ES2104771T3 - Procedimiento para purificar el virus de la hepatitis a (vha), el virus de dicha forma purificado y composiciones de vacunas que los contienen. - Google Patents
Procedimiento para purificar el virus de la hepatitis a (vha), el virus de dicha forma purificado y composiciones de vacunas que los contienen.Info
- Publication number
- ES2104771T3 ES2104771T3 ES92109524T ES92109524T ES2104771T3 ES 2104771 T3 ES2104771 T3 ES 2104771T3 ES 92109524 T ES92109524 T ES 92109524T ES 92109524 T ES92109524 T ES 92109524T ES 2104771 T3 ES2104771 T3 ES 2104771T3
- Authority
- ES
- Spain
- Prior art keywords
- virus
- hepatitis
- hav
- purify
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000700605 Viruses Species 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 241000709721 Hepatovirus A Species 0.000 title 2
- 239000000203 mixture Substances 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 238000004255 ion exchange chromatography Methods 0.000 abstract 1
- 239000011368 organic material Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
- C12N2770/32434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
- C12N2770/32451—Methods of production or purification of viral material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
SE DESCRIBE UN PROCESO PARA LA PURIFICACION DEL VIRUS DE LA HEPATITIS (A) QUE PERMITE OBTENER CON BUEN RENDIMIENTO UN PRODUCTO PURO, EN EL CUAL EL MATERIAL ORGANICO RECOGIDO MEDIANTE CENTRIFUGACION DESPUES DE LA LISIS DE LAS CELULAS DEL CULTIVO SE EXPONE A UN FILTRADO POR GEL Y SUCESIVAMENTE A UNA CROMATOGRAFIA DE INTERCAMBIO DE IONES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI911662A IT1248075B (it) | 1991-06-18 | 1991-06-18 | Processo per la purificazione del virus dell'epatite a (hav), virus cosi` purificato e composizioni vaccinali che lo contengono. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2104771T3 true ES2104771T3 (es) | 1997-10-16 |
Family
ID=11360137
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92109524T Expired - Lifetime ES2104771T3 (es) | 1991-06-18 | 1992-06-05 | Procedimiento para purificar el virus de la hepatitis a (vha), el virus de dicha forma purificado y composiciones de vacunas que los contienen. |
Country Status (8)
Country | Link |
---|---|
US (2) | US5607851A (es) |
EP (1) | EP0522291B1 (es) |
JP (1) | JPH07177882A (es) |
AT (1) | ATE156187T1 (es) |
DE (1) | DE69221225T2 (es) |
DK (1) | DK0522291T3 (es) |
ES (1) | ES2104771T3 (es) |
IT (1) | IT1248075B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ225583A (en) * | 1987-08-06 | 1991-07-26 | Merck & Co Inc | Process for purifying hepatitis a virions (hav) |
USRE37303E1 (en) * | 1992-01-10 | 2001-07-31 | Institut National Del La Sante Et De La Recherche Medicale | Imidazole compounds and their therapeutic applications |
FR2686084B1 (fr) * | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
FR2696748B1 (fr) * | 1992-10-14 | 1994-12-30 | Pasteur Merieux Serums Vacc | Procédé de préparation d'antigènes et de vaccins de l'hépatite A (HAV). |
JPH11511326A (ja) | 1995-08-30 | 1999-10-05 | ジエンザイム コーポレイション | アデノウィルスおよびaavの精製 |
US7732129B1 (en) * | 1998-12-01 | 2010-06-08 | Crucell Holland B.V. | Method for the production and purification of adenoviral vectors |
AU732703B2 (en) * | 1996-11-20 | 2001-04-26 | Crucell Holland B.V. | An improved method for the production and purification of adenoviral vectors |
US6544769B1 (en) | 1996-12-13 | 2003-04-08 | Schering Corporation | Compostions comprising viruses and methods for concentrating virus preparations |
US20080261289A1 (en) * | 1996-12-13 | 2008-10-23 | Schering-Plough Corporation | Compositions comprising viruses and methods for concentrating virus preparations |
US6261823B1 (en) | 1996-12-13 | 2001-07-17 | Schering Corporation | Methods for purifying viruses |
WO1998026048A1 (en) * | 1996-12-13 | 1998-06-18 | Schering Corporation | Methods for purifying viruses |
US6689600B1 (en) | 1998-11-16 | 2004-02-10 | Introgen Therapeutics, Inc. | Formulation of adenovirus for gene therapy |
US6855535B2 (en) * | 2001-12-10 | 2005-02-15 | Baxter Healthcare S.A. | Method of large scale production of Hepatitis A virus |
US7901921B2 (en) * | 2004-10-22 | 2011-03-08 | Oncolytics Biotech Inc. | Viral purification methods |
CN101080488A (zh) * | 2004-11-03 | 2007-11-28 | 因特罗根治疗公司 | 生产和纯化腺病毒载体的新方法 |
JP4670583B2 (ja) * | 2005-10-20 | 2011-04-13 | チッソ株式会社 | 水溶性カチオン性磁気微粒子を用いた脂質ベシクルの分離又は検出方法 |
WO2009100521A1 (en) * | 2008-02-12 | 2009-08-20 | Sanofi Pasteur Limited | Methods using ion exchange and gel filtration chromatography for poxvirus purification |
SG184833A1 (en) | 2010-04-14 | 2012-11-29 | Emd Millipore Corp | Methods of producing high titer, high purity virus stocks and methods of use thereof |
CN101816786B (zh) * | 2010-04-30 | 2012-09-05 | 长春生物制品研究所有限责任公司 | 一种甲型肝炎灭活疫苗及其制备方法 |
EP3695849A1 (en) | 2019-02-13 | 2020-08-19 | Mediagnost Gesellschaft für Forschung und Herstellung von Diagnostika GmbH | Method for extracting hepatitis a virus (hav) antigen from cell culture |
US20230212530A1 (en) * | 2020-06-16 | 2023-07-06 | Hoya Technosurgical Corporation | Virus purification method using apatite column |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8205892D0 (sv) * | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
US4624918A (en) * | 1984-07-09 | 1986-11-25 | Genentech, Inc. | Purification process for hepatitis surface antigen and product thereof |
JPS6147186A (ja) * | 1984-08-09 | 1986-03-07 | Chemo Sero Therapeut Res Inst | インフルエンザウイルスの精製方法 |
JPS6147185A (ja) * | 1984-08-09 | 1986-03-07 | Chemo Sero Therapeut Res Inst | 日本脳炎ウイルスの精製方法 |
US4673634A (en) * | 1985-03-08 | 1987-06-16 | The United States Of America As Represented By The Department Of Health And Human Services | Purified antigen from non-A, non-B hepatitis causing factor |
NZ225583A (en) * | 1987-08-06 | 1991-07-26 | Merck & Co Inc | Process for purifying hepatitis a virions (hav) |
US5011915A (en) * | 1987-10-26 | 1991-04-30 | Merck & Co., Inc. | Process for purifying recombinant hepatitis antigens |
EP0327801A1 (en) * | 1988-01-08 | 1989-08-16 | Deutsches Primatenzentrum Gesellschaft Mbh | HIV-2-type retroviruses of primates, vaccines, diagnostic and pharmaceutical compositions |
US5004688A (en) * | 1988-04-15 | 1991-04-02 | Phillips Petroleum Company | Purification of hepatitis proteins |
JPH085804B2 (ja) * | 1988-04-28 | 1996-01-24 | 財団法人化学及血清療法研究所 | A型及びb型肝炎混合アジュバントワクチン |
-
1991
- 1991-06-18 IT ITMI911662A patent/IT1248075B/it active IP Right Grant
-
1992
- 1992-06-05 ES ES92109524T patent/ES2104771T3/es not_active Expired - Lifetime
- 1992-06-05 EP EP92109524A patent/EP0522291B1/en not_active Expired - Lifetime
- 1992-06-05 DK DK92109524.6T patent/DK0522291T3/da active
- 1992-06-05 DE DE69221225T patent/DE69221225T2/de not_active Expired - Lifetime
- 1992-06-05 AT AT92109524T patent/ATE156187T1/de active
- 1992-06-17 JP JP4181643A patent/JPH07177882A/ja not_active Withdrawn
-
1994
- 1994-07-18 US US08/276,780 patent/US5607851A/en not_active Expired - Lifetime
-
1995
- 1995-06-01 US US08/457,310 patent/US5719049A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5719049A (en) | 1998-02-17 |
EP0522291A1 (en) | 1993-01-13 |
ITMI911662A0 (it) | 1991-06-18 |
ATE156187T1 (de) | 1997-08-15 |
DE69221225D1 (de) | 1997-09-04 |
JPH07177882A (ja) | 1995-07-18 |
ITMI911662A1 (it) | 1992-12-18 |
DK0522291T3 (da) | 1997-08-18 |
US5607851A (en) | 1997-03-04 |
DE69221225T2 (de) | 1998-03-19 |
IT1248075B (it) | 1995-01-05 |
EP0522291B1 (en) | 1997-07-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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