ES2094758T3 - Nuevos compuestos bis-platino como agentes quimioterapeuticos. - Google Patents

Nuevos compuestos bis-platino como agentes quimioterapeuticos.

Info

Publication number
ES2094758T3
ES2094758T3 ES90913955T ES90913955T ES2094758T3 ES 2094758 T3 ES2094758 T3 ES 2094758T3 ES 90913955 T ES90913955 T ES 90913955T ES 90913955 T ES90913955 T ES 90913955T ES 2094758 T3 ES2094758 T3 ES 2094758T3
Authority
ES
Spain
Prior art keywords
platinum
sulfoxide
carboxylate
substituted
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90913955T
Other languages
English (en)
Inventor
Nicholas Farrell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Vermont
University of Vermont and State Agricultural College
Original Assignee
University of Vermont
University of Vermont and State Agricultural College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Vermont, University of Vermont and State Agricultural College filed Critical University of Vermont
Application granted granted Critical
Publication of ES2094758T3 publication Critical patent/ES2094758T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UN COMPLEJO DE BIS (PLATINO) QUE TIENE LA ESTRUCTURA (I), EN DONDE X, Y, Z, X'', Y'' Y Z'' SON LOS MISMOS LIGANDOS O DIFERENTES Y SON HALURO, SULFATO, FOSFATO, NITRATO, CARBOXILATO, CARBOXILATO SUSTITUIDO, DICARBOXILATO, AMINA PRIMARIA O SECUNDARIA DE DICARBOXILATO SUSTITUIDO, SULFOXIDO, FOSFINA, NITROGENO DEL TIPO PIRIDINA Y SIMILARES; PREFERENTEMENTE, HAY AL MENOS UN ENLACE PT-ANION EN CADA MOLECULA DE PT; Y A ES UNA DIAMINA O POLIAMINA. COMPLEJOS DE TRANSGEOMETRIA [PTX SUB 2(L)(L'')] DONDE AL MENOS L ES UN LIGANDO PLANAR COMO POR EJEMPLO PIRIDINA PERO PREFERENTEMENTE QUINOLINA Y L'' PUEDE SER AMINA, SULFOXIDO O SULFOXIDO SUSTITUIDO Y X ES CLORURO, NITRATO O CARBOXILATO. UN PROCESO PARA LA OBTENCION DE COMPLEJOS DE BIS (PLATINO) DONDE LAS DOS ESFERAS DE COORDINACION DE PLATINO PUEDEN CONTENER LIGANDOS DIFERENTES EN CADA ESFERA Y DONDE LA GEOMETRIA DE CADA ESFERA DE COORDINACION DE PLATINO PUEDE SER IGUAL O DIFERENTE.
ES90913955T 1989-09-01 1990-09-04 Nuevos compuestos bis-platino como agentes quimioterapeuticos. Expired - Lifetime ES2094758T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/401,919 US5107007A (en) 1989-09-01 1989-09-01 Bis-platinum complexes as chemotherapeutic agents

Publications (1)

Publication Number Publication Date
ES2094758T3 true ES2094758T3 (es) 1997-02-01

Family

ID=23589786

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90913955T Expired - Lifetime ES2094758T3 (es) 1989-09-01 1990-09-04 Nuevos compuestos bis-platino como agentes quimioterapeuticos.

Country Status (9)

Country Link
US (1) US5107007A (es)
EP (1) EP0489850B1 (es)
JP (2) JP3142866B2 (es)
AT (1) ATE145210T1 (es)
AU (1) AU645266B2 (es)
CA (1) CA2065271C (es)
DE (1) DE69029138T2 (es)
ES (1) ES2094758T3 (es)
WO (1) WO1991003482A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206400A (en) * 1986-07-07 1993-04-27 Ohio State University Diastereomeric mono- and di-substituted diamino cyclohexane compounds and the method of preparation thereof
US5380897A (en) * 1993-05-25 1995-01-10 Hoeschele; James D. Tri(platinum) complexes
US5409915A (en) * 1993-09-14 1995-04-25 The University Of Vermont And State Agricultural College Bis-platinum (IV) complexes as chemotherapeutic agents
IT1273391B (it) * 1994-03-31 1997-07-08 Boehringer Mannheim Italia Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono
EP0897389B1 (fr) * 1996-03-11 2002-07-03 Yoshinori Kidani Complexes de platine dinucleaires, procede pour leur preparation et compositions pharmaceutiques en contenant
ZA976422B (en) * 1996-07-22 1998-01-22 Boehringer Mannheim Italia New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity.
ZA976421B (en) * 1996-07-22 1998-01-22 Boehringer Mannheim Italia New bis-platinum complexes with polyamine ligands as antitumor agents.
EP0870770A1 (en) * 1997-04-10 1998-10-14 Kreatech Biotechnology B.V. A trans-platinum based compound, a diagnostic kit comprising said compound and a method for labeling a bio-organic molecule wherein use is made of said compound
EP0973785B1 (en) * 1997-04-10 2003-12-03 Kreatech Biotechnology B.V. Trans-platinum compound, and diagnostic kit
SE9703396D0 (sv) 1997-09-19 1997-09-19 Lincoln Binuclear complex
US6130245A (en) * 1998-10-26 2000-10-10 Unitech Pharmaceuticals, Inc. Dinuclear platinum complexes as cisplatin analogs for cancer treatment
US6001872A (en) * 1999-03-05 1999-12-14 Virginia Commonwealth University Water soluble transplatinum complexes with anti-cancer activity and method of using same
US6310047B1 (en) * 1999-08-24 2001-10-30 Virginia Commonwealth University High affinity DNA binding compounds as adjuvants in antisense technology
US7160908B2 (en) * 2003-03-04 2007-01-09 Unitech Pharmaceuticals, Inc. Dynamic anticancer platinum compounds
JP5193032B2 (ja) * 2005-06-30 2013-05-08 バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド モノアゾールリガンド白金類似体
US7238823B2 (en) * 2005-06-30 2007-07-03 Bionumerik Pharmaceuticals, Inc. Platinum complexes with mononitrile-containing ligands
ITMI20052449A1 (it) 2005-12-22 2007-06-23 Cell Therapeutics Europe Srl Nuovi bis-platino complessi ad attivita' antitumorale
WO2010005548A2 (en) * 2008-07-07 2010-01-14 Northwestern University Functionalization of carbon nanotubes with metallic moieties
KR20110126644A (ko) * 2009-01-31 2011-11-23 아이쥐에프 온콜로지, 엘엘씨 항암 단백질-백금 결합체
WO2011085772A1 (en) 2010-01-15 2011-07-21 Basf Se "process for the dmc-catalyzed preparation of polyols"
US10946028B2 (en) 2015-12-22 2021-03-16 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of sulfoxide derivative-coordinated platinum(II) complex
KR102224578B1 (ko) * 2019-01-30 2021-03-05 전남대학교산학협력단 뱀장어를 비롯한 저서성 어류와 저서생물의 통합어도시스템

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560782A (en) * 1982-11-19 1985-12-24 Research Corporation Anti-tumor diplatinum coordination compounds
US4533502A (en) * 1983-02-22 1985-08-06 Rochon Fernande D Platinum (II) compounds and their preparation
US4565884A (en) * 1983-05-10 1986-01-21 Andrulis Research Corporation Bis-platinum complexes as antitumor agents
DE3432320A1 (de) * 1984-09-03 1986-03-13 Behringwerke Ag, 3550 Marburg Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel
US4797393A (en) * 1986-07-25 1989-01-10 University Of Vermont And State Agricultural College Bis-platinum complexes as chemotherapeutic agents
EP0396588A1 (en) * 1987-12-18 1990-11-14 Boehringer Mannheim Italia S.P.A. Amino anthracenediones-bis platinum complexes, useful as antitumoral agents

Also Published As

Publication number Publication date
JP3142866B2 (ja) 2001-03-07
AU645266B2 (en) 1994-01-13
EP0489850B1 (en) 1996-11-13
WO1991003482A1 (en) 1991-03-21
AU6405090A (en) 1991-04-08
EP0489850A4 (en) 1992-11-04
DE69029138T2 (de) 1997-03-06
JP3200421B2 (ja) 2001-08-20
ATE145210T1 (de) 1996-11-15
DE69029138D1 (de) 1996-12-19
CA2065271C (en) 1996-02-20
US5107007A (en) 1992-04-21
EP0489850A1 (en) 1992-06-17
JP2000001496A (ja) 2000-01-07
JPH05500218A (ja) 1993-01-21
CA2065271A1 (en) 1991-03-02

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