ES2117445T3 - Procedimiento para la obtencion de selegilina. - Google Patents

Procedimiento para la obtencion de selegilina.

Info

Publication number
ES2117445T3
ES2117445T3 ES95931978T ES95931978T ES2117445T3 ES 2117445 T3 ES2117445 T3 ES 2117445T3 ES 95931978 T ES95931978 T ES 95931978T ES 95931978 T ES95931978 T ES 95931978T ES 2117445 T3 ES2117445 T3 ES 2117445T3
Authority
ES
Spain
Prior art keywords
pct
selegiline
procedure
sec
hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95931978T
Other languages
English (en)
Inventor
Silvia Ott-Dembrowski
Richard Cyrus
Jorg Schmidt
Hans Waiblinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Knoll GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll GmbH filed Critical Knoll GmbH
Application granted granted Critical
Publication of ES2117445T3 publication Critical patent/ES2117445T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/60—Preparation of compounds containing amino groups bound to a carbon skeleton by condensation or addition reactions, e.g. Mannich reaction, addition of ammonia or amines to alkenes or to alkynes or addition of compounds containing an active hydrogen atom to Schiff's bases, quinone imines, or aziranes

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA OBTENCION DE HIDROCLORURO DE SELEGILINA POR REACCION DE R-(-)-N,{AL}-DIMETIL-FENILETILAMINA CON 3-BROMO-1-PROPINO, QUE CONSISTE, EN QUE SE HACEN REACCIONAR LAS SUSTANCIAS EN UNA RELACION MOLAR DE APROX. 2:1 A 30-50 OCARBURO AROMATICO Y AGUA Y SIN CATALIZADOR, AISLANDO LA SELEGILINA DE LA FASE ORGANICA Y TRANSFORMANDOLA EN EL HIDROCLORURO.
ES95931978T 1994-09-13 1995-09-02 Procedimiento para la obtencion de selegilina. Expired - Lifetime ES2117445T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4432610A DE4432610C1 (de) 1994-09-13 1994-09-13 Verfahren zur Herstellung von Selegilin-Hydrochlorid

Publications (1)

Publication Number Publication Date
ES2117445T3 true ES2117445T3 (es) 1998-08-01

Family

ID=6528113

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95931978T Expired - Lifetime ES2117445T3 (es) 1994-09-13 1995-09-02 Procedimiento para la obtencion de selegilina.

Country Status (15)

Country Link
US (1) US5847216A (es)
EP (1) EP0772584B1 (es)
JP (1) JPH10505602A (es)
AT (1) ATE167469T1 (es)
AU (1) AU3520895A (es)
CA (1) CA2198781C (es)
CZ (1) CZ287647B6 (es)
DE (2) DE4432610C1 (es)
DK (1) DK0772584T3 (es)
ES (1) ES2117445T3 (es)
FI (1) FI111713B (es)
HU (1) HU214840B (es)
IL (1) IL115157A (es)
MX (1) MX9701831A (es)
WO (1) WO1996008461A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19716905C1 (de) * 1997-04-22 1998-08-27 Iip Inst Fuer Ind Pharmazie Fo Stabile, wäßrige Lösung auf der Grundlage von Selegilin und Vorrichtung zu ihrer Verabreichung
US9446995B2 (en) 2012-05-21 2016-09-20 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
US10189803B2 (en) 2008-02-22 2019-01-29 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
WO2015051362A1 (en) 2013-10-04 2015-04-09 Illinois Institute Of Technology Multifunctional chelators, complexes, and compositions thereof, and methods of using same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH393306A (de) * 1962-03-30 1965-06-15 Wander Ag Dr A Verfahren zur Herstellung von tertiären Aminen der Phenylalkylreihe
GB1121857A (en) * 1965-01-05 1968-07-31 Science Union & Cie New phenylisopropylamine derivatives and process for their preparation and pharmaceutical preparations of such derivatives
US3485874A (en) * 1966-05-04 1969-12-23 Chinoin Gyogyszer Es Vegyeszet Ortho and para bromophenyl isopropyl methylamines
US4156017A (en) * 1977-02-22 1979-05-22 Schering Aktiengesellschaft Pesticides
HU187775B (en) * 1982-07-14 1986-02-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu New process for producing propargile-amines of pharmaceutical activity
CS269271B1 (en) * 1988-05-30 1990-04-11 Hajicek Josef Method of selegiline's hydrochloride production
HUT63579A (en) * 1991-12-20 1993-09-28 Chinoin Gyogyszer Es Vegyeszet Process for producing double-phase pharmaceutical compositions suitable for treating diseases occurring during neurodegenerative processes

Also Published As

Publication number Publication date
CA2198781A1 (en) 1996-03-21
FI971038A (fi) 1997-03-12
IL115157A0 (en) 1995-12-31
CZ287647B6 (en) 2001-01-17
US5847216A (en) 1998-12-08
DE59502606D1 (de) 1998-07-23
EP0772584A1 (de) 1997-05-14
HUT77185A (hu) 1998-03-02
WO1996008461A1 (de) 1996-03-21
JPH10505602A (ja) 1998-06-02
FI971038A0 (fi) 1997-03-12
EP0772584B1 (de) 1998-06-17
HU214840B (hu) 1998-06-29
FI111713B (fi) 2003-09-15
DK0772584T3 (da) 1998-10-19
DE4432610C1 (de) 1996-02-01
MX9701831A (es) 1997-06-28
CA2198781C (en) 2004-08-24
ATE167469T1 (de) 1998-07-15
AU3520895A (en) 1996-03-29
CZ77597A3 (cs) 1998-02-18
IL115157A (en) 1999-05-09

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