TW281668B - - Google Patents

Info

Publication number
TW281668B
TW281668B TW082105895A TW82105895A TW281668B TW 281668 B TW281668 B TW 281668B TW 082105895 A TW082105895 A TW 082105895A TW 82105895 A TW82105895 A TW 82105895A TW 281668 B TW281668 B TW 281668B
Authority
TW
Taiwan
Prior art keywords
lower alkyl
ring
cycloalkyl
containing nitrogen
alkyl substituted
Prior art date
Application number
TW082105895A
Other languages
English (en)
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Application granted granted Critical
Publication of TW281668B publication Critical patent/TW281668B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/54—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
TW082105895A 1992-07-21 1993-07-23 TW281668B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21545792 1992-07-21

Publications (1)

Publication Number Publication Date
TW281668B true TW281668B (zh) 1996-07-21

Family

ID=16672692

Family Applications (1)

Application Number Title Priority Date Filing Date
TW082105895A TW281668B (zh) 1992-07-21 1993-07-23

Country Status (11)

Country Link
US (1) US5480998A (zh)
EP (1) EP0581187B1 (zh)
JP (2) JP2691679B2 (zh)
KR (1) KR100191137B1 (zh)
AT (1) ATE145892T1 (zh)
CA (1) CA2100918C (zh)
DE (1) DE69306324T2 (zh)
DK (1) DK0581187T3 (zh)
ES (1) ES2097402T3 (zh)
GR (1) GR3022576T3 (zh)
TW (1) TW281668B (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100436812B1 (ko) 1995-01-06 2004-08-31 도레이 가부시끼가이샤 벤젠축합헤테로환유도체및그유도체를유효성분으로함유하는의약조성물
US5723666A (en) * 1996-06-21 1998-03-03 Allergan Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
DE19722848A1 (de) * 1997-05-23 1998-11-26 Schering Ag Leukotrien-B¶4¶-Derivate, insbesondere Oximo-LTB¶4¶-Antagonisten
EP1065233A1 (en) 1998-02-27 2001-01-03 Ono Pharmaceutical Co., Ltd. Carrier polymers migrating into target organs and drug-containing polymers
SK16412000A3 (sk) 1998-05-11 2001-08-06 Takeda Chemical Industries, Ltd. Deriváty kyseliny oxyiminoalkánovej
WO2000078350A1 (fr) * 1999-06-21 2000-12-28 Fujisawa Pharmaceutical Co., Ltd. Medicaments destines a un ulcere cutane
ES2393321T3 (es) * 2002-10-10 2012-12-20 Ono Pharmaceutical Co., Ltd. Promotores de la producción de factores de reparación endógenos
EP1627638B1 (en) 2003-05-09 2017-07-12 Toray Industries, Inc. Beraprost and a renin-angiotensin system inhibitor for use in the treatment of renal diseases
ES2459743T3 (es) * 2006-10-19 2014-05-12 Ono Pharmaceutical Co., Ltd. Preparación de liberación sostenida para terapia de regeneración tisular
JP6314349B2 (ja) 2012-09-21 2018-04-25 国立大学法人大阪大学 心筋・血管再生デバイスとしての重症心不全治療材
WO2014069401A1 (ja) 2012-10-29 2014-05-08 株式会社カルディオ 肺疾患特異的治療剤
US9968716B2 (en) 2013-10-15 2018-05-15 Ono Pharmaceutical Co., Ltd. Drug-eluting stent graft
WO2018124236A1 (ja) 2016-12-27 2018-07-05 国立大学法人大阪大学 難治性心疾患治療用医薬組成物
US20210113464A1 (en) 2017-11-27 2021-04-22 Osaka University Disease-site-specific liposomal formulation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004329A1 (de) * 1978-03-17 1979-10-03 Hagus C. Luchtenberg GmbH & Co. KG Zusatzrückspiegel für Kraftfahrzeuge
US4352804A (en) * 1978-07-25 1982-10-05 Acf Chemiefarma Nv Oxime ethers, their preparation and pharmaceutical compositions containing them
EP0013607B1 (en) * 1979-01-05 1983-03-23 National Research Development Corporation Substituted bicyclo (2,2,1)heptanes and bicyclo (2,2,1) hept-2-enes and their pharmaceutical compositions
ZA814307B (en) * 1980-07-01 1983-02-23 Nat Res Dev Prostaglandins
DE3504677A1 (de) * 1985-02-12 1986-08-14 A. Nattermann & Cie GmbH, 5000 Köln Neue imidazol-2-yloxyalkansaeuren und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
FI92189C (fi) * 1986-03-17 1994-10-10 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisen difenyylimetaanijohdannaisen valmistamiseksi
JP2765876B2 (ja) * 1988-10-24 1998-06-18 科研製薬株式会社 ピリジルケトオキシムエーテル誘導体
US5344836A (en) * 1991-11-11 1994-09-06 Ono Pharmaceutical Co., Ltd. Fused benzeneoxyacetic acid derivatives

Also Published As

Publication number Publication date
EP0581187A1 (en) 1994-02-02
JP2649507B2 (ja) 1997-09-03
JP2691679B2 (ja) 1997-12-17
GR3022576T3 (en) 1997-05-31
DE69306324T2 (de) 1997-05-22
DK0581187T3 (da) 1996-12-23
KR940005558A (ko) 1994-03-21
CA2100918A1 (en) 1994-01-22
JPH08109162A (ja) 1996-04-30
CA2100918C (en) 1997-01-21
JPH0687811A (ja) 1994-03-29
ATE145892T1 (de) 1996-12-15
US5480998A (en) 1996-01-02
ES2097402T3 (es) 1997-04-01
EP0581187B1 (en) 1996-12-04
DE69306324D1 (de) 1997-01-16
KR100191137B1 (ko) 1999-06-15

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