ES2055665A1 - Procedimiento para la obtencion de carbocalcitonina. - Google Patents

Procedimiento para la obtencion de carbocalcitonina.

Info

Publication number
ES2055665A1
ES2055665A1 ES09300197A ES9300197A ES2055665A1 ES 2055665 A1 ES2055665 A1 ES 2055665A1 ES 09300197 A ES09300197 A ES 09300197A ES 9300197 A ES9300197 A ES 9300197A ES 2055665 A1 ES2055665 A1 ES 2055665A1
Authority
ES
Spain
Prior art keywords
carbocalcitonin
fragment
procedure
obtaining
resin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09300197A
Other languages
English (en)
Other versions
ES2055665B1 (es
Inventor
Poblet Marcos Canas
Obiols Berta Ponsati
Farres Gemma Jodas
Martinez David Andreu
Hay Mas No
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BCN Peptides SA
Original Assignee
Lipotec SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipotec SA filed Critical Lipotec SA
Priority to ES09300197A priority Critical patent/ES2055665B1/es
Priority to DE69428006T priority patent/DE69428006T2/de
Priority to EP94500007A priority patent/EP0618219B1/en
Priority to JP6011104A priority patent/JPH072744A/ja
Priority to US08/193,755 priority patent/US5739272A/en
Publication of ES2055665A1 publication Critical patent/ES2055665A1/es
Application granted granted Critical
Publication of ES2055665B1 publication Critical patent/ES2055665B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/062—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha- or omega-carboxy functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE CARBOCALCITONINA. COMPRENDE CONDENSAR EL FRAGMENTO (1), DOCOSAPEPTIDO CORRESPONDIENTE AL EXTREMO CARBOXAMIDA DE LA SECUENCIA DE LA CARBOCALCITONINA CONVENIENTEMENTE PROTEGIDO Y ANCLADO SOBRE RESINA, CON EL FRAGMENTO (2 O 3), MONAPEPTIDO CORRESPONDIENTE AL EXTREMO AMINO DE LA SECUENCIA DE LA CARBOCALCITONINA DE SALMON, CON EL CICLO ENTRE LOS RESIDUOS ASUBS9 SC Y SERBS1 SC YA FORMADO; Y TRATAR EL ESQUELETO PEPTIDICO COMPLETO (FRAGMENTO 6 O 7) CON UN ACIDO PARA LIBERAR EL PEPTIDO DE LA RESINA TOTALMENTE DESPROTEGIDO.
ES09300197A 1993-02-03 1993-02-03 Procedimiento para la obtencion de carbocalcitonina. Expired - Fee Related ES2055665B1 (es)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES09300197A ES2055665B1 (es) 1993-02-03 1993-02-03 Procedimiento para la obtencion de carbocalcitonina.
DE69428006T DE69428006T2 (de) 1993-02-03 1994-01-24 Verfahren zur Gewinnung von Carbocalcitonin
EP94500007A EP0618219B1 (en) 1993-02-03 1994-01-24 Procedure for obtaining carbocalcitonin
JP6011104A JPH072744A (ja) 1993-02-03 1994-02-02 カルボカルシトニンの獲得方法
US08/193,755 US5739272A (en) 1993-02-03 1994-02-03 Procedure for obtaining carbocalcitonin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09300197A ES2055665B1 (es) 1993-02-03 1993-02-03 Procedimiento para la obtencion de carbocalcitonina.

Publications (2)

Publication Number Publication Date
ES2055665A1 true ES2055665A1 (es) 1994-08-16
ES2055665B1 ES2055665B1 (es) 1995-03-01

Family

ID=8280659

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09300197A Expired - Fee Related ES2055665B1 (es) 1993-02-03 1993-02-03 Procedimiento para la obtencion de carbocalcitonina.

Country Status (5)

Country Link
US (1) US5739272A (es)
EP (1) EP0618219B1 (es)
JP (1) JPH072744A (es)
DE (1) DE69428006T2 (es)
ES (1) ES2055665B1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2115543A1 (es) * 1996-08-06 1998-06-16 Lipotec Sa Procedimiento para la obtencion de carbetocina y sus sales de adicion de acido farmaceuticamente aceptables o complejos de la misma.

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996024617A1 (de) * 1995-02-06 1996-08-15 Lonza Ag Desaminononapeptide, verfahren zu deren herstellung sowie deren verwendung zur herstellung von elcatonin
US5962270A (en) * 1996-02-06 1999-10-05 Bionebraska, Inc. Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs
CN112062829B (zh) * 2020-08-19 2023-02-28 杭州固拓生物科技有限公司 依降钙素的制备方法
CN113512105B (zh) * 2021-04-08 2022-10-04 润辉生物技术（威海）有限公司 一种依降钙素的制备方法
CN113121673B (zh) * 2021-04-08 2022-03-29 润辉生物技术（威海）有限公司 一种固液结合法制备依降钙素的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4632978A (en) * 1985-10-15 1986-12-30 Armour Pharmaceutical Corp. 6-serine, des-19-leucine calcitonin
EP0232650A1 (fr) * 1985-12-24 1987-08-19 MILHAUD, Gérard Nouveaux analogues de composés polypeptidiques hypocalcémiants épargnant le calcium de l'organisme, leur préparation, leur applicaton à titre de médicaments et les compositions les renfermant
EP0287997A2 (en) * 1987-04-21 1988-10-26 RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) Des-19-leucine, 20-glutamine, 21-threonine-calcitonin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51128993A (en) * 1975-05-01 1976-11-10 Tanpakushitsu Kenkyu Shiyoureikai Process for preparing new polypeptides
US4804742A (en) * 1985-06-06 1989-02-14 Rorer Pharmaceutical Corporation Amide analogs of calcitonin
US4908475A (en) * 1986-01-16 1990-03-13 Smithkline Beckman Corporation Intermediates for preparing 1,6-dicarba-vasopressin compounds
JPH0678356B2 (ja) * 1986-12-04 1994-10-05 旭化成工業株式会社 カルシトニン遺伝子関連ペプチド誘導体
CA2030795C (en) * 1989-04-21 1999-11-30 Ronald C. Orlowski Novel physiologically active peptide and calcium metabolism-regulating agent comprising said peptide as effective ingredient
FR2675804B1 (fr) * 1991-04-25 1995-04-07 Propeptide Sa Procede de synthese de peptides, nouveaux derives d'acides amines mis en óoeuvre dans ce procede et leurs procedes de preparation.
EP0518295A3 (en) * 1991-06-14 1993-09-01 Millipore Corporation Allyl side chain protection in peptide synthesis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4632978A (en) * 1985-10-15 1986-12-30 Armour Pharmaceutical Corp. 6-serine, des-19-leucine calcitonin
EP0232650A1 (fr) * 1985-12-24 1987-08-19 MILHAUD, Gérard Nouveaux analogues de composés polypeptidiques hypocalcémiants épargnant le calcium de l'organisme, leur préparation, leur applicaton à titre de médicaments et les compositions les renfermant
EP0287997A2 (en) * 1987-04-21 1988-10-26 RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) Des-19-leucine, 20-glutamine, 21-threonine-calcitonin

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2115543A1 (es) * 1996-08-06 1998-06-16 Lipotec Sa Procedimiento para la obtencion de carbetocina y sus sales de adicion de acido farmaceuticamente aceptables o complejos de la misma.

Also Published As

Publication number Publication date
DE69428006T2 (de) 2002-04-18
ES2055665B1 (es) 1995-03-01
EP0618219B1 (en) 2001-08-22
DE69428006D1 (de) 2001-09-27
US5739272A (en) 1998-04-14
EP0618219A1 (en) 1994-10-05
JPH072744A (ja) 1995-01-06

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Legal Events

Date Code Title Description
PC2A Transfer of patent

Owner name: BCN PEPTIDES, S.A.

Effective date: 20120905

FD2A Announcement of lapse in spain

Effective date: 20141120