ES2107237T3 - Procedimiento para la preparacion de un acido oxazolidina-carboxilico util para preparar taxoides terapeuticamente activos. - Google Patents

Procedimiento para la preparacion de un acido oxazolidina-carboxilico util para preparar taxoides terapeuticamente activos.

Info

Publication number
ES2107237T3
ES2107237T3 ES94919710T ES94919710T ES2107237T3 ES 2107237 T3 ES2107237 T3 ES 2107237T3 ES 94919710 T ES94919710 T ES 94919710T ES 94919710 T ES94919710 T ES 94919710T ES 2107237 T3 ES2107237 T3 ES 2107237T3
Authority
ES
Spain
Prior art keywords
oxazolidine
procedure
useful
preparation
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94919710T
Other languages
English (en)
Inventor
Jean-Dominique Bourzat
Alain Commercon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2107237T3 publication Critical patent/ES2107237T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Abstract

PROCESO DE PREPARACION, A PARTIR DE UN ACIDO OXAZOLIDINOCARBOXILICO DE FORMULA GENERAL (II), DE UN ACIDO OXAZOLIDINOCARBOXILICO DE FORMULA GENERAL (I) UTILIZABLE PARA PREPARAR TAXOIDES TERAPEUTICAMENTE ACTIVOS DE FORMULA GENERAL (II). EN LA FORMULAS (I), (I) Y (III), R REPRESENTA UN ATOMO DE HIDROGENO O UN RADICAL ACETILO; R{SUB,1} REPRESENTA UN RADICAL ALCOILO EVENTUALMENTE SUSTITUIDO, ALCENILO, CICLOALCOILO, CICLOALCENILO, BICICLOALCOILO, FENILO, O HETEROCICLILO; R{SUB,3} Y R{SUB,4} IDENTICOS O DIFERENTES REPRESENTAN HIDROGENO, ALCOILO, ALCOXI, ARILO EVENTUALMENTE SUSTITUIDO, ARALCOILO EVENTUALENTE SUSTITUIDO O FORMAN JUNTOS UN CICLO DE 4 A 7 ESLABONES, R{SUB,5} REPRESENTA ALCENILO, ALCINILO FENILO, FORMILO, ALCANOILO, AROILO, HIDROXI-METILO, CARBOXI O ALCOILXICARBONILO Y R'' REPRESENTA UN ATOMO DE HIDROGENO O UN ATOMO DE METAL ALCALINO O ALCALINOTERROSO O UN RADICAL ALCOILO QUE CONTIENE 1 A 4 ATOMO DE CARBONO EVENTUALMENTE SUSTITUIDO POR UN RADICAL FENILO.
ES94919710T 1993-06-16 1994-06-15 Procedimiento para la preparacion de un acido oxazolidina-carboxilico util para preparar taxoides terapeuticamente activos. Expired - Lifetime ES2107237T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9307240A FR2706457B1 (fr) 1993-06-16 1993-06-16 Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.

Publications (1)

Publication Number Publication Date
ES2107237T3 true ES2107237T3 (es) 1997-11-16

Family

ID=9448182

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94919710T Expired - Lifetime ES2107237T3 (es) 1993-06-16 1994-06-15 Procedimiento para la preparacion de un acido oxazolidina-carboxilico util para preparar taxoides terapeuticamente activos.

Country Status (23)

Country Link
US (2) US6444825B1 (es)
EP (1) EP0703907B1 (es)
JP (1) JPH09500370A (es)
KR (1) KR960703118A (es)
AT (1) ATE156819T1 (es)
AU (1) AU678585B2 (es)
CA (1) CA2165328A1 (es)
CZ (1) CZ284051B6 (es)
DE (1) DE69404991T2 (es)
DK (1) DK0703907T3 (es)
ES (1) ES2107237T3 (es)
FI (1) FI956025A0 (es)
FR (1) FR2706457B1 (es)
GR (1) GR3024534T3 (es)
HU (1) HUT73972A (es)
NO (1) NO955112L (es)
NZ (1) NZ268037A (es)
PL (1) PL312212A1 (es)
RU (1) RU2128652C1 (es)
SK (1) SK156995A3 (es)
WO (1) WO1994029284A1 (es)
YU (1) YU37594A (es)
ZA (1) ZA943994B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
CA2170661A1 (en) * 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
AU708545B2 (en) 1996-05-08 1999-08-05 Pharmacia & Upjohn Company Process to prepare taxol
KR100225535B1 (ko) * 1996-08-27 1999-10-15 정지석 파클리탁셀의 제조방법
MXPA03002494A (es) * 2000-09-22 2004-05-24 Bristol Myers Squibb Co Metodo para reducir toxicidad de quimio terapias combinadas.
US8338617B2 (en) * 2004-11-19 2012-12-25 Dr. Reddy's Laboratories Limited Process for preparing oxazolidine derivatives
PL1871753T3 (pl) 2005-03-31 2012-12-31 Accord Healthcare Inc Wytwarzanie taksanów z 9-dihydro-13-acetylobakatyny iii

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4240987A (en) * 1979-10-29 1980-12-23 Xerox Corporation Chemical process
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2696458B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696459B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2698361B1 (fr) * 1992-11-20 1995-01-13 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5.
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2702212B1 (fr) * 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
US6043375A (en) 2000-03-28
JPH09500370A (ja) 1997-01-14
NO955112D0 (no) 1995-12-15
ZA943994B (en) 1995-02-03
DE69404991D1 (de) 1997-09-18
SK156995A3 (en) 1996-06-05
YU37594A (sh) 1997-03-07
DK0703907T3 (da) 1998-03-23
FR2706457B1 (fr) 1995-07-28
HU9503611D0 (en) 1996-02-28
PL312212A1 (en) 1996-04-01
DE69404991T2 (de) 1998-01-22
KR960703118A (ko) 1996-06-19
NO955112L (no) 1995-12-15
RU2128652C1 (ru) 1999-04-10
WO1994029284A1 (fr) 1994-12-22
AU678585B2 (en) 1997-06-05
GR3024534T3 (en) 1997-12-31
NZ268037A (en) 1997-11-24
EP0703907A1 (fr) 1996-04-03
EP0703907B1 (fr) 1997-08-13
AU7076294A (en) 1995-01-03
CA2165328A1 (fr) 1994-12-22
FI956025A (fi) 1995-12-14
ATE156819T1 (de) 1997-08-15
US6444825B1 (en) 2002-09-03
CZ284051B6 (cs) 1998-07-15
CZ329295A3 (en) 1996-03-13
HUT73972A (en) 1996-10-28
FI956025A0 (fi) 1995-12-14
FR2706457A1 (fr) 1994-12-23

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