ES2103130T3 - Inhibidores imidazoles como la lipoxigenasa. - Google Patents

Inhibidores imidazoles como la lipoxigenasa.

Info

Publication number
ES2103130T3
ES2103130T3 ES94916398T ES94916398T ES2103130T3 ES 2103130 T3 ES2103130 T3 ES 2103130T3 ES 94916398 T ES94916398 T ES 94916398T ES 94916398 T ES94916398 T ES 94916398T ES 2103130 T3 ES2103130 T3 ES 2103130T3
Authority
ES
Spain
Prior art keywords
alkyl
substituted
independently
alkoxy
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94916398T
Other languages
English (en)
Inventor
Rodney W Stevens
Takashi Mano
Kazuo Ando
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2103130T3 publication Critical patent/ES2103130T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

CIERTOS DERIVADOS DE IMIDAZOL NOVEDOSOS QUE TIENEN LA HABILIDAD DE INHIBIR LA ENZIMA LIPOXIGENASA DE FORMULA (I), DONDE Y ES HIDROGENO, ALQUILC{SUB,1}-C{SUB,8}, ALQUILC{SUB,1}-C{SUB,4} HALOSUSTITUIDO, FENIL, FENIL SUSTITUIDO, FENILALQUILC{SUB,7}C{SUB,14}, ALQUIL(FENIL SUSTITUIDO)C{SUB,7}-C{SUB,14}, PIRIDIL, PIRIDIL SUSTITUIDO, PRIRIDIL ALQUIL C{SUB,6}-C{SUB,13} O C{SUB,6}-C{SUB,13}(PIRIDIL SUSTITUIDO)ALQUIL, DONDE CADA SUSTITUYENTE ES INDEPENDIENTEMENTE HALO, NITRO, CIANO, C{SUB,1}C{SUB,4}ALQUIL, C{SUB,1}-C{SUB,4}ALCOXI, C{SUB,1}-C{SUB,4}ALQUIL HALOSUSTITUIDO, C{SUB,1}-C{SUB,4}ALCOXI HALOSUSTITUIDO, NH{SUP,4}R{SUP,5}, CO{SUB,2}R{SUP,4} O CONR{SUP,4}R{SUP,5}, DONDE R{SUP,4} Y R{SUP,5} SON CADA UNA INDEPENDIENTEMENTE HIDROGENO O C{SUB,1}-C{SUB,6}ALQUIL; AR{SUP,1} Y AR{SUP,2} SON CADA UNO INDEPENDIENTEMENTE FENILENO, FENILENO MONOSUSTITUIDO O FENILENO DISUSTITUIDO, DONDE LOS SUSTITUYENTES SON INDEPENDIENTEMENTE HALO, C{SUB,1}-C{SUB,4}ALQUIL, C{SUB,1}-C{SUB,4}ALCOXI, C{SUB,1}C{SUB,4}ALQUIL HALOSUSTITUIDO A C{SUB,1}-C{SUB,4}ALCOXI HALOSUSTITUIDO; X Y X{SUP,1} SON CADA UNO INDEPENDIENTEMENTE O, S, SO, O SO{SUB,2}; R{SUP,1} ES HIDROGENO O C{SUB,1}C{SUB,4}ALQUIL; Y R{SUP,2} Y R{SUP,3} SON CADA UNA INDEPENDIENTEMENTE METILENO, ETILENO O PROPILENO. ESTOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE ESTADOS DE ENFERMEDADES TALES COMO EL ASMA BRONQUIAL, DESORDENES CUTANEOS Y LA ARTRITIS EN MAMIFEROS Y COMO EL INGREDIENTE ACTIVO EN COMPOSICIONES FARMACEUTICAS PARA TRATAR TALES CONDICIONES.
ES94916398T 1993-06-14 1994-05-25 Inhibidores imidazoles como la lipoxigenasa. Expired - Lifetime ES2103130T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14220693 1993-06-14

Publications (1)

Publication Number Publication Date
ES2103130T3 true ES2103130T3 (es) 1997-08-16

Family

ID=15309865

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94916398T Expired - Lifetime ES2103130T3 (es) 1993-06-14 1994-05-25 Inhibidores imidazoles como la lipoxigenasa.

Country Status (23)

Country Link
US (1) US5753682A (es)
EP (1) EP0703913B1 (es)
KR (1) KR100190728B1 (es)
CN (2) CN1050840C (es)
AT (1) ATE154353T1 (es)
AU (1) AU685122B2 (es)
BR (1) BR9406822A (es)
CA (1) CA2163667C (es)
CZ (1) CZ282969B6 (es)
DE (1) DE69403795T2 (es)
DK (1) DK0703913T3 (es)
ES (1) ES2103130T3 (es)
FI (1) FI942792A (es)
GR (1) GR3024568T3 (es)
HU (1) HUT70767A (es)
IL (1) IL109903A (es)
NO (1) NO955046L (es)
NZ (1) NZ266541A (es)
PL (2) PL175987B1 (es)
RU (1) RU2126004C1 (es)
TW (1) TW374088B (es)
WO (1) WO1994029299A1 (es)
ZA (1) ZA944140B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063928A (en) * 1994-10-18 2000-05-16 Pfizer Inc 5-lipoxygenase inhibitors
SK281577B6 (sk) * 1994-10-18 2001-05-10 Pfizer Inc. Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze
US5883106A (en) * 1994-10-18 1999-03-16 Pfizer Inc. 5-lipoxygenase inhibitors
WO1997011079A1 (en) * 1995-09-18 1997-03-27 Pfizer Pharmaceuticals Inc. Novel imidazole lipoxygenase inhibitors
US6194585B1 (en) * 1998-12-22 2001-02-27 Pfizer Inc. Process for preparing 5-lipoxygenase inhibitors
US6344563B1 (en) * 1999-08-31 2002-02-05 Timothy Norris Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems
RS20090211A (en) 2006-11-27 2010-10-31 Pfizer Products Inc. Pyrazole analogs

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
DE3374656D1 (en) * 1982-08-12 1988-01-07 Smith & Nephew Ass Wound dressing and its manufacture
JPS60142966A (ja) * 1983-09-05 1985-07-29 Yoshitomi Pharmaceut Ind Ltd イミダゾ−ル誘導体
US4851526A (en) * 1987-09-04 1989-07-25 Schering A.G. 1-(4-Substituted phenyl)-1H-imidazoles compounds
US5234950A (en) * 1988-12-23 1993-08-10 Imperial Chemical Industries Plc Tetrahydrofuran derivatives
GB8926981D0 (en) * 1988-12-23 1990-01-17 Ici Plc Heterocyclic derivatives
US5223525A (en) * 1989-05-05 1993-06-29 Rhone-Poulenc Ag Company Pesticidal 1-arylimidazoles
IE64358B1 (en) * 1989-07-18 1995-07-26 Ici Plc Diaryl ether heterocycles
IE913866A1 (en) * 1990-11-28 1992-06-03 Ici Plc Aryl derivatives
GB9101375D0 (en) * 1991-01-22 1991-03-06 Erba Carlo Spa N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohepht(b)indole
GB9108811D0 (en) * 1991-04-24 1991-06-12 Erba Carlo Spa N-imidazolyl derivatives of substituted indole

Also Published As

Publication number Publication date
PL312006A1 (en) 1996-04-01
IL109903A0 (en) 1994-10-07
DE69403795T2 (de) 1997-09-18
DE69403795D1 (de) 1997-07-17
HUT70767A (en) 1995-10-30
PL176522B1 (pl) 1999-06-30
KR100190728B1 (ko) 1999-06-01
GR3024568T3 (en) 1997-12-31
CA2163667A1 (en) 1994-12-22
AU6807794A (en) 1995-01-03
NO955046L (no) 1996-02-13
IL109903A (en) 1998-10-30
CN1050840C (zh) 2000-03-29
CN1247191A (zh) 2000-03-15
EP0703913B1 (en) 1997-06-11
KR960703121A (ko) 1996-06-19
CA2163667C (en) 1998-12-15
FI942792A0 (fi) 1994-06-13
ZA944140B (en) 1995-12-13
AU685122B2 (en) 1998-01-15
CZ327695A3 (en) 1996-05-15
FI942792A (fi) 1994-12-15
HU9401762D0 (en) 1994-09-28
NZ266541A (en) 1997-11-24
WO1994029299A1 (en) 1994-12-22
BR9406822A (pt) 1996-03-26
PL175987B1 (pl) 1999-03-31
TW374088B (en) 1999-11-11
CN1125442A (zh) 1996-06-26
DK0703913T3 (da) 1997-10-20
ATE154353T1 (de) 1997-06-15
RU2126004C1 (ru) 1999-02-10
US5753682A (en) 1998-05-19
EP0703913A1 (en) 1996-04-03
CZ282969B6 (cs) 1997-11-12
NO955046D0 (no) 1995-12-13

Similar Documents

Publication Publication Date Title
HUP0202623A2 (hu) MEK-gátló vegyületek alkalmazása gyógyászati készítmények előállítására
PT1251848E (pt) Inibidores de girase e as sua utilizacoes
BR9916282A (pt) Composto, uso de um um composto e método de tratamento
DK0874812T3 (da) Hidtil ukendte 2,3,5-trimethyl-4-hydroxyanilidderivater, fremstilling deraf og terapeutisk anvendelse deraf
EE9700282A (et) Bensimidasooli ühendid, nimetatud ühendeid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine
NO963706L (no) Benzenkondenserte heterosykliske derivater og deres anvendelse
ES2103130T3 (es) Inhibidores imidazoles como la lipoxigenasa.
ID26622A (id) Senyawa-senyawa pengganti 2-benzylamino-2-phenyl-acetamide
AR001061A1 (es) Composición fungicida sinergica procedimiento par a combatir hongos nocivos uso de los compuestos que integran dicha composición como componentes sinergicos de la misma
HUP0200088A2 (hu) Piridazin-3-on-származékok és a vegyületeket tartalmazó gyógyszerkészítmények
KR960706476A (ko) 인터류킨-1 활성 억제제로서의 신규한 벤젠설포닐아민 유도체(Novel benzen-esulfonylimine derivatives as inhibitors of lL-1 action)
BR9912684A (pt) Composto de fórmula (i), composição farmacêutica compreendendo o composto, método, processo e seu uso
DE69630799D1 (en) Pyrimidinderivate
BR0014759A (pt) Inibidores de metaloprotease beta dissubstituìdos
ATE278676T1 (de) Imdazol-derivate, deren herstellung und deren verwendung als s-adenosylmethionin decarboxylase (=samdc) inhibitoren
DE69421183T2 (de) Heteroaryl-cyloalkenyl-hydroxy-harnstoeffe
DE69910738D1 (de) Fungizide zusammensetzung enthaltend ein n-benzoyl-n'-phenyl-harnstoff derivat
BR0116240A (pt) Mistura fungicida, método para controlar fungos nocivos, e, usos dos compostos de amida e dos derivados de imidazol
NZ501694A (en) Angiogenesis inhibiting 5-substituted-1,2,4-thiadiazolyl derivatives
BR9907301A (pt) Composto, processo para preparar um composto, composição farmacêutica, e, processo para tratar uma condição de doença

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 703913

Country of ref document: ES