94911225T ES 94911225 T ES94911225 T ES 94911225T ES 2118394 T3 ES2118394 T3 ES 2118394T3
Authority
ES
Spain
Prior art keywords
radical
pct
beta
preparation
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94911225T
Other languages
English (en)
Inventor
Eric Didier
Patrick Leon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2118394T3 publication Critical patent/ES2118394T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings

Abstract

PROCESO DE PREPARACION DE DERIVADOS DE LA BE -FENILISOSERINA DE FORMULA GENERAL (I) POR ACCION DE UN ANHIDRIDO Y DE HIDROGENO SOBRE UN PRODUCTO DE FORMULA GENERAL (II). LOS PRODUCTOS DE FORMULA GENERAL (I) SON PARTICULARMENTE UTILES PARA PREPARAR TAXOIDES QUE PRESENTAN PROPIEDADES ANTITUMORALES NOTABLES. EN LAS FORMULAS GENERALES (I) Y (II), AR REPRESENTA UN RADICAL ARILO, PH REPRESENTA UN RADICAL FENILO O {AL}- O {BE}-NAFTILO EVENTUALMENTE SUSTITUIDO, R REPRESENTA UN ATOMO DE HIDROGENO O UN RADICAL ALCOILO EVENTUALMENTE SUSTITUIDO POR UN RADICAL FENILO Y R{SUB,1} REPRESENTA UN RADICAL FENILO EVENTUALMENTE SUSTITUIDO O UN RADICAL R{SUB,2}-O EN EL QUE R{SUB,2} REPRESENTA ALCOILO, ALCENILO, CICLOALCOILO, FENILO O HETEROCICLILO.
ES94911225T 1993-03-29 1994-03-25 Procedimiento para la preparacion de derivados de beta-fenilisoserina. Expired - Lifetime ES2118394T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9303575A FR2703353B1 (fr) 1993-03-29 1993-03-29 Procédé de préparation de dérivés de la beta-phénylisosérine.

Publications (1)

Publication Number Publication Date
ES2118394T3 true ES2118394T3 (es) 1998-09-16

Family

ID=9445442

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94911225T Expired - Lifetime ES2118394T3 (es) 1993-03-29 1994-03-25 Procedimiento para la preparacion de derivados de beta-fenilisoserina.

Country Status (10)

Country Link
US (1) US5681970A (es)
EP (1) EP0691951B1 (es)
JP (1) JP3633619B2 (es)
AT (1) ATE167179T1 (es)
CA (1) CA2158060C (es)
DE (1) DE69411000T2 (es)
DK (1) DK0691951T3 (es)
ES (1) ES2118394T3 (es)
FR (1) FR2703353B1 (es)
WO (1) WO1994022813A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1260507A1 (en) * 1993-02-05 2002-11-27 Bryn Mawr College Synthesis of taxol, analogs and intermediates with variable A-nng side chains
KR100225534B1 (ko) * 1996-03-19 1999-10-15 정지석 (2R,3S)-베타-페닐이소세린 유도체의 입체선택적 제조방법[Storcospecific process for preparing(2R,3S)-β0phenylisoserine]
US6025516A (en) * 1998-10-14 2000-02-15 Chiragene, Inc. Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes
US6847778B1 (en) 1999-03-30 2005-01-25 Tivo, Inc. Multimedia visual progress indication system
EP2266607A3 (en) 1999-10-01 2011-04-20 Immunogen, Inc. Immunoconjugates for treating cancer
US20110223154A1 (en) * 2008-05-12 2011-09-15 University Of South Florida Compositions including triciribine and methods of use thereof
US20100009929A1 (en) * 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
US20100009928A1 (en) * 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and taxanes and methods of use thereof
US20110008327A1 (en) 2004-03-29 2011-01-13 Cheng Jin Q Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
MXPA06011219A (es) 2004-03-29 2007-05-08 Univ South Florida Tratamiento efectivo de tumores y cancer con triciribina y compuestos relacionados.
US20100028339A1 (en) * 2004-03-29 2010-02-04 Cheng Jin Q Compositions including triciribine and trastuzumab and methods of use thereof
US20100173864A1 (en) 2004-03-29 2010-07-08 Cheng Jin Q Compositions including triciribine and one or more platinum compounds and methods of use thereof
EP2300055A1 (en) 2008-05-12 2011-03-30 University Of South Florida Anticancer combination therapy including triciribine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL95436A (en) * 1989-08-23 1996-07-23 Centre Nat Rech Scient Process for preparing the history of phenylisosarine
MX9102128A (es) 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene

Also Published As

Publication number Publication date
ATE167179T1 (de) 1998-06-15
US5681970A (en) 1997-10-28
FR2703353A1 (fr) 1994-10-07
CA2158060A1 (fr) 1994-10-13
EP0691951A1 (fr) 1996-01-17
WO1994022813A1 (fr) 1994-10-13
DE69411000T2 (de) 1998-12-03
DE69411000D1 (de) 1998-07-16
EP0691951B1 (fr) 1998-06-10
JPH08508281A (ja) 1996-09-03
JP3633619B2 (ja) 2005-03-30
FR2703353B1 (fr) 1995-05-05
DK0691951T3 (da) 1998-10-19
CA2158060C (fr) 2006-11-21

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