ES2112988T3 - Formulaciones de aerosol que contienen dipropionato de beclometasona sin agentes tensioactivos. - Google Patents

Formulaciones de aerosol que contienen dipropionato de beclometasona sin agentes tensioactivos.

Info

Publication number
ES2112988T3
ES2112988T3 ES93917708T ES93917708T ES2112988T3 ES 2112988 T3 ES2112988 T3 ES 2112988T3 ES 93917708 T ES93917708 T ES 93917708T ES 93917708 T ES93917708 T ES 93917708T ES 2112988 T3 ES2112988 T3 ES 2112988T3
Authority
ES
Spain
Prior art keywords
aerosol formulations
formulations containing
beclometasone dipropionate
surface agents
containing beclometasone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93917708T
Other languages
English (en)
Inventor
Anthony James Taylor
Philip John Neale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929216381A external-priority patent/GB9216381D0/en
Priority claimed from GB929216382A external-priority patent/GB9216382D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ES2112988T3 publication Critical patent/ES2112988T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

ESTA INVENCION SE REFIERE A NUEVAS FORMULACIONES DE AEROSOLES PARA ADMINISTRAR FARMACOS, EN PARTICULAR PARA LA ADMINISTRACION DE UN ESTER DE BECLOMETASONA MEDIANTE INHALACION. EN PARTICULAR, LA INVENCION PROPORCIONA NUEVAS FORMULACIONES DE AEROSOLES, CONSTITUIDAS ESENCIALMENTE DE (A) DIPROPIONATO DE BECLOMETASONA, EN FORMA DE UN SOLVATO, CON 1''1''1''2 - TETRAFLUOROETANO (CF3CH2F), Y UNO O MAS FLUOROCARBUROS, O VEHICULOS DE CLOROFLUOROCARBURO CONTENIENDO HIDROGENO, O (B) DIPROPIONATO DE BECLOMETASONA ANHIDRO, Y 1''1''1''2''3''3''3'' - HEPTAFLURO - N - PROPANO COMO VEHICULO.
ES93917708T 1992-07-31 1993-07-30 Formulaciones de aerosol que contienen dipropionato de beclometasona sin agentes tensioactivos. Expired - Lifetime ES2112988T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929216381A GB9216381D0 (en) 1992-07-31 1992-07-31 Medicaments
GB929216382A GB9216382D0 (en) 1992-07-31 1992-07-31 Medicaments

Publications (1)

Publication Number Publication Date
ES2112988T3 true ES2112988T3 (es) 1998-04-16

Family

ID=26301356

Family Applications (2)

Application Number Title Priority Date Filing Date
ES97101101T Expired - Lifetime ES2206619T3 (es) 1992-07-31 1993-07-30 Formulaciones de aerosol sin tensioactivos que contienen dipropianato de beclometasona.
ES93917708T Expired - Lifetime ES2112988T3 (es) 1992-07-31 1993-07-30 Formulaciones de aerosol que contienen dipropionato de beclometasona sin agentes tensioactivos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES97101101T Expired - Lifetime ES2206619T3 (es) 1992-07-31 1993-07-30 Formulaciones de aerosol sin tensioactivos que contienen dipropianato de beclometasona.

Country Status (11)

Country Link
EP (2) EP0658101B1 (es)
JP (1) JPH07509475A (es)
CN (1) CN1052401C (es)
AT (2) ATE162709T1 (es)
AU (1) AU670616B2 (es)
DE (2) DE69333187T2 (es)
DK (1) DK0658101T3 (es)
ES (2) ES2206619T3 (es)
GR (1) GR3026185T3 (es)
MX (1) MX9304585A (es)
WO (1) WO1994003153A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
WO1994021386A2 (en) * 1993-03-25 1994-09-29 Research Corporation Technologies, Inc. Polymers useful in forming self-assembled bonded anisotropic ultrathin layers and their use
US5508023A (en) * 1994-04-11 1996-04-16 The Center For Innovative Technology Pharmaceutically acceptable agents for solubilizing, wetting, emulsifying, or lubricating in metered dose inhaler formulations which use HFC-227 propellant
GB9425160D0 (en) * 1994-12-10 1995-02-08 Glaxo Group Ltd Medicaments
US5747001A (en) * 1995-02-24 1998-05-05 Nanosystems, L.L.C. Aerosols containing beclomethazone nanoparticle dispersions
NZ306281A (en) * 1995-04-14 1999-07-29 Glaxo Wellcome Inc Metered dose inhaler with part or all internal surfaces coated with fluorocarbon polymers for dispensing beclomethasone dipropionate
BR9604976A (pt) * 1995-04-14 1998-06-09 Glaxo Wellcome Inc Inalador de dose medida sistema inalador de dose medida e uso do mesmo
GB9616237D0 (en) 1996-08-01 1996-09-11 Norton Healthcare Ltd Aerosol formulations
US6068832A (en) * 1996-08-29 2000-05-30 Schering Corporation Chlorofluorocarbon-free mometasone furoate aerosol formulations
BR9810409A (pt) * 1997-03-18 2000-08-22 Basf Ag Métodos e composições para a modulação de responsividade a corticosteróides
US6054487A (en) * 1997-03-18 2000-04-25 Basf Aktiengesellschaft Methods and compositions for modulating responsiveness to corticosteroids
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6086376A (en) * 1998-01-30 2000-07-11 Rtp Pharma Inc. Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant
US20060171899A1 (en) * 1998-12-10 2006-08-03 Akwete Adjei Water-stabilized aerosol formulation system and method of making
EP1169019B1 (en) 1999-04-14 2003-02-26 Glaxo Group Limited Pharmaceutical aerosol formulation
US6540982B1 (en) * 2000-01-25 2003-04-01 Aeropharm Technology Incorporated Medical aerosol formulation
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US7442388B2 (en) 2000-05-10 2008-10-28 Weers Jeffry G Phospholipid-based powders for drug delivery
AU2002234476B2 (en) * 2001-03-30 2006-04-27 Jagotec Ag Medical aerosol formulations
US6455028B1 (en) 2001-04-23 2002-09-24 Pharmascience Ipratropium formulation for pulmonary inhalation
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
CA2468958C (en) 2001-12-19 2012-07-03 Nektar Therapeutics Pulmonary delivery of aminoglycosides
CN100369608C (zh) * 2006-03-15 2008-02-20 修涞贵 一种治疗过敏性鼻炎的混悬液型喷雾剂及制备方法
BRPI0719825A2 (pt) * 2006-10-12 2014-05-06 Koninkl Philips Electronics Nv Sistema de detecção e método para detectar pelo menos uma molécula alvo
CA2677838C (en) 2007-02-11 2017-08-01 Map Pharmaceuticals, Inc. Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
IT1121513B (it) 1979-05-28 1986-04-02 Chiesi Farma Spa Processo per la conversione di umo steroide antiinfiammatorio in una forma suscettibile di essere somministarta come aerosol
EP0039369B1 (en) * 1980-05-02 1983-06-15 Schering Corporation Beclomethasone ester solvates, process for their preparation, and preparation of a formulation
FI63672C (fi) * 1980-05-19 1983-08-10 Orion Yhtymae Oy Foerfarande foer framstaellning av en blandning av beklometasondipropionat och triklorfluormetan eller diklordifluormetan
KR880001237B1 (ko) 1984-07-25 1988-07-12 호비온 인터 리미티드 베클로메타손 17,21-디프로피오네이트의 용매화합물의 제조방법
GB8432063D0 (en) 1984-12-19 1985-01-30 Riker Laboratories Inc Physically modified steroids
GB8828477D0 (en) * 1988-12-06 1989-01-05 Riker Laboratories Inc Medical aerosol formulations
DE69131867T2 (de) 1990-03-23 2000-05-18 Minnesota Mining & Mfg Anwendung von löslichen fluorhaltigen Tensiden zur Herstellung von Aerosol-Präparaten mit dosierter Abgabe
EP0536235B1 (en) * 1990-06-29 1997-01-22 FISONS plc Pressurised aerosol compositions
DK0553298T3 (da) * 1990-10-18 1995-04-18 Minnesota Mining & Mfg Aerosolformulering omfattende beclomethason-17,21-dipropionat
PT656207E (pt) * 1991-06-10 2001-11-30 Schering Corp Formulacoes de aerossois sem clorofluorocarbonetos
JPH06508149A (ja) * 1991-06-10 1994-09-14 シェリング・コーポレーション クロロフルオロカーボン不含エーロゾル製剤

Also Published As

Publication number Publication date
CN1052401C (zh) 2000-05-17
DE69333187D1 (de) 2003-10-09
DE69316760T2 (de) 1998-06-04
EP0775484A1 (en) 1997-05-28
JPH07509475A (ja) 1995-10-19
AU670616B2 (en) 1996-07-25
EP0658101A1 (en) 1995-06-21
DE69316760D1 (de) 1998-03-05
DE69333187T2 (de) 2004-07-15
ES2206619T3 (es) 2004-05-16
CN1088436A (zh) 1994-06-29
EP0658101B1 (en) 1998-01-28
ATE248582T1 (de) 2003-09-15
MX9304585A (es) 1994-03-31
AU4705093A (en) 1994-03-03
GR3026185T3 (en) 1998-05-29
ATE162709T1 (de) 1998-02-15
EP0775484B1 (en) 2003-09-03
DK0658101T3 (da) 1998-09-21
WO1994003153A1 (en) 1994-02-17

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