MX9701831A - Preparacion de la selegilina. - Google Patents

Preparacion de la selegilina.

Info

Publication number
MX9701831A
MX9701831A MX9701831A MX9701831A MX9701831A MX 9701831 A MX9701831 A MX 9701831A MX 9701831 A MX9701831 A MX 9701831A MX 9701831 A MX9701831 A MX 9701831A MX 9701831 A MX9701831 A MX 9701831A
Authority
MX
Mexico
Prior art keywords
selegilin
preparing
hydrochloride
propine
phenylethylamine
Prior art date
Application number
MX9701831A
Other languages
English (en)
Inventor
Silvia Ott-Dembrowski
Richard Cyrus
Jorg Schmidt
Hans Waiblinger
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Publication of MX9701831A publication Critical patent/MX9701831A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/60—Preparation of compounds containing amino groups bound to a carbon skeleton by condensation or addition reactions, e.g. Mannich reaction, addition of ammonia or amines to alkenes or to alkynes or addition of compounds containing an active hydrogen atom to Schiff's bases, quinone imines, or aziranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se describe un procedimiento para el clorhidrato para preparar el dimetilfenilletilamina con el 3-bromo-1-propino, a este procedimiento comprende hacer reaccionar las substancias en una relacion molar de aproximadamente 2:1 a una temperatura de 30 a 50 degree C, en una mezcla de solventes la selegilina de la fase orgánica y convertida en el clorhidrato.
MX9701831A 1994-09-13 1995-09-02 Preparacion de la selegilina. MX9701831A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4432610A DE4432610C1 (de) 1994-09-13 1994-09-13 Verfahren zur Herstellung von Selegilin-Hydrochlorid
PCT/EP1995/003460 WO1996008461A1 (de) 1994-09-13 1995-09-02 Verfahren zur herstellung von selegilin

Publications (1)

Publication Number Publication Date
MX9701831A true MX9701831A (es) 1997-06-28

Family

ID=6528113

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9701831A MX9701831A (es) 1994-09-13 1995-09-02 Preparacion de la selegilina.

Country Status (15)

Country Link
US (1) US5847216A (es)
EP (1) EP0772584B1 (es)
JP (1) JPH10505602A (es)
AT (1) ATE167469T1 (es)
AU (1) AU3520895A (es)
CA (1) CA2198781C (es)
CZ (1) CZ287647B6 (es)
DE (2) DE4432610C1 (es)
DK (1) DK0772584T3 (es)
ES (1) ES2117445T3 (es)
FI (1) FI111713B (es)
HU (1) HU214840B (es)
IL (1) IL115157A (es)
MX (1) MX9701831A (es)
WO (1) WO1996008461A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19716905C1 (de) * 1997-04-22 1998-08-27 Iip Inst Fuer Ind Pharmazie Fo Stabile, wäßrige Lösung auf der Grundlage von Selegilin und Vorrichtung zu ihrer Verabreichung
US9446995B2 (en) 2012-05-21 2016-09-20 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
US10189803B2 (en) 2008-02-22 2019-01-29 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
WO2015051362A1 (en) 2013-10-04 2015-04-09 Illinois Institute Of Technology Multifunctional chelators, complexes, and compositions thereof, and methods of using same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH393306A (de) * 1962-03-30 1965-06-15 Wander Ag Dr A Verfahren zur Herstellung von tertiären Aminen der Phenylalkylreihe
GB1121857A (en) * 1965-01-05 1968-07-31 Science Union & Cie New phenylisopropylamine derivatives and process for their preparation and pharmaceutical preparations of such derivatives
US3485874A (en) * 1966-05-04 1969-12-23 Chinoin Gyogyszer Es Vegyeszet Ortho and para bromophenyl isopropyl methylamines
US4156017A (en) * 1977-02-22 1979-05-22 Schering Aktiengesellschaft Pesticides
HU187775B (en) * 1982-07-14 1986-02-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu New process for producing propargile-amines of pharmaceutical activity
CS269271B1 (en) * 1988-05-30 1990-04-11 Hajicek Josef Method of selegiline's hydrochloride production
HUT63579A (en) * 1991-12-20 1993-09-28 Chinoin Gyogyszer Es Vegyeszet Process for producing double-phase pharmaceutical compositions suitable for treating diseases occurring during neurodegenerative processes

Also Published As

Publication number Publication date
CA2198781A1 (en) 1996-03-21
FI971038A (fi) 1997-03-12
IL115157A0 (en) 1995-12-31
CZ287647B6 (en) 2001-01-17
US5847216A (en) 1998-12-08
DE59502606D1 (de) 1998-07-23
EP0772584A1 (de) 1997-05-14
HUT77185A (hu) 1998-03-02
WO1996008461A1 (de) 1996-03-21
ES2117445T3 (es) 1998-08-01
JPH10505602A (ja) 1998-06-02
FI971038A0 (fi) 1997-03-12
EP0772584B1 (de) 1998-06-17
HU214840B (hu) 1998-06-29
FI111713B (fi) 2003-09-15
DK0772584T3 (da) 1998-10-19
DE4432610C1 (de) 1996-02-01
CA2198781C (en) 2004-08-24
ATE167469T1 (de) 1998-07-15
AU3520895A (en) 1996-03-29
CZ77597A3 (cs) 1998-02-18
IL115157A (en) 1999-05-09

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees