ES2097402T3 - Derivados oximas. - Google Patents

Derivados oximas.

Info

Publication number
ES2097402T3
ES2097402T3 ES93111689T ES93111689T ES2097402T3 ES 2097402 T3 ES2097402 T3 ES 2097402T3 ES 93111689 T ES93111689 T ES 93111689T ES 93111689 T ES93111689 T ES 93111689T ES 2097402 T3 ES2097402 T3 ES 2097402T3
Authority
ES
Spain
Prior art keywords
lower alkyl
ring
cycloalkyl
containing nitrogen
alkyl substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93111689T
Other languages
English (en)
Inventor
Nobuyuki Hamanaka
Kanji Takahashi
Hidekado Tokumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2097402T3 publication Critical patent/ES2097402T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/54—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

UN DERIVADO DE OXIMA (I): EN EL QUE EL ANILLO D Y EL ENLACE B AL ANILLO D SON (I) UIL INFERIOR; R2 ES HIDROGENO, ALQUIL, FENIL, CICLOALQUIL, UN ANILLO MONOCICLICO QUE CONTIENE NITROGENO; R3 ES ALQUIL, FENIL, CICLOALQUIL, UN ANILLO MONOCICLICO QUE CONTIENE NITROGENO, UN ALQUIL INFERIOR SUBSTITUIDO POR UN ANILLO DE BENCENO O UN CICLOALQUIL, UN ALQUIL INFERIOR SUBSTITUIDO POR UN ANILLO MONOCICLICO QUE CONTIENE NITROGENO; E ES DE 3-5, F ES DE 1-3, P ES DE 1-4, Q ES DE 1-2, R ES DE 1-3; LA POSICION DEL ENLACE AL ANILLO D EN (III) Y (IV) ES A O B, Y EL ANILLO EN R2 Y R3 SE PUEDE SUBSTITUIR POR UN ALQUIL INFERIOR, ALCOXI, HALOGENO, NITRO, TRIHALOMETIL; Y LAS SALES DEL MISMO, POSEEN ACTIVIDAD FAVORECEDORA SOBRE EL RECEPTOR PGI2, POR LO QUE SE ESPERA QUE SEA UTIL PARA LA PREVENCION Y/O TRATAMIENTO DE LA TROMBOSIS, ARTERIOSCLEROSIS, ENFERMEDADES ISQUEMICAS DEL CORAZON, ULCERA GASTRICA E HIPERTENSION.
ES93111689T 1992-07-21 1993-07-21 Derivados oximas. Expired - Lifetime ES2097402T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21545792 1992-07-21

Publications (1)

Publication Number Publication Date
ES2097402T3 true ES2097402T3 (es) 1997-04-01

Family

ID=16672692

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93111689T Expired - Lifetime ES2097402T3 (es) 1992-07-21 1993-07-21 Derivados oximas.

Country Status (11)

Country Link
US (1) US5480998A (es)
EP (1) EP0581187B1 (es)
JP (2) JP2691679B2 (es)
KR (1) KR100191137B1 (es)
AT (1) ATE145892T1 (es)
CA (1) CA2100918C (es)
DE (1) DE69306324T2 (es)
DK (1) DK0581187T3 (es)
ES (1) ES2097402T3 (es)
GR (1) GR3022576T3 (es)
TW (1) TW281668B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1092639C (zh) 1995-01-06 2002-10-16 东丽株式会社 苯稠合杂环衍生物及其用途
US5723666A (en) * 1996-06-21 1998-03-03 Allergan Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
DE19722848A1 (de) * 1997-05-23 1998-11-26 Schering Ag Leukotrien-B¶4¶-Derivate, insbesondere Oximo-LTB¶4¶-Antagonisten
EP1065233A1 (en) 1998-02-27 2001-01-03 Ono Pharmaceutical Co., Ltd. Carrier polymers migrating into target organs and drug-containing polymers
AU766831B2 (en) 1998-05-11 2003-10-23 Takeda Pharmaceutical Company Limited Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity
KR20020015345A (ko) * 1999-06-21 2002-02-27 후지야마 아키라 피부 궤양 치료제
HUE029417T2 (en) 2002-10-10 2017-02-28 Ono Pharmaceutical Co Microspheres containing ONO-1301
KR101187693B1 (ko) 2003-05-09 2012-10-05 도레이 카부시키가이샤 신장질환의 치료 또는 예방제
PT2087890E (pt) 2006-10-19 2014-05-12 Ono Pharmaceutical Co Preparação de libertação sustentada para terapêuticas de regeneração de tecidos
US9597436B2 (en) 2012-09-21 2017-03-21 Osaka University Advanced heart failure treatment material as myocardial/cardiovascular regeneration device
WO2014069401A1 (ja) 2012-10-29 2014-05-08 株式会社カルディオ 肺疾患特異的治療剤
JP6449166B2 (ja) 2013-10-15 2019-01-09 小野薬品工業株式会社 薬剤溶出性ステントグラフト
EP3569249A4 (en) 2016-12-27 2020-11-11 Osaka University MEDICAL COMPOSITION FOR TREATMENT OF CONTINUOUS HEART DISEASE
US20210113464A1 (en) 2017-11-27 2021-04-22 Osaka University Disease-site-specific liposomal formulation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004329A1 (de) * 1978-03-17 1979-10-03 Hagus C. Luchtenberg GmbH & Co. KG Zusatzrückspiegel für Kraftfahrzeuge
US4352804A (en) * 1978-07-25 1982-10-05 Acf Chemiefarma Nv Oxime ethers, their preparation and pharmaceutical compositions containing them
US4368332A (en) * 1979-01-05 1983-01-11 National Research Development Corporation Prostaglandins
ZA814307B (en) * 1980-07-01 1983-02-23 Nat Res Dev Prostaglandins
DE3504677A1 (de) * 1985-02-12 1986-08-14 A. Nattermann & Cie GmbH, 5000 Köln Neue imidazol-2-yloxyalkansaeuren und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
FI92189C (fi) * 1986-03-17 1994-10-10 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisen difenyylimetaanijohdannaisen valmistamiseksi
JP2765876B2 (ja) * 1988-10-24 1998-06-18 科研製薬株式会社 ピリジルケトオキシムエーテル誘導体
US5344836A (en) * 1991-11-11 1994-09-06 Ono Pharmaceutical Co., Ltd. Fused benzeneoxyacetic acid derivatives

Also Published As

Publication number Publication date
KR940005558A (ko) 1994-03-21
JP2691679B2 (ja) 1997-12-17
JPH08109162A (ja) 1996-04-30
JPH0687811A (ja) 1994-03-29
JP2649507B2 (ja) 1997-09-03
EP0581187B1 (en) 1996-12-04
DE69306324D1 (de) 1997-01-16
DK0581187T3 (da) 1996-12-23
TW281668B (es) 1996-07-21
US5480998A (en) 1996-01-02
EP0581187A1 (en) 1994-02-02
KR100191137B1 (ko) 1999-06-15
ATE145892T1 (de) 1996-12-15
CA2100918C (en) 1997-01-21
CA2100918A1 (en) 1994-01-22
GR3022576T3 (en) 1997-05-31
DE69306324T2 (de) 1997-05-22

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