ES2103412T3 - Dihidropiridinas sustituidas con 4-heterociclilo. - Google Patents

Dihidropiridinas sustituidas con 4-heterociclilo.

Info

Publication number
ES2103412T3
ES2103412T3 ES93116864T ES93116864T ES2103412T3 ES 2103412 T3 ES2103412 T3 ES 2103412T3 ES 93116864 T ES93116864 T ES 93116864T ES 93116864 T ES93116864 T ES 93116864T ES 2103412 T3 ES2103412 T3 ES 2103412T3
Authority
ES
Spain
Prior art keywords
substituted
heterocyclyl
dihydropyridines
heterociclilo
dihydropyridines substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93116864T
Other languages
English (en)
Inventor
Bodo Dr Junge
Wolfgang Dr Hartwig
Heinrich Dr Meier
Rudolf Dr Schohe-Loop
Zhan Dr Gao
Bernard Dr Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2103412T3 publication Critical patent/ES2103412T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

DIHIDROPIRIDINAS SUSTITUIDAS POR 4-HETEROCICLILO SON ELABORADAS MEDIANTE LA TRANSFORMACION DEL ALDEHIDO CORRESPONDIENTE CON BETAESTERCETONA Y ESTER ACIDO AMINO CROTONICO, O DONDE SE ESTERIFICA LOS ACIDOS CARBOXILICO DIHIDROPIRIDINA SUSTITUIDA POR 4-HETEROCICLILO. LAS DIHIDROPIRIDINAS SUSTITUIDAS POR DIHIDROPIRIDINOCARBOXILICOS 4HETEROCICLILO PUEDEN SER UTILIZADAS EN MEDICAMENTOS, EN PARTICULAR PARA EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL.
ES93116864T 1992-10-30 1993-10-19 Dihidropiridinas sustituidas con 4-heterociclilo. Expired - Lifetime ES2103412T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4236707A DE4236707A1 (de) 1992-10-30 1992-10-30 4-Heterocyclyl substituierte Dihydropyridine

Publications (1)

Publication Number Publication Date
ES2103412T3 true ES2103412T3 (es) 1997-09-16

Family

ID=6471753

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93116864T Expired - Lifetime ES2103412T3 (es) 1992-10-30 1993-10-19 Dihidropiridinas sustituidas con 4-heterociclilo.

Country Status (20)

Country Link
US (1) US5502064A (es)
EP (1) EP0595166B1 (es)
JP (1) JPH06220047A (es)
KR (1) KR940009180A (es)
CN (1) CN1094403A (es)
AT (1) ATE153335T1 (es)
AU (1) AU4873093A (es)
CA (1) CA2109352A1 (es)
CZ (1) CZ227693A3 (es)
DE (2) DE4236707A1 (es)
DK (1) DK0595166T3 (es)
ES (1) ES2103412T3 (es)
FI (1) FI934778A (es)
GR (1) GR3024295T3 (es)
HU (1) HUT68941A (es)
IL (1) IL107414A0 (es)
MX (1) MX9306509A (es)
NO (1) NO933718L (es)
SK (1) SK120793A3 (es)
ZA (1) ZA938088B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525600A (en) * 1994-11-28 1996-06-11 American Home Products Corporation (Thiophen-2-yl)-piperidin or tetrahydropyridin carboxamides
ATE548351T1 (de) * 1996-01-29 2012-03-15 Us Of America Represented By The Secretary Dept Of Health And Human Services Dihydropyridin-pyridin-, benzopyranon- und triazolochinazolin-derivate, deren herstellung und verwendung als adenosinrezeptor-antagonisten
WO1997037667A1 (en) 1996-04-10 1997-10-16 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Use of an a1 adenosine receptor agonist to treat cerebral ischaemia
KR100383514B1 (ko) * 2001-05-15 2003-05-12 한미반도체 주식회사 소형반도체 패키지 이송장치

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545873A1 (de) * 1965-11-10 1970-02-26 Bayer Ag Verfahren zur Herstellung von Dihydrodipyridylderivaten
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
FR2320750A1 (fr) * 1975-08-12 1977-03-11 Hexachimie Dihydro-1,4 pyridines et leur application therapeutique
DE2815578C2 (de) * 1978-04-11 1986-01-16 Bayer Ag, 5090 Leverkusen Neue pharmazeutische Verwendung von Nimodipin
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
DE3208628A1 (de) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3239273A1 (de) * 1982-10-23 1984-04-26 Bayer Ag, 5090 Leverkusen Tetrahydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
DE3445356A1 (de) * 1983-12-15 1985-06-27 Ciba-Geigy Ag, Basel Halogenierte thiophen-verbindungen
US4771057A (en) * 1986-02-03 1988-09-13 University Of Alberta Reduced pyridyl derivatives with cardiovascular regulating properties
DE3816361A1 (de) * 1987-05-18 1988-12-08 Byk Gulden Lomberg Chem Fab 1,4-dihydropyridindicarbonsaeure-(-)-menthylester

Also Published As

Publication number Publication date
FI934778A (fi) 1994-05-01
JPH06220047A (ja) 1994-08-09
HUT68941A (en) 1995-08-28
HU9303083D0 (en) 1994-01-28
MX9306509A (es) 1994-04-29
NO933718L (no) 1994-05-02
IL107414A0 (en) 1994-01-25
ZA938088B (en) 1994-06-07
ATE153335T1 (de) 1997-06-15
DE4236707A1 (de) 1994-05-05
CN1094403A (zh) 1994-11-02
EP0595166A1 (de) 1994-05-04
AU4873093A (en) 1994-05-12
GR3024295T3 (en) 1997-10-31
CA2109352A1 (en) 1994-05-01
SK120793A3 (en) 1994-11-09
FI934778A0 (fi) 1993-10-28
US5502064A (en) 1996-03-26
KR940009180A (ko) 1994-05-20
NO933718D0 (no) 1993-10-15
CZ227693A3 (en) 1994-05-18
DE59306506D1 (de) 1997-06-26
DK0595166T3 (da) 1997-12-01
EP0595166B1 (de) 1997-05-21

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