ES2095501T3 - Nuevos agentes yodados no ionicos de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen. - Google Patents

Nuevos agentes yodados no ionicos de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen.

Info

Publication number
ES2095501T3
ES2095501T3 ES92924727T ES92924727T ES2095501T3 ES 2095501 T3 ES2095501 T3 ES 2095501T3 ES 92924727 T ES92924727 T ES 92924727T ES 92924727 T ES92924727 T ES 92924727T ES 2095501 T3 ES2095501 T3 ES 2095501T3
Authority
ES
Spain
Prior art keywords
methyl
contain
new non
hydrogen
straight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92924727T
Other languages
English (en)
Inventor
Jimenez Jose L Martin
Colon Jose M Carretero
Sanz Antonio Martinez
Silva Ignacio Alonso
Martinez Juan R Harto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Invest Justesa Imagen S A Cent
Original Assignee
Invest Justesa Imagen S A Cent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Invest Justesa Imagen S A Cent filed Critical Invest Justesa Imagen S A Cent
Application granted granted Critical
Publication of ES2095501T3 publication Critical patent/ES2095501T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS AGENTES YODADOS NO IONICOS DE CONTRASTE A LOS RAYOS X DE ESTRUCTURA DIMERICA Y DE FORMULA GENERAL (I), EN LA QUE EL PUENTE DE UNION ES GLICINA O GLICINA N-SUSTITUIDA DONDE R1 ES UN RESTO POLIHIDROXIALQUILO LINEAL O RAMIFICADO DE 2 A 4 ATOMOS DE CARBONO, R2 ES HIDROGENO, METILO O UN RESTO POLIHIDROXIALQUILO LINEAL DE 2 A 3 ATOMOS DE CARBONO, R3 Y R8 IGUALES O DIFERENTES SON HIDROGENO, METILO O 2-HIDROXIETILO, R4 ES UN RESTO POLIHIDROXIALQUILO LINEAL O RAMIFICADO DE 2 A 4 ATOMOS DE CARBONO, R5 ES METILO, HIDROXIMETILO O METOXIMETILO, Y R6 Y R7 IGUALES O DIFERENTES SON HIDROGENO, METILO 2-HIDROXIETILO, E,3-DIHIDROXIPROPILO, R2 Y R5 JUNTOS PUENDEN FORMAR UN GRUPO DEL TIPO (A) DONDE N PUEDE SER DE 0 A 3. TAMBIEN SE REFIERE A LOS PROCEDIMIENTOS PARA LA OBTENCION DE LOS PRODUCTOS DE FORMULA (I) Y A LAS PREPARACIONES FARMACEUTICAS ACEPTABLES QUE CONTIENEN ESTOS PRODUCTOS.
ES92924727T 1991-11-18 1992-11-17 Nuevos agentes yodados no ionicos de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen. Expired - Lifetime ES2095501T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/ES1991/000080 WO1993010078A1 (es) 1991-11-18 1991-11-18 Nuevos agentes yodados no ionicos de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen

Publications (1)

Publication Number Publication Date
ES2095501T3 true ES2095501T3 (es) 1997-02-16

Family

ID=8270755

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92924727T Expired - Lifetime ES2095501T3 (es) 1991-11-18 1992-11-17 Nuevos agentes yodados no ionicos de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen.

Country Status (13)

Country Link
EP (1) EP0571593B1 (es)
JP (1) JPH06506478A (es)
AT (1) ATE144766T1 (es)
AU (1) AU665968B2 (es)
CA (1) CA2100338A1 (es)
DE (1) DE69214934T2 (es)
DK (1) DK0571593T3 (es)
ES (1) ES2095501T3 (es)
NO (1) NO932549L (es)
NZ (1) NZ245067A (es)
PT (1) PT101076B (es)
WO (2) WO1993010078A1 (es)
ZA (1) ZA928856B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9419203D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
DE19510864A1 (de) * 1995-03-16 1996-09-19 Schering Ag Röntgenkontrastmittel für die Computertomographie und Urographie
US5575905A (en) * 1995-05-24 1996-11-19 Nycomed Imaging As Iodination process
DE19627309C2 (de) * 1996-06-27 1999-07-29 Schering Ag Wäßrige injizierbare Formulierungen verwendbar als Kontrastmittel
EP4015509A1 (en) 2020-12-18 2022-06-22 Justesa Imagen S.A.U Organometallic compounds and their use as multimodal contrasting media for imaging diagnosis
CN115806498A (zh) * 2021-09-15 2023-03-17 大道隆达（北京）医药科技发展有限公司 5-氯乙酰胺基-2,4,6-三碘异酞酰氯的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065553A (en) * 1974-05-31 1977-12-27 Laboratoires Andre Guerbet X-Ray contrast media
AR207465A1 (es) * 1974-05-31 1976-10-08 Guerbet Lab Andre Procedimiento de preparacion de derivados de acido triiodoi2,4,6-(triiodo-2,4,6-benzoil)-amino-alcanoilaminobenzoico de acido triiodo-2,4,6-(triiodo-2,4,6-(triiodo-2,4,6-benzoil)-aminoalcanoilaminobenzoil)-amino-alcanoil-aminobenzoico y de acido triiodo-2,4,6-bis((triiodo-2,4,6-fenil)-carbamoil-metil)-aminoalcanoil-aminobenzoico
DE2852094A1 (de) * 1978-11-30 1980-06-12 Schering Ag Neue roentgenkontrastmittel
DE3038853A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)

Also Published As

Publication number Publication date
CA2100338A1 (en) 1993-05-19
PT101076A (pt) 1994-02-28
ATE144766T1 (de) 1996-11-15
NO932549D0 (no) 1993-07-14
ZA928856B (en) 1993-05-19
NZ245067A (en) 1994-09-27
NO932549L (no) 1993-09-17
JPH06506478A (ja) 1994-07-21
EP0571593B1 (en) 1996-10-30
DK0571593T3 (da) 1996-11-25
DE69214934T2 (de) 1997-02-27
WO1993010079A1 (es) 1993-05-27
WO1993010078A1 (es) 1993-05-27
PT101076B (pt) 1999-10-29
EP0571593A1 (en) 1993-12-01
AU3087292A (en) 1993-06-15
EP0571593A4 (en) 1993-09-17
DE69214934D1 (de) 1996-12-05
AU665968B2 (en) 1996-01-25

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