ES2112948T3 - Inhalador de polvos. - Google Patents

Inhalador de polvos.

Info

Publication number
ES2112948T3
ES2112948T3 ES93118280T ES93118280T ES2112948T3 ES 2112948 T3 ES2112948 T3 ES 2112948T3 ES 93118280 T ES93118280 T ES 93118280T ES 93118280 T ES93118280 T ES 93118280T ES 2112948 T3 ES2112948 T3 ES 2112948T3
Authority
ES
Spain
Prior art keywords
chamber
drug
metering plate
dwell
dispersing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93118280T
Other languages
English (en)
Inventor
Heiko Dipl-Ing Herold
Axel Dr Wollenschlager
Harald Dr Dr Landen
Franz Schmitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2112948T3 publication Critical patent/ES2112948T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0013Details of inhalators; Constructional features thereof with inhalation check valves
    • A61M15/0015Details of inhalators; Constructional features thereof with inhalation check valves located upstream of the dispenser, i.e. not traversed by the product
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0083Timers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00Characteristics of a physical parameter; associated device therefor
    • A61M2206/10Flow characteristics
    • A61M2206/16Rotating swirling helical flow, e.g. by tangential inflows

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Disintegrating Or Milling (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nozzles (AREA)

Abstract

EL INHALADOR DE POLVO SE BASA EN UN RECIPIENTE DE EXISTENCIAS (3) PARA EL PRODUCTO FARMACEUTICO, EL CUAL EN SU EXTREMO INFERIOR ESTA CERRADO DEL TODO O EN PARTE POR UNA PLACA DOSIFICADORA (4) ACCIONADA A MANO, GIRATORIA O DESPLAZABLE, PARA LA RECOGIDA Y ENTREGA DE UNA CANTIDAD DE PRODUCTO FARMACEUTICO DEL RECIPIENTE (3) PREFIJADA, REPRODUCIBLE, ASI COMO DE UNA BOQUILLA (14) PARA LA INHALACION, A LA CUAL PRECEDE UNA CAMARA DE DISPERSION (12). LA PLACA DOSIFICADORA (4) ESTA PROVISTA POR LO MENOS CON UNA ENTALLA (5), LA CUAL SE LLENA CON EL PRODUCTO FARMACEUTICO CUANDO SE ACCIONA EL INHALADOR. VISTO EN DIRECCION DE LA CIRCULACION, ESTA DISPUESTO DELANTE DE LA CAMARA DE DISPERSION (12) UN CANAL DE ACELERACION QUE CUBRE PARCIALMENTE CON UNA PARTE DE SU SUPERFICIE LONGITUDINAL LA PLACA DOSIFICADORA (4), EL CUAL DESEMBOCA TANGENCIALMENTE EN UNA CAMARA CILINDRICA DE TIEMPO DE ESPERA (9). LA CAMARA DE TIEMPO DE ESPERA (9) ESTA UNIDA A SU VEZ POR MEDIO DE UNA SALIDA CENTRAL (10) CON MENOR DIAMETRO QUE LA CAMARA CILINDRICA DE TIEMPO DE ESPERA (9), CON UNA CAMARA DE DESCARGA (11) DE FORMA CIRCULAR, EN LA CUAL SE UNE TANGENCIAL LA CAMARA DE DISPERSION (12).
ES93118280T 1992-11-24 1993-11-11 Inhalador de polvos. Expired - Lifetime ES2112948T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4239402A DE4239402A1 (de) 1992-11-24 1992-11-24 Pulverinhalator

Publications (1)

Publication Number Publication Date
ES2112948T3 true ES2112948T3 (es) 1998-04-16

Family

ID=6473484

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93118280T Expired - Lifetime ES2112948T3 (es) 1992-11-24 1993-11-11 Inhalador de polvos.

Country Status (18)

Country Link
US (1) US5435301A (es)
EP (1) EP0611577B1 (es)
JP (1) JPH06197966A (es)
AT (1) ATE163549T1 (es)
AU (1) AU666979B2 (es)
CA (1) CA2103481A1 (es)
DE (2) DE4239402A1 (es)
DK (1) DK0611577T3 (es)
ES (1) ES2112948T3 (es)
FI (1) FI935167A (es)
GR (1) GR3026162T3 (es)
HU (1) HU213495B (es)
IL (1) IL107693A (es)
MX (1) MX9307267A (es)
NO (1) NO306980B1 (es)
NZ (1) NZ250241A (es)
RU (1) RU2100035C1 (es)
ZA (1) ZA938760B (es)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8810032D0 (en) * 1988-04-28 1988-06-02 Secr Defence Hot electron transistors
DE4440734A1 (de) * 1994-11-15 1996-05-23 Bayer Ag Abscheidesystem für einen Pulverinhalator
DE19522415C2 (de) * 1995-06-21 2003-12-04 Sofotec Gmbh & Co Kg Arzneimittelpulverpatrone mit integrierter Dosiereinrichtung und Pulverinhalator mit Mitteln zum Betätigen der Dosiereinrichtung der Arzneimittelpulverpatrone
ATE209518T1 (de) * 1995-06-21 2001-12-15 Asta Medica Ag Arzneipulverkartusche mit integrierter dosiereinrichtung, sowie pulverinhalator
SE9503344D0 (sv) 1995-09-27 1995-09-27 Astra Ab Inhalation device
US5669378A (en) * 1995-12-21 1997-09-23 Pera; Ivo Inhaling device
US5699789A (en) * 1996-03-11 1997-12-23 Hendricks; Mark R. Dry powder inhaler
EP0907718B1 (en) * 1996-06-14 2004-12-29 Powderject Vaccines, Inc. Sample delivery module for particle acceleration apparatus
GB9626263D0 (en) 1996-12-18 1997-02-05 Innovata Biomed Ltd Powder inhaler
CN1292714B (zh) * 1998-03-16 2012-08-01 诺瓦帝斯公司 气溶胶化活性剂的输送
ES2228070T3 (es) 1998-06-22 2005-04-01 Astrazeneca Ab Dispositivo para aspirar y vaciar cavidades que contienen polvo.
DE19831525A1 (de) * 1998-07-14 2000-01-20 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
UA73924C2 (en) * 1998-10-09 2005-10-17 Nektar Therapeutics Device for delivering active agent formulation to lungs of human patient
GB2344533B (en) * 1998-12-11 2000-10-18 Bespak Plc Improvements in or relating to dispensing apparatus
NZ515557A (en) * 1999-06-05 2003-10-31 Innovata Biomed Ltd Delivery system
US6606992B1 (en) 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
US7214687B2 (en) 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
GB9920839D0 (en) 1999-09-04 1999-11-10 Innovata Biomed Ltd Inhaler
DE19956260A1 (de) * 1999-11-23 2001-05-31 Inamed Gmbh Abscheidevorrichtung, insbesondere für Trockenpulvermedikamente in Aerosolform
DE60020597D1 (de) * 1999-12-07 2005-07-07 Orion Corp Mehrfachpulverinhalator
FR2811576B1 (fr) * 2000-07-13 2003-01-24 Henri Bocquee Disposits ou appareils d'administration de produits actifs pulverurents du type medicaments ou vaccins, par voie pulmonaire
DE60221640T2 (de) * 2001-02-06 2008-05-21 Innovata Biomed Ltd., St. Albans Bimodale trockenpulverzusammensetzung zur inhalation
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
DE10129703A1 (de) * 2001-06-22 2003-01-02 Sofotec Gmbh & Co Kg Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren
GB0128148D0 (en) * 2001-11-23 2002-01-16 Innovata Biomed Ltd Assembly
DE10202940A1 (de) 2002-01-24 2003-07-31 Sofotec Gmbh & Co Kg Patrone für einen Pulverinhalator
US7258118B2 (en) * 2002-01-24 2007-08-21 Sofotec Gmbh & Co, Kg Pharmaceutical powder cartridge, and inhaler equipped with same
US7185651B2 (en) * 2002-06-18 2007-03-06 Nektar Therapeutics Flow regulator for aerosol drug delivery and methods
DE10244795A1 (de) * 2002-09-26 2004-04-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator
EP1488819A1 (en) * 2003-06-16 2004-12-22 Rijksuniversiteit te Groningen Dry powder inhaler and method for pulmonary inhalation of dry powder
US20050026948A1 (en) * 2003-07-29 2005-02-03 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a betamimetic
GB0320171D0 (en) 2003-08-28 2003-10-01 Optinose As Delivery devices
CA2562386C (en) * 2004-04-21 2014-11-18 Innovata Biomed Limited Inhaler
GB0409197D0 (en) 2004-04-24 2004-05-26 Innovata Biomed Ltd Device
PL1891974T3 (pl) 2004-05-31 2010-12-31 Almirall Sa Kombinacje zawierające środki przeciwmuskarynowe i inhibitory PDE4
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
CA2572790C (en) 2004-07-16 2014-12-23 Laboratorios Almirall, S.A. Inhaler for the administration of powdered pharmaceuticals, and a powder cartridge system for use with this inhaler
DE102004041524B4 (de) * 2004-08-27 2013-03-21 Sanofi Sa Inhalator für pulverförmige, insbesondere medizinische Substanzen
ES2265276B1 (es) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
US20070221211A1 (en) * 2006-03-27 2007-09-27 Boris Sagalovich Apparatus and process for inhaling medicines
GB0611659D0 (en) * 2006-06-13 2006-07-19 Cambridge Consultants Dry powder inhalers
ES2298049B1 (es) * 2006-07-21 2009-10-20 Laboratorios Almirall S.A. Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
US8567394B2 (en) * 2006-12-22 2013-10-29 Almirall, S.A. Inhalation device for drugs in powder form
ES2306595B1 (es) 2007-02-09 2009-09-11 Laboratorios Almirall S.A. Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2.
ES2320955B1 (es) 2007-03-02 2010-03-16 Laboratorios Almirall S.A. Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
CA2608561A1 (en) * 2007-10-29 2009-04-29 Carl Paluszkiewicz Motorcycle wind deflector accessory support
ES2320961B1 (es) 2007-11-28 2010-03-17 Laboratorios Almirall, S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor adrenergico beta2.
EP2230934B8 (en) 2007-12-14 2012-10-24 AeroDesigns, Inc Delivering aerosolizable food products
EP2096105A1 (en) * 2008-02-28 2009-09-02 Laboratorios Almirall, S.A. Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2108641A1 (en) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
EP2113503A1 (en) 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
EP2196465A1 (en) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
UY32297A (es) 2008-12-22 2010-05-31 Almirall Sa Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico
EP2221297A1 (en) 2009-02-18 2010-08-25 Almirall, S.A. 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one and its use in the treatment of pulmonary diseases
EP2221055A1 (en) 2009-02-18 2010-08-25 Almirall, S.A. 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one for the treatment of lung function
EP2226323A1 (en) 2009-02-27 2010-09-08 Almirall, S.A. New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives
EP2228368A1 (en) 2009-03-12 2010-09-15 Almirall, S.A. Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
EP2322176A1 (en) 2009-11-11 2011-05-18 Almirall, S.A. New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives
EP2380890A1 (en) 2010-04-23 2011-10-26 Almirall, S.A. New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
EP2394998A1 (en) 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
EP2441755A1 (en) 2010-09-30 2012-04-18 Almirall, S.A. Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
EP2463289A1 (en) 2010-11-26 2012-06-13 Almirall, S.A. Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors
EP2489663A1 (en) 2011-02-16 2012-08-22 Almirall, S.A. Compounds as syk kinase inhibitors
CN103917265B (zh) 2011-03-03 2017-02-15 英倍尔药业股份有限公司 鼻药递送装置
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
EP2518071A1 (en) 2011-04-29 2012-10-31 Almirall, S.A. Imidazopyridine derivatives as PI3K inhibitors
EP2518070A1 (en) 2011-04-29 2012-10-31 Almirall, S.A. Pyrrolotriazinone derivatives as PI3K inhibitors
EP2526945A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. New CRTH2 Antagonists
EP2527344A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases
EP2548876A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists
EP2548863A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists.
EP2554544A1 (en) 2011-08-01 2013-02-06 Almirall, S.A. Pyridin-2(1h)-one derivatives as jak inhibitors
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2592077A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
EP2647627A1 (en) 2012-04-02 2013-10-09 Almirall, S.A. Salts of 5-[(1r)-2-({2-[4-(2,2-difluoro-2-phenylethoxy)phenyl] ethyl}amino)-1-hydroxyethyl]-8-hydroxyquinolin-2(1h)-one.
EP2666465A1 (en) 2012-05-25 2013-11-27 Almirall, S.A. Novel dosage and formulation
EP2668941A1 (en) 2012-05-31 2013-12-04 Almirall, S.A. Novel dosage form and formulation of abediterol
WO2014060431A1 (en) 2012-10-16 2014-04-24 Almirall, S.A. Pyrrolotriazinone derivatives as pi3k inhibitors
EP2738172A1 (en) 2012-11-28 2014-06-04 Almirall, S.A. New bicyclic compounds as crac channel modulators
US9518050B2 (en) 2012-12-18 2016-12-13 Almirall, S.A. Cyclohexyl and quinuclidinyl carbamate derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activity
TW201446767A (zh) 2013-02-15 2014-12-16 Almirall Sa 作為磷脂肌醇3-激酶抑製劑之吡咯並三嗪衍生物
EP2848615A1 (en) 2013-07-03 2015-03-18 Almirall, S.A. New pyrazole derivatives as CRAC channel modulators
WO2015091287A1 (en) 2013-12-19 2015-06-25 Almirall S.A. Dosage formulation comprising salmeterol and fluticasone propionate
WO2016170009A1 (en) 2015-04-21 2016-10-27 Almirall, S.A. Amino-substituted heterocyclic derivatives as sodium channel inhibitors
WO2016202800A1 (en) 2015-06-16 2016-12-22 Almirall, S.A. Pyrrolotriazinone derivatives as pi3k inhibitors
WO2017076990A1 (en) 2015-11-05 2017-05-11 Almirall, S.A. Addition salts of n-[4-(4-{[(1s)-1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-5-yl)-1h-indol-6-yl]sulfamide
TW201919682A (zh) 2017-08-08 2019-06-01 西班牙商阿爾米雷爾有限公司 活化Nrf2路徑的新穎化合物
WO2023044132A2 (en) * 2021-09-17 2023-03-23 Shawn Walker Use of chitosan complexes or compositions to reduce infiltration of environmental factors into the brain

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2587215A (en) * 1949-04-27 1952-02-26 Frank P Priestly Inhalator
GB1122284A (en) * 1965-03-19 1968-08-07 Fisons Pharmaceuticals Ltd Inhalation device
IT941426B (it) * 1971-07-17 1973-03-01 Isf Spa Inalatore a camera di turbinio per sostanze medicamentose polveriformi
US3948264A (en) * 1975-05-21 1976-04-06 Mead Johnson & Company Inhalation device
GB1521000A (en) * 1975-06-13 1978-08-09 Syntex Puerto Rico Inc Inhalation device
DE2716323C2 (de) * 1977-04-07 1986-03-13 Schering AG, 1000 Berlin und 4709 Bergkamen Vorrichtung zur Inhalation von Arzneimitteln
SU848035A1 (ru) * 1979-10-08 1981-07-23 Предприятие П/Я В-2572 Устройство дл введени лекарственныхпОРОшКОВ
CY1492A (en) * 1981-07-08 1990-02-16 Draco Ab Powder inhalator
US4570630A (en) * 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
DE3345722A1 (de) * 1983-12-17 1985-06-27 Boehringer Ingelheim KG, 6507 Ingelheim Inhalator
FI69963C (fi) * 1984-10-04 1986-09-12 Orion Yhtymae Oy Doseringsanordning
SE448277B (sv) * 1985-04-12 1987-02-09 Draco Ab Indikeringsanordning vid en doseringsanordning for lekemedel
SE453566B (sv) * 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
DK479189D0 (da) * 1989-01-06 1989-09-28 Hans Gernot Schenk Inhalator
US5176132A (en) * 1989-05-31 1993-01-05 Fisons Plc Medicament inhalation device and formulation
DE69012458T3 (de) * 1989-05-31 2000-01-20 Fisons Plc Medikament und Inhalationsvorrichtung dafür.
DE3927170A1 (de) * 1989-08-17 1991-02-21 Boehringer Ingelheim Kg Inhalator
US5113855A (en) * 1990-02-14 1992-05-19 Newhouse Michael T Powder inhaler
DE4004904A1 (de) * 1990-02-16 1990-09-13 Gerhard Brendel Trommel-applikator
GB9015522D0 (en) * 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
GB9025705D0 (en) * 1990-11-27 1991-01-09 Britains Petite Ltd Powder inhaler
GB9026025D0 (en) * 1990-11-29 1991-01-16 Boehringer Ingelheim Kg Inhalation device
DE69122388T2 (de) * 1991-04-15 1997-03-27 Leiras Oy Vorrichtung zum dosieren eines pulverförmigen medikaments für die inhalation

Also Published As

Publication number Publication date
DK0611577T3 (da) 1998-11-23
AU5056393A (en) 1994-06-09
EP0611577A1 (de) 1994-08-24
IL107693A0 (en) 1994-02-27
ZA938760B (en) 1994-06-30
GR3026162T3 (en) 1998-05-29
EP0611577B1 (de) 1998-03-04
JPH06197966A (ja) 1994-07-19
HUT67279A (en) 1995-03-28
DE59308218D1 (de) 1998-04-09
NZ250241A (en) 1995-10-26
AU666979B2 (en) 1996-02-29
FI935167A0 (fi) 1993-11-22
NO934069D0 (no) 1993-11-10
MX9307267A (es) 1994-07-29
US5435301A (en) 1995-07-25
NO306980B1 (no) 2000-01-24
HU9303321D0 (en) 1994-03-28
DE4239402A1 (de) 1994-05-26
RU2100035C1 (ru) 1997-12-27
ATE163549T1 (de) 1998-03-15
IL107693A (en) 1997-07-13
CA2103481A1 (en) 1994-05-25
FI935167A (fi) 1994-05-25
NO934069L (no) 1994-05-25
HU213495B (en) 1997-07-28

Similar Documents

Publication Publication Date Title
ES2112948T3 (es) Inhalador de polvos.
US5429122A (en) Inhaler devices provided with a reservoir for several doses of medium for inhaling, transporting device, whirl chamber
US5320714A (en) Powder inhalator
AU722098B2 (en) Device for dispensing liquids
CA2159622A1 (en) Inhalation device
TW333459B (en) Powdered medication inhaler
TW350795B (en) Powder atomizer
GB1502150A (en) Devices for the administration by inhalation or insufflation of powdered substances contained in a capsule
ES2154272T3 (es) Nebulizador de baja velocidad de flujo.
JPH06502784A (ja) 吸入装置
CA2225396A1 (en) Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments
RU93043618A (ru) Ингалятор без нагнетательного газа
KR940701282A (ko) 에어로졸화된 약제를 전달하는 방법 및 장치
AU7432491A (en) Device for the administration of powdered medicinal substances
CA2179202A1 (en) Powder inhalator
RU94042242A (ru) Устройство для ингаляции порошкового лекарства
NZ334047A (en) Device comprising a reservoir which achieves a tumbling effect on rotation at the inflow path leading to a metering chamber
AU6415298A (en) Inhalation device
US3698390A (en) Dispensing for medicaments
AU4122500A (en) Powder inhaler
GB9416486D0 (en) Inhaler apparatus with optimisation chamber
UA50712C2 (uk) Пристрій для дозованого видавання разових доз матеріалу із макрочастинок і змінний патрон для інгалятора
RU2150965C1 (ru) Ингалятор
CA2197758A1 (en) Inhaler apparatus with optimisation chamber

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 611577

Country of ref document: ES