ES2103433T3 - Procedimiento para preparar derivados de 1-halo-2-desoxi-2,2-difluoro-d-ribofuranosilo enriquecidos en anomero alfa. - Google Patents
Procedimiento para preparar derivados de 1-halo-2-desoxi-2,2-difluoro-d-ribofuranosilo enriquecidos en anomero alfa.Info
- Publication number
- ES2103433T3 ES2103433T3 ES93304820T ES93304820T ES2103433T3 ES 2103433 T3 ES2103433 T3 ES 2103433T3 ES 93304820 T ES93304820 T ES 93304820T ES 93304820 T ES93304820 T ES 93304820T ES 2103433 T3 ES2103433 T3 ES 2103433T3
- Authority
- ES
- Spain
- Prior art keywords
- difluoro
- alpha
- halo
- enriched
- ribofuranosilo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000004820 halides Chemical class 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90230692A | 1992-06-22 | 1992-06-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2103433T3 true ES2103433T3 (es) | 1997-09-16 |
Family
ID=25415658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93304820T Expired - Lifetime ES2103433T3 (es) | 1992-06-22 | 1993-06-21 | Procedimiento para preparar derivados de 1-halo-2-desoxi-2,2-difluoro-d-ribofuranosilo enriquecidos en anomero alfa. |
Country Status (15)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100449618B1 (ko) * | 1998-03-27 | 2004-11-16 | 부광약품 주식회사 | 2'-플루오로-5-메틸-β-L-아라비노푸라노실유리딘의 제조방법 |
| US7214791B2 (en) * | 2004-07-01 | 2007-05-08 | Shenzhen Hande Technology Co., Ltd. | Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material |
| CN101023094B (zh) | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| KR100578616B1 (ko) * | 2004-07-23 | 2006-05-10 | 한미약품 주식회사 | Ｄ-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법 |
| AU2005265494B2 (en) * | 2004-07-29 | 2009-01-08 | Hanmi Science Co., Ltd. | 1-alpha-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivatives and process for the preparation thereof |
| KR100699099B1 (ko) * | 2004-07-29 | 2007-03-22 | 한미약품 주식회사 | 1-α-할로-2,2-다이플루오로-2-데옥시-Ｄ-라이보퓨라노스유도체 및 이의 제조방법 |
| CN101437524B (zh) * | 2004-09-14 | 2012-01-11 | 法莫赛特股份有限公司 | 2＇-氟-2＇-烷基-取代的或其它任选取代的呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| BRPI0515279A (pt) | 2004-09-14 | 2008-07-15 | Pharmasset Inc | preparação de ribofuranosil pirimidinas e purinas 2'fluoro-2'-alquil- substituìdas ou outras opcionalmente substituìdas e seus derivados |
| AT502221A1 (de) * | 2005-07-20 | 2007-02-15 | Pharmacon Forschung & Beratung Gmbh | Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung |
| KR100858842B1 (ko) | 2007-03-23 | 2008-09-22 | 동우신테크 주식회사 | 키랄아민을 이용한 광학활성 옥소라이보스유도체의제조방법 |
| US7994310B2 (en) * | 2007-03-23 | 2011-08-09 | Dongwoo Syntech Co., Ltd. | Process for preparing 2′-deoxy-2′, 2′-difluorocytidine |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| US8716263B2 (en) | 2008-12-23 | 2014-05-06 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
| EP2752422B1 (en) | 2010-03-31 | 2017-08-16 | Gilead Pharmasset LLC | Stereoselective synthesis of phosphorus containing actives |
| ES2716158T3 (es) | 2010-11-30 | 2019-06-10 | Gilead Pharmasset Llc | 2'-spiro-nucleótidos para el tratamiento de hepatitis C |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| ES2792503T3 (es) | 2013-08-27 | 2020-11-11 | Gilead Pharmasset Llc | Formulación combinada de dos compuestos antivirales |
| CN106317147B (zh) * | 2015-07-06 | 2018-11-27 | 扬州硒瑞恩生物医药科技有限公司 | 核苷类化合物及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3277077A (en) * | 1964-06-03 | 1966-10-04 | Merck & Co Inc | 3-deoxy ribofuranosyl halides |
| US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
| US5256797A (en) * | 1992-06-22 | 1993-10-26 | Eli Lilly And Company | Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers |
| US5252756A (en) * | 1992-06-22 | 1993-10-12 | Eli Lilly And Company | Process for preparing beta-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-arylsulfonates |
| US5256798A (en) * | 1992-06-22 | 1993-10-26 | Eli Lilly And Company | Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates |
-
1993
- 1993-06-21 DK DK93304820.9T patent/DK0576231T3/da active
- 1993-06-21 JP JP14914993A patent/JP3291071B2/ja not_active Expired - Fee Related
- 1993-06-21 KR KR1019930011310A patent/KR940000475A/ko not_active Abandoned
- 1993-06-21 EP EP93304820A patent/EP0576231B1/en not_active Expired - Lifetime
- 1993-06-21 BR BR9302427A patent/BR9302427A/pt not_active Application Discontinuation
- 1993-06-21 ES ES93304820T patent/ES2103433T3/es not_active Expired - Lifetime
- 1993-06-21 HU HU9301828A patent/HU214030B/hu not_active IP Right Cessation
- 1993-06-21 CA CA002098887A patent/CA2098887C/en not_active Expired - Lifetime
- 1993-06-21 AT AT93304820T patent/ATE153669T1/de active
- 1993-06-21 MX MX9303713A patent/MX9303713A/es not_active IP Right Cessation
- 1993-06-21 DE DE69311000T patent/DE69311000T2/de not_active Expired - Lifetime
- 1993-06-21 IL IL10607593A patent/IL106075A/xx not_active IP Right Cessation
- 1993-06-22 TW TW082104990A patent/TW224102B/zh active
- 1993-07-29 US US08/099,014 patent/US5453499A/en not_active Expired - Lifetime
-
1997
- 1997-06-26 GR GR970401559T patent/GR3023911T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL106075A (en) | 2000-12-06 |
| EP0576231A1 (en) | 1993-12-29 |
| IL106075A0 (en) | 1993-10-20 |
| HUT64550A (en) | 1994-01-28 |
| HU9301828D0 (en) | 1993-09-28 |
| ATE153669T1 (de) | 1997-06-15 |
| GR3023911T3 (en) | 1997-09-30 |
| EP0576231B1 (en) | 1997-05-28 |
| JPH0656863A (ja) | 1994-03-01 |
| DK0576231T3 (da) | 1997-08-25 |
| TW224102B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1994-05-21 |
| HU214030B (en) | 1997-12-29 |
| CA2098887A1 (en) | 1993-12-23 |
| DE69311000T2 (de) | 1997-11-27 |
| US5453499A (en) | 1995-09-26 |
| JP3291071B2 (ja) | 2002-06-10 |
| KR940000475A (ko) | 1994-01-03 |
| BR9302427A (pt) | 1994-01-11 |
| CA2098887C (en) | 2003-10-28 |
| DE69311000D1 (de) | 1997-07-03 |
| MX9303713A (es) | 1994-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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