ES2095208T3 - Compuestos de tienotriazolodiazepina y usos farmaceuticos de los mismos. - Google Patents

Compuestos de tienotriazolodiazepina y usos farmaceuticos de los mismos.

Info

Publication number
ES2095208T3
ES2095208T3 ES89101581T ES89101581T ES2095208T3 ES 2095208 T3 ES2095208 T3 ES 2095208T3 ES 89101581 T ES89101581 T ES 89101581T ES 89101581 T ES89101581 T ES 89101581T ES 2095208 T3 ES2095208 T3 ES 2095208T3
Authority
ES
Spain
Prior art keywords
compounds
pharmaceutical uses
tienotriazolodiazepine
paf
tienotriazolodiacepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89101581T
Other languages
English (en)
Inventor
Minoru Moriwaki
Hiroshi Tanaka
Michio Terasawa
Tetsuya Tahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Application granted granted Critical
Publication of ES2095208T3 publication Critical patent/ES2095208T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

COMPUESTOS DE TIENOTRIAZOLODIACEPINA DE LA FORMULA: DONDE CADA SIMBOLO SE DEFINE COMO EN LA ESPECIFICACION Y SALES ACEPTABLES FARMACEUTICAMENTE DE ELLOS, Y SUS USOS FARMACEUTICOS. DICHOS COMPUESTOS EXHIBEN ACTIVIDAD ANTAGONICA PAF Y SE USAN PARA LA PREVENCION O TRATAMIENTO DE VARIAS DOLENCIAS INDUCIDAS POR PAF.
ES89101581T 1988-01-30 1989-01-30 Compuestos de tienotriazolodiazepina y usos farmaceuticos de los mismos. Expired - Lifetime ES2095208T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2040088 1988-01-30
JP10322188 1988-04-26
JP30836588 1988-12-06
JP31168888 1988-12-08

Publications (1)

Publication Number Publication Date
ES2095208T3 true ES2095208T3 (es) 1997-02-16

Family

ID=27457375

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89101581T Expired - Lifetime ES2095208T3 (es) 1988-01-30 1989-01-30 Compuestos de tienotriazolodiazepina y usos farmaceuticos de los mismos.

Country Status (7)

Country Link
US (1) US4937240A (es)
EP (1) EP0328924B1 (es)
KR (1) KR910004448B1 (es)
AT (1) ATE141605T1 (es)
CA (1) CA1324863C (es)
DE (1) DE68926972T2 (es)
ES (1) ES2095208T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
DE4010528A1 (de) * 1990-04-02 1991-10-17 Boehringer Ingelheim Kg Praeparativ chromatographisches trennverfahren zur herstellung enantiomerenreiner hetrazepine
DE4027470A1 (de) * 1990-08-30 1992-03-05 Boehringer Ingelheim Kg Neue hetrazepinoide amide
JP2959598B2 (ja) * 1990-10-12 1999-10-06 吉富製薬株式会社 光学活性なチエノトリアゾロジアゼピン化合物
DE4107521A1 (de) * 1991-03-08 1992-09-10 Boehringer Ingelheim Kg Neue acylaminosubstituierte hetrazepine
JP2009511437A (ja) * 2005-09-29 2009-03-19 インファーマティカ リミテッド Ｐｐａｒ作動薬ｉとしてのチオフェン誘導体
WO2012075456A1 (en) 2010-12-02 2012-06-07 Constellation Pharmaceuticals Bromodomain inhibitors and uses thereof
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
EP2705039B1 (en) 2011-05-04 2017-07-26 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
EP2721031B1 (en) 2011-06-17 2016-01-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
WO2013184878A1 (en) 2012-06-06 2013-12-12 Constellation Pharmaceuticals, Inc. Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof
US9969747B2 (en) 2014-06-20 2018-05-15 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[C]isoxazolo[4,5-e]azepin-4-yl)acetamide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3994941A (en) * 1975-10-20 1976-11-30 The Upjohn Company Preparation of 1-(2-phthalimidoethyl)-4H-s-tiazolo[4,3-a][1,4]benzodiazepines
DE3435973A1 (de) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
DE3502392A1 (de) * 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
ES2037013T3 (es) * 1986-01-21 1993-06-16 Boehringer Ingelheim Kg Procedimiento para preparar tieno-1,4-diazepinas.
DE3610848A1 (de) * 1986-04-01 1987-10-15 Boehringer Ingelheim Kg Neue 1,4-diazepine
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
ATE86256T1 (de) * 1987-05-28 1993-03-15 Yoshitomi Pharmaceutical Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben.
WO1988009792A1 (en) * 1987-06-08 1988-12-15 Yoshitomi Pharmaceutical Industries, Ltd. Ester-substituted thienotriazolodiazepine compounds and their medicinal use
EP0368175A1 (de) * 1988-11-06 1990-05-16 Boehringer Ingelheim Kg 3S,7S-3-(Morpholinocarbonyl)-5-(2-chlorphenyl)-7,10-dimethyl-3,4-dihydro-2H,7H-cyclopenta[4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin.

Also Published As

Publication number Publication date
KR910004448B1 (ko) 1991-06-29
DE68926972D1 (de) 1996-09-26
CA1324863C (en) 1993-11-30
EP0328924B1 (en) 1996-08-21
KR890011892A (ko) 1989-08-23
EP0328924A2 (en) 1989-08-23
EP0328924A3 (en) 1991-03-20
ATE141605T1 (de) 1996-09-15
DE68926972T2 (de) 1997-01-16
US4937240A (en) 1990-06-26

Similar Documents

Publication Publication Date Title
PT932398E (pt) Utilizacao do topiramento ou dos seus derivados para a producao de um medicamento para o tratamento de disturbios bipolares maniaco- depressivos
ES2095208T3 (es) Compuestos de tienotriazolodiazepina y usos farmaceuticos de los mismos.
UA19808A (uk) Спосіб одержаhhя феhілалкіламіhів або солей цих сполук
DE297436T1 (de) Behandlung von hyperhidrose, ichtyosis und faltenbildung.
NO871549D0 (no) Medikament for behandling av oeyenbetennelser.
ES2175161T3 (es) Derivados de piperazina como antagonistas de taquiquinina.
ES2177084T3 (es) Uso de derivados de benzohidrilo sulfinilo para tratar la somnolencia de origen medicamentoso.
DK143588D0 (da) Substituerede 9-amino-tetrahydroacridiner, deres fremstilling og anvendelse som laegemidler
NO871165L (no) 2-azolylmetyl-2-aryl-1,3-dioksolaner og deres salter, fremgangsmaate til deres fremstilling, midler inneholdende dem og deres anvendelse.
DE68909970D1 (de) Hautbehandlungsmittel.
DK166018C (da) N-oe2-(4-fluorphenyl)-1-methyl)-ethyl-n-methyl-n-propynylamin, isomere og salte deraf, deres fremstilling og farmaceutiske praeparater indeholdende dem
NO870998D0 (no) Fremgangsmaate for fremstilling av nye, terapeutisk aktive acetamid-derivater.
DE3687097D1 (de) Therapeutisches mittel zur behandlung haematopoietischer krankheiten.
DK366888A (da) Castanosperminestre og -glykosider, deres fremstilling og anvendelse som laegemidler
DK165985C (da) 1-cytosinderivater, fremgangsmaader til deres fremstilling, samt anvendelse af dem i og til fremstilling af laegemidler
MX7723A (es) Procedimiento de sintesis para obtener nuevos (benzofuran-2-il) imidazoles que tienen actividad farmaceutica y sus sales.
NO873835L (no) Fremgangsmaate for fremstilling av terapeutisk aktive karbocykliske pyridiner.
ES2089286T3 (es) Nuevas 2-amino-5-ciano-1,4-dihidropiridinas, procedimiento para su preparacion y su uso en medicamentos.
NL7801359A (nl) Actieve stof tegen nierstenen, niersteen geneesmiddel en hun toepassing.
ES2118248T3 (es) Esteres y amidas de 9-cloro-prostaglandina y su empleo para preparar medicamentos.
NO881768D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive 1,3-dioksaner.
DE3687233T2 (de) Pharmazeutische zusammensetzungen zur behandlung von hautkrankheiten.
ES2036533T3 (es) Derivados de 1,6-naftiridina, procedimientos para su obtencion y de medicamentos que los contienen para el tratamiento de enfermedades de los vasos sanguineos.
DK249288A (da) Substituerede silylalkylenaminer og farmaceutisk acceptable salte deraf, deres fremstilling og anvendelse
DE68905076T2 (de) Pharmazeutische Zusammensetzung für die Behandlung von Hautwunden.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 328924

Country of ref document: ES