ES2097242T3 - Procedimiento para la saponificacion de esteres de aminoacidos/peptidicos. - Google Patents
Procedimiento para la saponificacion de esteres de aminoacidos/peptidicos.Info
- Publication number
- ES2097242T3 ES2097242T3 ES92111238T ES92111238T ES2097242T3 ES 2097242 T3 ES2097242 T3 ES 2097242T3 ES 92111238 T ES92111238 T ES 92111238T ES 92111238 T ES92111238 T ES 92111238T ES 2097242 T3 ES2097242 T3 ES 2097242T3
- Authority
- ES
- Spain
- Prior art keywords
- peptidic
- saponification
- esters
- procedure
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
- C07K1/126—Aminolysis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Steroid Compounds (AREA)
Abstract
2.1 BIOMOLECULAS ACTIVAS OPTICAS COMO PEPTIDOS, AMINOACIDOS Y ACIDOS NUCLEICOS SON SENSIBLES FRENTE A TEMPERATURAS ELEVADAS, VALORES EXTREMOS DE PH Y/O TIEMPOS DE REACCION LARGOS. ESTAS MOLECULAS SUCUMBEN POR ELLO FACILMENTE EN SINTESIS QUIMICAS DE PROCESOS DE RACEMIZACION O DESNATURACION. CON EL NUEVO PROCESO DEBE SER POSIBLE BAJO CONDICIONES DE REACCION SUAVES LA SAPONIFICACION, AMONOLISIS O TRANSESTERIFICACION DE DERIVADOS ACIDOS O DESDOBLAMIENTO DE MOLECULAS LIGADAS DE POLIMEROS. 2.2 LA TRANSESTERIFICACION, SAPONIFICACION O DESDOBLAMIENTO DE MOLECULAS LIGADAS DE POLIMEROS, COMO POR EJEMPLO EN LA SINTESIS MERRIFIELD SE CONSIGUE A TRAVES DE LA UTILIZACION COMBINADA DE UNA BASE AMIDINA Y UN COMPUESTO METALICO EN PRESENCIA DE UN ALCOHOL O AGUA. EN LA SOPONIFICACION DE ESTER AMINOACIDO O PEPTIDO SE CONSIGUE EL DESDOBLAMIENTO UNICAMENTE CON HIDROXIDO DE LITIO BAJO CONDICIONES SUAVES. LA UTILIZACION DE UNA BASE ANILINA, EN PARTICULAR DBU O DBN, EN COMBINACION CON LA SAL METALICA ACELERA LA REACCION DE FORMA INTENSA, DE MODO QUE TAMBIEN PUEDEN SER TRANSFORMADOS DERIVADOS ACIDOS SENSIBLES BAJO CONDICIONES AGRADABLES. 2.3 REPRESENTACION DE ESTER COMPLEJO, DESDOBLAMIENTO POSITIVO DE PEPTICOS DE PORTADORES, SAPONIFICACION POSITIVA DE AMIDAS O ESTERES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4123408 | 1991-07-15 | ||
DE4124283A DE4124283A1 (de) | 1991-07-15 | 1991-07-22 | Umesterung von peptiden |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2097242T3 true ES2097242T3 (es) | 1997-04-01 |
Family
ID=25905493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92111238T Expired - Lifetime ES2097242T3 (es) | 1991-07-15 | 1992-07-02 | Procedimiento para la saponificacion de esteres de aminoacidos/peptidicos. |
Country Status (10)
Country | Link |
---|---|
US (1) | US6090913A (es) |
EP (2) | EP0523461B1 (es) |
JP (1) | JPH05271104A (es) |
AT (2) | ATE148090T1 (es) |
CA (1) | CA2073818A1 (es) |
CZ (1) | CZ286094B6 (es) |
DE (3) | DE4124283A1 (es) |
DK (1) | DK0523461T3 (es) |
ES (1) | ES2097242T3 (es) |
HU (2) | HU220069B (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2156050A1 (es) * | 1998-03-31 | 2001-06-01 | Nicolau Francisco E Palomo | Mejoras introducidas en la patente principal num. 9700745, por "sales de aminoacidos solubles de disolventes organicos y su uso en la preparacion de dipeptidos". |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4825448A (en) * | 1986-08-07 | 1989-04-25 | International Mobile Machines Corporation | Subscriber unit for wireless digital telephone system |
ES2156037B1 (es) * | 1997-04-01 | 2002-03-01 | Nicolau Francisco E Palomo | Sales de aminoacidos solubles en disolventes organicos y su uso en la preparacion de dipeptidos. |
DE10107051C2 (de) | 2001-02-13 | 2003-06-26 | Dorma Gmbh & Co Kg | Elektromechanischer Drehflügelantrieb |
US8541477B2 (en) | 2011-03-04 | 2013-09-24 | International Business Machines Corporation | Methods of depolymerizing terephthalate polyesters |
CN107043339B (zh) | 2011-07-19 | 2019-09-06 | 希默赛生物技术有限责任公司 | 新交联试剂、大分子、治疗用偶联物及其合成方法 |
GB201119871D0 (en) | 2011-11-17 | 2011-12-28 | Davy Process Techn Ltd | Process |
GB201218078D0 (en) | 2012-10-09 | 2012-11-21 | Davy Process Techn Ltd | Process |
US9969769B2 (en) | 2014-12-19 | 2018-05-15 | Cem Corporation | Coupling method for peptide synthesis at elevated temperatures |
US10308677B2 (en) | 2014-12-19 | 2019-06-04 | Cem Corporation | Coupling method for peptide synthesis at elevated temperatures |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8005121A (nl) * | 1979-09-20 | 1981-03-24 | Erba Farmitalia | Biologisch actieve peptiden. |
US4559180A (en) * | 1982-11-26 | 1985-12-17 | Bp Chemicals Limited | Transesterification of esters |
JPH062397B2 (ja) * | 1983-11-28 | 1994-01-12 | 三井石油化学工業株式会社 | 共縮合ポリエステル層を有する積層体 |
GB8401919D0 (en) | 1984-01-25 | 1984-02-29 | Bp Chem Int Ltd | Transesterification process |
US5015753A (en) * | 1986-07-14 | 1991-05-14 | The Dow Chemical Company | Process for preparing poly(alkylene carbonate) monoahls and polyahls useful as surfactants |
US4876378A (en) * | 1988-05-23 | 1989-10-24 | Eastman Kodak Company | Recovery of dialkyl naphthalene-2,6-dicarboxylates from naphthalene-2,6-dicarboxylic acid-containing polyesters |
-
1991
- 1991-07-22 DE DE4124283A patent/DE4124283A1/de not_active Withdrawn
-
1992
- 1992-07-02 AT AT92111238T patent/ATE148090T1/de not_active IP Right Cessation
- 1992-07-02 DE DE59209289T patent/DE59209289D1/de not_active Expired - Fee Related
- 1992-07-02 EP EP92111238A patent/EP0523461B1/de not_active Expired - Lifetime
- 1992-07-02 DK DK92111238.9T patent/DK0523461T3/da active
- 1992-07-02 ES ES92111238T patent/ES2097242T3/es not_active Expired - Lifetime
- 1992-07-02 AT AT95108067T patent/ATE165078T1/de not_active IP Right Cessation
- 1992-07-02 EP EP95108067A patent/EP0675101B1/de not_active Expired - Lifetime
- 1992-07-02 DE DE59207927T patent/DE59207927D1/de not_active Expired - Fee Related
- 1992-07-14 JP JP4186658A patent/JPH05271104A/ja active Pending
- 1992-07-14 CA CA002073818A patent/CA2073818A1/en not_active Abandoned
- 1992-07-14 HU HU9202315A patent/HU220069B/hu not_active IP Right Cessation
- 1992-07-14 CZ CS19922202A patent/CZ286094B6/cs not_active IP Right Cessation
- 1992-07-14 HU HU0004999A patent/HU221753B1/hu not_active IP Right Cessation
-
1997
- 1997-03-27 US US08/826,258 patent/US6090913A/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2156050A1 (es) * | 1998-03-31 | 2001-06-01 | Nicolau Francisco E Palomo | Mejoras introducidas en la patente principal num. 9700745, por "sales de aminoacidos solubles de disolventes organicos y su uso en la preparacion de dipeptidos". |
Also Published As
Publication number | Publication date |
---|---|
CZ286094B6 (cs) | 2000-01-12 |
ATE148090T1 (de) | 1997-02-15 |
JPH05271104A (ja) | 1993-10-19 |
EP0523461B1 (de) | 1997-01-22 |
EP0523461A2 (de) | 1993-01-20 |
HU221753B1 (hu) | 2002-12-28 |
DE59207927D1 (de) | 1997-03-06 |
EP0675101B1 (de) | 1998-04-15 |
HU0004999D0 (en) | 2001-03-28 |
CZ220292A3 (en) | 1993-02-17 |
DK0523461T3 (da) | 1997-05-12 |
EP0675101A1 (de) | 1995-10-04 |
HUT61577A (en) | 1993-01-28 |
HU220069B (hu) | 2001-10-28 |
ATE165078T1 (de) | 1998-05-15 |
HU9202315D0 (en) | 1992-10-28 |
DE4124283A1 (de) | 1993-01-21 |
EP0523461A3 (en) | 1993-10-20 |
CA2073818A1 (en) | 1993-01-16 |
DE59209289D1 (de) | 1998-05-20 |
US6090913A (en) | 2000-07-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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