ES2115543A1 - Procedimiento para la obtencion de carbetocina y sus sales de adicion de acido farmaceuticamente aceptables o complejos de la misma. - Google Patents
Procedimiento para la obtencion de carbetocina y sus sales de adicion de acido farmaceuticamente aceptables o complejos de la misma.Info
- Publication number
- ES2115543A1 ES2115543A1 ES09601755A ES9601755A ES2115543A1 ES 2115543 A1 ES2115543 A1 ES 2115543A1 ES 09601755 A ES09601755 A ES 09601755A ES 9601755 A ES9601755 A ES 9601755A ES 2115543 A1 ES2115543 A1 ES 2115543A1
- Authority
- ES
- Spain
- Prior art keywords
- carbetocin
- complexes
- obtaining
- pharmaceutically acceptable
- addition salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE CARBETOCINA Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES O COMPLEJOS DE LA MISMA. CONSISTE EN UN PROCEDIMIENTO SIMPLE DE SINTESIS EN FASE SOLIDA QUE CONSTA DE: 1) CONSTRUCCION DE LA ESTRUCTURA LINEAL CON LA INCORPORACION DEL ACIDO 4-CLOROBUTIRICO EN EL EXTREMO AMINO TERMINAL. 2) DESPROTECCION DEL GRUPO TIOL DE LA CISTEINA Y SIMULTANEA ROTURA DEL ENLACE PEPTIDO RESINA. 3) CICLACION INTRAMOLECULAR EN MEDIO BASICO POR ATAQUE NUCLEOFILO DEL GRUPO S- SOBRE EL GRUPO CL PARA FORMAR EL ENLACE TIOETER.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9601755A ES2115543B1 (es) | 1996-08-06 | 1996-08-06 | Procedimiento para la obtencion de carbetocina y sus sales de adicion de acido farmaceuticamente aceptables o complejos de la misma. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9601755A ES2115543B1 (es) | 1996-08-06 | 1996-08-06 | Procedimiento para la obtencion de carbetocina y sus sales de adicion de acido farmaceuticamente aceptables o complejos de la misma. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2115543A1 true ES2115543A1 (es) | 1998-06-16 |
ES2115543B1 ES2115543B1 (es) | 1999-02-16 |
Family
ID=8295767
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9601755A Expired - Fee Related ES2115543B1 (es) | 1996-08-06 | 1996-08-06 | Procedimiento para la obtencion de carbetocina y sus sales de adicion de acido farmaceuticamente aceptables o complejos de la misma. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2115543B1 (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103833831A (zh) * | 2013-10-22 | 2014-06-04 | 海南双成药业股份有限公司 | 一种卡贝缩宫素的制备方法 |
CN112142825A (zh) * | 2020-10-13 | 2020-12-29 | 山东辰龙药业有限公司 | 片段方式合成卡贝缩宫素的方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103467573B (zh) * | 2013-09-02 | 2017-12-15 | 深圳翰宇药业股份有限公司 | 一种卡贝缩宫素的制备方法 |
CN103992390A (zh) * | 2013-09-10 | 2014-08-20 | 杭州诺泰制药技术有限公司 | 一种合成卡贝缩宫素的方法 |
CN104592362A (zh) * | 2015-01-05 | 2015-05-06 | 苏州天马医药集团天吉生物制药有限公司 | 卡贝缩宫素的合成工艺 |
CN112094324B (zh) * | 2020-09-21 | 2022-05-03 | 宁波三生生物科技股份有限公司 | 一种卡贝缩宫素的合成方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS270051B1 (cs) * | 1988-06-03 | 1990-06-13 | Lebl Michal | Analogy oxytocinu |
WO1992018144A1 (en) * | 1991-04-12 | 1992-10-29 | Michal Lebl | Substituted benzhydrylamines as handles for solid phase peptide synthesis |
ES2055665A1 (es) * | 1993-02-03 | 1994-08-16 | Lipotec Sa | Procedimiento para la obtencion de carbocalcitonina. |
-
1996
- 1996-08-06 ES ES9601755A patent/ES2115543B1/es not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS270051B1 (cs) * | 1988-06-03 | 1990-06-13 | Lebl Michal | Analogy oxytocinu |
WO1992018144A1 (en) * | 1991-04-12 | 1992-10-29 | Michal Lebl | Substituted benzhydrylamines as handles for solid phase peptide synthesis |
ES2055665A1 (es) * | 1993-02-03 | 1994-08-16 | Lipotec Sa | Procedimiento para la obtencion de carbocalcitonina. |
Non-Patent Citations (1)
Title |
---|
BASE DE DATOS CA en STN, Chemical Abstracts, Columbus, Ohio, USA. Vol. 116, resumen n‘ 106809 & CS 270051 B1 (LEBL MICHAL) 27.02.91 * Resumen * * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103833831A (zh) * | 2013-10-22 | 2014-06-04 | 海南双成药业股份有限公司 | 一种卡贝缩宫素的制备方法 |
CN112142825A (zh) * | 2020-10-13 | 2020-12-29 | 山东辰龙药业有限公司 | 片段方式合成卡贝缩宫素的方法 |
Also Published As
Publication number | Publication date |
---|---|
ES2115543B1 (es) | 1999-02-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19980616 Kind code of ref document: A1 Effective date: 19980616 |
|
PC2A | Transfer of patent |
Owner name: BCN PEPTIDES, S.A. Effective date: 20120905 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20161125 |